PULMONARY TB

2006 ◽  
Vol 13 (04) ◽  
pp. 647-650
Author(s):  
FAISAL NAVEED AKHTAR ◽  
WARIS ALI RANA ◽  
SAJJAD AHMAD ANSARI ◽  
Imad Ahmed Toor
Keyword(s):  
Diagnostic Yield ◽  
Sampling Technique ◽  
Descriptive Study ◽  
Sampling Procedure ◽  
Sputum Smear ◽  
X Rays ◽  
Pulmonary Tb ◽  
Smear Negative ◽  
Selection Of Patients ◽  
Selection Of

Objective: To determine the diagnostic yield of microscopy of endobronchialsecretions collected by bronchoscopy in patients who were suspected to have pulmonary TB but their sputum smearwas negative for AFB with ZN staining. Study Design: Descriptive study. Place and Duration of Study: At MilitaryHospital Rawalpindi from June 2004 to May 2005. Subjects and Methods: Fifty patients were included in the study.Convenience sampling technique of non-probability sampling procedure was used for the selection of patients. Onlythose patients suspected to have pulmonary TB on clinical grounds, raised ESR and X-rays chest showing pulmonaryinfiltrates but sputum smear negative for AFB on a minimum of three examinations were included in the study.Bronchoscopy of these patients was done, endobronchial secretions taken and sent for microscopy for AFB. Results:Out of 50 patients, 16(32%) patients were positive for AFB while 34(68%) were negative on endobronchial secretion’smicroscopy. Conclusion: Microscopy of endobronchial secretions collected by bronchoscopy is a useful technique inthe diagnosis of pulmonary TB in patients who are suspected to have pulmonary TB but their sputum smear is negativefor AFB with ZN staining.

scholarly journals Should Sputum Smear Examination Be Carried Out at the End of the Intensive Phase and End of Treatment in Sputum Smear Negative Pulmonary TB Patients?

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49238 ◽  
Author(s):  
Sumit Malhotra ◽  
Sanjay P. Zodpey ◽  
Shivani Chandra ◽  
Ram Pal Vashist ◽  
Srinath Satyanaryana ◽  
...  
Keyword(s):  
Sputum Smear ◽  
Intensive Phase ◽  
Pulmonary Tb ◽  
Smear Examination ◽  
End Of Treatment ◽  
Smear Negative ◽  
Sputum Smear Examination

Diagnostic performance of automated liquid culture and molecular line probe assay in smear-negative pulmonary tuberculosis

2016 ◽  
Vol 47 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Aarti Kotwal ◽  
Debasis Biswas ◽  
Shailendra Raghuvanshi ◽  
Girish Sindhwani ◽  
Barnali Kakati ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Liquid Culture ◽  
Diagnostic Yield ◽  
Drug Susceptibility ◽  
Complete Agreement ◽  
Sputum Smear ◽  
Molecular Line ◽  
Diagnostic Potential ◽  
Smear Negative ◽  
Probe Assay

The diagnosis of smear-negative pulmonary tuberculosis (PTB) is particularly challenging, and automated liquid culture and molecular line probe assays (LPA) may prove particularly useful. The objective of our study was to evaluate the diagnostic potential of automated liquid culture (ALC) technology and commercial LPA in sputum smear-negative PTB suspects. Spot sputum samples were collected from 145 chest-symptomatic smear-negative patients and subjected to ALC, direct drug susceptibility test (DST) testing and LPA, as per manufacturers’ instructions. A diagnostic yield of 26.2% was observed among sputum smear-negative TB suspects with 47.4% of the culture isolates being either INH- and/or rifampicin-resistant. Complete agreement was observed between the results of ALC assay and LPA except for two isolates which demonstrated sensitivity to INH and rifampicin at direct DST but were rifampicin-resistant in LPA. Two novel mutations were also detected among the multidrug isolates by LPA. In view of the diagnostic challenges associated with the diagnosis of TB in sputum smear-negative patients, our study demonstrates the applicability of ALC and LPA in establishing diagnostic evidence of TB.

