scholarly journals Dose Analysis of Gadolinium Neutron Capture Therapy (GdNCT) on Cancer Using SHIELD-HIT12A

2018 ◽  
Vol 35 (3) ◽  
pp. 209-212 ◽  
Author(s):  
Bagus Novrianto Fasni ◽  
Yohannes Sardjono ◽  
Boni Pahlanop Lapanporo
Keyword(s):  
Atomic Nucleus ◽  
Soft Tissue ◽  
Cancer Therapy ◽  
Neutron Capture ◽  
Recoil Energy ◽  
Cancer Tissue ◽  
Neutron Capture Therapy ◽  
Output Data ◽  
Dose Determination ◽  
Atomic Nuclei

This research aimed to determine the dose of radiation received in cancer therapy for each decay of Gadolinium atomic nuclei with isotope 157 (157Gd) in Gadolinium Neutron Capture Therapy using the SHIELD-HIT12A program. Knowing the amount of dose given to cancer tissue should aid in minimizing the damage that could occur in the healthy tissue around the cancer tissue, effectively killing only the cancer cells. The simulation employed in this research used the SHIELD-HIT12A program by providing input on beam.dat, mat.dat, detect.dat, and geo.dat files. The output data from the program comprised the value of recoil energy lost (energy absorbed into the target materials) for each of the 157Gd atomic nuclei, which was then processed by the dose determination equation to determine the dose given by the 157Gd nucleus to soft tissue. Based on the results, the amount of the dose given by each atomic nucleus 157Gd to soft tissue was 5.44 × 1011 Gy/decay.

Dose determination using alanine detectors in a mixed neutron and gamma field for boron neutron capture therapy of liver malignancies

2011 ◽  
Vol 50 (6) ◽  
pp. 817-822 ◽  
Author(s):  
Tobias Schmitz ◽  
Matthias Blaickner ◽  
Markus Ziegner ◽  
Niels Bassler ◽  
Catrin Grunewald ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Liver Malignancies ◽  
Dose Determination ◽  
Boron Neutron Capture ◽  
Gamma Field

scholarly journals Boron neutron capture therapy: Moving toward targeted cancer therapy

2016 ◽  
Vol 12 (2) ◽  
pp. 520 ◽  
Author(s):  
Hamed Mirzaei ◽  
HamidReza Mirzaei ◽  
Amirhossein Sahebkar ◽  
Rasoul Salehi ◽  
JavidSadri Nahand ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Targeted Cancer Therapy ◽  
Boron Neutron Capture

scholarly journals DOSE ANALYZE OF BORON NEUTRON CAPTURE THERAPY (BNCT) AT SKIN CANCER MELANOMA USING MCNPX WITH NEUTRON SOURCE FROM THERMAL COLUMN OF KARTINI REACTOR

2017 ◽  
Vol 2 (3) ◽  
pp. 111
Author(s):  
Siti Rosidah ◽  
Yohannes Sardjono ◽  
Yosaphat Sumardi
Keyword(s):  
Skin Cancer ◽  
Neutron Flux ◽  
Dose Rate ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Irradiation Time ◽  
Cancer Tissue ◽  
Neutron Capture Therapy ◽  
Radiation Dose Rate ◽  
Boron Neutron Capture

<span>This research aims to determine the amount of radiation dose rate that can be accepted and the irradiation time that is required from Boron Neutron Capture Therapy (BNCT) cancer therapy to treat melanoma skin cancer. This research used the simulation program, MCNPX by defining the geometric dimensions of the tissue component, and describing the radiation source that were used. The outputs obtained from the MCNPX simulation were the neutron flux and the neutron scattering dose that came out from the collimator. The value of neutron flux was used to calculate the dose which comes from the interaction between the neutron and the material in the cancer tissue. Based on the results of the research, the dose rate to treat cancer tissue for boron is 10 μg/g of tumor, which translates to about 0.019241 Gy/second and  requires 25.98 minutes of irradiation time, 15 μg/g of tumor translates to 0.021854 Gy/second and requires 2.,87 minutes, 20 μg/g of tumor translates to 0.022902 Gy/second and requires 21,83 minutes, 25 μg/g of tumor translates to 0.0271275 Gy/second and requires 18.43 minutes, 30 μg/g of tumor translates to 0.0297658 Gy/second and requires 16.79 minutes, and 35 μg/g of tumor translates to 0.0343472 Gy/second and requires 14.55 minutes . The irradiation time needed for cancer tissue is shorter when boron concentration greater at the cancerous tissue.</span>

scholarly journals ANIMATION OF BORON NEUTRON CAPTURE CANCER THERAPY

2018 ◽  
Vol 3 (3) ◽  
pp. 102-112
Author(s):  
Indra Maulana
Keyword(s):  
Cancer Therapy ◽  
Neutron Capture ◽  
Normal Cell ◽  
Causes Of Death ◽  
Advanced Technology ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Common Causes ◽  
New Knowledge ◽  
The World

One of the most common causes of death in the world is cancer. Scientists have been trying to find the best cure for cancer ever since it was discovered. There are some ways that are used to treat cancer patients. Lately, scientists have developed a new way in treating cancer, it’s called Boron Neutron Capture Therapy (BNCT). BNCT is a selective cancer therapy, it only selects the cancer cells to be treated and leaves the normal cell untouched. It may have no effect or only a little effect on normal cells. As new knowledge that needs to be known by all people, what is the best way to introduce BNCT? What is the best media to introduce BNCT? Is it enough to just read it in a newspaper or in a book? How about using advanced technology such as animation to introduce BNCT? The use of animation as a form of media to introduce something new is already being done in many fields. Can animation be used as a form of media to introduce BNCT too? Will it be effective? By this study, the author gives information about the effect of using animation as a tool to explain and understand BNCT more.

scholarly journals Dendrimer-based nanoparticles for cancer therapy

Hematology ◽  
2009 ◽  
Vol 2009 (1) ◽  
pp. 708-719 ◽  
Author(s):  
James R. Baker
Keyword(s):  
Cancer Therapy ◽  
Contrast Agents ◽  
Neutron Capture ◽  
New Technologies ◽  
Imaging Techniques ◽  
Neutron Capture Therapy ◽  
Cancer Therapies ◽  
Diagnosis And Therapy ◽  
Boron Neutron Capture ◽  
Cancer Diagnosis And Therapy

AbstractRecent work has suggested that nanoparticles in the form of dendrimers may be a keystone in the future of therapeutics. The field of oncology could soon be revolutionized by novel strategies for diagnosis and therapy employing dendrimer-based nanotherapeutics. Several aspects of cancer therapy would be involved. Diagnosis using imaging techniques such as MRI will be improved by the incorporation of dendrimers as advanced contrast agents. This might involve novel contrast agents targeted specifically to cancer cells. Dendrimers can also be being applied to a variety of cancer therapies to improve their safety and efficacy. A strategy, somewhat akin to the “Trojan horse,” involves targeting anti-metabolite drugs via vitamins or hormones that tumors need for growth. Further applications of dendrimers in photodynamic therapy, boron neutron capture therapy, and gene therapy for cancer are being examined. This presentation will cover the fundamentals of research utilizing dendrimers for cancer diagnosis and therapy. An evaluation of this new technologies will detail what advantage dendrimer based therapeutics might have over conventional cancer drugs.

Sign in / Sign up

Export Citation Format

Share Document