Correlations between oropharyngeal and laryngeal anatomy and the frequency of singing voice: A population-based study, in Greece

The aim of this study is to explore if there is correlation between the typical voice classification and oropharyngeal anatomy, using cervical posterior-anterior radiography on professional singers in Epirus, Greece. Methods: 70 professional singers, 35 men and 35 women, were recruited for this study. All participants underwent a cervical posterior-anterior radiographic imaging of their oral pharyngeal and laryngeal area. Results: A statistically significant difference of mean distance was observed for the CI-MHP area (p=0,004), the MHP- SCV area (F=2,62, p=0,032), as well as SCV-AI area (F=11,82, p=0,000). For the average length measured in mm of the phonetic area PA, statistically significant differences were computed among all the singers in the group (F [5] = 5.368, p = 0.001), as well as the OPC area (F = 6,48, p = 0,000). Conclusions: The cervical posteroanterior radiography provided new correlations of the voice category of professional singers with their Oropharyngeal and Laryngeal Anatomy.

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Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality

Blood ◽

10.1182/blood.2019001793 ◽

2020 ◽

Vol 135 (4) ◽

pp. 261-268 ◽

Cited By ~ 12

Author(s):

Jakob Werner Hansen ◽

Dorthe Almind Pedersen ◽

Lisbeth Aagaard Larsen ◽

Simon Husby ◽

Signe Bedsted Clemmensen ◽

...

Keyword(s):

Genetic Predisposition ◽

Population Based ◽

Specific Gene ◽

Variant Allele Frequency ◽

Population Based Study ◽

Clonal Hematopoiesis ◽

Significant Difference ◽

Significant Heritability ◽

Gene Subgroup

Abstract Clonal hematopoiesis (CH) of indeterminate potential (CHIP) is defined by mutations in myeloid cancer–associated genes with a variant allele frequency of at least 2%. Recent studies have suggested a possible genetic predisposition to CH. To further explore this phenomenon, we conducted a population-based study of 594 twins from 299 pairs aged 73 to 94 years, all with >20 years’ follow-up. We sequenced DNA from peripheral blood with a customized 21-gene panel at a median coverage of 6179X. The casewise concordance rates for mutations were calculated to assess genetic predisposition. Mutations were identified in 214 (36%) of the twins. Whereas 20 twin pairs had mutations within the same genes, the exact same mutation was only observed in 2 twin pairs. No significant difference in casewise concordance between monozygotic and dizygotic twins was found for any specific gene, subgroup, or CHIP mutations overall, and no significant heritability could be detected. In pairs discordant for CHIP mutations, we tested if the affected twin died before the unaffected twin, as a direct measurement of the association of having CH when controlling for familial factors. A total of 127 twin pairs were discordant for carrying a mutation, and in 61 (48%) cases, the affected twin died first (P = .72). Overall, we did not find a genetic predisposition to CHIP mutations in this twin study. The previously described negative association of CHIP mutations on survival could not be confirmed in a direct comparison among twin pairs that were discordant for CHIP mutations.

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Growth-Related Differences in Maximum Laterotrusion and Retrusion between Children and Adults

The Angle Orthodontist ◽

10.2319/011508-21.1 ◽

2009 ◽

Vol 79 (2) ◽

pp. 265-270 ◽

Cited By ~ 6

Author(s):

Claudia A. Reicheneder ◽

Peter Proff ◽

Uwe Baumert ◽

Tomas Gedrange

Keyword(s):

