A new three-dimensional Co(II)-mixed-ligand MOF: protective effect against acute cerebral infarction by reducing hs-CRP content and inflammatory response

2020 ◽  
Vol 61 (7) ◽  
Keyword(s):  
Inflammatory Response ◽  
Cerebral Infarction ◽  
Protective Effect ◽  
Three Dimensional ◽  
Mixed Ligand ◽  
Acute Cerebral Infarction ◽  
Hs Crp

Plaque enhancement in multi-cerebrovascular beds associates with acute cerebral infarction

2020 ◽  
pp. 028418512091560
Author(s):  
Bin Cui ◽  
Dandan Yang ◽  
Weimin Zheng ◽  
Ye Wu ◽  
Qi Yang ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Vessel Wall ◽  
Characteristic Curve ◽  
Three Dimensional ◽  
Area Under The Curve ◽  
Acute Cerebral Infarction ◽  
Intraplaque Hemorrhage ◽  
3D Mri ◽  
Vascular Bed ◽  
Traditional Risk Factors

Background It is valuable to explore the relationship between plaque characteristics and stroke by using three-dimensional (3D) magnetic resonance imaging (MRI) of the vessel wall. Purpose To investigate the association between plaque enhancement score (PES) of co-existing intracranial and extracranial carotid plaques and ischemic stroke using 3D MRI. Material and Methods Symptomatic patients were recruited and underwent cerebrovascular 3D MRI of the vessel wall. The number, enhancement degree, and stenosis of plaques in intracranial and extracranial carotid arteries were evaluated. The PES calculated by summing enhancement degree of all detected plaques was compared between patients with and without acute cerebral infarction (ACI) and its association with ACI was determined. Results Of 157 recruited patients, 118 (75.2%) had co-existing plaques. Patients with ACI had significantly greater PES of co-existing plaques compared with those without ACI (9, interquartile range [IQR] 5–11 vs. 5, IQR 2–7, P<0.001). The odds ratio for PES of co-existing plaques in discriminating ACI was 1.410 (95% confidence interval [CI] 1.146–1.735, P = 0.001) after adjustment for stenosis, intraplaque hemorrhage, and traditional risk factors. Receiver operating characteristic curve analysis showed that, in discriminating ACI, PES had higher area under the curve (AUC 0.693–0.764) than plaque number (AUC 0.625–0.683) and enhancement degree (AUC 0.570–0.706) alone in any vascular bed. The AUC of PES of co-existing plaques combined with stenosis, NIHSS scores, intraplaque hemorrhage, hyperlipidemia, and blood pressure reached 0.847. Conclusion Cerebrovascular plaque enhancement score combining plaque number and enhancement degree is independently associated with ACI. The enhancement score of co-existing plaques has higher strength in discriminating ACI compared with plaques in a single vascular bed.

Protective Effect of Paeoniflorin on Acute Cerebral Infarction in Rats

2020 ◽  
Vol 21 (8) ◽  
pp. 702-709
Author(s):  
Weilin Wu ◽  
Chenfeng Qiu ◽  
Xuewen Feng ◽  
Xiaoxiao Tao ◽  
Qian Zhu ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Cerebral Ischemia ◽  
Cerebral Infarction ◽  
Protective Effect ◽  
Brain Tissue ◽  
Cell Damage ◽  
Acute Cerebral Infarction ◽  
Neurological Deficits ◽  
Sod Activity ◽  
Acute Cerebral Ischemia

Objective: The purpose of this paper was to study the protective effect of paeoniflorin on acute cerebral ischemia. The animal model of cerebral infarction induced by Middle Cerebral Artery Occlusion (MCAO) was blocked by the suture method. Sixty SD rats were randomly divided into the shame group, MCAO group, paeoniflorin (60, 120, 240 mg/kg, respectively) and Nimodipine (NMDP) group (n = 10 per group). Methods: The rats were intragastrically administered immediately after the operation. After 7 days of gavage, the brains were decapitated at 24 h. Hematoxylin and Eosin (HE) staining was used to observe the degree of cell damage in the cerebral cortex of rats. Immunohistochemistry was used to detect silver plating and to observe changes in nerve cells. Rats in the model group showed obvious symptoms of neurological deficits, such as the ischemic morphological changed, the Malondialdehyde (MDA), Lactate Dehydrogenase (LD) content and lactate dehydrogenase (LDH) activity were significantly increased in the ischemic brain tissue, while the Superoxide Dismutase (SOD) activity was decreased. Results: The decrease in Na+-K+-ATPase activity was significantly lower than that in the sham group. The neurological symptoms and signs of MCAO in the different doses of paeoniflorin group were improved, and the neuronal edema in the cortical area was alleviated. The activities of SOD, LDH and Na+-K+-ATPase were significantly increased, and the contents of MDA and LD were decreased. Conclusion: Therefore, paeoniflorin could alleviate the degree of tissue damage in rats with acute cerebral infarction, inhabit the formation of free radicals in the brain tissue after ischemia, and reduce the degree of lipid peroxidation. Thus, the degree of cell damage was reduced greatly and a protective effect was showed on cerebral ischemia.

scholarly journals Effects of Intravenous Thrombolytic Therapy with Alteplase on Neurological Function, Coagulation Function and Serum Inflammatory Factors in Patients with Acute Cerebral Infarction

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Xianfang Yue ◽  
Hua Zhou
Keyword(s):  
Cerebral Infarction ◽  
Intravenous Thrombolysis ◽  
Neurological Function ◽  
Acute Cerebral Infarction ◽  
Inflammatory Factors ◽  
Control Group ◽  
Routine Treatment ◽  
Coagulation Function ◽  
Hs Crp ◽  
Thrombolysis Therapy

