Outcome measures following Sono and Photodynamic Therapy – A Case Series

Sono and Photodynamic Therapy (SPDT) is a novel therapeutic modality that utilises a non-toxic photosensitive agent with reported ultrasound-activated properties. SPDT has previously demonstrated significant tumour cell inhibition in animal studies. There has been much research into the efficacy of photodynamic therapy and development in understanding of the underlying mechanism of tumour cytotoxicity. Synergistic ultrasound activation represents a promising development to Photodynamic Therapy, as photo-activation is limited by access and penetrance issues. Ultrasound has been demonstrated to activate a number of sono-sensitive agents allowing the possibility of non-invasive targeted treatment of deeper tumour sites than is currently achievable with photodynamic therapy. This case series of 17 consecutive patients with a variety of cancer diagnoses outlines clinical outcomes over a four-year period of SPDT. The results have been encouraging in that all cases who carried our Circulating Tumour Cell Tests before and after SPDT showed a significant drop in tumour cells post-SPDT. SPDT is worthy of further investigation as an effective and well tolerated treatment for a wide variety of primary and metastatic tumours, including those refractory to Chemotherapy.

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Regenerative treatment of peri-implantitis following implant surface decontamination with titanium brush and antimicrobial photodynamic therapy: a case series with reentry

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-20-00093 ◽

2020 ◽

Author(s):

Pier Poli ◽

Francisley Avila Souza ◽

Mattia Manfredini ◽

Carlo Maiorana ◽

Mario Beretta

Keyword(s):

Photodynamic Therapy ◽

Clinical Case ◽

Case Series ◽

Antimicrobial Photodynamic Therapy ◽

Implant Surface ◽

Surface Decontamination

Not required for Clinical case letters according to the authors' guidelines.

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Evaluating Vitality and Periodontal Sensitivity of Teeth Adjacent to the Site of Open Sinus Lift Surgery before and after Treatment: A Case Series Study

Journal of Long-Term Effects of Medical Implants ◽

10.1615/jlongtermeffmedimplants.2020035426 ◽

2020 ◽

Vol 30 (2) ◽

pp. 77-81

Author(s):

Amir Moeintaghavi ◽

Negar Azami ◽

Mohammad Sadegh Zohrevand ◽

Farid Shiezadeh ◽

Hamid Jafarzadeh ◽

...

Keyword(s):

Case Series ◽

Sinus Lift ◽

Case Series Study ◽

Before And After ◽

Series Study

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Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors

Current Drug Targets ◽

10.2174/1389450122999210101230743 ◽

2021 ◽

Vol 22 ◽

Author(s):

Maria Bernadete Riemma Pierre

Keyword(s):

Photodynamic Therapy ◽

Drug Delivery Systems ◽

Active Agent ◽

Therapeutic Modality ◽

Tissue Penetration ◽

Promising Tool ◽

Skin Cancers ◽

Superficial Basal Cell Carcinoma ◽

The Stability ◽

Disor Ders

Abstract: Photodynamic Therapy (PDT) is a therapeutic modality used for several malignant and premalignant skin disor-ders, including Bowen's disease skin cancers and Superficial Basal Cell Carcinoma (BCC). Several photosensitizers (PSs) have been explored for tumor destruction of skin cancers, after their activation by a light source of appropriate wavelength. Topical release of PSs avoids prolonged photosensitization reactions associated with systemic administration; however, its clinical usefulness is influenced by its poor tissue penetration and the stability of the active agent. Nanotechnology-based drug delivery systems are promising tool to enhance the efficiency for PDT of cancer. This review focuses on PSs encap-sulated in nanocarriers explored for PDT of skin tumors.

