OCCUPATIONAL CANCER BURDEN: THE CONTRIBUTION OF EXPOSURE TO PROCESS-GENERATED SUBSTANCES AT THE WORKPLACE

Mapping Intimacies ◽

10.31089/978-5-6042929-2-1-2021-1-617-620 ◽

2021 ◽

Author(s):

A. Olsson ◽

◽

H. Kromhout ◽

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Occupational Exposures ◽

Welding Fumes ◽

Occupational Cancer ◽

Engine Exhaust ◽

Lung Cancers ◽

Diesel Engine Exhaust ◽

Cancer Burden ◽

Occupational Lung Cancer

Abstract. Occupational exposure to respirable crystalline silica, diesel engine exhaust emissions and welding fumes are widespread risk factors for lung cancer, and account for approximately half of the occupational lung cancer burden. If employers succeed in controlling workplace exposures to these process-generated substances, the fraction of lung cancers attributable to occupational exposures could be reduced dramatically.

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Arbeidsmiljø og røyking som årsak til lungekreft: noen epidemiologiske betraktninger

Norsk Epidemiologi ◽

10.5324/nje.v5i2.257 ◽

2009 ◽

Vol 5 (2) ◽

Author(s):

Tom K. Grimsrud

Keyword(s):

Lung Cancer ◽

Occupational Exposures ◽

English Summary ◽

Cigarette Consumption ◽

Occupational Cancer ◽

Font Size ◽

Geographical Regions ◽

The World ◽

Occupational Lung Cancer ◽

Cancer Diseases

SAMMENDRAGLungekreft er en av de hyppigst forekommende og alvorligste kreftsykdommene i verden. Etter denvoldsomme økningen i sigarettforbruket i første halvdel av dette århundret har røykevanene inntatten dominerende plass blant årsakene til lungekreft, mens yrkeseksponeringer er regnet for å væreden nest viktigste årsak. Lungekreft er den vanligste yrkesbetingete kreftsykdom i Norge. Røykevaneneer en potensiell confounder i vurderingen av yrkesmessige årsaker til lungekreft, men bådeteoretiske betraktninger og gjennomførte studier tyder på at problemet er relativt lite. Samvirkningmellom røykevaner og yrkeseksponering er best beskrevet når det gjelder asbeststøv og radon, og serut til å følge et multiplikativt mønster. For andre eksponeringer er forholdet mer ufullstendig belyst.Andelen lungekrefttilfeller som tilskrives yrkeseksponering, kan være betydelig i yrkesgrupper ellergeografiske områder hvor kreftfremkallende stoffer har vært i utstrakt bruk.Grimsrud TK. Occupational exposures and smoking as causes of lung cancer: Someepidemiological considerations. Nor J Epidemiol 1995; 5 (2): 121-127. ENGLISH SUMMARYLung cancer is one of the the most common and most serious cancer diseases in the world. Theenormous increase in cigarette consumption during the first half of this century made smoking thedominating cause of lung cancer. Occupational exposures are considered to be the second mostimportant cause. Lung cancer is the most frequent occupational cancer in Norway. Smoking is apotential confounder in the study of occupational lung cancer. Theoretical and empirical considerationsdo however indicate that the problem is of minor magnitude. Interaction between smokingand occupational exposures is described for asbestos and radon and appears to follow a multiplicativepattern. Interaction with other occupational exposures is less well studied. The proportion oflung cancer cases attributable to occupational factors can be significant in certain occupations andgeographical regions.

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Burden of lung cancer attributable to occupational diesel engine exhaust exposure in Canada

Occupational and Environmental Medicine ◽

10.1136/oemed-2017-104950 ◽

2018 ◽

Vol 75 (9) ◽

pp. 617-622 ◽

Cited By ~ 8

Author(s):

Joanne Kim ◽

Cheryl E Peters ◽

Victoria H Arrandale ◽

France Labrèche ◽

Calvin B Ge ◽

...

Keyword(s):

Lung Cancer ◽

Diesel Engine ◽

Occupational Exposure ◽

Labour Force ◽

Population Attributable Fraction ◽

Engine Exhaust ◽

Lung Cancers ◽

Diesel Engine Exhaust ◽

Cancer Statistics ◽

Exposed Population

ObjectiveTo estimate the population attributable fraction (PAF) and number of incident and fatal lung cancers in Canada from occupational exposure to diesel engine exhaust (DEE).MethodsDEE exposure prevalence and level estimates were used with Canadian Census and Labour Force Survey data to model the exposed population across the risk exposure period (REP, 1961–2001). Relative risks of lung cancer were calculated based on a meta-regression selected from the literature. PAFs were calculated using Levin’s equation and applied to the 2011 lung cancer statistics obtained from the Canadian Cancer Registry.ResultsWe estimated that 2.4% (95% CI 1.6% to 6.6%) of lung cancers in Canada are attributable to occupational DEE exposure, corresponding to approximately 560 (95% CI 380 to 1570) incident and 460 (95% CI 310 to 1270) fatal lung cancers in 2011. Overall, 1.6 million individuals alive in 2011 were occupationally exposed to DEE during the REP, 97% of whom were male. Occupations with the highest burden were underground miners, truck drivers and mechanics. Half of the attributable lung cancers occurred among workers with low exposure.ConclusionsThis is the first study to quantify the burden of lung cancer attributable to occupational DEE exposure in Canada. Our results underscore a large potential for prevention, and a large public health impact from occupational exposure to low levels of DEE.

