scholarly journals Unintentional weight loss as a predictor of all-cause and cardiovascular disease mortality in older Korean men

2021 ◽  

Background and objective: Little is known regarding the prognostic role of unintentional weight loss (UWL) in mortality risk among older Korean men. This study examined the associations of UWL and unhealthy behaviors with all-cause and cardiovascular disease (CVD) mortality in Korean men aged 60 years and older. Material and Methods: Data (n = 2,309) obtained from the Korean longitudinal study of aging were analyzed. Exposures were UWL, smoking, alcohol abuse, underweight/obesity, and physical inactivity. Primary outcomes were all-cause mortality and CVD mortality. Covariates included parameters of sociodemographics and health conditions. Results: Individuals with three or more risk factors had significantly higher risks of all-cause mortality (hazard ratio [HR] = 1.536, 95% confidence interval [CI] = 1.084∼2.175, P = 0.016) and CVD mortality (HR = 2.925, 95% CI = 1.386∼6.174, P = 0.005) even after adjustments for parameters of sociodemographics, health conditions, and UWL compared to individuals with zero risk factors (HR = 1). Additionally, individuals with UWL had a significantly higher risk of all-cause mortality (HR = 1.307, 95% CI = 1.052∼1.623, P = 0.016) even after adjustments for the covariates and lifestyle risk factors compared to individuals with normal weight (HR = 1). Conclusion: The current findings show that exposure to three or more lifestyle risk factors is an independent predictor of all-cause mortality and CVD mortality, and UWL was a predictor of all-cause mortality in older Korean men.

Author(s):  
Inhwan Lee ◽  
Shinuk Kim ◽  
Hyunsik Kang

This study examined the association between lifestyle risk factors and all-cause and cardiovascular disease (CVD) mortality in 9945 Korea adults (56% women) aged 45 years and older. Smoking, heavy alcohol intake, underweight or obesity, physical inactivity, and unintentional weight loss (UWL) were included as risk factors. During 9.6 ± 2.0 years of follow-up, there were a total of 1530 cases of death from all causes, of which 365 cases were from CVD. Compared to a zero risk factor (hazard ratio, HR = 1), the crude HR of all-cause mortality was 1.864 (95% CI, 1.509–2.303) for one risk factor, 2.487 (95% confidence interval, CI, 2.013–3.072) for two risk factors, and 3.524 (95% CI, 2.803–4.432) for three or more risk factors. Compared to a zero risk factor (HR = 1), the crude HR of CVD mortality was 2.566 (95% CI, 1.550–4.250) for one risk factor, 3.655 (95% CI, 2.211–6.043) for two risk factor, and 5.416 (95% CI, 3.185–9.208) for three or more risk factors. The HRs for all-cause and CVD mortality remained significant even after adjustments for measured covariates. The current findings showed that five lifestyle risk factors, including smoking, at-risk alcohol consumption, underweight/obesity, physical inactivity, and UWL, were significantly associated with an increased risk of all-cause and CVD mortality in Korean adults.


2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Melissa S. Burroughs Peña ◽  
Dhaval Patel ◽  
Delfin Rodríguez Leyva ◽  
Bobby V. Khan ◽  
Laurence Sperling

Cardiovascular disease is the leading cause of mortality in Cuba. Lifestyle risk factors for coronary heart disease (CHD) in Cubans have not been compared to risk factors in Cuban Americans. Articles spanning the last 20 years were reviewed. The data on Cuban Americans are largely based on the Hispanic Health and Nutrition Examination Survey (HHANES), 1982–1984, while more recent data on epidemiological trends in Cuba are available. The prevalence of obesity and type 2 diabetes mellitus remains greater in Cuban Americans than in Cubans. However, dietary preferences, low physical activity, and tobacco use are contributing to the rising rates of obesity, type 2 diabetes mellitus, and CHD in Cuba, putting Cubans at increased cardiovascular risk. Comprehensive national strategies for cardiovascular prevention that address these modifiable lifestyle risk factors are necessary to address the increasing threat to public health in Cuba.


2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Adam A. Lucero ◽  
Danielle M. Lambrick ◽  
James A. Faulkner ◽  
Simon Fryer ◽  
Michael A. Tarrant ◽  
...  

Objective. To identify modifiable cardio-metabolic and lifestyle risk factors among indigenous populations from Australia (Aboriginal Australians/Torres Strait Islanders), New Zealand (Māori), and the United States (American Indians and Alaska Natives) that contribute to cardiovascular disease (CVD).Methods. National health surveys were identified where available. Electronic databases identified sources for filling missing data. The most relevant data were identified, organized, and synthesized.Results. Compared to their non-indigenous counterparts, indigenous populations exhibit lower life expectancies and a greater prevalence of CVD. All indigenous populations have higher rates of obesity and diabetes, hypertension is greater for Māori and Aboriginal Australians, and high cholesterol is greater only among American Indians/Alaska Natives. In turn, all indigenous groups exhibit higher rates of smoking and dangerous alcohol behaviour as well as consuming less fruits and vegetables. Aboriginal Australians and American Indians/Alaska Natives also exhibit greater rates of sedentary behaviour.Conclusion. Indigenous groups from Australia, New Zealand, and the United States have a lower life expectancy then their respective non-indigenous counterparts. A higher prevalence of CVD is a major driving force behind this discrepancy. A cluster of modifiable cardio-metabolic risk factors precede CVD, which, in turn, is linked to modifiable lifestyle risk factors.


Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Michael Mendelson ◽  
Asya Lyass ◽  
Sarah D de Ferranti ◽  
Charlotte Andersson ◽  
Caroline Fox ◽  
...  

Introduction: In the U.S., obesity among women of childbearing age is highly prevalent. Maternal obesity is associated with offspring obesity and cardiovascular disease (CVD) risk factors, potentially through epigenetic and early developmental mechanisms. There is limited evidence on the association of maternal overweight with offspring CVD events and mortality. Methods: We analyzed prospectively collected data from 1971 to 2012 on 879 Framingham Heart Study Offspring cohort participants with either directly measured pre-pregnancy maternal body mass index (BMI) (n=361) or offspring-reported maternal pre-pregnancy overweight status (n=518). Our outcomes included a composite measure of any CVD event or mortality, CVD mortality and all-cause mortality. Cox proportional hazard models were conducted, initially age and sex adjusted, and then additionally adjusted for potential mediators including traditional CVD risk factors. Pharmacologic treatments for diabetes, hypertension, and/or dyslipidemia were included as time-varying covariates. Results: Maternal pre-pregnancy overweight (BMI >= 85th percentile or self-report) was available for 879 Framingham Offspring Study participants (mean age [SD] at baseline 30 [5] years; 49% female; mean follow-up [SD] 32 [8] years). There were 193 CVD events, 28 CVD deaths, and 138 total deaths among the offspring. Maternal overweight was associated with an increased hazard ratio (HR) with CVD mortality (HR 10.5 [2.6-43]; p=0.001), all-cause mortality (HR 3.1 [1.5-6.4]; p=0.002), and marginally associated with the composite endpoint of CVD events and mortality (HR 1.7 [95% CI 0.99-2.8]; p=0.05). Adjustment for offspring BMI, diabetes, hypertension, and dyslipidemia attenuated the associations. In sensitivity analyses restricted to only those with directly measured maternal pre-pregnancy BMI, effect estimates remained robust (similar hazard ratios but larger confidence intervals). Conclusions: Maternal pre-pregnancy overweight is associated with offspring CVD mortality. The association is likely mediated in part through classical CVD risk factors such as offspring obesity, hypertension, diabetes, and dyslipidemia.


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