Chronic fatigue is prevalent and associated with hormonal dysfunction in long-term non-Hodgkin lymphoma survivors treated with radiotherapy to the head and neck region

2015 ◽  
Vol 56 (12) ◽  
pp. 3306-3314 ◽  
Author(s):  
Mette Seland ◽  
Harald Holte ◽  
Trine Bjøro ◽  
Thomas Schreiner ◽  
Jens Bollerslev ◽  
...  
2020 ◽  
Vol 28 (1) ◽  
pp. 30-36
Author(s):  
Chiranjib Das ◽  
Pritam Chatterjee

Introduction Majority of lymphomas involving the head and neck are Non-Hodgkin lymphoma (NHL). Most of them present as cervical lymphadenopathy. The objectives of this study are to present the problems encountered in the diagnosis of extra-nodal NHL in head and neck region and show the importance of thorough clinical examination and proper investigation. Materials and Methods A prospective study was done in the department of ENT in a tertiary care hospital of West Bengal from July 2015 to June 2018. Patients diagnosed as NHL on the basis of histopathology and immunohistochemistry were included in this study. Patients who were lost in follow up were excluded from the study. Patients were treated with chemotherapy and radiotherapy by Oncologist. All patients were followed up routinely both by Otorhinolaryngologist and Oncologist.     Results There were 26 male and 11 female patients in this study. Patients were between 22 years to 76 years of age with highest incidence in 6th decade of life. Patients presented with only cervical lymphadenopathy; asymmetrical tonsillar enlargement with cervical lymphadenopathy; unilateral tonsillar enlargement only; huge inta-oral mass with stridor; parotid gland swelling; thyroid swelling with multiple cervical lymphadenopathy; epistaxis, palatal ulcer and cheek swelling; severe trismus with inconspicuous retro-mandibular mass. Majority of patients did well with chemoradiotherapy. Two patients succumbed to death, one with huge intra-oral NHL and another with nasal T/NK-cell lymphoma.  Conclusion Good knowledge of the clinical characteristics of extra-nodal NHL and the methods to establish the diagnosis are essential for a correct and timely therapy of the disease.


2021 ◽  
pp. 1-9
Author(s):  
Matthew R. LeBlanc ◽  
Sheryl Zimmerman ◽  
Thomas W. LeBlanc ◽  
Ashley Leak Bryant ◽  
Kathryn E. Hudson ◽  
...  

1997 ◽  
Vol 111 (5) ◽  
pp. 424-430 ◽  
Author(s):  
H. D. Vuyk

AbstractProminent ears are the most frequent congenital deformity in the head and neck region. Anatomy of normal and prominent ears as well as the psychological aspects of prominent ears are reviewed. Two types of surgical technique are described with emphasis on the cartilage-sparing technique.A sound pre-operative analysis, focusing on all partsof the deformity, and surgical techniques which are gradually applied to these deformities should result in pleasing, permanent changes for the vast majority of patients. In our opinion, a combination of cartilage-sparing techniques augmented with cartilage-weakeningprocedures give predictable long-term results with a natural appearing ear and concomitant few, easily treated complications.


2016 ◽  
Vol 25 (3) ◽  
pp. 739-748 ◽  
Author(s):  
Shah-Jalal Sarker ◽  
Sophia K. Smith ◽  
Kashfia Chowdhury ◽  
Patricia A. Ganz ◽  
Sheryl Zimmerman ◽  
...  

2017 ◽  
Vol 71 (6) ◽  
pp. 14-21 ◽  
Author(s):  
Katarzyna Bojanowska-Poźniak ◽  
Wioletta Pietruszewska