Temporomandibular Joint ◽

Null Hypothesis ◽

Population Based ◽

Adult Group ◽

Population Based Study ◽

Significant Difference ◽

Left And Right ◽

The Mean ◽

The Right

Abstract Objective: To test the null hypothesis that there are no differences between children and adults in maximum laterotrusion and maximum retrusion on the right and left sides. Materials and Methods: This population-based study included 81 randomly selected children between the ages of 6 and 10 years and 67 adults. Kinematic variables were measured with the ultrasonic JMA-System for registration. Results: The mean maximum laterotrusion of the children's group (10.6 ± 1.5 mm on the left, 11.0 ± 1.7 mm on the right) was significantly smaller than that of the adult group (11.7 ± 2.0 mm on the left, 12.2 ± 1.7 mm on the right). The maximum laterotrusion of the children's group corresponded to about 90% on the left and right sides of that of the adult group. The mean maximum retrusion of the children's group was significantly bigger than that of the adult group. There, the adult values corresponded to 66.7% on the left and 50% on the right side of the children's values. No significant difference in maximum laterotrusion and retrusion was noted on the right and left sides, and no significant differences according to gender specificities were observed in either group. Conclusions: The hypothesis is rejected. In development of the temporomandibular joint, maximum laterotrusion on the right and left sides increases significantly with age, and maximum retrusion decreases significantly with age.

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Adjuvant Treatment of Early Ovarian Clear Cell Carcinoma: A Population-Based Study of Whole Abdominal Versus Pelvic Nodal Radiotherapy

Journal of the National Comprehensive Cancer Network ◽

10.6004/jnccn.2020.7609 ◽

2021 ◽

Vol 19 (2) ◽

pp. 172-180

Author(s):

Soumyajit Roy ◽

Paul Hoskins ◽

Anna Tinker ◽

Harinder Brar ◽

Gale Bowering ◽

...

Keyword(s):

Adjuvant Chemotherapy ◽

Cell Carcinoma ◽

Adjuvant Treatment ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Final Analysis ◽

Population Based ◽

Ovarian Clear Cell Carcinoma ◽

Population Based Study ◽

Significant Difference

Background: Adjuvant treatment in early ovarian clear cell carcinoma (OCCC) is not yet standardized. The objective of this population-based study was to compare the outcome of patients with early OCCC treated with adjuvant chemotherapy versus chemoradiotherapy (chemoRT) and evaluate the association of adjuvant radiotherapy regimens (whole abdominal radiotherapy [WART] versus pelvic nodal radiotherapy [PRT]) with outcome. Patients and Methods: Chart review was conducted to identify patients with stage I and II OCCC with complete information on staging. Patients with stage IA, IB, or IC OCCC purely resulting from capsular rupture were excluded because the provincial protocol does not recommend adjuvant treatment. Results: Overall, 403 patients were identified and 343 received adjuvant treatment, of whom 255 had stage IC or II OCCC and 153 were eligible for final analysis. On Cox multivariable regression, receipt of chemoRT (n=90) was associated with an improvement in failure-free survival (FFS) (hazard ratio [HR], 0.57; 95% CI, 0.34–0.94) compared with chemotherapy alone (n=63). Use of chemoRT also resulted in 54% reduction in the cumulative incidence of cancer-specific mortality (subdistribution HR, 0.46; 95% CI, 0.24–0.89). However, there was no significant difference in the HR for overall survival (OS) between the chemoRT (HR, 0.70; 95% CI, 0.43–1.13) and chemotherapy group. Relative to chemotherapy + WART (chemo-WART), chemotherapy + PRT (chemo-PRT) was not associated with any significant difference in HR for FFS (HR, 1.34; 95% CI, 0.40–4.44) or OS (HR, 1.13; 95% CI, 0.37–3.46). Conclusions: Adjuvant chemoRT was associated with a lower risk of failure compared with chemotherapy alone. However, there was no difference in OS between the adjuvant chemotherapy and chemoRT regimens. Additionally, no significant difference in terms of FFS or OS was found between the chemo-WART and chemo-PRT groups.

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Nutrient Patterns and Their Relation With Obesity in Iranian Adults: A Population-based Study

10.21203/rs.3.rs-40532/v1 ◽

2020 ◽

Author(s):

Mohammad Reza Amini ◽

Zahra Akbarzade ◽

Farhang Djafari ◽

Habib Yarizadeh ◽

Mahshid Shahavandi ◽

...

