scholarly journals Chronic thromboembolic pulmonary hypertension in an obese patient with type 2 diabetes mellitus

2021 ◽  
Vol 36 (3) ◽  
pp. 154-160
Author(s):  
E. N. Kliver ◽  
O. Vasiltseva ◽  
A. G. Edemskiy ◽  
D. S. Grankin ◽  
D. F. Zeinalov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Inferior Vena ◽  
Vena Cava ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Thromboembolic Pulmonary Hypertension ◽  
The Right ◽  
Vein Disease

Metabolic disorders represent a serious medical and social problem and are risk factors for the development of thromboembolic complications. Disturbances of both carbohydrate and fat metabolism contribute to an increase in blood viscosity, creating prothrombotic conditions, which are not always objectively assessed even by specialists. In addition, multiple comorbid conditions usually significantly complicate the prognosis. The article presents a clinical case of recurrent thrombosis of the right atrium and the orifices of the superior and inferior vena cava in a 39-year-old patient with type 2 diabetes mellitus, obesity, arterial hypertension, and varicose vein disease.

scholarly journals Test-Retest Reliability of Isokinetic Knee Strength Measurements in Type 2 Diabetes Mellitus Patients

2021 ◽  
Vol 13 (3) ◽  
pp. 1343
Author(s):  
José Carmelo Adsuar ◽  
Jose Parraca ◽  
Armando Raimundo ◽  
Miguel Angel Garcia-Gordillo ◽  
Patricia Polero ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peak Torque ◽  
Total Sample ◽  
Good For ◽  
The Right ◽  
Test Retest Reliability ◽  
Standard Error Of Measurement

Background: Reliability studies are used to verify the evaluation accuracy of a given device. Strength is an important factor for the development of daily activities and its correct management is fundamental. The objective of this study was to examine the reliability of a concentric strength test in people with type 2 diabetes mellitus (T2DM). Methods: Twenty-seven individuals with T2DM performed three repetitions of extension-flexion in concentric-concentric action at 60°/s, for both legs, using an isokinetic dynamometer. For the reliability analysis, we performed an intra-session test retest. Results: The total sample and men sub-group intra-class correlation coefficient (ICC) values were excellent for peak torque and work. In the women sub-group, ICC values were excellent for extensors in both peak torque and work; however, concerning flexor, the ICC values were good for peak torque while, for work, they were good for the right leg and moderate for the left leg. Standard error of measurement (SEM) percentage oscillated from 3.85% to 6.80%, with the smallest real difference (SRD) percentage being from 10.66% to 18.86% for peak torque. Furthermore, the SEM (%) was around 5.5% and SRD (%) was around 15% for work. Conclusions: The isokinetic dynamometry had “good” to “excellent” relative reliability for peak torque (0.862–0.983) and work (0.744–0.982) of extension-flexion in concentric-concentric action at 60°/s. In addition, our study showed that, in general, an SRD < 20% could indicate a true change in strength regarding this protocol in T2DM.

scholarly journals A patient who does not like insulin

ABOUTOPEN ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. 122-125
Author(s):  
Paola Ubaldi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
General Population ◽  
Bone Metastases ◽  
Cancer Symptoms ◽  
The Past ◽  
The Right ◽  
Hypoglycemic Therapy

Hypoglycemic therapy over the past 20 years has expanded considerably with the use of new classes of more effective and safer medicines. Alongside the aging of the general population, the survival of diabetic subjects has significantly increased, thus exposing them to a greater risk of developing co-morbidities. This represents a challenge for the diabetologist, who must acquire ever broader concepts for the management of a complex and multi-organ disease. We report the case of a 72-year-old woman with type 2 diabetes mellitus and pulmonary adenocarcinoma of the right upper lobe with brain and bone metastases who, subjected to innovative and integrated treatments agreed between specialists of different disciplines, is still alive and free of cancer symptoms 23 months after diagnosis (Diabetology)

scholarly journals Aberrant Brain Spontaneous Activity and Synchronization in Type 2 Diabetes Mellitus Subjects Without Mild Cognitive Impairment

2021 ◽  
Vol 15 ◽  
Author(s):  
Yifan Li ◽  
Mingrui Li ◽  
Yue Feng ◽  
Xiaomeng Ma ◽  
Xin Tan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Spontaneous Activity ◽  
Supplementary Information ◽  
Middle Occipital Gyrus ◽  
The Right

