scholarly journals Innovative technology and equipment for calves rearing during preweaning period

2020 ◽  
Vol 58 (2) ◽  
pp. 226-234
Author(s):  
V. I. Perednya ◽  
Y. A. Tsoy ◽  
N. G. Bakach ◽  
V. F. Radchikov ◽  
A. A. Romanovich ◽  
...  
Keyword(s):  
Body Weight ◽  
Digestive Tract ◽  
Early Life ◽  
High Energy ◽  
High Body Weight ◽  
High Body ◽  
Life Period ◽  
Whole Milk ◽  
Weight Gains ◽  
Preweaning Period

High dairy performance of adult animals is directly dependent on the conditions of calves growing and feeding during the preweaning period. Since cattle has a low so-called “critical temperature”, it is advisable to use this property of the body when rearing calves in the open air year-round in individual houses. It is known that among the entire complex of factors affecting the intensive growth of calves, the quality of food and the method of calves feeding in the first periods of postembryonic development of young animals from birth to 12 months deserve the most attention. In order to reduce consumption of whole milk for feeding calves and accelerate development of digestive tract in calves in early life period with high body weight gains, in practice specialists try to achieve it by introducing plant foods into diets for calves. However, plant feeds, even high-energy ones (cereals and legumes), containing large amount of protein, carbohydrates, starch, etc., are digested by calves very slowly and in small quantities. It is shown that to eliminate these drawbacks it is advisable to extrude all the plant feeds. The paper describes in detail the technology and equipment for preparing easily digestible feeds based on legumes for calves feeding during preweaning period, allowing to accelerate the development of digestive tract in the early life period of calves with high body weight gains, reduce consumption of whole milk or its replacers and energy costs for its production. Studies on the effect of feeding young cattle with feed concentrate during preweaning period showed increase in performance by 6.6 % and a decrease in feed costs by 5.73 %.

Direct Oral Anticoagulant Concentrations in Obese and High Body Weight Patients: A Cohort Study

2020 ◽  
Author(s):  
Anne Céline Martin ◽  
William Thomas ◽  
Zahra Mahir ◽  
Maeve P. Crowley ◽  
Terry Dowling ◽  
...  
Keyword(s):  
Body Weight ◽  
Creatinine Clearance ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Factor Xa ◽  
High Body Weight ◽  
High Body ◽  
Trough Concentrations ◽  
Fxa Inhibitor ◽  
Age Range

Abstract Background Direct oral anticoagulants (DOACs) are prescribed for atrial fibrillation (AF) and venous thromboembolism (VTE) and both occur more frequently in obese patients. Outcomes from DOAC trials included few individuals ≥ 120 kg leading to uncertainty whether high body weight (BW) reduces DOAC concentrations. Objectives This article investigates the relationship between factor Xa (FXa) inhibitor concentrations, BW, and renal function, and compares them in high BW patients with unselected populations. Methods Consecutive patients in two United Kingdom centers, weighing ≥ 120 kg receiving 5 mg twice daily apixaban or 20 mg once daily rivaroxaban for AF or VTE were prospectively included. Peak or trough concentrations were measured using specific chromogenic assays, expressed in mean or median (5th–95th percentiles). On-therapy range was the interval from the 5th percentile trough concentration to the 95th percentile peak concentration. Results One hundred patients were included; age range: 23 to 78 years, 31% were women, 58% had AF, creatinine clearance range: 67 to 474 mL/min. Median BW was 139 kg, and 84% had body mass index (BMI) ≥ 40 kg/m2. DOAC peak and trough concentrations varied from 44 to 727 and 14 to 299 ng/mL, respectively. There was no linear relationship between FXa inhibitor concentrations at peak or trough and BW or BMI, and creatinine clearance. Apixaban troughs in AF and rivaroxaban peaks in VTE were lower than in unselected populations. However, only two trough concentrations were below the expected range, and 109/116 were within the on-therapy range. Conclusion These data indicated that obese or high BW patients generally achieve therapeutic FXa inhibitor concentrations. However, further investigations assessing clinical outcomes are required.

