scholarly journals Literatur review: Peran selenium pada diare akut anak

2020 ◽  
Vol 5 (2) ◽  
pp. 140
Author(s):  
Nolitriani Nolitriani ◽  
Yusri Dianne Jurnalis ◽  
Yorva Sayoeti
Keyword(s):  
Oxidative Stress ◽  
Gastrointestinal Tract ◽  
Literature Review ◽  
Glutathione Peroxidase ◽  
Acute Diarrhea ◽  
Gastrointestinal Disease ◽  
Persistent Diarrhea ◽  
Gastrointestinal Dysfunction ◽  
In Infants And Children

Acute diarrhea is a manifestation of gastrointestinal dysfunction. If it lasts more than 14 days is called persistent diarrhea. Diarrhea is a leading cause of death in infants and children in Indonesia. Acute diarrhea is a gastrointestinal disease that is considered oxidative stress. Selenium is also thought to be involved in the acute diarrhea process because it contains the gastrointestinal glutathione peroxidase (GPx2 / GPx GI) enzyme which is most commonly found in the epithelial mucosa of the gastrointestinal tract. The aim of this review is to study and analyze the role of selenium in the treatment of pediatric acute diarrhea. This study is a literature review with a narrative method that analyzes research related to the role of selenium in the treatment of acute diarrhea. The results of this study indicate that the administration of selenium reduces the duration of diarrhea. The conclusion of this study is selenium functions in the process of healing acute diarrhea

The Role of Oxidative Stress in Gastrointestinal Tract Tissues Induced by Arsenic Toxicity in Cocks

2015 ◽  
Vol 168 (2) ◽  
pp. 490-499 ◽  
Author(s):  
Ying Guo ◽  
Panpan Zhao ◽  
Guangyang Guo ◽  
Zhibo Hu ◽  
Li Tian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastrointestinal Tract ◽  
Arsenic Toxicity

Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats

2008 ◽  
Vol 52 (6) ◽  
pp. 1134-1147 ◽  
Author(s):  
Eun-Joo Shin ◽  
Kwang Ho Ko ◽  
Won-Ki Kim ◽  
Jong Seok Chae ◽  
Tran Phi Hoang Yen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase

scholarly journals Diarrheagenic Escherichia coli and Acute and Persistent Diarrhea in Returned Travelers

2000 ◽  
Vol 38 (10) ◽  
pp. 3550-3554 ◽  
Author(s):  
C. Schultsz ◽  
J. van den Ende ◽  
F. Cobelens ◽  
T. Vervoort ◽  
A. van Gompel ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Multivariate Analysis ◽  
Acute Diarrhea ◽  
Case Control Study ◽  
Persistent Diarrhea ◽  
E Coli ◽  
Diarrheagenic Escherichia Coli ◽  
Stool Samples ◽  
Control Study

To determine the role of diarrheagenic Escherichia coliin acute and persistent diarrhea in returned travelers, a case control study was performed. Enterotoxigenic E. coli (ETEC) was detected in stool samples from 18 (10.7%) of 169 patients and 4 (3.7%) of 108 controls. Enteroaggregative E. coli (EAggEC) was detected in 16 (9.5%) patients and 7 (6.5%) controls. Diffuse adherent E. coli strains were commonly present in both patients (13%) and controls (13.9). Campylobacter andShigella species were the other bacterial enteropathogens most commonly isolated (10% of patients, 2% of controls). Multivariate analysis showed that the presence of ETEC was associated with acute diarrhea (odds ratio [OR], 6.7; 95% confidence interval [CI], 1.5 to 29.1; P = 0.005), but not with persistent diarrhea (OR, 1.6; 95% CI, 0.4 to 7.4). EAggEC was significantly more often present in patients with acute diarrhea than in controls (P = 0.009), but no significant association remained after multivariate analysis. ETEC and EAggEC are frequently detected in returned travelers with diarrhea. The presence of ETEC strains is associated with acute but not with persistent diarrhea.

scholarly journals Induction of Erythrocyte Shrinkage by Omeprazole

Dose-Response ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 155932582094694
Author(s):  
Ayesha Naveed ◽  
Kashif Jilani ◽  
Abu Bakar Siddique ◽  
Muhammad Akbar ◽  
Muhammad Riaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Size Measurement ◽  
Cell Shrinkage ◽  
Membrane Blebbing ◽  
Channel Inhibition ◽  
Measurement Results ◽  
Gastric Parietal Cells