Objective: We aimed to explore whether the percent amplitude of fluctuation (PerAF) measurement could provide supplementary information for amplitude of low-frequency fluctuation (ALFF) about spontaneous activity alteration in type 2 diabetes mellitus (T2DM) subjects without mild cognitive impairment (MCI). Then we further evaluated the synchronization through the method of functional connectivity (FC) to better demonstrate brain changes in a more comprehensive manner in T2DM.Methods: Thirty T2DM subjects without MCI and thirty well-matched healthy subjects were recruited in this study. Subjects’ clinical data, neuropsychological test results, and resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired. Voxel-based group difference comparisons between PerAF and ALFF were conducted. Then, seed-based FC between the recognized brain regions based on PerAF and ALFF and the rest of the whole brain was performed.Results: Compared with healthy group, T2DM group had significantly decreased PerAF in the bilateral middle occipital gyrus and the right calcarine, increased ALFF in the right orbital inferior frontal gyrus and decreased ALFF in the right calcarine. Seed-based FC analysis showed that the right middle occipital gyrus of T2DM subjects exhibited significantly decreased FC with the right caudate nucleus and right putamen. According to the partial correlation analyses, hemoglobin A1c (HbA1c) and immediate memory scores on the auditory verbal learning test (AVLT) were negatively correlated in the T2DM group. However, we found that total cholesterol was positively correlated with symbol digit test (SDT) scores.Conclusion: PerAF and ALFF may have different sensitivities in detecting the abnormal spontaneous brain activity in T2DM subjects. We suggest PerAF values may add supplementary information and indicate additional potential neuronal spontaneous activity in T2DM subjects without MCI, which may provide new insights into the neuroimaging mechanisms underlying early diabetes-associated cognitive decline.

scholarly journals Right costophrenic angle abscess due to Salmonella Dublin infection in combination with type 2 diabetes mellitus

2021 ◽  
Vol 49 (12) ◽  
pp. 030006052110664
Author(s):  
Nanxi Dong ◽  
Fujun Wang ◽  
Yuekao Li ◽  
Hongfang Ma ◽  
Na Xing ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ct Guided ◽  
Persistent Fever ◽  
Salmonella Dublin ◽  
Short Period ◽  
Costophrenic Angle ◽  
The Right

The main manifestations of type 2 diabetes mellitus are excessive drinking, polyphagia, polyuria and wasting or weight loss in a short period of time, but it is rare to have persistent fever of unknown origin as the main manifestation. This case report describes a 68-year-old male patient with type 2 diabetes mellitus presenting with unexplained fever with persistent exacerbation and a cystic lesion in the right costophrenic horn on abdominal computed tomography (CT). A cytoculture examination of the puncture fluid suggested that the infection was due to Salmonella Dublin. The patient was treated with drainage of the abscess in the right costophrenic angle area, which then healed successfully. These findings suggest that Salmonella Dublin infection should be considered when a patient with type 2 diabetes mellitus presents with an unexplained persistent fever. At the same time, CT-guided abscess puncture can be performed to improve the patient's symptoms, aid diagnosis and improve the quality of life.

scholarly journals Silent myocardial ischemia in patients with type 2 diabetes mellitus: a clinical case

2021 ◽  
Vol 17 (4) ◽  
pp. 39-42
Author(s):  
O.O. Prokhorova ◽  
M.S. Brynza
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Coronary Artery ◽  
Lower Extremities ◽  
Left Ventricular ◽  
Silent Myocardial Ischemia ◽  
Type 2 Dm ◽  
The Right

Background. Type 2 diabetes mellitus (DM) is an important medical, social, and economic problem due to the high prevalence of the disease, which often leads to disability and significantly increases mortality in elderly people. One of the causes of coronary heart disease (CHD) in patients with type 2 DM is autonomic cardiovascular neuropathy, which is characterized by damage to the autonomic nervous system and manifests itself in a varying clinical picture, including silent myocardial ischemia (SMI). The prevalence of SMI among patients with type 2 DM is much higher than in people without it. The purpose was to study the cli­nical case of a patient with type 2 DM and CHD, raise awareness of the prevalence and influence of type 2 DM on CHD progression by focusing on diagnostic research and treatment strategies. Materials and methods. The clinical case of the detected silent ischemia in a patient with type 2 DM was analyzed. The complaints were as following: high blood pressure, moderate shortness of breath du­ring walking, pain, and numbness of the lower extremities. Ana­mnesis: type 2 DM over 20 years; endovascular stenting of the right common iliac artery due to obliterating atherosclerosis of the arteries of the lower extremities; hypertension over 10 years; obesity. Based on this data, CHD was suspected. Results. The Holter monitoring revealed rare episodes of reversible ischemic repolarization. ECG demonstrated the deviation of the electrical axis to the left, hypertrophy of the left ventricular myocardium, diffuse violation of repolarization processes. Ultrasound of the heart found aortic atherosclerosis, left ventricular myocardial hypertrophy, a moderate decrease in myocardial contractility. Ultrasound of vessels of the lower extremities showed the signs of oblitera­ting atherosclerosis with decompensation of peripheral blood flow. Coronary angiography demonstrated left coronary artery with critical subocclusions (90 %), right coronary artery with chronic occlusion in the middle segment (100 %). There was established the diagnosis: coronary heart disease (silent ischemia); diffuse stenotic atherosclerosis of the coronary artery (coronary angiography May 2019); arterial hypertension II stage, degree 2; HF II stage; II NYHA; type 2 diabetes mellitus, insulin-dependent, decompensated; obesity I stage; obliterating atherosclerosis of the arteries of the lower extremities (condition after endovascular stenting of the right common iliac artery on January 2018); chronic pancreatitis in remission, peptic ulcer of the duodenum (operated in 1981); chronic cholecystitis in remission. The treatment was prescribed: insulin therapy, nebivolol, eplerenone, candesartan, clopidogrel, rosuvastatin. Coronary artery bypass grafting is recommended. Conclusions. Thereby, timely diagnosis and adequate treatment can avoid complications of type 2 DM and improve quality and lifetime. With type 2 DM, CHD is often masked and remains undiagnosed, leading to complications and death, therefore more attention to such patients is needed.

