Neuropsychiatric symptoms are common in immunocompetent adult patients with Toxoplasma gondii acute lymphadenitis

Toxoplasmosis, despite its mild course in immunocompetent individuals, it may have a more severe course in immunosuppressed patients such as hematology and oncology patients. This study aimed to contribute to the importance of that issue by evaluating the seropositivity rates of Toxoplasma gondii (T. gondii) in Hematology and Oncology patients and sharing the data obtained. Serum samples sent from pediatric and adult Hematology/Oncology outpatient clinic to the Microbiology Laboratory between January 2017 and August 2019 were analysed using Architect Toxo IgG and IgM Reagent Kit with chemiluminescent microparticular enzyme immunoassay method on Architect system. A total of 673 patient samples belonging to 131 pediatric patients and 542 adult patients were analysed in the study. Median age of the study group was 29 (range: 0 - 83) and 53.5% of them were male. While T. gondii IgM positivity was 8% IgG positivity was 28.7%. T. gondii IgG seropositivities in male and female patients were 27.2% and 30.4% respectively (p = 0.44). T. gondii IgM seropositivities in pediatric and adult patients were 6.9% and 8.3% respectively and IgG seropositivities were 24.4% and 29.7% (p = 0.78 and p = 0.46 respectively). T. gondii IgM positivity was found as 8% and IgG positivity as 28.7% in the study group. In conclusion, data obtained from the study were in compliance with both domestic and foreign data and the highest rate of IgM and IgG seropositivity was found in patients with lymphoma.

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Radiographic Findings of Pulmonary Tuberculosis in Non-AIDS Immunocompromised adult Patients: Comparison with Immunocompetent Adult Patients

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1994.31.5.889 ◽

1994 ◽

Vol 31 (5) ◽

pp. 889

Author(s):

Young Chul Kim ◽

Young Sook Kim ◽

Eun Gyung Kim ◽

Jae Hee Oh ◽

Joung Kim ◽

...

Keyword(s):

Pulmonary Tuberculosis ◽

Adult Patients ◽

Immunocompetent Adult ◽

Radiographic Findings

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Cervical necrotizing fasciitis affects only immunocompromized patients? Diagnostic challenges, treatment outcomes and clinical management of eleven immunocompetent adult patients with a still fatal disease

American Journal of Otolaryngology ◽

10.1016/j.amjoto.2020.102613 ◽

2020 ◽

Vol 41 (6) ◽

pp. 102613

Author(s):

Giorgos Sideris ◽

Thomas Nikolopoulos ◽

Alexander Delides

Keyword(s):

Necrotizing Fasciitis ◽

Treatment Outcomes ◽

Clinical Management ◽

Adult Patients ◽

Fatal Disease ◽

Immunocompetent Adult

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Long-Term Neurological Outcomes of Adult Patients with Phenylketonuria before and after Newborn Screening in Japan

International Journal of Neonatal Screening ◽

10.3390/ijns7020021 ◽

2021 ◽

Vol 7 (2) ◽

pp. 21

Author(s):

Kenji Yamada ◽

Seiji Yamaguchi ◽

Kazunori Yokoyama ◽

Kikumaro Aoki ◽

Takeshi Taketani

Keyword(s):

Newborn Screening ◽

Neuropsychiatric Symptoms ◽

Adult Patients ◽

Psychiatric Disabilities ◽

Long Term Effects ◽

Japanese Adult ◽

Neurological Outcomes ◽

Before And After ◽

Almost All

Japanese newborn screening (NBS) for phenylketonuria (PKU) was initiated in 1977. We surveyed the neurological outcomes of Japanese adult patients with PKU to investigate the long-term effects and of and issues with NBS. Eighty-five patients with PKU aged over 19 years who continued to be treated with a phenylalanine-free amino acid formula were investigated by administering questionnaires regarding clinical characteristics, such as mental ability, education status, and therapeutic condition. Of the 85 subjects, 68 patients were detected by NBS (NBS group), while the other 17 were clinically diagnosed before the initiation of NBS (pre-NBS group). Further, 10 of the 68 NBS patients presented intellectual and/or psychiatric disabilities, 5 of whom had a history of treatment discontinuation; in contrast, 12 of the 17 pre-NBS patients presented with neuropsychiatric symptoms. Regarding social outcomes, almost all patients in the NBS group could live an independent life, while over half of the patients in the pre-NBS group were not employed or lived in nursing-care facilities. Neurological outcomes are obviously improved by NBS in Japan. However, some patients, even those detected by NBS, developed neuropsychiatric symptoms due to treatment disruption. Lifelong and strict management is essential to maintain good neurological and social prognoses for patients with PKU.

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