scholarly journals Accuracy of Uric Acid and Cholesterol Levels Examination in Distinguishing Pleural Effusion Fluid Exudates and Transudates

2021 ◽  
Vol 6 (2) ◽  
pp. 159-167
Author(s):  
Yusup Subagio Sutanto ◽  
Keyword(s):  
Uric Acid ◽  
Pleural Effusion ◽  
Cholesterol Levels ◽  
Effusion Fluid

scholarly journals EVALUATION OF PLEURA EFUSION DETERMINATION BY LIGHT’S DAN HEFFNER’S CRITERIA

2019 ◽  
Vol 26 (1) ◽  
pp. 76
Author(s):  
Nor Jannah Ali ◽  
Ani Kartini Dr ◽  
Darmawaty Effendi Dr
Keyword(s):  
Pleural Effusion ◽  
Sensitivity And Specificity ◽  
Clinical Pathology ◽  
Medical Doctor ◽  
University Hospital ◽  
Fluid Accumulation ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Effusion Fluid

EVALUATION OF  PLEURA EFUSION DETERMINATION BY LIGHT’S DAN HEFFNER’S CRITERIANordjannah1, Ani Kartini2, Darmawaty ER 31 Medical Doctor Specialist Education Programe of Clinical Pathology, Faculty of Medicine Hasanuddin University/dr.Wahidin Sudirohusodo Hospital, Makassar2  Department of Clinical Pathology Faculty of Medicine, Hasanuddin University/ Labuang Baji Hospital  Makassar3 Department of Clinical Pathology Faculty of Medicine, Hasanuddin University/ Hospital Islam Faisal Hospital  Makassar  ABSTRACT Background : Pleural effusion is a condition of abnormal pleural fluid accumulation in the pleural cavity due to excessive transudation or exudation. Light’s criteria is used as the standard method to distinguish between exudates and transudates. Some recent studies reported misclassifications so several alternative criteria are developed, one of which is Heffner’s criteria. The purpose of this study was to determine the sensitivity and specificity of Heffner’s criteria in determining the type of pleural effusion.Methods : An observational study with cross sectional method using a pleural effusion fluid sample of patients examined at the Clinical Pathology Laboratory Instalation at Wahidin Sudirohusodo Hospital on July 2018. Total protein, LDH and cholesterol levels were examined in all samples that met the inclusion and exclusion criteria.Results : There were 45 samples of pleural effusion, 30 of which classified as transudate and 15 samples as exudates. Based on clinical diagnosis, the Light’s criteria obtained 3 misclassifications and Heffner’s criteria obtained 2 misclassifications. Based on the data above, the statistical data showed that Light’s criteria has sensitivity of 96,7 % and specificity of 86,7 %. Heffner’s criteria has sensitivity of 100 % and specificity of 86,7 %.  Conclusion : Heffner’s criteria offers better sensitivity and specificity than Light’s criteria. Heffner’s criteria can be used as an alternative in determining the type of pleural effusion Keywords: Heffner’s criteria, Light’s criteria, transudate, exudate, pleural effusion 

scholarly journals Significance of Serological Markers in Neurological Function and Progression Rate of Amyotrophic Lateral Sclerosis

2021 ◽  
Author(s):  
Xiaowen Chen ◽  
Junrong Li ◽  
Yingying Lv ◽  
Wei Zhang ◽  
xiujian Xu ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Creatine Kinase ◽  
Uric Acid ◽  
Total Cholesterol ◽  
Cystatin C ◽  
Control Group ◽  
Progression Rate ◽  
Cholesterol Levels ◽  
Als Patients ◽  
Lateral Sclerosis

