The practical teaching method is proposed based on the comprehensive training, applies virtual sandbox in practical teaching of mechanical engineering project management, and makes detailed researches on the advantages of virtual sandbox applied in project management as well as design of practical teaching system, in order to improve the practical ability on project management of students in major of mechanical engineering; it is shown from the results that the method is capable of effectively helping students strengthening vocational skills under teaching mode of comprehensive training and enhancing their overall quality and practical ability.