Introduction: Malignant lymphoma (ML) is a neoplasm caused by clonal expansion of undifferentiated B, T and NK-lymphoid cells. WHO classification divides lymphomas into two main types, i.e. Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL), with numerous subtypes. The majority of MLs are localized in lymph nodes, but extranodal locations are also possible. MLs represent approximately 3-5% of all malignant neoplasms in Poland, but their incidence has been increasing in recent years, especially in young patients. The objective of the study was to evaluate clinical manifestations and diagnostic process in patients with malignant lymphomas of the head and neck region as diagnosed in the Department of Otorhinolaryngology of the Medical University of Lodz in years 2013-2017. Material and method: 30 patients diagnosed with malignant lymphomas of the head and neck region at the Departbadament of Otorhinolaryngology of the Medical University of Lodz in 2013-2017. Results: The study group consisted of 8 cases of nodal lymphomas and 22 cases of extranodal lymphomas. In 29 cases B-cell lymphomas were diagnosed. The most common symptoms included lymphadenopathy or neck tumor. Other symptoms were associated with the location of tumors in particular body organs. The diagnosis was based on histopathological examination of biopsy (needle or surgical) samples. Conclusion: Malignant lymphomas should be taken into account during differential diagnosis of the tumor or lymphadenopathy of the neck. The diagnosis is difficult because of the nonspecificity of symptoms and the need for interdisciplinary cooperation of many specialists.


Cancer ◽  
2007 ◽  
Vol 109 (8) ◽  
pp. 1659-1667 ◽  
Author(s):  
Floortje Mols ◽  
Neil K. Aaronson ◽  
Ad J. J. M. Vingerhoets ◽  
Jan-Willem W. Coebergh ◽  
Gerard Vreugdenhil ◽  
...  

2018 ◽  
Vol 26 (1) ◽  
pp. 69-72
Author(s):  
Raman Wadhera ◽  
Usha Sehrawat ◽  
Sharad Hernot ◽  
Pawan Kumar Gahlawat ◽  
Aman Jakhar

Introduction Primitive neuroectodermal tumors (PNETs) are malignant tumors comprised of small round cells of neuro-ectodermal origin that affect soft tissue and bone. Though the occurrence of pPNETs in the head and neck region is rare, these are aggressive malignant tumors, and long-term survival rates following diagnosis remain poor. Case Report In the present case, a tumour was located in larynx (as globular/cystic mass of epiglottis) of the patient and was diagnosed as pPNET. Immunohistochemical analysis indicated that tumor cells were positive for CD99 and NSE, focally positive for EMA but negative for synaptophysin and chromogranin. The mass was surgically excised with negative margins. In post op period patient was planned for post-op chemotherapy and radiotherapy. Conclusion pPNETs are very rare in head and neck region. Significant advances in the neoadjuvant and adjuvant chemotherapeutic regimens, as well as improved facility in diagnosing these tumors through cytogenetic and immunohistochemical analysis improves the long-term disease-free survival.


Author(s):  
Chavan Shrinivas

Introduction: Special senses are group of sensory organs that help us to connect with external environment by various modes of elements like sound, sight, touch and smell. Any damage to these organs though may not be physically handicapping but can affect the quality of life of any individual. Bullet injuries to the head and neck region are life-threatening and demand a detailed clinical examination and meticulous operative management due to the complexity of craniofacial anatomy. Head and neck region also house sense organs, but most of the time their functions are not properly assessed during the primary care provided in firearm injuries. The main aim of this study was – To study the long term effects of firearm injuries on special senses. To study the impact of these injuries on facial visage causing impairment on quality of life. To set a standard protocol that can be applied in such injuries for a bedside evaluation of sense organs of victims. Materials and Methods: The following study was conducted by the Department of Otorhinolaryngology & Head and Neck Surgery, Department of Forensic Medicine and Department of Community Medicine, at Grant Government Medical College and Sir JJ Group of Hospitals. A retrospective study of 532 patients who were victims of various firearm injuries in isolated civil incidents and terrorist attacks in Mumbai between January 1990 to July 2018. Institutional ethical clearance was obtained prior to initiating the study. Data regarding the patients were obtained from hospital records. Results: The age group which was most affected was between 20- 40 years i.e.; the working population of the country. Most of the patients were of the male gender, nearly 70.3%. The sense organ to be affected the most in these incidents was ear(55.2%) ,followed by eyes(39.3%) . Facial scar caused a significant social impact on the quality of life among females. Conclusion: This study aims to set a standard protocol in the post-critical phase in firearm injuries; giving priority to functions of sense organs and facial visage to ensure a good quality of life in the post-trauma period.


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