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RE: “REANALYSIS OF DIESEL ENGINE EXHAUST AND LUNG CANCER MORTALITY IN THE DIESEL EXHAUST IN MINERS STUDY COHORT USING ALTERNATIVE EXPOSURE ESTIMATES AND RADON ADJUSTMENT” AND “DIESEL EXHAUST AND LUNG CANCER—AFTERMATH OF BECOMING AN IARC GROUP 1 CARCINOGEN”

American Journal of Epidemiology ◽

10.1093/aje/kwy166 ◽

2018 ◽

Vol 188 (2) ◽

pp. 484-485 ◽

Cited By ~ 4

Author(s):

Matthias Möhner

Keyword(s):

Lung Cancer ◽

Diesel Engine ◽

Diesel Exhaust ◽

Cancer Mortality ◽

Lung Cancer Mortality ◽

Study Cohort ◽

Engine Exhaust ◽

Diesel Engine Exhaust ◽

Group 1

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Diesel engine exhaust and lung cancer risks – evaluation of the meta-analysis by Vermeulen et al. 2014

Journal of Occupational Medicine and Toxicology ◽

10.1186/s12995-015-0073-6 ◽

2015 ◽

Vol 10 (1) ◽

Cited By ~ 4

Author(s):

Peter Morfeld ◽

Michael Spallek

Keyword(s):

Lung Cancer ◽

Diesel Engine ◽

Meta Analysis ◽

Cancer Risks ◽

Engine Exhaust ◽

Diesel Engine Exhaust

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Exposure-Response Estimates for Diesel Engine Exhaust and Lung Cancer Mortality Based on Data from Three Occupational Cohorts

Environmental Health Perspectives ◽

10.1289/ehp.1306880 ◽

2014 ◽

Vol 122 (2) ◽

pp. 172-177 ◽

Cited By ~ 78

Author(s):

Roel Vermeulen ◽

Debra T. Silverman ◽

Eric Garshick ◽

Jelle Vlaanderen ◽

Lützen Portengen ◽

...

Keyword(s):

Lung Cancer ◽

Diesel Engine ◽

Cancer Mortality ◽

Lung Cancer Mortality ◽

Engine Exhaust ◽

Diesel Engine Exhaust ◽

Exposure Response

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Common risk factors of Lung cancer, an observational study in a National Institute, Dhaka

Community Based Medical Journal ◽

10.3329/cbmj.v8i1.55666 ◽

2019 ◽

Vol 8 (1) ◽

pp. 23-29

Author(s):

MM Bodiuzzaman ◽

Muhammad Zubaer Hussain ◽

SM Munawar Morshed ◽

Md Rafiqul Islam ◽

- Md Akhtaruzzaman ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Observational Study ◽

Tobacco Smoking ◽

Age Groups ◽

Malignant Neoplasm ◽

Preventive Measure ◽

Occupational Exposures ◽

Lung Carcinogenesis ◽

Common Risk Factors

Lung cancer is the most prevalent malignant neoplasm in most of the countries, and is leading cause of mortality worldwide. Till date tobacco consumption is the main etiological factor in lung carcinogenesis. Other factors such as genetic susceptibility, poor diet, occupational exposures and air pollution may act independently. Treatment of lung cancer is time consuming, costly and need special care during its management. Post treatment complications also more and sometimes it is more serious and becomes life threatening to the patients. The study was done to find out the most common risk factors of lung cancer, for this we can take necessary preventive measure from those risk factors to prevent health burden and mortality from lung cancer.This observational study was done in the department of Medical Oncology, National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka, from January 2012 to May 2012. One hundred and six (106) patients, aged over 30 years, included all sexes, were diagnosed as a lung cancer by histopathology and came for chemotherapy, were selected randomly in this study after informed written consent. In this study we found males are predominantly affected (92.45%) by lung cancer and common age groups affected are between 51-60 years (39.62%). Among the occupation farmers are more affected (77.35%) and most of them were active smokers (64.15%). In our study we found that right side of lung is more affected (58.49%) than left side and adenocarcinoma was predominant (35.84%). Control of tobacco smoking is the most important preventive measure. This study may help us to identify the etiological aspect and future preventive efforts and research be needed to focus on tobacco smoking and non-cigarette tobacco smoking products, as well as better understanding of risk factors underlying lung carcinogenesis in never-smokers. CBMJ 2019 January: vol. 08 no. 01 P: 23-29