Keyword(s):

Blood Pressure ◽

Nutrient Intake ◽

Factor Loading ◽

Population Based ◽

Cross Sectional Study ◽

Cross Sectional ◽

Population Based Study ◽

Significant Difference ◽

Major Nutrient ◽

Nutrient Patterns

Abstract Objective: In spite of growing evidence on the associations between nutrient patterns and obesity. A few study examined the association between patterns of nutrient intake and obesity we aimed to explore the association between nutrient pattern and obesity in Iranian adults.Results: In this cross-sectional study, a total of 850 subjects aged years 20 to 59 were randomly selected. Our statistical analysis revealed three major nutrient patterns that show the principle factor loading of nutrient intake. We observed a significant association between quintiles in men for Fasting Blood Sugar (FBS) (P<0.006) in the first nutrient pattern. Moreover, we identified a significant difference between quintiles in the first nutrient pattern in women for obesity (P=0.007), Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) (P<0.02). In the third nutrient pattern, we identified a significant association for SBP in women (P<0.02).

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Head & neck acinar cell carcinoma: a population-based study using the seer registry

10.21203/rs.3.rs-26412/v2 ◽

2020 ◽

Author(s):

Feiluore Yibulayin ◽

Lei Feng ◽

Meng Wang ◽

Meng-meng Lu ◽

Yuan Luo ◽

...

Keyword(s):

Prognostic Factors ◽

Cell Carcinoma ◽

Acinar Cell ◽

Acinar Cell Carcinoma ◽

Population Based ◽

Clinicopathologic Characteristics ◽

Population Based Study ◽

Ajcc Stage ◽

Significant Difference ◽

Grade Iii

Abstract Background: to explore the clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively. Methods: A population-based study was conducted using data from the Surveillance, Epidemiology, and End Results database (1975- 2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression. Results: A total of 2624 primary HNACC cases (1052 males, 1572 females) were identified. There was a significant difference in gender distribution. Among the total cohort, 2416 cases originated from salivary glands, including 2325 parotid gland ACC cases. Regardless of confounding factors, the 10-year and 20-year disease-specific survival (DSS) was 93.6% and 90%, respectively. Surgery was favourably associated with better DSS and OS [HR = 0.13, P = 0.0092 and HR = 0.23, P = 0.0203]. Gender was the only demographic independent prognostic factor for both DSS and OS [male vs female, HR = 3.3, P = 0.0028 for DSS; HR = 2.44, P = 0.0376 for OS]. Higher pathological grade was adversely associated with DSS and OS [Grade II, HR= 4.03, P = 0.0444; Grade III + IV, HR = 35.64, P = 0.0000 for DSS; Grade III + IV, HR = 4.49, P = 0.0000 for OS, Grade I as reference]. In addition, TNM/AJCC stage was commonly associated with prognosis. Conclusion: Surgery was the only favourable prognostic indicator for both DSS and OS. Gender, age, pathological differentiation and TNM/AJCC stage were independent prognostic factors for survival.

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Rivaroxaban Versus Low Molecular Weight Heparin For The Prevention Of Venous Thromboembolism After Orthopedic Surgery: A Population-Based Study

Blood ◽

10.1182/blood.v122.21.215.215 ◽

2013 ◽

Vol 122 (21) ◽

pp. 215-215 ◽

Cited By ~ 1

Author(s):

Alejandro Lazo-Langner ◽

Jamie L. Fleet ◽

Eric McArthur ◽

Amit X. Garg

Keyword(s):

