Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients

Initial Phase ◽

Human Chondrocytes ◽

Degenerative Arthritis ◽

First-In-Human Phase I Study of a Next-Generation, Oral, Transforming Growth Factor-Beta Receptor 1 Inhibitor, LY3200882 in Patients with Advanced Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-21-1504 ◽

2021 ◽

pp. clincanres.1504.2021

Author(s):

Timothy A. Yap ◽

María Vieito ◽

Capucine Baldini ◽

Juan Manuel Sepúlveda-Sánchez ◽

Shunsuke Kondo ◽

...

Keyword(s):

Growth Factor ◽

Phase I ◽

Advanced Cancer ◽

Phase I Study ◽

Next Generation ◽

Beta Receptor ◽

Pre-clinical studies of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 (TG-C)

Cytotherapy ◽

10.3109/14653240903470639 ◽

2010 ◽

Vol 12 (3) ◽

pp. 384-393 ◽

Cited By ~ 29

Author(s):

Moon Jong Noh ◽

R. Ogden Copeland ◽

Youngsuk Yi ◽

Kyoung-Baek Choi ◽

Carol Meschter ◽

...

Keyword(s):

Growth Factor ◽

Clinical Studies ◽

Human Chondrocytes ◽

156 TISSUE INHIBITOR OF METALLOPROTEINASES-3 INDUCTION BY TRANSFORMING GROWTH FACTOR BETA IN HUMAN CHONDROCYTES IS MEDIATED BY SMAD SIGNALING

Osteoarthritis and Cartilage ◽

10.1016/s1063-4584(07)61789-0 ◽

2007 ◽

Vol 15 ◽

pp. C94-C95

Author(s):

H. Qureshi ◽

G. Ricci ◽

M. Zafarullah

Keyword(s):

Growth Factor ◽

Human Chondrocytes ◽

Tissue Inhibitor Of Metalloproteinases ◽

Tissue Inhibitor ◽

Smad Signaling ◽

Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma

PLoS ONE ◽

10.1371/journal.pone.0090353 ◽

2014 ◽

Vol 9 (3) ◽

pp. e90353 ◽

Cited By ~ 179

Author(s):

John C. Morris ◽

Antoinette R. Tan ◽

Thomas E. Olencki ◽

Geoffrey I. Shapiro ◽

Bruce J. Dezube ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Monoclonal Antibody ◽

Growth Factor ◽

Malignant Melanoma ◽

Phase I ◽

Phase I Study ◽

Advanced Malignant Melanoma ◽

CD109 inhibits transforming growth factor-beta signaling and extracellular matrix protein production in human chondrocytes

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2015.02.901 ◽

2015 ◽

Vol 23 ◽

pp. A152

Author(s):

Y. Chi ◽

J. Antoniou ◽

A. Philip

Keyword(s):

Extracellular Matrix ◽

Growth Factor ◽

Protein Production ◽

Matrix Protein ◽

Human Chondrocytes ◽

Extracellular Matrix Protein ◽

Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ◽

10.1016/j.bbamcr.2008.04.005 ◽

2008 ◽

Vol 1783 (9) ◽

pp. 1605-1612 ◽

Cited By ~ 27

Author(s):

Hamid Yaqoob Qureshi ◽

Gemma Ricci ◽

Muhammad Zafarullah

Keyword(s):

Growth Factor ◽

Signaling Pathway ◽

Human Chondrocytes ◽

Tissue Inhibitor Of Metalloproteinases ◽

Tissue Inhibitor ◽

Smad Signaling ◽

Smad Signaling Pathway ◽

Phase I/II study of GC1008: A human anti-transforming growth factor-beta (TGFβ) monoclonal antibody (MAb) in patients with advanced malignant melanoma (MM) or renal cell carcinoma (RCC)

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.9028 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 9028-9028 ◽

Cited By ~ 41

Author(s):

J. C. Morris ◽

G. I. Shapiro ◽

A. R. Tan ◽

D. P. Lawrence ◽

T. E. Olencki ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Monoclonal Antibody ◽

Growth Factor ◽

Malignant Melanoma ◽

Phase I ◽

Renal Cell ◽

Advanced Malignant Melanoma ◽

Detection of transforming growth factor-beta in sputum from patients with bronchial asthma by eosinophil survival assay and enzyme-linked immunosorbent assay

Clinical & Experimental Allergy ◽

10.1046/j.1365-2222.1996.d01-346.x ◽

1996 ◽

Vol 26 (5) ◽

pp. 557-562 ◽

Cited By ~ 1

Author(s):

T. ADACHI ◽

S. MOTOJIMA ◽

A. HIRATA ◽

T. FUKUDA ◽

N. KIHARA ◽

...

Keyword(s):

Growth Factor ◽

Bronchial Asthma ◽

Immunosorbent Assay ◽

Enzyme Linked Immunosorbent Assay ◽

Eosinophil Survival ◽

Survival Assay ◽

UP‐REGULATION OF TRANSFORMING GROWTH FACTOR BETA‐1 (TGF β 1 ) IN FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS (FSGS). A STUDY OF HUMAN RENAL BIOPSY TISSUE USING COMPETITIVE RT‐PCR, AND IN‐SITU HYBRIDISATION

Nephrology ◽

10.1046/j.1440-1797.2000.0abs6.x ◽

2000 ◽

Vol 5 (3) ◽

pp. A68-A68

Author(s):

Langham R ◽

Egan M ◽

Dowling J ◽

Gilbert R ◽

Thomson N.

Keyword(s):

Growth Factor ◽

Renal Biopsy ◽

In Situ Hybridisation ◽

Rt Pcr ◽

Focal And Segmental Glomerulosclerosis ◽

Biopsy Tissue ◽

Fetuin inhibits the effect of transforming growth factor beta in activated hepatic stellate cells

Gastroenterology ◽

10.1016/s0016-5085(01)80131-1 ◽

2001 ◽

Vol 120 (5) ◽

pp. A27-A27

Author(s):

M VERMA ◽

T PETERSON

Keyword(s):

Growth Factor ◽

Hepatic Stellate Cells ◽

Stellate Cells ◽

Growth Factor Beta ◽

Activated Hepatic Stellate Cells