scholarly journals Analyze the Animal Model of Pruritus Based on Clinical Symptoms of Chinese and Western Medicine

2017 ◽  
Author(s):  
Ya-juan WEN ◽  
Ming BAI ◽  
Ming-san MIAO
Keyword(s):  
Animal Model ◽  
Western Medicine ◽  
Clinical Symptoms

Neonatal Insult to the Hippocampal Region and Schizophrenia: A Review and a Putative Animal Model

1996 ◽  
Vol 41 (7) ◽  
pp. 446-456 ◽  
Author(s):  
Mario Beauregard ◽  
Jocelyne Bachevalier
Keyword(s):  
Animal Model ◽  
Social Interactions ◽  
Time Course ◽  
Clinical Symptoms ◽  
Hippocampal Region ◽  
Hippocampal Lesions ◽  
Schizophrenic Patients ◽  
Experimental Findings ◽  
Early Trauma ◽  
Normal Controls

Objective: To review the mounting evidence implicating early hippocampal dysfunction in the pathogenesis and the pathophysiology of schizophrenia. An account is made of recent neurodevelopmental hypotheses indicating how an early dysfunction of the hippocampal region disrupts maturational events in brain systems connected to that structure, thus inducing dysfunctional connectional development. Finally, an animal model is presented. Method: Socioemotional behaviour of monkeys (Macaca mulatta) with selective neonatal hippocampal lesions was assessed by analyzing their interactions with their age-matched controls at 2 months, 6 months, and 5 to 8 years of age and by comparing the social interactions at each age with those of normal controls paired together. Results: At 2 months of age, monkeys with neonatal hippocampal lesions presented minor disturbances in initiation of social interactions. These subtle changes of behaviour were less evident at 6 months, although by that age, the operated monkeys displayed more withdrawals in response to an increase in aggressive responses from their unoperated peers. In adulthood, the amount of time spent by the hippocampectomized monkeys in social contacts with their normal peers decreased markedly. In addition, operated monkeys exhibited more locomotor stereotypies than normal controls. Conclusion: These experimental findings indicate that the time-course and nature of the behavioural disturbances resulting from early trauma to the hippocampal region have some similarities with the clinical symptoms of schizophrenic patients and the typical time-course of the disease.

scholarly journals Evaluation of Itch by Using NC/NgaTnd Mice: A Model of Human Atopic Dermatitis

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Akane Tanaka ◽  
Hiroshi Matsuda
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Clinical Symptoms ◽  
Skin Barrier ◽  
Sensory Nerves ◽  
Laboratory Animals ◽  
Skin Barrier Function ◽  
The Novel ◽  
Suitable Animal Model ◽  
Spontaneous Animal Model

Atopic dermatitis (AD) is the extremely complicated syndrome that various abnormalities develop in a heap. There are various factors in patients for the onset and exacerbation of AD, including genetic cofactors of individuals, environmental factors, the failure of the skin barrier function, unfavorable regulation of the immune system, and the hypersensitivity of sensory nerves. In recent years, there have been many trials of the drug discovery that targets itch, because itch is one of the most serious clinical symptoms of AD. The selection of the suitable animal model that represents the condition of patients, as well as innovative analyzing protocols that can precisely evaluate itch, is indispensable for investigation of an effective drug for AD. In the paper, the unique spontaneous animal model for AD (NC/NgaTnd mice) and the novel quantification system of the laboratory animals that may bring a great progress in the future study of itch are outlined.

Microimmunotherapeutic administration of cytokines improve the clinical symptoms in EAE an animal model of multiple sclerosis

Homeopathy ◽  
2016 ◽  
Vol 105 (1) ◽  
pp. 10 ◽  
Author(s):  
Anna Camps ◽  
Beatriz Almolda ◽  
Berta Gonzalez ◽  
Bernardo Castellano
Keyword(s):  
Multiple Sclerosis ◽  
Animal Model ◽  
Clinical Symptoms

scholarly journals Post Transplantation Cyclophosphamide Improves Outcome of Autologous Hematopoietic Stem Cell Transplantation in Animal Model of Multiple Sclerosis

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Kaja Kasarełło ◽  
Emilian Snarski ◽  
Dorota Sulejczak ◽  
Tomasz Ciesielski ◽  
Agnieszka Wiśniewska ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Animal Model ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Low Dose ◽  
Clinical Symptoms ◽  
High Dose ◽  
Post Transplantation ◽  
Hematopoietic Stem

AbstractExperimental allergic encephalomyelitis (EAE) is the animal model of multiple sclerosis (MS). Autologous hematopoietic stem cell transplantation (AHSCT) has recently been recognized as the standard treatment for MS. The aim of our experiment was to investigate the effect of AHSCT with the addition of low-dose post-transplantation cyclophosphamide (Cy) on EAE in rats. Low dose post-transplantation Cy is used in haploidentical HSCT to reduce the risk of graft versus host disease. We hypothesized that it could bring additional benefit in autologous HSCT in autoimmune diseases. Rats with evoked EAE were treated with high dose (125 mg/kg) Cy, followed by AHSCT or high dose (125 mg/kg) Cy followed by AHSCT followed by low dose (20 mg/kg) Cy in two-time schedules—with the therapy applied during the pre-symptomatic or symptomatic phase of the disease. Both AHSCT and AHSCT with post-transplantation Cy in accordance with both time schedules reduce the intensity of the inflammatory response in the CNS, in comparison with non-treated EAE rats. The reduction of clinical symptoms was present in all AHSCT treatment protocols, however, it was significantly stronger when post-transplantation Cy was given during the symptomatic phase of the disease. AHSCT with the addition of post HSCT low dose Cy improved the results of AHSCT by not only reducing the intensity of inflammation in the CNS but also by significantly reducing the clinical symptoms in treated animals when compared to AHSCT alone. We provide an experimental rationale that the addition of post-transplantation Cy may improve the outcome of HSCT in MS. Graphic Abstract

