scholarly journals Perubahan Mikrostruktur Jaringan Hati pada Mencit Model Sindrom Metabolik yang Diberi Fraksi Zingiber officinale

2019 ◽  
Vol 1 (1) ◽  
pp. 25-31
Author(s):  
Dilla Latul Anjaniah ◽  
Eka Nurhayati ◽  
Herry Garna ◽  
Annisa Rahmah Furqaani ◽  
Maya Tejasari
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Ethyl Acetate ◽  
Liver Tissue ◽  
Fatty Liver Disease ◽  
Zingiber Officinale ◽  
Ethyl Acetate Fraction ◽  
Mice Model ◽  
Alcoholic Fatty Liver

Non-alcoholic fatty liver disease (NAFLD) merupakan penyakit perlemakan pada hati yang terjadi pada penderita sindrom metabolik. Penderita sindrom metabolik terjadi peningkatan kadar stres oksidatif sehingga muncul sel steatosis dan pelebaran sinusoid hati. Senyawa flavonoid dalam Zingiber officinale (jahe gajah) diketahui memiliki efek hepatoprotektif dan antiinflamasi dengan cara menghambat pembentukan reactive oxygen species (ROS). Tujuan penelitian ini mengetahui pengaruh  fraksi etil asetat jahe gajah terhadap mikrostruktur jaringan hati pada mencit model sindrom metabolik. Objek penelitian ini menggunakan mencit jantan galur Swiss Webster yang berusia 36−40 minggu dibagi menjadi 4 kelompok. Penelitian dilakukan di Laboratorium Farmasi Institut Teknologi Bandung. Kelompok kontrol yang diberi pakan tinggi lemak tanpa diberikan terapi selama 28 hari. Kelompok II−IV diberi pakan tinggi lemak dan diterapi dengan diberi fraksi etil asetat jahe gajah dengan konsentrasi 0,78 mg, 1,56 mg,  dan 3,12 mg per kilogram bobot per hari diberikan secara oral. Observasi dan kuantifikasi mikrostruktur jaringan hati dilakukan menggunakan mikroskop cahaya. Hasil statistik jumlah sel steatosis belum menunjukkan hasil yang signifikan (p>0,05), sedangkan pada jumlah pelebaran sinusoid menunjukkan hasil yang signifikan (p<0,05).   Kekuatan korelasi konsentrasi fraksi jahe gajah dengan jumlah sel steatosis rendah, tetapi pasti (r=-0,381)  dan pelebaran sinusoid cukup berarti (r=-0,451). Simpulan penelitian ini adalah pemberian fraksi etil asetat jahe gajah memengaruhi mikrostruktur jaringan hati pada mencit model sindrom metabolik. LIVER TISSUE MORPHOLOGICAL CHANGES BY ZINGIBER OFFICINALE FRACTIONS IN METABOLIC SYNDROME MICE MODELSNon-alcoholic fatty liver disease (NAFLD) is a fatty liver disease that occurs in patients with metabolic syndrome. Patients with metabolic syndrome occur closer to oxidative stress that occurs in steatosis and dilation of the liver sinusoid. Flavonoid compounds in Zingiber officinale have hepatoprotective and anti inflammatory effects by inhibiting the formation of reactive oxygen species (ROS). The purpose of this study was to determine the content of Zingiber officinale ethyl acetate fraction on liver tissue microstructure in mice model of metabolic syndrome. This research method using mice of Swiss webster strain which had 36−40 weeks, divided into 4 groups. The study  conducted at Pharmacology Laboratory Institut Teknologi Bandung. Control group fed high fat without therapy for 28 days. Group II−IV were fed high fat and treated with ginger elephant ethyl acetate fraction with a concentration of 0.78 mg, 1.56 mg and 3.12 mg per kilograms of body weight per day, given orally. Observation and quantification of liver tissue microstructure was performed using a light microscope. The statistical results on steatosis cell counts did not show significant results (p>0.05), whereas the number of sinusoid enlargement showed significant results (p<0.05). Alternative strength of the Zingiber officinale fraction with a low but definite steatosis cell number (r=−0.381) and significant sinusoid widening (r=−0.451). In conclusion, that administration of ginger elephant ethyl acetate fraction affected microstructure of liver tissue in mice model of metabolic syndrome.

scholarly journals Mechanisms of Non-Alcoholic Fatty Liver Disease in the Metabolic Syndrome. A Narrative Review

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 270
Author(s):  
Luca Rinaldi ◽  
Pia Clara Pafundi ◽  
Raffaele Galiero ◽  
Alfredo Caturano ◽  
Maria Vittoria Morone ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Smoking Habit ◽  
Lifestyle Modifications ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are two different entities sharing common clinical and physio-pathological features, with insulin resistance (IR) as the most relevant. Large evidence leads to consider it as a risk factor for cardiovascular disease, regardless of age, sex, smoking habit, cholesterolemia, and other elements of MS. Therapeutic strategies remain still unclear, but lifestyle modifications (diet, physical exercise, and weight loss) determine an improvement in IR, MS, and both clinical and histologic liver picture. NAFLD and IR are bidirectionally correlated and, consequently, the development of pre-diabetes and diabetes is the most direct consequence at the extrahepatic level. In turn, type 2 diabetes is a well-known risk factor for multiorgan damage, including an involvement of cardiovascular system, kidney and peripheral nervous system. The increased MS incidence worldwide, above all due to changes in diet and lifestyle, is associated with an equally significant increase in NAFLD, with a subsequent rise in both morbidity and mortality due to both metabolic, hepatic and cardiovascular diseases. Therefore, the slowdown in the increase of the “bad company” constituted by MS and NAFLD, with all the consequent direct and indirect costs, represents one of the main challenges for the National Health Systems.

scholarly journals Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome

2010 ◽  
Vol 69 (2) ◽  
pp. 211-220 ◽  
Author(s):  
J. Bernadette Moore
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Response To Treatment ◽  
Health Concern ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease in both adults and children worldwide. As a disease spectrum, NAFLD may progress from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. An estimated 20–35% of the general population has steatosis, 10% of whom will develop the more progressive non-alcoholic steatohepatitis associated with markedly increased risk of cardiovascular- and liver-related mortality. Development of NAFLD is strongly linked to components of the metabolic syndrome including obesity, insulin resistance, dyslipidaemia and type 2 diabetes. The recognition that NAFLD is an independent risk factor for CVD is a major public health concern. There is a great need for a sensitive non-invasive test for the early detection and assessment of the stage of NAFLD that could also be used to monitor response to treatment. The cellular and molecular aetiology of NAFLD is multi-factorial; genetic polymorphisms influencing NAFLD have been identified and nutrition is a modifiable environmental factor influencing NAFLD progression. Weight loss through diet and exercise is the primary recommendation in the clinical management of NAFLD. The application of systems biology to the identification of NAFLD biomarkers and factors involved in NAFLD progression is an area of promising research.

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