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Environmental and occupational cancer in Argentina: a case-control lung cancer study

Cadernos de Saúde Pública ◽

10.1590/s0102-311x1998000700008 ◽

1998 ◽

Vol 14 (suppl 3) ◽

pp. S77-S86 ◽

Cited By ~ 2

Author(s):

Elena Matos ◽

Marta Vilensky ◽

Paolo Boffetta

Keyword(s):

Lung Cancer ◽

Developing Country ◽

Motor Vehicle ◽

Occupational Exposures ◽

Case Control ◽

Alcoholic Beverages ◽

Occupational Cancer ◽

Metal Workers ◽

Shoe Industry ◽

Former Smokers

The main objective of this study was to analyze the risks for lung cancer associated with occupational exposures in a developing country where lung cancer is the first cause of mortality from cancer in men. The study involved 200 men with lung cancer and 397 hospital controls. The OR for current smokers was 8.5, whereas former smokers displayed an OR of 5.3. The fraction attributable to smoking was 85%. Statistically significant high ORs were observed for employment in the alcoholic beverages industry (4.5, 95% CI:1.02-20.2), sawmills and wood mills (4.6, 95% CI:1.1-18.4), chemicals/plastics (1.8, 95% CI:1.04-3.2), and pottery, glass, or mineral manufactures (3.4, 95% CI:1.1-10.6). Other high, but not statistically significant, risks were observed for employment in leather shoe industry and repair (2.1, 95% CI:0.8-5.4), rubber industries (3.4, 95% CI:0.9-12.4), metal workers, including welders (1.9, 95% CI:0.8-4.4), motor vehicle mechanics (2.0, 95% CI:0.9-4.2), workers in cleaning services (1.9, 95% CI:0.8-4.5), and for workers in agriculture (2.4, 95% CI:0.9-6.0). Although some of the present results may be due to chance, most are consistent with those of previous investigations in other countries.

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0374 Exposure-Response Estimates for Diesel Engine Exhaust and Lung Cancer Mortality Based on Data from Three Occupational Cohorts

Occupational and Environmental Medicine ◽

10.1136/oemed-2014-102362.145 ◽

2014 ◽

Vol 71 (Suppl 1) ◽

pp. A47.1-A47 ◽

Cited By ~ 1

Author(s):

Roel Vermeulen ◽

Debra Silverman ◽

Eric Garshick ◽

Jelle Vlaanderen ◽

Lützen Portengen ◽

...

Keyword(s):

Lung Cancer ◽

Diesel Engine ◽

Cancer Mortality ◽

Lung Cancer Mortality ◽

Engine Exhaust ◽

Diesel Engine Exhaust ◽

Exposure Response

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Radon-induced lung cancer deaths may be overestimated due to failure to account for confounding by exposure to diesel engine exhaust in BEIR VI miner studies

PLoS ONE ◽

10.1371/journal.pone.0184298 ◽

2017 ◽

Vol 12 (9) ◽

pp. e0184298 ◽

Cited By ~ 4

Author(s):

Xiaodong Cao ◽

Piers MacNaughton ◽

Jose Cedeno Laurent ◽

Joseph G. Allen

Keyword(s):

Lung Cancer ◽

Diesel Engine ◽

Engine Exhaust ◽

Diesel Engine Exhaust

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Strategies of the International Agency for Research on Cancer (IARC/WHO) to reduce the occupational cancer burden

Russian Journal of Occupational Health and Industrial Ecology ◽

10.31089/1026-9428-2021-61-3-140-154 ◽

2021 ◽

Vol 61 (3) ◽

pp. 140-154

Author(s):

Ann Olsson ◽

Mary Schubauer-Berigan ◽

Joachim Schüz

Keyword(s):

Russian Federation ◽

Western Europe ◽

Occupational Exposures ◽

Cancer Surveillance ◽

International Agency ◽

Occupational Cancer ◽

Sources Of Information ◽

Multiple Sources ◽

Cancer Burden ◽

The Russian Federation

The main mission of the International Agency for Research on Cancer (IARC/WHO) is to conduct research for cancer prevention worldwide. The strategies of the IARC to reduce the occupational cancer burden include enhancing cancer surveillance, evaluating and classifying potential human carcinogens, and conducting epidemiological research to fill gaps in knowledge on occupationally related cancers. Beyond the IARC work, it is essential to systematically monitor occupational exposures in workplaces, in order to effectively protect workers. There are multiple sources of information about occupational exposures in workplaces, but they are often not used for hazard surveillance or for research. The Russian Federation has great potential to advance research and worker protection due to their strong tradition to monitor and record exposure concentrations in workplaces. Currently most evidence regarding occupational cancer burden comes from Western Europe and North America. Estimation of the burden of occupational cancer requires accurate data from local settings as extrapolating data from other settings may be misleading due to major differences in exposures, exposure pathways and baseline cancer risks. To fill this knowledge gap, it is important to conduct exposure surveillance and epidemiological studies on occupational cancer in the Russian Federation.

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