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Activated Cancer Therapy Using Light and Ultrasound - A Case Series of Sonodynamic Photodynamic Therapy in 115 Patients Over a 4 Year Period

Current Drug Therapy ◽

10.2174/157488509789055036 ◽

2009 ◽

Vol 4 (3) ◽

pp. 179-193 ◽

Cited By ~ 24

Author(s):

Julian Kenyon ◽

Richard Fulle ◽

Thomas Lewis

Keyword(s):

Photodynamic Therapy ◽

Cancer Therapy ◽

Case Series

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Exercise-Induced Scalenus Syndrome

The American Journal of Sports Medicine ◽

10.1177/0363546507312166 ◽

2008 ◽

Vol 36 (2) ◽

pp. 369-374 ◽

Cited By ~ 15

Author(s):

Panagiotis Baltopoulos ◽

Charalampos Tsintzos ◽

George Prionas ◽

Maria Tsironi

Keyword(s):

Quality Of Life ◽

Thoracic Outlet Syndrome ◽

Surgical Intervention ◽

Case Series ◽

Signs And Symptoms ◽

Underlying Mechanism ◽

Level Of Evidence ◽

Full Activity ◽

Exercise Induced

Background Thoracic outlet syndrome is described as a group of distinct disorders producing signs and symptoms attributed to compression of nerves and blood vessels in the thoracic outlet region. Purpose To describe the exercise-induced scalenus anticus syndrome attributed to the anterior scalenus hypertrophy as a thoracic outlet syndrome underlying mechanism and to give recommendations for a safe and effective surgical treatment. Study Design Case series; Level of evidence, 4. Methods Twelve young professional athletes admitted for thoracic outlet syndrome (8 cases of neurologic thoracic outlet syndrome, 4 cases of mixed neurologic and vascular thoracic outlet syndrome) who reported numbness, tingling, early fatigue, muscle weakness, and pain were enrolled in the study. Scalenus hypertrophy was suspected to be the causative factor. Scalenectomy was performed in all cases. Results All patients had moderate to severe hypertrophy of the anterior scalenus muscle. Scalenectomy was performed, and there were no intraoperative or postoperative complications. Full activity was quickly achieved, and no recurrence of symptoms was documented. Conclusion Surgical intervention for scalenus anticus syndrome can allow an athlete to return to full activity and improve quality of life. Surgical intervention seems to be the treatment of choice in terms of restoring quality of life and physical activity.

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Fundus Autofluorescence before and after Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Ophthalmologica ◽

10.1159/000210386 ◽

2009 ◽

Vol 223 (4) ◽

pp. 263-268 ◽

Cited By ~ 20

Author(s):

Emin Özmert ◽

Figen Batıoğlu

Keyword(s):

Photodynamic Therapy ◽

Central Serous Chorioretinopathy ◽

Fundus Autofluorescence ◽

Chronic Central Serous Chorioretinopathy ◽

Before And After

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The efficacy of transcatheter arterial embolization for knee pain on patients with knee osteoarthritis: A case series

Journal of Back and Musculoskeletal Rehabilitation ◽

10.3233/bmr-210043 ◽

2021 ◽

pp. 1-6

Author(s):

Kun Yung Kim ◽

Gi-Wook Kim

Keyword(s):

Conservative Treatment ◽

Knee Osteoarthritis ◽

Knee Pain ◽

Transcatheter Arterial Embolization ◽

Rating Scale ◽

Case Series ◽

Arterial Embolization ◽

Numeric Rating Scale ◽

Knee Oa ◽

Before And After

BACKGROUND: Knee osteoarthritis (OA) is accompanied by inflammation and angiogenesis. Modifying angiogenesis through transcatheter arterial embolization (TAE) can be a potential treatment for knee OA. OBJECTIVE: We subjected five OA knees in three patients to TAE and report the results of our post-treatment observations. CASE DESCRIPTION: Three patients that had experienced knee pain for a minimum of one year prior to the study, and whose pain had persisted despite conservative treatment, were included in this study. Patients more often chose conservative treatment over surgical treatment. Pain and functional scales were evaluated before, immediately, and 1 month after TAE using the Numeric Rating Scale (NRS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). TAE was performed by an experienced interventional radiologist. The average values of NRS evaluated before and after 5 TAEs were 5.2 before TAE, 3 immediately after TAE, and 3.6 after 1 month of TAE, and the average values of WOMAC were 52, 38.4, and 36.4, respectively. There were no major adverse effects. CONCLUSION: The examined cases support the conclusion that TAE is an effective treatment for patients with knee OA. Substantial pain relief and WOMAC improvement were observed both immediately and one month after TAE.