Genetic variation in a line of mice selected to its limit for high body weight

1974 ◽  
Vol 19 (3) ◽  
pp. 273-289 ◽  
Author(s):  
W. K. Al-Murrani ◽  
R. C. Roberts
Keyword(s):  
Body Weight ◽  
Genetic Variance ◽  
Genetic Model ◽  
Random Mating ◽  
Inbred Lines ◽  
High Body Weight ◽  
High Body ◽  
Lower Body Weight ◽  
Recessive Genes ◽  
Selection For

SUMMARYA line of mice, at its limit to selection for high body weight did not decline in performance over 11 generations of random mating, neither did it respond when selection was renewed. The experiment tested a method of improving body weight by a scheme which had earlier increased litter size under similar circumstances. The scheme was to derive partially inbred lines from the plateaued line, to select during inbreeding and, finally, to cross the best inbreds. Body weight was not increased, but the study allowed further examination of the residual genetic variance in the line.During inbreeding, the inbred lines became clearly differentiated in body weight, proving that loci controlling body weight had not become fixed. There was also a significant response to selection for a lower body weight during inbreeding. The pattern of results suggested the segregation of recessive genes, detrimental to high body weight but which selection had become inefficient at removing. A genetic model compatible with the results accommodated several such recessives, perhaps as many as 10, each with an effect of about two-thirds of a standard deviation (or some equivalent combination of gene number and effect), and at frequencies of around 0·2. Nevertheless, the total improvement in body weight to be gained by their elimination was only half a gram, or less than 2 %. Thus, substantial genetic effects can occur at individual loci despite trivially low heritabilities and negligible potential gains.

Direct-acting oral anticoagulant use at extremes of body weight: Literature review and recommendations

2020 ◽  
Vol 77 (11) ◽  
pp. 865-876
Author(s):  
Kelly Covert ◽  
Donald L Branam
Keyword(s):  
Body Weight ◽  
Oral Anticoagulants ◽  
Careful Consideration ◽  
Cardioembolic Stroke ◽  
Safety And Efficacy ◽  
High Body Weight ◽  
High Body ◽  
Published Evidence ◽  
Agent Selection ◽  
Direct Acting

Abstract Purpose To review the literature on treatment of venous thromboembolism (VTE) and prevention of cardioembolic stroke with direct-acting oral anticoagulants (DOACs) in low- and high-body-weight patients and to make recommendations regarding agent selection and dosing in these patient populations. Summary The selection and optimal dosing of DOACs in low- and high-body-weight patients has not yet been fully elucidated by clinical trials; however, evidence suggests that issues of both safety and efficacy in patients at the extremes of body weight may warrant careful consideration when selecting a DOAC for such patients. This review provides a thorough discussion of the use of DOACs in the treatment of VTE and prevention of cardioembolic stroke in patients at the extremes of body weight and provides guidance regarding agent selection. Conclusion While the published evidence on use of DOACs in patients at extremes of body weight is sparse, apixaban and rivaroxaban appear to have the most favorable safety and efficacy profiles. Edoxaban and dabigatran should be avoided.

scholarly journals Determinants of inequalities in years with disability: an international-comparative study

2020 ◽  
Author(s):  
Wilma J Nusselder ◽  
José Rubio Valverde ◽  
Matthias Bopp ◽  
Henrik Brønnum-Hansen ◽  
Patrick Deboosere ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Risk Factor ◽  
Low Income ◽  
Vegetable Consumption ◽  
High Body Weight ◽  
High Body ◽  
International Comparative ◽  
Low Educated ◽  
Manual Occupation