scholarly journals Role of fiberoptic bronchoscopy in sputum smear negative suspected cases of pulmonary tuberculosis: a study conducted in Southern part of Rajasthan

2020 ◽  
Vol 8 (12) ◽  
pp. 4302
Author(s):  
Atul Luhadia ◽  
Shanti K. Luhadia ◽  
Shubham Jain ◽  
Mohammad Hamza Hanfe ◽  
Divax Oza ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Diagnostic Yield ◽  
Radiological Finding ◽  
Fiberoptic Bronchoscopy ◽  
Sputum Smear ◽  
Tuberculosis Patients ◽  
Acid Fast Bacilli ◽  
Predominant Symptom ◽  
Smear Negative

Background: Sputum smear negative pulmonary tuberculosis is a common problem faced by clinicians. Fiberoptic bronchoscopy may be very useful in diagnosing these cases which have no sputum or whose sputum smear is negative for acid fast bacilli. Objective of the current study was to assess the role of fiberoptic bronchoscopy in sputum smear negative under NTEP and radiologically suspected cases of pulmonary tuberculosis.Methods: Clinico-radiological suspected cases of pulmonary tuberculosis patients in whom two sputum smear for acid fast bacilli by Ziehl Neelsen stain under NTEP was negative were included in the study. Fiberoptic bronchoscopy was performed in all these patients and samples taken were sent for investigations.Results: Fiberoptic bronchoscopy was performed in 250 patients of suspected pulmonary tuberculosis whose sputum for AFB smear was negative. Cough was the most predominant symptom. Radiologically, right side disease was more common and upper zone was most commonly involved and infiltrates were common radiological finding. During bronchoscopy, congestion and hyperaemia (36%) and mucopurulent/mucoid secretions (32%) was seen in maximum number of cases. BAL was positive in 200 patients (80%), post bronchoscopy sputum was positive in 70 cases (28%) and biopsy was positive in 12 patients out of 16 performed biopsies (75%). The total TB positive cases after combining all the methods were 215 making the overall diagnostic yield of 86%.Conclusions: Fiberoptic bronchoscopy and post bronchoscopy sputum can be very useful for diagnosing sputum for AFB smear negative but clinico-radiological suspected cases of pulmonary tuberculosis patients.

TB-PCR and drug resistance pattern in BALF in smear-negative active pulmonary TB

2017 ◽  
Vol 21 (12) ◽  
pp. 1294-1299 ◽  
Author(s):  
K. Chavalertsakul ◽  
V. Boonsarngsuk ◽  
S. Saengsri ◽  
P. Santanirand
Keyword(s):  
Predictive Value ◽  
Resistance Pattern ◽  
Sputum Smear ◽  
Pcr Assay ◽  
Tertiary Referral Hospital ◽  
Standard Drug ◽  
Pulmonary Tb ◽  
Drug Resistance Pattern ◽  
Smear Negative ◽  
Tb Pcr

SETTING: A tertiary referral hospital in Bangkok, Thailand.OBJECTIVES: To evaluate the efficacy of a bronchoalveolar lavage fluid (BALF) tuberculosis (TB) polymerase chain reaction (PCR) assay for the diagnosis of sputum smear-negative pulmonary TB (PTB) and the usefulness of a drug-resistant (DR) TB-PCR assay compared with standard drug susceptibility testing (DST).DESIGN: BALF samples from 918 patients with acid-fast bacilli (AFB) negative sputum smears who underwent bronchoscopy for diagnostic evaluations of pulmonary diseases were prospectively determined for specific genetic elements of TB using the AnyplexTM MTB/NTM Real-Time Detection kit. Positive TB-PCR samples were subsequently evaluated for DR-TB using the Anyplex II MTB/MDR Detection kit.RESULTS: A total of 224 patients were finally diagnosed with PTB. The sensitivity, specificity, positive predictive value and negative predictive value of the TB-PCR assay were respectively 38.8%, 100%, 100%, and 83.5%. The TB-PCR assay was more sensitive than culture (30.4%) and smear (6.7%). Of the 68 TB-positive culture samples, three cases with either isoniazid (INH) or rifampicin (RMP) resistance were detected by DST. The Anyplex II MTB/MDR assay provided similar results.CONCLUSIONS: The BALF TB-PCR assay is a useful tool in the diagnosis of sputum smear-negative PTB. It can also provide INH and RMP susceptibility patterns similar to those of standard DST.

