scholarly journals Autologous blood transfusion in hip replacement: No effect on blood loss but less increase of plasminogen activator inhibitor in a randomized series of 80 patients

1996 ◽  
Vol 67 (4) ◽  
pp. 317-320 ◽  
Author(s):  
Margareta Hedstrom ◽  
Per-Anders Flordal ◽  
Torbjorn Ahl ◽  
Jan Svensson ◽  
Nils Dalen
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Plasminogen Activator ◽  
Hip Replacement ◽  
Autologous Blood ◽  
Plasminogen Activator Inhibitor ◽  
Autologous Blood Transfusion ◽  
Activator Inhibitor

Acute Isovolaemic Haemodilution: The Best Option for Autologous Blood Transfusion in Africa?

1995 ◽  
Vol 25 (4) ◽  
pp. 152-155 ◽  
Author(s):  
Zacharia A Berege ◽  
Bart Jacobs ◽  
Michael R Matasha ◽  
Frank Mpelumbe ◽  
Ernestini Kimaro
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Autologous Blood ◽  
Autologous Blood Transfusion ◽  
Total Blood Volume ◽  
East African ◽  
Homologous Blood ◽  
Total Blood ◽  
Induction Of Anaesthesia ◽  
Donated Blood

The purpose of this study was to identify the best method of autologous blood transfusion to be applied in an East African hospital. One hundred and nine consecutive patients for whom major blood loss was anticipated were enrolled. Seventeen patients donated 1 unit of blood 3 days preoperatively and 92 underwent acute isovolaemic haemodilution prior to induction of anaesthesia. For the haemodiluted patients a 2:1 ratio of sterile pryogen-free saline to collected blood was used. One of the 16 patients from whom 2 units were withdrawn by haemodilution experienced hypovolaemia which was rapidly restored by additional transfusion of colloid. Of the patients who donated blood preoperatively only 23.5% were autotransfused compared to 98.9% of the haemodiluted patients. Of the latter 23.9% (22) had an intraoperative blood loss exceeding 15% of their total blood volume and 7.6% (7) lost more than 25%. Only one received homologous blood in addition. For hospitals with limited blood bank facilities and regular cancellation of surgery, the use of acute isovolaemic haemodilution is recommended. A 3:1 ratio of saline to blood is now advised when 1 unit is withdrawn and a part replacement with crystalloid when 2 units are collected.

Be your own donor: An insight into the technique of Autologous blood transfusion

2011 ◽  
Vol 3 (2) ◽  
pp. 28-30
Author(s):  
Rajendra Desai ◽  
Johnathan Theodore ◽  
Shubhalakshmi LNU ◽  
Kiran V. Nesvi
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Autologous Blood ◽  
Maxillofacial Surgery ◽  
Major Influence ◽  
Oral And Maxillofacial Surgery ◽  
Autologous Blood Transfusion ◽  
Mortality And Morbidity ◽  
Insight Into

Abstract Blood loss has a major influence on mortality and morbidity after surgery. Homologous transfusion has long been in use. With the awareness of associated complications such as risk of transmission of hepatitis and HIV associated with use of homologous transfusion, autologous blood transfusion has gained importance. This paper is an attempt to review the method of autologous blood transfusion, as well as its application in oral and maxillofacial surgery.

scholarly journals Postoperative Bleeding in Cardiac Surgery

2008 ◽  
Vol 108 (4) ◽  
pp. 596-602 ◽  
Author(s):  
Jose L. Iribarren ◽  
Juan J. Jimenez ◽  
Domingo Hernández ◽  
Maitane Brouard ◽  
Debora Riverol ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Blood Loss ◽  
Plasminogen Activator ◽  
Chest Tube ◽  
Postoperative Bleeding ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Transfusion Requirements ◽  
Activator Inhibitor ◽  
Pai 1

Background Plasminogen activator inhibitor 1 (PAI-1) attenuates the conversion of plasminogen to plasmin. Polymorphisms of the PAI-1 gene are associated with varying PAI-1 levels and risk of prothrombotic events in nonsurgical patients. The purpose of this study, a secondary analysis of a clinical trial, was to investigate whether PAI-1 genotype affects the efficacy of tranexamic acid (TA) in reducing postoperative chest tube blood loss of patients undergoing cardiopulmonary bypass. Methods Fifty patients were classified according to PAI-1 genotype (4G/4G, 4G/5G, or 5G/5G). Twenty-four received 2 g TA before and after cardiopulmonary bypass, whereas 26 received placebo. The authors recorded data related to coagulation, fibrinolysis, and bleeding before surgery, at admission to the intensive care unit (0 h), and 4 and 24 h later. Results In patients not receiving TA, those with the 5G/5G genotype had significantly higher chest tube blood loss and transfusion requirements compared with patients with the other genotypes at all time points. Patients with the 5G/5G genotype receiving TA showed significantly lower blood loss compared with the placebo group. There were no significant differences in blood loss or transfusion requirements between patients with the 4G/4G genotype when TA was used. Conclusions Plasminogen activator inhibitor-1 5G/5G homozygotes who did not receive TA showed significantly greater postoperative bleeding than patients with other PAI-1 genotypes. 5G/5G homozygotes who received TA showed the greatest blood-sparing benefit.

