Prevalence and Independent Factors for Fatty Liver and Significant Hepatic Fibrosis Using B-Mode Ultrasound Imaging and Two Dimensional-Shear Wave Elastography in Health Check-up Examinees

The study examines the possibilities of transient and two-dimensional shear wave elastography in the diagnosis of fibrosis in the most common chronic diffuse liver diseases of non-viral etiology: alcoholic and non-alcoholic fatty liver disease, as well as their combination. It was found that in patients suffering from these diseases, the values of aspartate and alanine aminotransferase, gamma-glutamyl transpeptidase, cholesterol, triglycerides, as well as the oblique vertical size of the right lobe of the liver were significantly (p0,05) higher than in patients of the control group. Moreover, most of these indicators reliably (p0,01) reached the highest values in patients suffering from fatty liver disease of alcohol-metabolic etiology, which confirms a more pronounced damaging effect on the liver with a combination of alcohol and metabolic factors. It has been established that the use of transient and two-dimensional elastography is characterized by high diagnostic significance in determining the stage of fibrosis in chronic diffuse liver diseases of non-viral etiology. The greatest diagnostic significance of elastographic research methods is noted in the third and fourth stages of fibrosis. In the second stage of fibrosis, the quality of diagnostic significance when using transient elastography was higher than when using two-dimensional shear wave. The use of transient and two-dimensional shear wave elastography in most cases avoids liver biopsy in patients suffering from chronic diffuse liver diseases of non-viral etiology. Therefore, in the diagnosis of chronic diffuse liver diseases, the presence and degree of fibrosis is a factor that will largely determine the prognosis, treatment tactics and the likelihood of complications in a particular patient.

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Extrahepatic biliary obstruction can interfere with hepatic fibrosis prediction using two‐dimensional shear wave elastography in dogs

Veterinary Radiology & Ultrasound ◽

10.1111/vru.12969 ◽

2021 ◽

Author(s):

Masahiro Tamura ◽

Hiroshi Ohta ◽

Tatsuyuki Osuga ◽

Noboru Sasaki ◽

Keitaro Morishita ◽

...

Keyword(s):

Shear Wave ◽

Hepatic Fibrosis ◽

Biliary Obstruction ◽

Shear Wave Elastography ◽

Two Dimensional ◽

Extrahepatic Biliary Obstruction

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Ultrasound elastography in patients with fatty liver disease

Radiologia Brasileira ◽

10.1590/0100-3984.2019.0028 ◽

2020 ◽

Vol 53 (1) ◽

pp. 47-55 ◽

Cited By ~ 1

Author(s):

Luiza de Campos Moreira da Silva ◽

Julia Teixeira de Oliveira ◽

Sandra Tochetto ◽

Claudia Pinto Marques Souza de Oliveira ◽

Rosa Sigrist ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Shear Wave ◽

Hepatic Fibrosis ◽

Fatty Liver Disease ◽

Transient Elastography ◽

Early Stage ◽

Effective Means ◽

Shear Wave Elastography ◽

Ultrasound Elastography

Abstract Hepatic steatosis, or fatty liver disease, occurs due to the accumulation of lipids in hepatocytes. When it becomes chronic, lobular inflammation develops and the disease can evolve to hepatic fibrosis, liver cirrhosis, or hepatocellular carcinoma. Early diagnosis is desirable because patients diagnosed in the early stage of the disease respond better to treatment. In the early stages of fatty liver disease, the physical examination is often unremarkable. Fatty liver disease and hepatic fibrosis can be diagnosed and monitored through laboratory tests, imaging, and biopsy. Among the imaging methods, ultrasound stands out as an effective means of diagnosing and following patients with liver disease. Ultrasound used in conjunction with elastography (ultrasound elastography) has recently shown great utility in the follow-up of such patients. Ultrasound elastography studies the degree of deformation (stiffness) of an organ or lesion, so that when there is hardening, fibrosis, or cirrhosis of the liver, those alterations are well demonstrated. In this review article, we discuss the application of the different types of ultrasound elastography for liver studies: transient elastography, point shear wave elastography, and two-dimensional shear wave elastography. Although magnetic resonance elastography may also be used in the analysis of liver fibrosis, it will not be addressed in this article.

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Noninvasive Assessment of Liver Diseases using 2D Shear Wave Elastography

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.254.lup ◽

2016 ◽

Vol 25 (4) ◽

pp. 525-532 ◽

Cited By ~ 8

Author(s):

Monica Lupșor-Platon ◽

Radu Badea ◽

Mirela Gersak ◽

Anca Maniu ◽

Ioana Rusu ◽

...

Keyword(s):

Shear Wave ◽

Predictive Value ◽

Liver Diseases ◽

Venous Pressure ◽

Liver Stiffness ◽

Shear Wave Elastography ◽

Acoustic Radiation Force Impulse ◽

Two Dimensional ◽

Non Invasive ◽

Examination Technique

There has been great interest in the development of non-invasive techniques for the diagnosis of liver fibrosis in chronic liver diseases, including ultrasound elastographic methods. Some of these methods have already been adequately studied for the non-invasive assessment of diffuse liver diseases. Others, however, such as two-dimensional Shear Wave Elastography (SWE), of more recent appearance, have yet to be validated and some aspects are for the moment incompletely elucidated. This review discusses some of the aspects related to two-dimensional SWE: the examination technique, the examination performance indicators, intra and interobserver agreement and clinical applications. Recommendations for a high-quality examination technique are formulated. Key words: – – – Two-dimensional Shear Wave Elastography. Abbreviations: 2D- SWE: Two-dimensional Shear Wave Elastography; 3D- SWE: Three-dimensional Shear Wave Elastography; AUROC: area under the receiver operating characteristic curves; ARFI Acoustic Radiation Force Impulse Elastography; EFSUMB: European Federation of Societies for Ultrasound in Medicine and Biology; HVPG: hepatic venous pressure gradient; LS: liver stiffness; LR: likelihood ratio; NPV: negative predictive value; PPV: positive predictive value; ROI: region of interest; RT-E: Real Time-Elastography; Se: sensitivity; Sp: specificity; TE: Transient Elastography; US: ultrasound; VM: valid measurement; E: Young’s modulus

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