scholarly journals Utility of Bronchoalveolar Lavage in the Diagnosis of Sputum Negative Pulmonary Tuberculosis

2020 ◽  
Vol 8 (1) ◽  
pp. 19-22
Author(s):  
Subodh Sagar Dhakal ◽  
Ashmita Neupane ◽  
Shatdal Chaudhary ◽  
Navin Mishra ◽  
Damber Bdr Karki
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Bronchoalveolar Lavage ◽  
Diagnostic Yield ◽  
Cross Sectional Study ◽  
Fibreoptic Bronchoscopy ◽  
Sputum Smear ◽  
Cross Sectional ◽  
Acid Fast Bacilli ◽  
Smear Negative

INTRODUCTION: Sputum smear examination for acid fast bacilli (AFB) by Ziehl-Neelsen stain (ZN stain) is the initial approach to the diagnosis of pulmonary tuberculosis (PTB). But 50% of the cases are reported to be sputum smear negative. This study was aimed to investigate the diagnostic yield of fibreoptic bronchoscopy (FOB) guided bronchoalveolar lavage (BAL) in patients suspected to have tuberculosis. The sample was tested for Mycobacterium tuberculosis using the XpertMTB/RIF assay, which is a new test that detects Mycobacterium tuberculosis complex and resistance to rifampin in less than two hours. MATERIAL AND METHODS: This is a prospective cross sectional study carried out on 58 sputum smear negative patients who were clinically suspected to have pulmonary tuberculosis from April 2017 to January 2019. All patients are subjected to FOB, BAL and BAL specimens were stained for AFB and also sent for Xpert (MTB)/RIF. RESULTS: Among 58 patients enrolled for the study 26 patients were positive for acid fast bacilli (AFB) through BAL stain and Xpert (MTB)/RIF combined. CONCLUSION: FOB guided BAL is a reliable, alternative and rapid method for diagnosing smear negative pulmonary tuberculosis with minimal complications.

scholarly journals Yield Of Bronchoalveolar Lavage In Suspected Pulmonary TB With Negative Induced-Sputum Smear

JMS SKIMS ◽  
2016 ◽  
Vol 19 (2) ◽  
pp. 75-81
Author(s):  
Javid Ahmad Malik ◽  
Ramees Mohi Ud Din Mir ◽  
Shabir Ahmad Lone ◽  
M Umar Majid ◽  
Majid Khalil Rather ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Diagnostic Yield ◽  
Final Diagnosis ◽  
Lung Abscess ◽  
Induced Sputum ◽  
Sputum Smear ◽  
High Diagnostic Yield ◽  
Negative Results ◽  
Smear Negative ◽  
Lung Infiltrates

Background: Bronchoalveolar lavage (BAL) has been used to recover mycobacterium tuberculosis (MTB) from the respiratory tract of patients with lung infiltrates as nearly 50% of pulmonary tuberculosis (PTB) cases are sputum smear negative for acid fast bacilli (AFB). We prospectively compared the diagnostic yield of induced sputum (IS) smear with BALsmear and culture to assess its role in the early diagnosis of sputum negative PTB.Methods: We performed bronchoscopy to obtain BAL in 52 consecutive patients of suspected PTB between December 2013 and November 2015 after negative results on 2 samples of IS smears. BALsamples were stained with Ziehl-Neelsen (ZN) stain and cultured on L-J media.Results: Cohort of 52 IS negative patients had a mean age of 46 years (SD 15.6) with 58% male participants. Comorbidities were present in 31% participants whereas 42% were current smokers. Tuberculosis was the final diagnosis in 37% (n =19) patients and rest 63% (n = 33) had nontubercular etiologies like bronchiectasis (n = 6), pneumonia (n = 5), interstitial lung disease (n = 3), lung abscess (n = 2), lung cancer (n = 1), PCP (n = 1), hydatid cyst (n = 2), pneumonia (n = 5) and non- specific infection (n = 13). In tuberculosis group 33% patients had bronchoscopic abnormalities. Tuberculosis was confirmed by BALMTB culture in 90% (n = 17) and by biopsy in 10% (n = 2).Conclusion: BAL has high diagnostic yield and should be considered in the evaluation of suspected PTB. Bronchoscopy also picked up alternative diagnoses. JMS 2016; 19(2):75-81.

