scholarly journals Relationship of Sirenomelia with Gestational Diabetes Mellitus and Hypothyroidism

2021 ◽  
Vol 14 (4) ◽  
pp. em2117
Author(s):  
Hilal Karabag Citlak ◽  
Huseyin Kaya ◽  
Ismail Kursad Gokce
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Relationship Of

scholarly journals Relationship of Early Vitamin D Concentrations and Gestational Diabetes Mellitus in Indian Pregnant Women

2019 ◽  
Vol 6 ◽  
Author(s):  
Pratibha Dwarkanath ◽  
Ponnusamy Vinotha ◽  
Tinku Thomas ◽  
Siji Joseph ◽  
Annamma Thomas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Relationship Of

scholarly journals Surfactant Protein D Gene Polymorphism was Associated with the Susceptibility of Gestational Diabetes Mellitus: A Case Control Study

2021 ◽  
Author(s):  
Jingwei Xu ◽  
Yi Chen ◽  
Liangfang Tang ◽  
Xinyuan Teng ◽  
Lin Feng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gene Polymorphism ◽  
Gestational Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Coding Region ◽  
Increased Risk ◽  
Relationship Of

Abstract BackgroundSurfactant protein D (SP-D) is a critical component of the innate immune system intrinsically linked to energetic metabolism. However, the relationship of SP-D gene polymorphisms and gestational diabetes mellitus (GDM) remains unclear yet. In this study, we analyzed SP-D gene polymorphisms in GDM patients and non-diabatic controls, and then determined the association of SP-D gene polymorphisms with GDM.MethodsWe examined a common genetic polymorphism located in the SP-D coding region (rs721917, Met31Thr) with GDM patients (n = 147) and healthy pregnant controls (n = 97) by using a PCR-RFLP technique. The level of SP-D protein in serum of GDM patients and non-diabetic controls was determined by ELISA method. The gene and allele frequencies od SP-D and their association with GDM as well as SP-D protein level were analyzed using SPSS software.ResultsWe found that there exists a significant association of the SP-D polymorphism (rs721917) with GDM. SP-D (T/T) genotype had 11.6% and 21.6% in GDM and matched healthy controls, respectively (P<0.05); indicating women with (T/T) genotype have lower prevalence of GDM (OR = 0.473). Women with T/C genotypes showed an increased risk of GDM (OR = 2.440). We did not observe corrections between glucose homeostasis markers and SP-D genotypes in the women patients with GDM. Furthermore, serum SP-D level was higher in the GDM compared to matched healthy controls.ConclusionsThis study has found the first evidence that SP-D gene polymorphism (rs721917) was associated with GDM, which may provide the basis for further study how SP-D plays a regulatory role in GDM.

scholarly journals The relationship of flavonoid intake during pregnancy with excess body weight and gestational diabetes mellitus

2019 ◽  
Author(s):  
Mariana de Andrade Balbi ◽  
Lívia Castro Crivellenti ◽  
Daniela Cristina Candelas Zuccolotto ◽  
Laércio Joel Franco ◽  
Daniela Saes Sartorelli
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Excess Body Weight ◽  
Flavonoid Intake ◽  
Relationship Of ◽  
The Relationship

Relationship of neonatal body composition to maternal glucose control in women with gestational diabetes mellitus

2002 ◽  
Vol 12 (6) ◽  
pp. 396-401 ◽  
Author(s):  
J. Uvena-Celebrezze ◽  
C. Fung ◽  
A. J. Thomas ◽  
A. Hoty ◽  
L. Huston-Presley ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Composition ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Glucose Control ◽  
Neonatal Body Composition ◽  
Relationship Of ◽  
Maternal Glucose

scholarly journals Common Variants in NUS1 and GP2 Genes Contributed to the Risk of Gestational Diabetes Mellitus