Abstract Background Persons with a lower socioeconomic position spend more years with disability, despite their shorter life expectancy, but it is unknown what the important determinants are. This study aimed to quantify the contribution to educational inequalities in years with disability of eight risk factors: father’s manual occupation, low income, few social contacts, smoking, high alcohol consumption, high body-weight, low physical exercise and low fruit and vegetable consumption. Methods We collected register-based mortality and survey-based disability and risk factor data from 15 European countries covering the period 2010–14 for most countries. We calculated years with disability between the ages of 35 and 80 by education and gender using the Sullivan method, and determined the hypothetical effect of changing the prevalence of each risk factor to the prevalence observed among high educated (‘upward levelling scenario’), using Population Attributable Fractions. Results Years with disability among low educated were higher than among high educated, with a difference of 4.9 years among men and 5.5 years among women for all countries combined. Most risk factors were more prevalent among low educated. We found the largest contributions to inequalities in years with disability for low income (men: 1.0 year; women: 1.4 year), high body-weight (men: 0.6 year; women: 1.2 year) and father’s manual occupation (men: 0.7 year; women: 0.9 year), but contributions differed by country. The contribution of smoking was relatively small. Conclusions Disadvantages in material circumstances (low income), circumstances during childhood (father’s manual occupation) and high body-weight contribute to inequalities in years with disability.

scholarly journals A model of pre-pubertal broiler breeder estradiol-17β levels predicts advanced sexual maturation for birds with high body weight or short juvenile day-length exposure

2019 ◽  
Vol 98 (10) ◽  
pp. 5137-5145 ◽  
Author(s):  
S.A.S. van der Klein ◽  
S.H. Hadinia ◽  
F.E. Robinson ◽  
G.Y. Bédécarrats ◽  
M.J. Zuidhof
Keyword(s):  
Body Weight ◽  
Sexual Maturation ◽  
Day Length ◽  
Broiler Breeder ◽  
High Body Weight ◽  
High Body ◽  
Estradiol 17Β

Short Stature Is Associated With Overweight but Not With High Energy Intake in Low-Income Quilombola Women

2017 ◽  
Vol 38 (2) ◽  
pp. 216-225 ◽  
Author(s):  
Haroldo da Silva Ferreira ◽  
Andreza A. Luna ◽  
Telma Maria M. T. Florêncio ◽  
Monica L. Assunção ◽  
Bernardo L. Horta
Keyword(s):  
Body Weight ◽  
Short Stature ◽  
Energy Intake ◽  
Low Income ◽  
Early Life ◽  
Energy Requirement ◽  
High Energy ◽  
Excess Body Weight ◽  
Thrifty Phenotype ◽  
High Energy Intake

Background: Population exposed to chronic undernutrition in early life seems to be more susceptible to obesity in adulthood due to the development of mechanisms that improve the efficiency of energy use. Therefore, these individuals have relatively reduced energy requirements (thrifty phenotype). Objective: To investigate, among women living on severe socioeconomic vulnerability, whether short stature, a marker for undernutrition in early life, is associated with excess body weight but not with a high energy intake. Methods: This cross-sectional study, carried out between July and November 2008, evaluated 1308 women from all (N = 39) Quilombola communities of Alagoas. Adequacy of energy intake was estimated by the ratio between energetic ingestion and the estimated energy requirement (EER). Results: The prevalence of short stature (≤ 154.8 cm) was 43.0% and 52.4% had excess body weight (body mass index ≥ 25 kg/m2), being that 33.1% were overweight and 19.3% obese. Excess body weight was higher among women with short stature (56.6% vs 49.2%; P = .008), even after adjusting for age, energy intake, and per capita income (prevalence ratio = 1.16; 95% confidence interval = 1.04; 1.28). The ratio of energy intake/EER was independent of women’s stature. Conclusion: Excess body weight among Quilombola women represents a serious health problem. Short stature was significantly associated with excess body weight but not with a high energy intake. “Thrifty phenotype” may be one of the plausible explanations for this finding.

Sign in / Sign up

Export Citation Format

Share Document