A Stable Multiple Emulsion System Bearing Isoniazid: Preparation and Characterization

Calcium carbonate (CaCO3) has been utilized as a pH-responsive component in various products. In this present work, palm tocotrienols-rich fraction (TRF) was successfully entrapped in a self-assembled oil-in-water (O/W) emulsion system by using CaCO3 as the stabilizer. The emulsion droplet size, viscosity and tocotrienols entrapment efficiency (EE) were strongly affected by varying the processing (homogenization speed and time) and formulation (CaCO3 and TRF concentrations) parameters. Our findings indicated that the combination of 5000 rpm homogenization speed, 15 min homogenization time, 0.75% CaCO3 concentration and 2% TRF concentration resulted in a high EE of tocotrienols (92.59–99.16%) and small droplet size (18.83 ± 1.36 µm). The resulting emulsion system readily released the entrapped tocotrienols across the pH range tested (pH 1–9); with relatively the highest release observed at pH 3. The current study presents a potential pH-sensitive emulsion system for the entrapment and delivery of palm tocotrienols.

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Engineering motile aqueous phase-separated droplets via liposome stabilisation

Nature Communications ◽

10.1038/s41467-021-21832-x ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Shaobin Zhang ◽

Claudia Contini ◽

James W. Hindley ◽

Guido Bolognesi ◽

Yuval Elani ◽

...

Keyword(s):

Aqueous Phase ◽

Marangoni Effect ◽

Living Systems ◽

Biological Processes ◽

Biological Applications ◽

Emulsion System ◽

Biotechnological Potential ◽

New Directions ◽

Directional Motion ◽

The Stability

AbstractThere are increasing efforts to engineer functional compartments that mimic cellular behaviours from the bottom-up. One behaviour that is receiving particular attention is motility, due to its biotechnological potential and ubiquity in living systems. Many existing platforms make use of the Marangoni effect to achieve motion in water/oil (w/o) droplet systems. However, most of these systems are unsuitable for biological applications due to biocompatibility issues caused by the presence of oil phases. Here we report a biocompatible all aqueous (w/w) PEG/dextran Pickering-like emulsion system consisting of liposome-stabilised cell-sized droplets, where the stability can be easily tuned by adjusting liposome composition and concentration. We demonstrate that the compartments are capable of negative chemotaxis: these droplets can respond to a PEG/dextran polymer gradient through directional motion down to the gradient. The biocompatibility, motility and partitioning abilities of this droplet system offers new directions to pursue research in motion-related biological processes.

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Synthesis of PMMA-b-PS Block Copolymer by Emulsion ATRP and its Self-Assembly Property

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.705.115 ◽

2013 ◽

Vol 705 ◽

pp. 115-119

Author(s):

Bao Yong Tian ◽

Er Jun Tang ◽

Miao Yuan ◽

Rui Xia Hao ◽

Cun Man Li ◽

...

Keyword(s):

Drug Delivery ◽

Block Copolymer ◽

Self Assembly ◽

Potential Application ◽

Morphological Characteristic ◽

Living Polymerization ◽

The Self ◽

Emulsion System ◽

Copolymer Concentration ◽

Ft Ir

The well-defined block copolymer PMMA-b-PS was prepared by two-step ATRP in emulsion system. GPC results indicate that Mn increased linearly with conversion and polydispersity remained relatively narrow. It presents the characteristics of living polymerization in emulsion system. FT-IR demonstrated that block copolymer PMMA-b-PS could be successfully synthesized by ATRP with macroinitiator PMMA-Cl in emulsion system. The morphological characteristic of the self-assembly depends on the block copolymer concentration and transforms between spheres and rodlike micelles. The property indicates a perfect potential application in drug delivery materials.

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