Molecular Weight ◽

Venous Thromboembolism ◽

Emergency Room ◽

Population Based ◽

Low Molecular Weight ◽

Routine Practice ◽

Bleeding Events ◽

Population Based Study ◽

Major Hemorrhage ◽

Significant Difference

Abstract Introduction Venous thromboembolism (VTE) occurs in up to 25% of patients undergoing total hip (THA) or knee arthroplasty (TKA) without the use of prophylactic anticoagulation. Low molecular weight heparins (LMWH) are the standard agents for preventing VTE in this setting. In recent years, rivaroxaban, apixaban and dabigatran have been approved for this indication and, although results from randomized trials suggest that they are non-inferior and potentially superior to LMWH, information regarding outcomes in routine use is lacking. Objectives To evaluate the safety and efficacy of rivaroxaban for the prevention of VTE in patients undergoing THR or TKR in routine practice. Methods We conducted a population-based retrospective cohort study using linked healthcare databases in Ontario, Canada, including information on hospital discharge, emergency room visits, medication use, demographics and physician billing. In Ontario older patients have universal drug coverage and thus we included patients aged 66 years or older who received an outpatient prescription for a LMWH, (including dalteparin, tinzaparin and enoxaparin) or rivaroxaban after discharge from THR or TKR between 2002 and 2012 across 121 hospitals. Patients were excluded if they had other indications for anticoagulation. Primary efficacy and safety outcomes in the 30 days after surgery were the occurrence of an Emergency Room visit or hospitalization with a VTE (either deep vein thrombosis or pulmonary embolism) or a hospitalization with non traumatic major hemorrhage, respectively. Secondary outcomes included the previous 2 endpoints at 90 days as well as hospitalization for digestive system endoscopy (a proxy for gastrointestinal hemorrhage) and all cause mortality, both at 30 and 90 days after surgery. Unadjusted and adjusted odds ratios with 95% confidence intervals (CI) were obtained using logistic regression and reported as relative risks (RR) (appropriate given the incidence observed). Results The cohort included 24,321 patients and there was no significant difference on over 35 baseline characteristics between the LMWH (n=11,471) and rivaroxaban (n=12,850) groups. The median age for both groups was 73 years, 14,366 patients were women (59.1%) and 8,612 patients (35.4%) underwent THR. Anticoagulants were prescribed for a median of 14 days after discharge (interquartile range 10 to 21). The main results are shown in the table. Results were consistent in multiple additional analyses accounting for years rivaroxaban was approved in provincial formulary, adjusting for potential confounders, secular trends, individual LMWH, prescriber characteristics, and for subgroup analyses examining THR and TKR separately. Conclusions In this routine practice population-based study, the use of rivaroxaban compared to LMWH was associated with a lower risk of VTE without an increase in bleeding events. Financial Support Canadian Institutes of Health Research; ICES Western Scholars program. Disclosures: Lazo-Langner: Pfizer: Honoraria; Leo Pharma: Honoraria; Boehringer Ingelheim: Honoraria.

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DEFINITION OF A TIMBRE OF A SINGING VOICE: FACH VOICE CLASSIFICATION

Muzykal'nyj al'manah Tomskogo gosudarstvennogo universiteta ◽

10.17223/26188929/10/11 ◽

2020 ◽

pp. 112-122

Author(s):

Sofia Fedotova ◽

Keyword(s):

Personal Interest ◽

Singing Voice ◽

Italian School ◽

Definition Of ◽

The Individual ◽

Voice Classification ◽

Physical Capacities ◽

Russian Opera ◽

The Voice

Timbre of a singing voice is a multifaceted and difficult concept considered by researchers in aspects of acoustics, physiology, specifics of opera singing and expressiveness of an opera image. Vocal methodical literature contains certain criteria for definition of type of voice. However, due to the variety of voices, timbres and physical capacities of singers, the individual approach to each voice is necessary. In addition, the voice definition problem can be complicated by defects of sound formation, which only can avoid few beginner vocalists. The main classification of voices was formed gradually, it developed by the XVII century, in process of development of opera art by vocal researchers a new subtypes in each type of a voice were allocated. In the article are shown some of the existing approaches to classification of the types of singing voices which choice was determined by a personal interest and availability of sources to the author. The separate section of the article is devoted to the classification of opera voices by the Fach system used in Europe, which is somewhat similar to classifications of masters of the Italian school and the Soviet researchers, but it is more differentiated, connects subtypes of a voice not only with characteristics of timbre, but also diverse skills of actors and texture of singers, and also contains examples of the opera parties not extended on the Russian opera scene – which represented the interest to the author.

