scholarly journals EXPERIMENTAL STUDY OF NOCARDIOSIS IN GUINEA PIGS

2000 ◽  
Vol 24 (2) ◽  
pp. 251-268
Author(s):  
M. J. ALWAN
Keyword(s):  
Experimental Study ◽  
Post Infection ◽  
Guinea Pigs ◽  
Pathological Examination ◽  
Nocardia Asteroides ◽  
Pathological Changes ◽  
Bacterial Counts ◽  
Chronic Form ◽  
Epithelioid Granuloma

The pathology of local isolated strain of Nocardia asteroides was study in pigs . 60 animals were divided into two groups. The 1st group (40 animals) was given a single intrapulmonary of 3.3X10'CFU of N. astoroides. The 2 nd group (20 animals) served as control . Eight animals died during the first 3 weeks post – infection while the remaining were sacrificed at 6, 12, 24, 48 hrs and 4, 8, 16, 24 and 62 days P.I. Early pathological examination revealed acute suppurative changes which seen turned into disseminated chronic form. Pyogranul matous and epithelioid granuloma have represented the main pathological changes at 8-24 days P.J. The results revealed arisein the level of bacterial counts followed by drop in count within 8-24 days P.I. Excepted kidney in which high bacterial counts persisted toward the end of the experiment

Phenylalanine Metabolism is Dysregulated in Human Hippocampus with Alzheimer’s Disease Related Pathological Changes

2021 ◽  
pp. 1-14
Author(s):  
Pan Liu ◽  
Qian Yang ◽  
Ning Yu ◽  
Yan Cao ◽  
Xue Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Brain ◽  
Pathological Examination ◽  
Pathological Changes ◽  
Targeted Metabolomics ◽  
Phenylpyruvic Acid ◽  
Postmortem Human Brain ◽  
Metabolic Dysregulation ◽  
Phenylalanine Metabolism

Background: Alzheimer’s disease (AD) is one of the most challenging diseases causing an increasing burden worldwide. Although the neuropathologic diagnosis of AD has been established for many years, the metabolic changes in neuropathologic diagnosed AD samples have not been fully investigated. Objective: To elucidate the potential metabolism dysregulation in the postmortem human brain samples assessed by AD related pathological examination. Methods: We performed untargeted and targeted metabolomics in 44 postmortem human brain tissues. The metabolic differences in the hippocampus between AD group and control (NC) group were compared. Results: The results show that a pervasive metabolic dysregulation including phenylalanine metabolism, valine, leucine, and isoleucine biosynthesis, biotin metabolism, and purine metabolism are associated with AD pathology. Targeted metabolomics reveal that phenylalanine, phenylpyruvic acid, and N-acetyl-L-phenylalanine are upregulated in AD samples. In addition, the enzyme IL-4I1 catalyzing transformation from phenylalanine to phenylpyruvic acid is also upregulated in AD samples. Conclusion: There is a pervasive metabolic dysregulation in hippocampus with AD-related pathological changes. Our study suggests that the dysregulation of phenylalanine metabolism in hippocampus may be an important pathogenesis for AD pathology formation.

The effect of vitamin E on lung pathology in sulfur mustard-exposed guinea pigs

2016 ◽  
Vol 32 (12) ◽  
pp. 1971-1977 ◽  
Author(s):  
Zahra Gholamnezhad ◽  
Mohammad Hossein Boskabady ◽  
Sediqa Amery ◽  
Nassim Vahedi ◽  
Abass Tabatabaei ◽  
...  
Keyword(s):  
Vitamin E ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Sulfur Mustard ◽  
Pulmonary Complications ◽  
Control Group ◽  
Lung Pathology ◽  
Pathological Changes ◽  
Bronchial Stenosis ◽  
Pathological Evaluation

Pulmonary complications of exposure to sulfur mustard (SM) gas range from no effect or mild symptoms to severe bronchial stenosis. In the present study, the protective effect of vitamin E on the lung inflammation of SM-exposed guinea pigs was examined. Guinea pigs ( n = 5 for each group) were exposed to ethanol (control group), 40 mg/m3 inhaled SM (SME group), SME treated with vitamin E (SME + E), SME treated with dexamethasone (SME + D), and SME treated with both treatments (SME + E + D). Pathological evaluation of the lung was done 14 days postexposure. The epithelial desquamation of trachea and other pathologic changes in the lung of the SME group were significantly higher than those in the control group. Furthermore, the pathological changes of trachea and lung in the SME + E and SME + E + D groups were significantly improved compared with those of SME group. In addition, the pathological changes of trachea and lung of SME + E and SME + E + D animals were significantly less than those of SME + D group.

