Non-invasive evaluation of bone formation: Measurements of serum alkaline phosphatase, whole body retention of diphosphonate and serum osteocalcin in metabolic bone disorders and thyroid disease

1988 ◽  
Vol 48 (7) ◽  
pp. 611-619 ◽  
Author(s):  
L. Hyldstrup ◽  
I. Clemmensen ◽  
B. A. Jensen ◽  
I. Transbøl
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Formation ◽  
Thyroid Disease ◽  
Serum Alkaline Phosphatase ◽  
Whole Body ◽  
Serum Osteocalcin ◽  
Non Invasive ◽  
Body Retention ◽  
Metabolic Bone ◽  
Invasive Evaluation

scholarly journals Bone Density, Osteocalcin and Deoxypyridinoline for Early Detection of Osteoporosis in Obese Children

2015 ◽  
Vol 3 (3) ◽  
pp. 413-419 ◽  
Author(s):  
Ghada El-Dorry ◽  
Hala Ashry ◽  
Tarek Ibrahim ◽  
Tahany Elias ◽  
Fatma Alzaree
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Density ◽  
Serum Calcium ◽  
Negative Correlation ◽  
Total Mass ◽  
Serum Alkaline Phosphatase ◽  
Significant Negative Correlation ◽  
Whole Body ◽  
Serum Osteocalcin ◽  
Obese Children

AIM: This study aimed at comparing between bone density using DEXA, serum osteocalcin and urinary DPD in obese and non obese prepubertal children. METHODS: After taking the consent of eighty children they were subjected to: full examination, anthropometric measurements, blood samples were withdrawn to determine serum osteocalcin, Ca, Ph, alkaline phosphatase, and urinary DPD. Bone densities, body composition of the whole body were examined using DEXA. Data were analyzed using SPSS.RESULTS: All anthropometric variables showed significant increase in obese children except for height in comparison to control group. Total mass, lean + BMC, lean, fat, area, BMC, BMD and Z score of the whole body were significantly increased in obese children. Serum calcium showed significant increase while alkaline phosphatase was significantly decreased in obese children. DPD showed no significant difference between obese and non obese children. Significant negative correlation was found between ca, lean, lean + BMC and total mass. Serum alkaline phosphatase showed also a significant negative correlation with (lean + BMC and total mass). Serum osteocalcin showed negative significant correlation with area, BMC, BMD, lean and Z score.CONCLUSION: Obese children showed significant increase in anthropometric and DEXA parameters, increase in serum calcium and significant decrease in serum alkaline phosphatase. Osteocalcin was negatively correlated with most of DEXA results.

Comparison between CEA, TPA, CA 15/3 and Hydroxyproline, Alkaline Phosphatase, Whole Body Retention of 99mTc MDP in the follow-up of Bone Metastases in Breast Cancer

1990 ◽  
Vol 5 (2) ◽  
pp. 65-72 ◽  
Author(s):  
G. Francini ◽  
M. Montagnani ◽  
R. Petrioli ◽  
P. Paffetti ◽  
S. Marsili ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alkaline Phosphatase ◽  
Bone Metastases ◽  
Serum Alkaline Phosphatase ◽  
Whole Body ◽  
Lower Sensitivity ◽  
Osteoblastic Activity ◽  
Body Retention ◽  
Hydroxyproline Excretion

The development of bone metastases in cancer can be monitored easily using three markers: 24 h urinary hydroxyproline excretion (HOP) (an index of osteoclastic activity), serum alkaline phosphatase (Alk.Ph.) (an index of osteoblastic activity) and 24 h whole body retention of 99mTc-methylene diphosphonate (WBR%) (an index of bone turnover). To evaluate the effectiveness of this group of bone tumor markers in breast cancer we compared it with the following group of three markers which are commonly used in the monitoring of breast cancer and in the follow-up of advanced disease with or without bone metastases: carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and breast carcinoma antigen (CA 15/3). In 48 patients with bone metastases CEA, TPA and CA 15/3 were shown to be sensitive (79%, 85%, 90% respectively), while HOP, Alk.Ph. and WBR%, which are commonly accepted as reliable markers of bone activity, showed a lower sensitivity (67%, 46%, 75% respectively). These results may be explained by the lack of osteoclastic or osteoblastic (or both) activity at the time of diagnosis. This explanation is supported by the fact that the bone markers HOP, Alk.Ph. and WBR% were found to be more sensitive than the others in the subsequent follow-up study. We conclude that in our study, CEA, TPA and CA 15/3 are at first more sensitive than Alk. Ph., HOP and WBR% but during the follow-up Alk.Ph., HOP and WBR% are possibly both more specific and more sensitive