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Liver Resection Combined with Radiotherapy versus Liver Resection Alone in the Treatment of Hepatocellular Carcinoma: A Population-based Study

10.21203/rs.3.rs-60448/v1 ◽

2020 ◽

Author(s):

Lei Chen ◽

Xiaopeng Guo ◽

Shi Chen ◽

Yanqiao Ren ◽

Tao Sun ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Resection ◽

Mortality Risk ◽

Univariate Analysis ◽

Population Based ◽

Cancer Specific Survival ◽

Population Based Study ◽

Significant Difference ◽

Cancer Specific Mortality ◽

Better Than

Abstract BackgroundRadiotherapy has been used in the treatment of hepatocellular carcinoma (HCC) more widely. However, little research focus on comparing the efficacy of patients with liver resection combined with radiotherapy with that received liver resection alone. The study was conducted to evaluate whether the efficacy of liver resection combined with radiotherapy in the treatment of patients with HCC is better than liver resection alone.MethodsThe study utilized the data from the Surveillance, Epidemiology, and End Results 18 registry (SEER-18). Patients diagnosed with HCC between 2004 and 2015 who received liver resection or the combination of liver resection and radiotherapy were included in the analysis. The propensity score matching model (PSM) was used to reduce selection bias and potential confounding factors.ResultsBefore PSM, the median overall survival (mOS) and median cancer-specific survival (mCSS) of patients treated with liver resection alone were longer than in patients treated with the combination of liver resection and radiotherapy (P<0.001). However, there was no statistically significant difference in mOS and mCSS between the groups after PSM (P>0.05). The subgroup analysis after PSM documented that patients with American Joint Committee on Cancer (AJCC) stage I and II who were treated with liver resection and radiotherapy had no longer mOS and mCSS than patients subjected to the combination of liver resection alone (P=0.151 and P=0.185). Similar results were obtained in the subgroup group of patients with a single tumor smaller than 5 cm. Univariate analysis showed that patients undergoing liver resection combined with radiotherapy did not have an increased all-cause mortality risk (HR:1.214, 95%CI: 0.950-1.553; P=0.122) and cancer-specific mortality risk (HR:1.132, 95%CI: 0.848-1.510; P=0.401) when compared to patients treated with liver resection alone after PSM.ConclusionThe combination of liver resection and radiotherapy does not prolong the survival of HCC patients more than liver resection alone.

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Head & Neck Acinar Cell Carcinoma: A Population-Based Study Using the Seer Registry

10.21203/rs.3.rs-26412/v1 ◽

2020 ◽

Author(s):

Feiluore Yibulayin ◽

Meng Wang ◽

Meng-meng Lu ◽

Yuan Luo ◽

Hui Liu ◽

...

Keyword(s):

Prognostic Factors ◽

Cell Carcinoma ◽

Acinar Cell ◽

Acinar Cell Carcinoma ◽

Population Based ◽

Clinicopathologic Characteristics ◽

Population Based Study ◽

Ajcc Stage ◽

Significant Difference ◽

Grade Iii

Abstract Background:to explorethe clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively.Methods:A population-based study was conductedusing data from the Surveillance, Epidemiology, and End Results database (1975- 2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression.Results:A total of 2624 primary HNACC cases (1052 males, 1572 females) were identified. There was a significant difference in gender distribution. Among the total cohort, 2416 cases originated from salivary glands, including 2325 parotid gland ACC cases. Regardless of confounding factors, the 10-year and 20-year disease-specific survival (DSS) was 93.6% and 90%, respectively. Surgery was favourably associated with better DSS and OS [HR= 0.13, P = 0.0092 andHR = 0.23, P = 0.0203]. Gender was the only demographic independent prognostic factor for both DSS and OS [male vs female, HR = 3.3, P = 0.0028 for DSS; HR = 2.44, P = 0.0376 for OS]. Higher pathological grade was adversely associated with DSS and OS [Grade II, HR= 4.03, P = 0.0444; Grade III + IV, HR = 35.64, P = 0.0000 for DSS; Grade III + IV, HR = 4.49, P = 0.0000 for OS, Grade I as reference]. In addition, TNM/AJCC stage was commonly associated with prognosis.Conclusion:Surgerywasthe only favourable prognostic indicator for both DSS and OS. Gender, age, pathological differentiation and TNM/AJCC stage were independent prognostic factors for survival.

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