EBV LMP2A-specific T Cell Immune Responses Elicited by Dendritic Cells Loaded with LMP2A Protein

The article presents the modern data on the most important component of natural immunity – cells of the mononuclear phagocyte system. The questions of origin, the spectrum of expressed markers of differentiation, the classification of monocytes (classical, intermediate, non-classical), macrophages (pro-inflammatory and anti-inflammatory) and dendritic cells (myeloid, plasmacytoid), their immunobiological functions, their role in humoral and T-cell immune responses, anergy and tolerance are considered. The possibility of obtaining cellular immunobiological products (adjuvant and tolerogenic) for immunotherapy of oncological, infectious and autoimmune diseases on their basis is analyzed.

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Baculovirus activates murine dendritic cells and induces non-specific NK cell and T cell immune responses

Cellular Immunology ◽

10.1016/j.cellimm.2009.12.005 ◽

2010 ◽

Vol 262 (1) ◽

pp. 35-43 ◽

Cited By ~ 37

Author(s):

Tomoyuki Suzuki ◽

Myint Oo Chang ◽

Masayuki Kitajima ◽

Hiroshi Takaku

Keyword(s):

Dendritic Cells ◽

T Cell ◽

Immune Responses ◽

Nk Cell ◽

T Cell Immune Responses

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Mice Lacking Expression of the Chemokines Ccl21-Ser and Ccl19 (plt Mice) Demonstrate Delayed but Enhanced T Cell Immune Responses

Journal of Experimental Medicine ◽

10.1084/jem.193.2.207 ◽

2001 ◽

Vol 193 (2) ◽

pp. 207-218 ◽

Cited By ~ 128

Author(s):

Shigeyuki Mori ◽

Hideki Nakano ◽

Kentaro Aritomi ◽

Chrong-Reen Wang ◽

Michael D. Gunn ◽

...

Keyword(s):

T Cells ◽

Dendritic Cells ◽

T Cell ◽

Immune Responses ◽

Cell Response ◽

T Cell Response ◽

Lymphoid Organs ◽

Cell Responses ◽

T Cell Immune Responses ◽

Secondary Lymphoid Organs

The paucity of lymph node T cells (plt) mutation leads to a loss of CCL21 and CCL19 expression in secondary lymphoid organs. plt mice have defects in the migration of naive T cells and activated dendritic cells into the T cell zones of lymphoid organs, suggesting that they would have defects in T cell immune responses. We now demonstrate T cell responses in plt mice are delayed but ultimately enhanced. Responses to contact sensitization are decreased at day 2 after priming but increased at day 6. After subcutaneous immunization, antigen-specific T cell proliferation and cytokine production in plt mice are increased and remain markedly elevated for at least 8 wk. Compared with wild-type mice, a proportion of T cell response in plt mice are shifted to the spleen, and prior splenectomy reduces the T cell response in draining lymph nodes. After immunization of plt mice, T cells and dendritic cells colocalize in the superficial cortex of lymph nodes and in splenic bridging channels, but not in T cell zones. These results demonstrate that plt mice mount robust T cell responses despite the failure of naive T cells and activated dendritic cells to enter the thymus dependent areas of secondary lymphoid organs.

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Uric acid enhances T cell immune responses to hepatitis B surface antigen-pulsed-dendritic cells in mice

World Journal of Gastroenterology ◽

10.3748/wjg.v13.i7.1060 ◽

2007 ◽

Vol 13 (7) ◽

pp. 1060 ◽

Cited By ~ 13

Author(s):

Xiao-Jun Ma

Keyword(s):

Dendritic Cells ◽

Uric Acid ◽

T Cell ◽

Hepatitis B ◽

Immune Responses ◽

Surface Antigen ◽

Hepatitis B Surface Antigen ◽

T Cell Immune Responses

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Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells

Nature Immunology ◽

10.1038/ni.1729 ◽

2009 ◽

Vol 10 (5) ◽

pp. 504-513 ◽

Cited By ~ 145

Author(s):

Anne S Dejean ◽

Daniel R Beisner ◽

Irene L Ch'en ◽

Yann M Kerdiles ◽

Anna Babour ◽

...

Keyword(s):

Dendritic Cells ◽

Transcription Factor ◽

T Cell ◽

Immune Responses ◽

T Cell Immune Responses

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Aryloxy Triester Phosphonamidates of Phosphoantigens Exhibit Favorable Stability and Potent Activation of Vγ9/Vδ2 T‐Cells

10.26434/chemrxiv.6755033.v1 ◽

2018 ◽

Cited By ~ 1

Author(s):

Hachemi Kadri ◽

Taher E. Taher ◽

Qin Xu ◽

Richard T. Bryan ◽

Benjamin E. Willcox ◽

...

Keyword(s):

T Cells ◽

T Cell ◽

Immune Responses ◽

Serum Stability ◽

T Cell Immune Responses ◽

Further Development

We previously reported the application of the aryloxy triester phosphoramidate prodrug technology to the phosphoantigen (E)-4-hydroxybut-2-enyl phosphate (HMBP). Although these prodrugs exhibited potent activation of Vγ9/Vδ2 T‐cell immune responses, their stability was low due to the rapid cleavage of the -O-P- bond. To address this, we herein report the application of the same prodrug strategy to two HMBP phosphonates, which have stable -CH2-P- or -CF2-P- bonds. These HMBP phosphonate prodrugs, phosphonamidates, exhibited excellent serum stability and potent activation of Vgama9/Vdelta2 T‐cells making them attractive compounds for further development as potential immunotherapeutics.

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Aryloxy Triester Phosphonamidates of Phosphoantigens Exhibit Favorable Stability and Potent Activation of Vγ9/Vδ2 T‐Cells

10.26434/chemrxiv.6755033 ◽

2018 ◽

Author(s):

Hachemi Kadri ◽

Taher E. Taher ◽

Qin Xu ◽

Richard T. Bryan ◽

Benjamin E. Willcox ◽

...

Keyword(s):

T Cells ◽

T Cell ◽

Immune Responses ◽

Serum Stability ◽

T Cell Immune Responses ◽

Further Development

We previously reported the application of the aryloxy triester phosphoramidate prodrug technology to the phosphoantigen (E)-4-hydroxybut-2-enyl phosphate (HMBP). Although these prodrugs exhibited potent activation of Vγ9/Vδ2 T‐cell immune responses, their stability was low due to the rapid cleavage of the -O-P- bond. To address this, we herein report the application of the same prodrug strategy to two HMBP phosphonates, which have stable -CH2-P- or -CF2-P- bonds. These HMBP phosphonate prodrugs, phosphonamidates, exhibited excellent serum stability and potent activation of Vgama9/Vdelta2 T‐cells making them attractive compounds for further development as potential immunotherapeutics.

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