scholarly journals Experimental model of the burn wound topical treatment

2003 ◽  
Vol 3 (4) ◽  
pp. 61-66
Author(s):  
Amra Čabaravdić ◽  
Irfan Zulić ◽  
Zakira Mornjaković ◽  
Mirjana Mijanović ◽  
Fahir Bečić
Keyword(s):  
Animal Model ◽  
Clinical Symptoms ◽  
Healing Process ◽  
Surrounding Tissue ◽  
Control Group ◽  
Wound Healing Process ◽  
Herbal Preparation ◽  
Burn Wound ◽  
Experimental Animals ◽  
Significant Difference

AbstractBACKGROUND AND PURPOSE:Clinical research of drugs is a researching step subsequent to the preclinical studies in experimental animals. The aim of our research was to evaluate animal model of wound healing process after the burninducement and effects of the ointment containing natural plants on the process of burn healing.MATERIAL AND METHODS:Burn wounds were experimentally induced in two species of experimental animals which were treated with topically applied herbal preparation with concomitant monitoring of the healing process. Experimental groups (1) of 15 animals each (mice and rats), while control group (2) of 10 animals each (mice and rats) that were not being treated with herbal ointment. After the hair removal, burn was induced on the back of animals by heated brass seal. Different clinical symptoms including oedema of surrounding tissue, redness, exudation, size of the burn surface, histological and microbiological findings were monitored on the days 1, 3, 7, 14 and 21. A statistically significant difference was observed throughout descriptive statistics and paired Student's t-test.CONCLUSION:Physiological healing processes of the acute burn wound following the topical application of herbal preparation can be monitored on the utilized animal model. A three-week treatment resulted in the 90% of completed epithelization in both animal species, indicating the effectiveness of topically applied herbal preparation.

scholarly journals Neuroprotective Effect of Glatiramer Acetate on Neurofilament Light Chain Leakage and Glutamate Excess in an Animal Model of Multiple Sclerosis

2021 ◽  
Vol 22 (24) ◽  
pp. 13419
Author(s):  
Rina Aharoni ◽  
Raya Eilam ◽  
Shaul Lerner ◽  
Efrat Shavit-Stein ◽  
Amir Dori ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Animal Model ◽  
Cell Death ◽  
Glatiramer Acetate ◽  
Clinical Symptoms ◽  
Apoptotic Cell ◽  
Neuroprotective Effect ◽  
Neuronal Cell ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

Axonal and neuronal pathologies are a central constituent of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), induced by the myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide. In this study, we investigated neurodegenerative manifestations in chronic MOG 35–55 induced EAE and the effect of glatiramer acetate (GA) treatment on these manifestations. We report that the neuronal loss seen in this model is not attributed to apoptotic neuronal cell death. In EAE-affected mice, axonal damage prevails from the early disease phase, as revealed by analysis of neurofilament light (NFL) leakage into the sera along the disease duration, as well as by immunohistological examination. Elevation of interstitial glutamate concentrations measured in the cerebrospinal fluid (CSF) implies that glutamate excess plays a role in the damage processes inflicted by this disease. GA applied as a therapeutic regimen to mice with apparent clinical symptoms significantly reduces the pathological manifestations, namely apoptotic cell death, NFL leakage, histological tissue damage, and glutamate excess, thus corroborating the neuroprotective consequences of this treatment.

scholarly journals SCID Mouse Model for Lethal Q Fever

2003 ◽  
Vol 71 (8) ◽  
pp. 4717-4723 ◽  
Author(s):  
Masako Andoh ◽  
Takashi Naganawa ◽  
Akitoyo Hotta ◽  
Tsuyoshi Yamaguchi ◽  
Hideto Fukushi ◽  
...  
Keyword(s):  
Animal Model ◽  
Scid Mouse ◽  
Clinical Symptoms ◽  
Q Fever ◽  
Lethal Dose ◽  
Scid Mice ◽  
Chronic Q Fever ◽  
Liver And Kidney ◽  
Scid Mouse Model ◽  
Immunocompetent Mice

ABSTRACT Q fever, a worldwide zoonosis caused by Coxiella burnetii, has many manifestations in humans. Endocarditis is the most serious complication of Q fever. Animal models are limited to acute pulmonary or hepatic disease and reproductive disorders. An appropriate experimental animal model for Q fever endocarditis does not yet exist. In this study, severe combined immunodeficient (SCID) mice infected with C. burnetii showed persistent clinical symptoms and died, whereas immunocompetent mice similarly infected became asymptomatic and survived. The SCID mice examined in this study had severe chronic lesions in their primary organs: the heart, lung, spleen, liver, and kidney. The heart lesions of the SCID mice were similar to those in humans with chronic Q fever endocarditis: they had focal calcification and expanded macrophages containing C. burnetii. The 50% lethal dose of C. burnetii in SCID mice was at least 108 times less than that in immunocompetent mice. The SCID mouse is highly susceptible to C. burnetii, and the immunodeficiency of the host enhances the severity of Q fever. This animal model could provide a new tool for the study of chronic Q fever and Q fever in immunodeficient hosts.

Sign in / Sign up

Export Citation Format

Share Document