scholarly journals Pelestarian Koleksi Langka Berbasis Flipbook di Perpustakaan Umum

2021 ◽  
Vol 1 (2) ◽  
pp. 99-110
Author(s):  
Ifon Margiati Rahayu
Keyword(s):  
Sampling Technique ◽  
Descriptive Study ◽  
Rare Book ◽  
Digital Books ◽  
Qualitative Descriptive ◽  
Book Collections ◽  
Rare Books ◽  
Text Content ◽  
The Impact ◽  
Selection Of

Introduction. Currently, the office limits access to collections of rare books for users to preserve the physical collection. Users who want to access the display will only get a synopsis. However, this policy makes users challenging to access the full-text content. The collection of rare books has also not received proper preservation and creates some rare book collections to be damaged. This study aims to determine the process of digitizing the rare book collections at the Archives and Library Office of Banjarnegara Regency based on Flipbook.Methodology. This study is a qualitative descriptive study. The selection of informants in this study is a purposive sampling technique. The data collection in this study is observation, interview, and literature study.Result and discussion. This study shows that digitizing the rare book collections includes selection, scanning, editing, flipbook making, and uploading on the OPAC INLISLite application 3.1. Users can access rare book collections in the form of flipbooks or interesting digital books. The obstacles found in digitizing rare book collections are the absence of SOPs of digitizing, inadequate digitization facilities and infrastructures, the absence of Human Resources (HR). Nevertheless, they master the digitization of collections and the lack of budget allocations for digitizing the collection.Conclusion. The impact of digitization with Flipbook is that users have full access to a collection of rare books needed by users and become an alternative to the preservation and empowerment of libraries and users that are more attractive and safe.

scholarly journals Statistical Analysis of X-ray Images and Laboratory Studies of COVID-19 Patients

2021 ◽  
pp. 10-16
Author(s):  
Enrique SÁNCHEZ-TORRECITAS ◽  
Juan Israel YAÑEZ-VARGAS ◽  
Joel QUINTANILLA-DOMÍNGUEZ ◽  
José Gabriel AGUILERA-GONZÁLEZ
Keyword(s):  
Statistical Study ◽  
X Rays ◽  
Laboratory Studies ◽  
Statistical Process ◽  
X Ray ◽  
Area Of Interest ◽  
Box And Whisker Plot ◽  
Whisker Plot ◽  
Selection Of Patients ◽  
Selection Of

The large increase in COVID-19 cases that continue occurring in Mexico has generated the need to learn more about the damage caused by this virus, for which it has been proposed to carry out a statistical study of the 164 ray images database X and 29 laboratory studies provided by the Salamanca State Center for Critical Care (CECCS) of patients diagnosed with COVID-19 and not COVID-19, the purpose is to analyze if there is any correlation between X-rays and laboratory studies. First, the entire database was organized by patient, both for X-ray and laboratory studies. Afterwards, the statistical process of the laboratory studies was carried out. Subsequently, we worked on the selection of patients with a greater number of X-rays, segment of these the area of the lungs, since it was our area of interest. In these radiographs, the statistical process of entropy and box-and-whisker plot is performed. Finally, the results of some laboratory studies are correlated with the entropy and box-and-whisker plot results.

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