scholarly journals MONOCYTES, MACROPHAGES, DENDRITIC AND MYELOID SUPPRESSOR CELLS: GENESIS, CLASSIFICATION, IMMUNOBIOLOGICAL PROPERTIES

2018 ◽  
Vol 15 (3) ◽  
pp. 363-382
Author(s):  
L. P. Titov
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Immune Responses ◽  
Autoimmune Diseases ◽  
Suppressor Cells ◽  
Mononuclear Phagocyte ◽  
Natural Immunity ◽  
Myeloid Suppressor Cells ◽  
T Cell Immune Responses

The article presents the modern data on the most important component of natural immunity – cells of the mononuclear phagocyte system. The questions of origin, the spectrum of expressed markers of differentiation, the classification of monocytes (classical, intermediate, non-classical), macrophages (pro-inflammatory and anti-inflammatory) and dendritic cells (myeloid, plasmacytoid), their immunobiological functions, their role in humoral and T-cell immune responses, anergy and tolerance are considered. The possibility of obtaining cellular immunobiological products (adjuvant and tolerogenic) for immunotherapy of oncological, infectious and autoimmune diseases on their basis is analyzed.

Baculovirus activates murine dendritic cells and induces non-specific NK cell and T cell immune responses

2010 ◽  
Vol 262 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Tomoyuki Suzuki ◽  
Myint Oo Chang ◽  
Masayuki Kitajima ◽  
Hiroshi Takaku
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Immune Responses ◽  
Nk Cell ◽  
T Cell Immune Responses

scholarly journals Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Yan Wang ◽  
Xiaodong Gu ◽  
Jianbin Xiang ◽  
Zongyou Chen
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Molecular Mechanisms ◽  
Cell Function ◽  
Suppressor Cells ◽  
Heterogeneous Population ◽  
Myeloid Derived Suppressor Cells ◽  
Transplant Tolerance ◽  
Pathological Conditions ◽  
T Cell Immune Responses

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.

scholarly journals Mice Lacking Expression of the Chemokines Ccl21-Ser and Ccl19 (plt Mice) Demonstrate Delayed but Enhanced T Cell Immune Responses

2001 ◽  
Vol 193 (2) ◽  
pp. 207-218 ◽  
Author(s):  
Shigeyuki Mori ◽  
Hideki Nakano ◽  
Kentaro Aritomi ◽  
Chrong-Reen Wang ◽  
Michael D. Gunn ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Immune Responses ◽  
Cell Response ◽  
T Cell Response ◽  
Lymphoid Organs ◽  
Cell Responses ◽  
T Cell Immune Responses ◽  
Secondary Lymphoid Organs

The paucity of lymph node T cells (plt) mutation leads to a loss of CCL21 and CCL19 expression in secondary lymphoid organs. plt mice have defects in the migration of naive T cells and activated dendritic cells into the T cell zones of lymphoid organs, suggesting that they would have defects in T cell immune responses. We now demonstrate T cell responses in plt mice are delayed but ultimately enhanced. Responses to contact sensitization are decreased at day 2 after priming but increased at day 6. After subcutaneous immunization, antigen-specific T cell proliferation and cytokine production in plt mice are increased and remain markedly elevated for at least 8 wk. Compared with wild-type mice, a proportion of T cell response in plt mice are shifted to the spleen, and prior splenectomy reduces the T cell response in draining lymph nodes. After immunization of plt mice, T cells and dendritic cells colocalize in the superficial cortex of lymph nodes and in splenic bridging channels, but not in T cell zones. These results demonstrate that plt mice mount robust T cell responses despite the failure of naive T cells and activated dendritic cells to enter the thymus dependent areas of secondary lymphoid organs.

scholarly journals EBV LMP2A-specific T Cell Immune Responses Elicited by Dendritic Cells Loaded with LMP2A Protein

2009 ◽  
Vol 6 (4) ◽  
pp. 269-276 ◽  
Author(s):  
Yun Chen ◽  
Hua Sun ◽  
Genyan Liu ◽  
Bing Wang ◽  
Fang Wang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Immune Responses ◽  
T Cell Immune Responses

scholarly journals Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells

2009 ◽  
Vol 10 (5) ◽  
pp. 504-513 ◽  
Author(s):  
Anne S Dejean ◽  
Daniel R Beisner ◽  
Irene L Ch'en ◽  
Yann M Kerdiles ◽  
Anna Babour ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Transcription Factor ◽  
T Cell ◽  
Immune Responses ◽  
T Cell Immune Responses

Aryloxy Triester Phosphonamidates of Phosphoantigens Exhibit Favorable Stability and Potent Activation of Vγ9/Vδ2 T‐Cells

2018 ◽  
Author(s):  
Hachemi Kadri ◽  
Taher E. Taher ◽  
Qin Xu ◽  
Richard T. Bryan ◽  
Benjamin E. Willcox ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Immune Responses ◽  
Serum Stability ◽  
T Cell Immune Responses ◽  
Further Development

We previously reported the application of the aryloxy triester phosphoramidate prodrug technology to the phosphoantigen (E)-4-hydroxybut-2-enyl phosphate (HMBP). Although these prodrugs exhibited potent activation of Vγ9/Vδ2 T‐cell immune responses, their stability was low due to the rapid cleavage of the -O-P- bond. To address this, we herein report the application of the same prodrug strategy to two HMBP phosphonates, which have stable -CH2-P- or -CF2-P- bonds. These HMBP phosphonate prodrugs, phosphonamidates, exhibited excellent serum stability and potent activation of Vgama9/Vdelta2 T‐cells making them attractive compounds for further development as potential immunotherapeutics.

Aryloxy Triester Phosphonamidates of Phosphoantigens Exhibit Favorable Stability and Potent Activation of Vγ9/Vδ2 T‐Cells

2018 ◽  
Author(s):  
Hachemi Kadri ◽  
Taher E. Taher ◽  
Qin Xu ◽  
Richard T. Bryan ◽  
Benjamin E. Willcox ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Immune Responses ◽  
Serum Stability ◽  
T Cell Immune Responses ◽  
Further Development

We previously reported the application of the aryloxy triester phosphoramidate prodrug technology to the phosphoantigen (E)-4-hydroxybut-2-enyl phosphate (HMBP). Although these prodrugs exhibited potent activation of Vγ9/Vδ2 T‐cell immune responses, their stability was low due to the rapid cleavage of the -O-P- bond. To address this, we herein report the application of the same prodrug strategy to two HMBP phosphonates, which have stable -CH2-P- or -CF2-P- bonds. These HMBP phosphonate prodrugs, phosphonamidates, exhibited excellent serum stability and potent activation of Vgama9/Vdelta2 T‐cells making them attractive compounds for further development as potential immunotherapeutics.

scholarly journals B and T cell immune responses elicited by the Comirnaty® COVID-19 vaccine in nursing home residents

2021 ◽  
Author(s):  
Ignacio Torres ◽  
Eliseo Albert ◽  
Estela Giménez ◽  
María Jesús Alcaraz ◽  
Pilar Botija ◽  
...  
Keyword(s):  
Nursing Home ◽  
T Cell ◽  
Immune Responses ◽  
Nursing Home Residents ◽  
T Cell Immune Responses
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