Staphylococcal wound infection an experimental study in guinea-pigs

1962 ◽  
Vol 49 (217) ◽  
pp. 569-571 ◽  
Author(s):  
G. W. Taylor ◽  
R. A. Shooter ◽  
P. H. Frandsen ◽  
W. R. Fielder ◽  
W. J. Kerth
Keyword(s):  
Experimental Study ◽  
Wound Infection ◽  
Guinea Pigs

scholarly journals Calves Infected with Virulent and Attenuated Mycoplasma bovis Strains Have Upregulated Th17 Inflammatory and Th1 Protective Responses, Respectively

Genes ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 656 ◽  
Author(s):  
Chao ◽  
Han ◽  
Liu ◽  
Li ◽  
Peng ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Post Infection ◽  
Mononuclear Cells ◽  
Clinical Signs ◽  
Mycoplasma Bovis ◽  
Pathological Changes ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Induced Immunity

Mycoplasma bovis is a critical bovine pathogen, but its pathogenesis remains poorly understood. Here, the virulent HB0801 (P1) and attenuated HB0801-P150 (P150) strains of M. bovis were used to explore the potential pathogenesis and effect of induced immunity from calves’ differential transcriptomes post infection. Nine one-month-old male calves were infected with P1, P150, or mock-infected with medium and euthanized at 60 days post-infection. Calves in P1 group exhibited other clinical signs and pathological changes compared to the other two groups. Transcriptome profiles of peripheral blood mononuclear cells revealed seven and 10 hub differentially expressed genes (DEGs) in P1 and P150 groups compared with mock-infected group, respectively. Then, P1-induced pathogenesis was predicted to be associated with enhanced Th17, and P150-induced immunity with Th1 response and expression of ubiquitination-associated enzymes. Association analysis showed that 14 and 11 DEGs were positively and negatively correlated with pathological changes, respectively. Furthermore, up-regulated expression in molecules critical to differentiation of pathogenic Th17 cells in lung and peripheral blood mononuclear cells in P1 group was validated at RNA and protein levels. The results confirmed virulent and attenuated strains might be associated with biased differentiation of pro-inflammatory pathogenic Th17 and Th1 subsets respectively.

scholarly journals CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC

1915 ◽  
Vol 22 (5) ◽  
pp. 535-543 ◽  
Author(s):  
Wade H. Brown ◽  
Louise Pearce
Keyword(s):  
Guinea Pigs ◽  
Pathological Changes ◽  
Chemical Constitution ◽  
Therapeutic Doses ◽  
Adrenal Injury

1. Toxic doses of all arsenicals of which we have any knowledge produce definite pathological changes in the adrenals of guinea pigs. These changes include congestion, hemorrhage, disturbances in the lipoid content, cellular degenerations and necroses, and reduction in the chromaffin content. 2. The character and severity of the injury produced by different arsenicals varies with the chemical constitution of the compounds. 3. From these facts, we believe that adrenal injury is an important factor in arsenical intoxication and suggest that therapeutic doses of some arsenicals may produce adrenal stimulation.

Intracochlear application of steroids: an experimental study in guinea pigs

2004 ◽  
Vol 5 (sup1) ◽  
pp. 17-18
Author(s):  
Qing Ye ◽  
Jan Kiefer ◽  
Jochen Tillein ◽  
Rainer Klinke ◽  
Wolfgang Gstoettner
Keyword(s):  
Experimental Study ◽  
Guinea Pigs
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