Serum Alkaline Phosphatase as an Indicator of Heterotopic Bone Formation Following Total Hip Arthroplasty

1988 ◽  
Vol &NA; (234) ◽  
pp. 102???109 ◽  
Author(s):  
PER KJ??RSGAARD-ANDERSEN ◽  
POUL PEDERSEN ◽  
S??REN SKYDT KRISTENSEN ◽  
STEEN ASMUS SCHMIDT ◽  
NIELS WISBECH PEDERSEN
Keyword(s):  
Alkaline Phosphatase ◽  
Total Hip Arthroplasty ◽  
Bone Formation ◽  
Hip Arthroplasty ◽  
Serum Alkaline Phosphatase ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Total Hip

scholarly journals Neonatal Lethal Osteochondrodysplasia with Low Serum Levels of Alkaline Phosphatase and Osteocalcin

2005 ◽  
Vol 90 (2) ◽  
pp. 1233-1240 ◽  
Author(s):  
Myra H. Wyckoff ◽  
Chirine El-Turk ◽  
Abbot Laptook ◽  
Charles Timmons ◽  
Francis H. Gannon ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Formation ◽  
Serum Alkaline Phosphatase ◽  
Serum Levels ◽  
Normal Lung ◽  
Endochondral Bone Formation ◽  
Cleidocranial Dysplasia ◽  
Core Binding Factor ◽  
Endochondral Bone ◽  
Binding Factor

Neonatal lethal skeletal dysplasias are rare and typically involve thoracic malformations and severe limb shortening. We report on a newborn boy manifesting an osteochondrodysplasia associated with fatal respiratory insufficiency who had normal lung volumes and extremity lengths. His disorder featured aberrant skeletal patterning and defective ossification including a severely osteopenic skull, apparent absence of clavicles, and clefting of the mandible and vertebrae. Serum alkaline phosphatase and osteocalcin levels were markedly low. Biochemical studies suggested parathyroid insufficiency probably from critical illness. Histopathology at autopsy excluded impaired mineralization of skeletal matrix, but endochondral bone formation appeared disorganized with growth plate clustering of chondrocytes in hypertrophic zones and in zones of provisional calcification. Parathyroid glands were not found. Despite features of two distinctive heritable entities, hypophosphatasia and cleidocranial dysplasia, the cumulative findings did not match either condition, and no mutations were found in either the tissue nonspecific ALP isoenzyme or core-binding factor genes, respectively, or in the genes encoding osteocalcin or the osteoblast transcription factor osterix. This patient could represent the extreme of cleidocranial dysplasia (a disorder not always associated with structural mutation in core-binding factor A1), but more likely he defines a unique osteochondrodysplasia disrupting both intramembranous and endochondral bone formation.

scholarly journals Radiographic imaging of metabolic bone disorders and their relative management

2016 ◽  
Vol 5 (1) ◽  
pp. 264
Author(s):  
Parveen Chandna ◽  
Pramod Setty J. ◽  
Jeevika M. U. ◽  
Praveen Kumar T. Kochar ◽  
Siddesh M. B.
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Calcium ◽  
Structural Integrity ◽  
Serum Alkaline Phosphatase ◽  
Bone Diseases ◽  
The Body ◽  
Cell Physiology ◽  
Radiographic Imaging ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone

Background: Bone is a strong dynamic organ of the endoskeleton playing a vital role in structural integrity envisaging to keep proper shape and maintenance of the body, mineral reservoirs, blood production, coagulation and immunity. Metabolic bone diseases are a heterogeneous group of disorders that interrupt the normal homeostasis of bone formation and resorption. Bone regulates as well as acts as a host for hematopoiesis by providing niche for proliferation and differentiation of hematopoietic cell. Bone is a dynamic tissue but metabolically active as it is being constantly formed (modelling) and reformed (remodelling). Metabolic bone diseases comprise of a broad spectrum of inherited and acquired disorders characterized by abnormalities in calcium metabolism and bone cell physiology- that lead to an altered serum calcium concentration and skeletal failure.Methods: After taking a properly informed written consent and complete history, thorough clinical examination was done and these patients were subjected to radiographic imaging and biochemical analysis.Results: Serum alkaline phosphatase is a good marker in rickets and osteomalacia, ICTP in osteoporosis, pyridinoline, deoxypyridinoline in primary hyperparathyroidism, serum PICP in renal osteodystrophy.Conclusions: In cases of rickets and osteomalacia either decreased or normal values of serum calcium and serum phosphorus were obtained. But the cases pertaining to renal failure with rickets values of serum phosphorous were found to be raised. However, in all cases of rickets and osteomalacia values of serum alkaline phosphatase were also found to be raised.

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