Abstract Objective The present study was to investigate the significance of creatinine, uric acid, creatine kinase, total cholesterol, triglyceride, HCY (Homocysteine), and cystatin C in neurological function and progression rate of amyotrophic lateral sclerosis. Methods According to the diagnostic criteria of EI-Escorial (2000), 103 patients with ALS were enrolled. All patients were given corresponding serological tests at the initial diagnosis. The Revised ALS Functional Rating Scale (ALSFRS-R) and Disease Progression Rate (DPR) were evaluated. The detected indexes in blood tests included creatinine, uric acid, creatine kinase, total cholesterol, triglycerides, homocysteine, and cystatin C. All data were input into the computer, and the data analysis was performed by SPSS22.0 statistical software.Results 1. There were significant differences in creatinine, uric acid, creatine kinase,
total cholesterol, HCY and cystatin C between the two groups (P<0.05). The levels of uric acid and creatinine of ALS group were lower than those of the control group, and the levels of creatine kinase, total cholesterol, triglyceride, HCY and cystatin C were higher than that in the control group.
2. The results from correlation analysis demonstrated that there was a significant correlation between ALSFRS-R and creatinine (P<0.01), the correlation coefficient was 0.567 (positive correlation); There was also a significant correlation between DPR and creatinine (P<0.01), and the correlation coefficient was -0.808 (negative correlation). The correlations of DPR with triglyceride and total cholesterol were significantly negative correlated (P<0.05), with -0.201 and -0.210 of correlation coefficients, respectively. The remaining indexes did not show any correlation with ALSFRS-R and DPR.
Conclusions 1. Uric acid and creatinine of ALS patients were lower than that in healthy people. Creatine kinase, triglyceride, total cholesterol, HCY, and cystatin C in ALS patients were higher than those in health controls. There were significant metabolic abnormalities in ALS patients.
2. Creatinine level is an independent risk factor affecting ALSFRS-R. The creatinine and total cholesterol levels are also the independent risk factors affecting DPR. Creatinine and total cholesterol levels could be used as reliable indicators to evaluate the ALSFRS-R and DPR of ALS patients.

Changes in serum uric acid and cholesterol levels in men undergoing job loss

JAMA ◽  
1968 ◽  
Vol 206 (7) ◽  
pp. 1500-1507 ◽  
Author(s):  
S. V. Kasl
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Job Loss ◽  
Cholesterol Levels

Serum Uric Acid and Cholesterol Levels in Mongoloid and Non-Mongoloid Oligophrenics

1966 ◽  
Vol 112 (482) ◽  
pp. 91-94 ◽  
Author(s):  
L. M. Dalderup ◽  
H. Affourtit-Leeuw ◽  
P. A. F. van der Spek ◽  
G. H. M. Keller ◽  
H. J. Duin ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Serum Cholesterol ◽  
Dietary Fat ◽  
Acid Level ◽  
Serum Cholesterol Level ◽  
Serum Uric Acid Level ◽  
Elevated Serum ◽  
Cholesterol Levels ◽  
Fat Composition

A number of observations have been published with regard to elevated serum uric acid levels in patients with atherosclerotic (Eidlitz, 1961, 1962) and coronary disease (Gertler, Garn and Levine, 1951) and hyperuricaemia after myocardial infarction (Dreyfuss, 1959; Kohn and Prozan, 1959). Work has also been done on dominant traits for hyperuricaemia together with hypercholesterolaemia (Adlersberg, 1949; Harris-Jones, 1957; Salvini and Verdi, 1959; Schoenfeld and Goldberger, 1963). A greater incidence of cardiovascular diseases among gouty patients than among others has been noted (Gertler and Oppenheimer, 1953), as well as a tendency for spontaneous changes in the serum cholesterol level to be associated with changes of similar direction and magnitude in the serum uric acid level (Schoenfeld and Goldberger, 1963). In view of all these observations, an investigation was undertaken to ascertain whether the serum uric acid levels change with dietary fat composition as do the serum cholesterol levels.

scholarly journals Pleural Fluid Cholesterol Level in Differentiating Exudate from Trasudate Pleural Effusion

2020 ◽  
Vol 11 (4) ◽  
pp. 6478-6485
Author(s):  
Babu Rajendran ◽  
Suwetha Babu ◽  
Sheju Jonathan Jha J
Keyword(s):  
Pleural Effusion ◽  
Positive Predictive Value ◽  
Cholesterol Level ◽  
Negative Predictive Value ◽  
Pleural Fluid ◽  
Predictive Value ◽  
P Value ◽  
Cholesterol Levels ◽  
Specificity And Sensitivity

