Association of Early-onset Androgenetic Alopecia and Metabolic Syndrome

Objectives. The study aimed to confirm the association between androgenetic alopecia (AGA) and Metabolic Syndrome (MetS). It also aimed to determine if early-onset AGA among males and AGA among females increases the risk of developing MetS, and if severity of AGA increases the odds of developing MetS. Methods. Observational studies from electronic databases were selected by the consensus of three independent review authors. The Newcastle-Ottawa Scale for assessing the quality of non-randomized studies in meta-analysis was used. Statistical analyses were accomplished using Review Manager software. Results. A total of 11 case-control studies, one prospective cohort study, and five cross-sectional studies were selected. In the meta-analysis of ten case-control studies and three cross-sectional studies (3840 participants), AGA was significantly correlated with MetS (OR 2.59, 95% CI 1.51 to 4.44; p<0.0005). Early-onset AGA among males (<35 years old) showed significant association (OR 3.69, 95% CI 2.15 to 6.33; p<0.00001). AGA among females also increased the odds of developing MetS (OR 5.59, 95% CI 2.06 to 15.12; p<0.0007). Moderate to severe AGA in males, Norwood-Hamilton IV or higher, was also significant (OR 1.65, 95% CI 1.12 to 2.42; p=0.01). The same trend was noted for females with Ludwig II and III (OR 5.82, 95% CI 2.54 to 13.34; p<0.00001). Conclusion. Although the pathophysiology still remains under investigation, the present study points to an association between AGA and MetS. It can be used as a marker to identify patients who should be screened for MetS and managed accordingly.

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The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia

European Journal of Dermatology ◽

10.1684/ejd.2010.1193 ◽

2011 ◽

Vol 21 (1) ◽

pp. 79-82 ◽

Cited By ~ 19

Author(s):

Ceyda MUMCUOGLU ◽

Tugba Rezan EKMEKCI ◽

Sema UCAK

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Early Onset ◽

Androgenetic Alopecia ◽

Male Patients

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Early-onset Male Androgenetic Alopecia and Metabolic Syndrome: Are They Associated?

International Journal of Recent Surgical and Medical Sciences ◽

10.5005/jp-journals-10053-0002 ◽

2016 ◽

Vol 02 (01) ◽

pp. 005-009

Author(s):

Sampada Thakare ◽

Adarshlata Singh

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Early Onset ◽

Tertiary Care ◽

Androgenetic Alopecia ◽

Control Group ◽

P Value ◽

Case Group ◽

Large Sample Size

Abstract Aims and objectives: To study the pattern of early-onset male androgenetic alopecia (AGA) and its association with metabolic syndrome (MetS). Study design: A case–control study was conducted in the tertiary care center, Department of Dermatology, from year 2012 to 2014. Materials and methods: A total number of 100 patients, 50 male patients with early-onset AGA cases and 50 age-matched controls, were enrolled. The Norwood–Hamilton classification was used to assess the grade of AGA. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Blood pressure, blood glucose, and lipid parameters along with waist circumference were assessed in all the study participants. Statistical analysis was done by using descriptive and inferential statistics using chi-square test and Z test for difference between two means. The statistical software used in the analysis was Statistical Package for the Social Sciences 17.0 and Graph Pad Prism 5.0, and the results with (p < 0.05) were considered significant. Results: Most common grades of early-onset male AGA were 38% with grade IV, 26% with grade IIIv (vertex), and 16% with grade III. 50% of the case group with early-onset male AGA and 10% of control group patients had MetS (p < 0.05). As compared with controls, patients with early-onset AGA had a statistically significant mean value for fasting blood sugar level (p-value 0.001), triglyceride level (p-value 0.013), waist circumference (p-value 0.004), systolic blood pressure (p-value 0.006), and diastolic blood pressure (p-value 0.010) respectively. There was no significant association between early-onset male AGA and serum levels of HDL, LDL, VLDL, and cholesterol (p > 0.05). Conclusion: It is inferred from this study that the most common grade of early-onset male AGA was grades IV and III vertex. There also was association of early-onset male AGA with MetS. More prospective studies are required with a large sample size to justify the association between early-onset male AGA and MetS.

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