scholarly journals Effect of sitagliptine and vildagliptine on carotid intima/media thickness in patients with type 2 diabetes mellitus

2021 ◽  
Vol 9 (5) ◽  
pp. 1388
Author(s):  
Ganeswar Sethy ◽  
Geetanjali Sethy ◽  
Ranjit Rout ◽  
Abinash Panda ◽  
Adya Anwesha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Control Group ◽  
P Value ◽  
Media Thickness ◽  
The Right

Background: Atherosclerosis is a known macro-vascular complication of diabetes mellitus. Gliptins, as a drug class have non-glycemic beneficial action on blood vessels and in addition to their anti-diabetic effects. This study was carried out to find out the effects of sitagliptin and vildagliptin on common carotid intima-media thickness in patients with type 2 diabetes mellitus.Methods: The observational longitudinal study was carried out on 100 patients with 80 patients with confirmed clinical diagnosis of type 2 diabetes mellitus. They were divided in 3 groups. Group A and Group B received drugs, either sitagliptine or vildagliptin and Group C control group did not receive any drug. High resolution B-mode ultrasonography was carried out for the measurement of intima-media thickness (IMT) of both the common carotid arteries (CCA). Data analysis was done using Microsoft excel spreadsheet and GraphPad Prism version 7.0 (free trial version) software package. A p value of ≤ 0.05 was considered as statistically significant.Results: The baseline value for the control group was 0.812±0.0748 mm for both the right and left CCA. At 52 weeks the CCA IMT for the right and left CCA were 1.0185± 0.272 mm and 0.936±0.149 mm respectively. At 104 weeks the CCA IMT for the right and left CCA were 0.923±0.243 mm and 0.859±0.123 mm respectively.Conclusions: There was a significant decrease in carotid intima-media thickness in patients of type-2 diabetes mellitus treated with sitagliptin and vildagliptin.

scholarly journals Case Report on pyoderma gangrenosum associated with Ulcerative Colitis

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2900-2902
Author(s):  
Anusha Narayanan ◽  
Rama P Venu ◽  
Roshni PR
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Ulcerative Colitis ◽  
Type 2 Diabetes Mellitus ◽  
Pyoderma Gangrenosum ◽  
Pedal Oedema ◽  
Neutrophilic Dermatoses ◽  
History Of ◽  
The Right

Pyoderma gangrenosum is rare neutrophilic dermatoses that exist as inflammatory and ulcerative disorders of the skin and is neither an infectious nor gangrenous condition. It is commonly associated with an autoimmune disease like ulcerative colitis and crohn’s disease. It has an estimated incidence of 3-10 cases per million people per year. This is a case of a 28-year-old patient who was admitted with features of pyoderma gangrenosum: papule over the shin of the right leg which progressively increased in size. She had a history of ulcerative colitis and type 2 Diabetes mellitus and developed a papule in the right leg one month back which progressed to a larger ulcer and a similar lesion developing proximal to this. The lesions were painful, two lesions over the right tibial shin each measuring about 5x5cm, with erythema, pedal oedema and associated with fever and She was treated with antibiotics, steroids (hydrocortisone), cyclosporine and other supportive care. Daily dressing of the wound was done, and saline compresses were applied and was advised to continue the same after discharge. With the above measures, she improved clinically and was stable at discharge. As there is no diagnostic test for PG (since it is a diagnosis of exclusion) and if the disease is present but unrecognized, the results can be devastating. Hence timely onset of therapeutic approach is of utmost importance.

Sign in / Sign up

Export Citation Format

Share Document