2021 ◽  
Vol 12 ◽  
Author(s):  
Tianxiao Zhang ◽  
Longrui Zhao ◽  
Shujin Wang ◽  
Juan Liu ◽  
Ying Chang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Fasting Glucose ◽  
Serum Levels ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Association Analyses ◽  
Relationship Of

BackgroundRecently, NUS1 and GP2 genes were reported to be associated with the risk of type 2 diabetes (T2D) in a Japanese population. Given the sharing of pathogenic contribution from genetic factors between T2D and gestational diabetes mellitus (GDM), we conducted the study to systematically examine the relationship of NUS1 and GP2 genes with the susceptibility to GDM in Chinese Han population.MethodsA total of 4,250 subjects comprised of 1,282 patients with GDM and 2,968 controls were recruited, and 20 tag single nucleotide polymorphisms (SNPs) (10 from NUS1 and 10 from GP2) were selected for genotyping. Association analyses were conducted for GDM and its related biomedical indexes including fasting glucose and HbA1c levels.ResultsTwo SNPs, rs80196932 from NUS1 (P=2.93×10-5) and rs117267808 from GP2 (P=5.68×10-5), were identified to be significantly associated with the risk of GDM. Additionally, SNP rs80196932 was significantly associated with HbA1c level in both patients with GDM (P=0.0009) and controls (P=0.0003), while SNP rs117267808 was significantly associated with fasting glucose level in both patients with GDM (P=0.0008) and controls (P=0.0007). Serum levels of protein NUS1 and GP2 were measured for the study subjects, and significant differences were identified among groups with different genotypes of SNP rs80196932 and rs117267808, respectively.ConclusionsOur findings indicate that NUS1 and GP2 genes contribute to the risk of GDM, which would help to offer the potential to improve our understanding of the etiology of GDM and, in turn, could facilitate the development of novel medicines and treatments for GDM.

scholarly journals PO-51 Status of Relationship of Risk of Gestational Diabetes Mellitus and Physical Activity intervention

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Xian Guo ◽  
Yi Wang
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Exercise Intervention ◽  
Physical Activity Intervention ◽  
Regular Physical Activity ◽  
Relationship Of ◽  
The Relationship

Objective Gestational diabetes mellitus is the first time or any degree of glucose tolerance abnormalities discovered during the pregnancy. In the global the incidence of GDM can reach 15%. In China also reached 6.6%. Numerous studies have demonstrated that lifestyle intervention for the pregnant woman, especially to increase physical activity can significantly reduce the risk of GDM. Our research aims to search and analyze researches about the relationship of risk of gestational diabetes mellitus and physical activity intervention. Then we clear the effect of physical activity intervention and provide some advices for the future in this field.  Methods The literature data were used though Pubmed, Web of Science, EBSCO, CNKI et al. database and we searched with the keywords of “physical activity”, “exercise”, “exercise intervention”, “gestational diabetes mellitus”, “glucose tolerance”, “postpartum diabetes prevention” in all these database. Finally we reviewed researches on physical activity interventions in GDM patients, discussed the relationship of before pregnancy, during pregnancy and postpartum physical activity intervention between the GDM risk. And we used the comparative analysis to get the corresponding conclusions. Results 1. Women of European and American countries during pregnancy who participated in physical activity and achieve the recommended amount was common, but only about 1/5 of Chinese women can achieve the physical activity amount which was recommended. 2. Join in regular physical activity before, during and after pregnancy, women could reduce the risk of GDM. 3. Aerobic training and/or resistance training could effectively improve glucose metabolism and insulin in patients with GDM and the recommended exercise prescription was moderate intensity, 3 to 5 days a week, last longer than 6 weeks. Conclusions The incidence of GDM is closely connected with pregnancy lifestyle changes. Women take part in regular physical activity before, during and after pregnancy could reduce the risk of GDM. But this kind of research is rare and behindhand in China. In the future, we should put forward the corresponding suggestions for our country to make pregnancy physical activity guidelines. In the other hand, researchers should verify the effect of health of pregnant women after the exercise intervention.

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