Objective: To investigate the effects of intravenous thrombolysis therapy with alteplase on neurological function, coagulation function and serum inflammatory factors in patients with acute cerebral infarction. Methods: A total of 96 patients with acute cerebral infarction admitted to our hospital from September 2017 to October 2019 were randomly divided into two groups, with 48 patients in each group. The control group (n=48) received routine treatment, and the observation group received intravenous thrombolysis therapy with alteplase on the basis of routine treatment. The neurological deficit score, prothrombin time(PT), activated partial thromboplastin time (APTT), tumor necrosis factor-a level (TNF-?), and high-sensitivity C-reactive protein (hs-CRP) were compared between the two groups after 15 days of treatment. Results: After treatment, NIHSS scores in both groups were lower than those before treatment; PT levels were increased, while APTT, TNF-? and hs-CRP levels were all decreased in both groups, and the changes in the observation group were greater than those in the control group, with statistically significant difference (P<0.05). Conclusions: Intravenous thrombolysis therapy with alteplase can improve the neurological function, coagulation function and serum levels of inflammatory factors in patients with acute cerebral infarction, which is worthy of clinical application.

scholarly journals Incidental Unruptured Intracranial Aneurysms Do Not Impact Outcome in Patients With Acute Cerebral Infarction

2021 ◽  
Vol 12 ◽  
Author(s):  
Xuan Wu ◽  
Zuowei Duan ◽  
Yihui Liu ◽  
Changwu Zhou ◽  
Zhiyun Jiao ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Infarction ◽  
Multivariable Analysis ◽  
Three Dimensional ◽  
Acute Cerebral Infarction ◽  
Nihss Score ◽  
Good Outcome ◽  
Poor Outcome ◽  
Tof Mra ◽  
Unruptured Intracranial Aneurysms

Background: This study was to examine the patients with acute cerebral infarction (ACI) treated at a single center over 9 years and who underwent Unruptured intracranial aneurysm (UIA) screening by three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA), and to explore the factors associated with outcomes.Methods: The outcome was the modified Rankin scale (mRS) score at 90 days after stroke onset. The outcome was classified into a good outcome (mRS score of 0–2 points) and poor outcome (mRS score of 3–6 points).Results: UIAs were found in 260 (6.5%) of 4,033 patients with ACI; 2,543 (63.1%) had a good outcome, and 1,490 (36.9%) had a poor outcome. There was no difference in outcomes between the two groups (P = 0.785). The multivariable analysis showed that age (OR = 1.009, 95%CI: 1.003–1.014, P = 0.003), diabetes (OR = 1.179, 95%CI: 1.035–1.342, P = 0.013), ischemic stroke history (OR = 1.451, 95%CI: 1.256–1.677, P &lt; 0.001), and baseline NIHSS score (OR = 1.034, 95%CI: 1.018–1.050, P &lt; 0.001) were independently associated with the 90-day outcomes in patients with ACI. The presence of incidental UIA was not associated with outcomes after ACI.Conclusions: Age, diabetes, ischemic stroke history, and baseline NIHSS score were independently associated with the early outcomes of patients with ACI.

STUDY ABOUT THE EFFECTIVENESS OF ATORVASTATIN AND ASPIRIN COMBINATION IN ANTI-INFLAMMATORY IN PATIENTS WITH ACUTE CEREBRAL INFARCTION

2012 ◽  
pp. 58-66
Author(s):  
Chuyen Le ◽  
Thi Bich Thuan Le ◽  
Dien Tuong Ho
Keyword(s):  
Treatment Group ◽  
Cerebral Infarction ◽  
Acute Cerebral Infarction ◽  
University Hospital ◽  
Inflammatory Factors ◽  
Fibrinogen Concentration ◽  
Hospital Data ◽  
Anti Inflammatory ◽  
Hs Crp ◽  
Inflammatory Effect

Background: The relationship between effective therapy of Atorvastatin+Aspirin in patients with acute cerebral infarction and inflammatory factors hs-CRP, fibrinogen. Materials and Methods: Clinical research trials and longitudinal follow-up, 66 patients with acute cerebral infarction treated at General-endocrinology internal Department-Hue University Hospital. Data were processing by conventional statistics methods and SPSS 15.0. Results: i) The concentration of hs-CRP, serum fibrinogen in patients with acute cerebral infarction increased very high: hs-CRP concentration was 6.46±4.49mg/L; fibrinogen was 4.59±1.52g/L. There was a close correlation between hs-CRP and fibrinogen at hospitalization (r=0.5055; p<0.001); moderate positive correlation between hs-CRP with the size of acute cerebral infarction at hospitalization (r=0.3775; p<0.01) and between fibrinogen with NMN the size of acute cerebral infarction (r=0.3343; p<0.01). ii) The anti-inflammatory effect of Atorvastatin and aspirin combination versus aspirin alone: +The difference of the hs-CRP, fibrinogen concentration at the hospital and after 1 month of treatment with Atorvastatin+Aspirin was (paired t 6.16; p<0.01) and (paired t 6.51; p<0.01), respectively. In the group treated with alone Aspirin, hs-CRP levels was (paired t 3.12; p<0.01) and fibrinogen was (paired t 4.93; p<0.01). + Significant anti-inflammatory effect of the combination treatment group compared with the treatment group alone: difference of concentration of hs-CRP between the two groups (1.60±0.65 vs. 4.11±2.54mg/l) with paired t -3.06 and p<0.05; difference of fibrinogen concentration (2.80±0.93 vs. 3.30±0.73g/l) with paired t -2.41 and p<0.05. Conclusion: Patients with acute cerebral infarction treated by Atorvastatin+Aspirin combination have significant effectiveness in reducing the concentration of inflammatory factors hs-CRP, fibrinogen compared with aspirin therapy alone.

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