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Modified Graded Motor Imagery for Musicians’ Focal Dystonia: A Case Series

Medical Problems of Performing Artists ◽

10.21091/mppa.2021.1002 ◽

2021 ◽

Vol 36 (1) ◽

pp. 10-17

Author(s):

Marina Ramella ◽

Francesca Borgnis ◽

Giulia Giacobbi ◽

Anna Castagna ◽

Frncesca Baglio ◽

...

Keyword(s):

Motor Imagery ◽

Treatment Protocol ◽

Case Series ◽

Focal Dystonia ◽

Rehabilitative Treatment ◽

Cortical Organization ◽

Cortical Motor ◽

Home Based ◽

Before And After ◽

Graded Motor Imagery

PURPOSE: This study aimed to assess the effectiveness of the “modified graded motor imagery” (mGMI) protocol as a rehabilitative treatment of musician’s focal dystonia (MFD). METHODS: Six musicians with MFD (age 43.83±17.24 yrs) performed the home-based mGMI protocol (laterality training, imagined hand movements and visual mirror feedback) once a day for 4 weeks. The mMGI protocol was designed to sequentially activate cortical motor networks and improve cortical organization. Subjects were evaluated before and after treatment with the dystonia evaluation scale (DES), arm dystonia disability scale (ADDS), Tubiana-Chamagne scale (TCS), and performing scale (PS). RESULTS: All participants were compliant with the mGMI treatment protocol without any adverse events. A significant improvement was measured in ADDS (p=0.047) and TCS scores (p=0.014) but not in DES (p=0.157). The severity of MFD decreased from moderate to mild in four patients. After mGMI treatment, all musicians were able to play easy pieces (TCS: median 3.5, IR 3.5–4). CONCLUSION: The findings from this pilot study suggest that home-based mGMI treatment is a feasible and promising rehabilitative approach for patients with mild to moderate MFD.

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Human mobility models reveal the underlying mechanism of seasonal movements across China

International Journal of Modern Physics C ◽

10.1142/s0129183122500541 ◽

2021 ◽

Author(s):

Bing Song ◽

Xiao-Yong Yan ◽

Suoyi Tan ◽

Bin Sai ◽

Shengjie Lai ◽

...

Keyword(s):

Traffic Engineering ◽

Human Mobility ◽

Underlying Mechanism ◽

Gravity Models ◽

Mobility Models ◽

Temporal And Spatial Distribution ◽

Population Movements ◽

Different Types ◽

Before And After ◽

Time Periods

Understanding the spatial interactions of human mobility is crucial for urban planning, traffic engineering, as well as for the prevention and control of infectious diseases. Although many models have been developed to model human mobility, it is not clear whether such models could also capture the traveling mechanisms across different time periods (e.g. workdays, weekends or holidays). With one-year long nationwide location-based service (LBS) data in China, we investigate the spatiotemporal characteristics of population movements during different time periods, and make thorough comparisons for the applicability of five state-of-the-art human mobility models. We find that population flows show significant periodicity and strong inequality across temporal and spatial distribution. A strong “backflow” effect is found for cross-city movements before and after holidays. Parameter fitting of gravity models reveals that travels in different type of days consider the attractiveness of destinations and cost of distance differently. Surprisingly, the comparison indicates that the parameter-free opportunity priority selection (OPS) model outperforms other models and is the best to characterize human mobility in China across all six different types of days. However, there is still an urgent need for development of more dedicated models for human mobility on weekends and different types of holidays.

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