Omeprazole, a proton pump inhibitor blocks the H+/K+-ATPase channels of gastric parietal cells. It is used for the treatment of peptic ulcer. Prolonged use of omeprazole may involve in inducing anemia. The key marker of eryptosis includes membrane blebbing, cell shrinkage and phosphatidylserine (PS) exposure at the cell surface. In current study, the eryptotic, oxidative as well as hemolytic effects of therapeutical doses (0.5, 1 and 1.5 µM) of omeprazole were investigated after exposing erythrocytes for 48 hours. Investigation of eryptosis was done by cell size measurement, PS exposure determination and calcium channel inhibition. As a possible mechanism of omeprazole induced eryptosis, oxidative stress was investigated by determining the catalase, glutathione peroxidase and superoxide dismutase activities. Similarly, necrotic effect of omeprazole on erythrocytes was also evaluated through hemolysis measurement. Results of our study illustrated that 1.5 µM of omeprazole may induce significant decrease in superoxide dismutase, glutathione peroxidase and catalase activities as well as triggered the erythrocytes shrinkage, PS exposure and hemolysis. Role of calcium was also confirmed in inducing erythrocyte shrinkage. It is concluded that the exposure of erythrocytes with 1.5 µM omeprazole may enhance the rate of eryptosis and hemolysis by inducing oxidative stress.

Stir-Fried White Pepper Can Treat Diarrhea in Infants and Children Efficiently: A Randomized Controlled Trial

2013 ◽  
Vol 41 (04) ◽  
pp. 765-772 ◽  
Author(s):  
Cheng-Qiang Jin ◽  
Yan-Xia Jia ◽  
Hai-Xin Dong ◽  
Jian-Wei Zhou ◽  
Guang-Fei Sun ◽  
...  
Keyword(s):  
Acute Diarrhea ◽  
Controlled Trial ◽  
Pediatric Emergency ◽  
Infants And Children ◽  
Persistent Diarrhea ◽  
Cure Rate ◽  
White Pepper ◽  
Medical College ◽  
Success Of Treatment ◽  
In Infants And Children

We evaluated the efficacy and safety of stir-fried white pepper in the treatment of infant and children diarrhea. This was a randomized trial conducted in the pediatric emergency department of the hospital affiliated to Jining Medical College. One hundred seventy four patients were selected from outpatients from 2011 to 2012. Participants were randomly assigned to treatment with stir-fried white pepper (n = 88) or montmorillonite powder (n = 86). The proportions of chronic diarrhea patients (n = 52) showing success of treatment were similar for both groups. There were great differences between the two groups in acute diarrhea (n = 62) and persistent diarrhea (n = 60), and the cure rate of stir-fried white pepper was higher than montmorillonite powder in both groups. The prescription of stir-fried white pepper significantly decreased the frequency of diarrhea in infants and children under 2.5 years with diarrhea compared to treatment with montmorillonite powder, especially for the patients with acute diarrhea or persistent diarrhea.

COLONIC MICROBIOTA AND CHRONIC KIDNEY DISEASE. MESSAGE ONE

2018 ◽  
Vol 22 (4) ◽  
pp. 57-73 ◽  
Author(s):  
B. G. Lukichev ◽  
A. Sh. Rumyantsev ◽  
V. Akimenko
Keyword(s):  
Chronic Kidney Disease ◽  
Gastrointestinal Tract ◽  
Kidney Disease ◽  
Literature Review ◽  
Biologically Active ◽  
Main Attention ◽  
Mechanical Removal ◽  
Starting Point ◽  
Active Substances

Interest in studying the role of the gastrointestinal tract in maintaining homeostasis in chronic kidney disease is a traditional one. It served, in particular, as a starting point for the  creation of enterosorbents. However, if earlier the main attention  was paid to the mechanical removal of a number of potentially  dangerous biologically active substances, recently an intestinal  microbiota has become an object of interest. The first part of the  literature review on this topic is devoted to questions of terminology, the normal physiology of the colon microbiota. A  detailed description of dysbiosis is given. The features of the main  groups of microorganisms are reflected. The hypothetical and  confirmed interrelations of the intestine-kidney axis are presented.  The pathogenetic mechanisms of the colon dysbiosis influence on the processes of local and systemic inflammation are discussed. The  influence of dysbiosis on the state of the kidney parenchyma and its  participation in the progression of CKD are debated.

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