Correlation of pleural fluid cholesterol level with light’s criteria to differentiate exudate from transudate pleural effusion. Classification of transudate and exudate clinically was done independently based on the light's criteria. Pleural fluid cholesterol levels of 100 selected patients were obtained. The cholesterol levels were compared with the earlier obtained data to study its specificity and sensitivity in differentiating exudate from transudate effusion. It was found that pleural fluid cholesterol in comparison to protein values in differentiating exudate from transudate showed a sensitivity of 79.55%, specificity of 91.07%, the positive predictive value of 87.50%, the negative predictive value of 85.00%, with a P-value of <0.001. Comparison of pleural fluid cholesterol with LDH values showed a sensitivity of 86.36% specificity of 94.64%, the positive predictive value of 92.68%, the negative predictive value of 89.83%, with a P-value of <0.001. Also, a comparison of pleural fluid cholesterol to light's criteria showed a sensitivity of 100% and 86.4% in the transudative group and sensitivity of 100% and 91.1 % in the exudative group, respectively. Routine measurement of pleural fluid cholesterol may serve as a valuable diagnostic indicator for differentiating exudate from transudate effusion.

scholarly journals A study of uric acid levels in serum and pleural fluid as to differentiate between transudate and exudate in pleural effusion

2020 ◽  
Vol 7 (2) ◽  
pp. 216-220
Author(s):  
Kishore Y Jothula ◽  
◽  
Irigu V Kumar ◽  
N Vani ◽  
◽  
...  
Keyword(s):  
Uric Acid ◽  
Pleural Effusion ◽  
Pleural Fluid

scholarly journals Eosinophilic pleural effusion in an eleven-year-old boy

2021 ◽  
Vol 10 (2) ◽  
pp. 95-97
Author(s):  
Kashyap Narsingh Shakya ◽  
Anup Shrestha ◽  
Arabindra Yadav ◽  
Uttara Gautam ◽  
Rajesh Kumar Panday ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Autoimmune Disease ◽  
Eosinophil Count ◽  
Inadequate Response ◽  
Pleural Effusions ◽  
Effusion Fluid ◽  
Eosinophilic Pleural Effusion

Pleural effusion fluid with ?10% eosinophils may be seen in 5-16% of exudative pleural effusions. Its association with helminthic infestation is reported in the literature. This patient with left-sided eosinophilic pleural effusion was a referred case from another hospital and treated initially as parapneumonic. With inadequate response to antibiotics and a markedly high IgE level praziquantel was started. This resulted in rapid disappearance of symptoms, decrease in the eosinophil count, and radiological improvement. After exclusion of parapneumonic, tuberculosis, autoimmune disease, and malignancy, a trial of antihelminthics should be considered an option. This may spare unnecessary investigations.

scholarly journals Application of the Drowning Index to Opioid & Multidrug Intoxication Deaths: A Retrospective Analysis

2019 ◽  
Vol 9 (1-2) ◽  
pp. 44-50
Author(s):  
Lindsey T Ellis ◽  
Madeleine Opsahl ◽  
Deiter J. Duff ◽  
Carl C. Stacy
Keyword(s):  
Pleural Effusion ◽  
Retrospective Analysis ◽  
Cause Of Death ◽  
Weight Ratio ◽  
Spleen Weight ◽  
Organ Weights ◽  
Autopsy Findings ◽  
Effusion Fluid

Introduction: Drowning deaths present a challenge for forensic pathologists, because the autopsy findings may occur in many nondrowning scenarios. Previous studies have attempted to identify patterns in organ weights that may be specific for drowning. The drowning index (DI) has been defined as the weight ratio of the lungs and pleural effusion fluid to the spleen. Studies have suggested DI may be useful in confirming drowning as the cause of death. No studies have yet compared autopsy findings in drownings to those in drug-related deaths, in spite of their qualitative similarities. Materials and Methods: We compared the lung and pleural effusion weight, spleen weight, and DI from 536 autopsies ruled drowning, opioid, or multidrug intoxication, or hanging in Columbia, Missouri, from 2011 to 2016. Results: Opioid overdoses result in heavier lungs and spleens than drownings, multidrug overdoses, or hangings. There is no DI value at which a death can be definitively ascribed to drowning. The median DI was significantly higher in drownings than in opioid intoxications, multidrug intoxications, or hangings ( P < .0001; P = .001; P = .005). However, very few drowning cases (13.33%) had a DI >14.1. Additionally, many opioid and multidrug overdoses had a DI >14.1. The highest calculated DI value (DI = 33) was associated with multidrug intoxication. Conclusion: In our opinion, the DI has little, if any, utility in distinguishing between drowning and drug-related deaths.

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