scholarly journals Fresh Autologous Blood Transfusion and Platelet Counts after Cardiopulmonary Bypass Surgery

1982 ◽  
Vol 10 (4) ◽  
pp. 348-352 ◽  
Author(s):  
V. S. Iyer ◽  
W. J. Russell
Keyword(s):  
Platelet Count ◽  
Blood Transfusion ◽  
Blood Loss ◽  
Autologous Blood ◽  
Early Postoperative Period ◽  
Postoperative Blood Loss ◽  
Control Group ◽  
Substantial Part ◽  
Autologous Blood Transfusion ◽  
Platelet Counts

The effect of fresh autologous blood transfusion on platelet count and blood requirement in the early postoperative period is examined in a control group and in patients receiving early and late autologous replacement. Withdrawal of blood in the autologous groups appeared to enhance platelet numbers as the autologous groups had higher mean platelet counts than the control group immediately after bypass, in spite of having lower mean haematocrit. After bypass all groups showed a progressive rise in platelet count with time. A substantial part of the rise was explained by haemoconcentration resulting from fluid shifts but there was also an increase in the total circulating platelet numbers. There was no difference in postoperative blood loss between the three groups. Autologous blood replacement hastens the postoperative rise in platelet count but does not alter the postoperative blood loss.

scholarly journals Management of intraperitoneal hemorrhage bleeding as a complication of a gynecologic disease

2014 ◽  
Vol 95 (2) ◽  
pp. 211-216
Author(s):  
O Ya Nazarenko ◽  
S V Timofeyeva
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Blood Transfusion ◽  
Blood Loss ◽  
Autologous Blood ◽  
Blood Substitutes ◽  
Autologous Blood Transfusion ◽  
Blood Products ◽  
Female Patients ◽  
Intraperitoneal Hemorrhage

Aim. To evaluate the effectiveness of intra- and post-surgical resuscitation targeted at blood loss replacement in patients with moderate, severe and profuse intraperitoneal hemorrhage caused by ectopic pregnancy and ovarian apoplexy. Methods. Heart rate variability and cardiac intervals assessment were used as additional criteria for patient monitoring. 97 female patients with intraperitoneal hemorrhage of 500-1500 ml underwent endoscopic surgery. Autologous blood transfusion, as well as packed blood products and blood substitutes were used for blood loss replacement. Heart rate variability assessment and analysis of cardiac intervals indicate that pathogenesis of adaptation and blood loss compensation in female patients with intraperitoneal hemorrhage exceeding 500 ml depends on blood loss volume and methods of blood loss replacement. Results. Parameters of adaptation and blood loss compensatory mechanisms in patients with moderate and severe blood loss, who underwent intrasurgical autologous blood transfusion, were close to normal values at days 7 and 14 after treatment. Patients with severe and profuse intraperitoneal hemorrhage treated with packed blood products had the longest red blood count and heart rate variability recovery period. Conclusion. Heart rate variability assessment allowed effectively estimating the treatment effect in female patients with intraperitoneal hemorrhage as a complication of a gynecologic disease exceeding 500 ml.

Comparison of Recombinant Plasminogen Activator Inhibitor-1 and Epsilon Amino Caproic Acid in a Hemorrhagic Rabbit Model

1992 ◽  
Vol 67 (06) ◽  
pp. 692-696 ◽  
Author(s):  
Adrienne L Racanelli ◽  
Mark J Diemer ◽  
A Cathy Dobies ◽  
Joan R Dubin ◽  
Thomas M Reilly
Keyword(s):  
Blood Loss ◽  
Plasminogen Activator ◽  
Active Form ◽  
Rabbit Model ◽  
Plasminogen Activator Inhibitor ◽  
Caproic Acid ◽  
Tissue Type ◽  
Plasminogen Activator Inhibitor 1 ◽  
Type Plasminogen Activator ◽  
Activator Inhibitor

SummaryA rabbit ear model of blood loss was developed to compare the effects of an active form of recombinant plasminogen activator inhibitor-1 (rPAI-1) with epsilon amino caproic acid (EACA) in antagonizing tissue-type plasminogen activator (r-tPA)-induced blood loss. The antagonism of both rebleeding, which occurs as a result of hemostatic plug degradation, and r-tPA-induced hemorrhage, where rabbits lose approximately 30% of their blood volume, was studied. rPAI-1 (1 mg/kg i. v.) or EACA (70 mg/kg i. v.) antagonized the rebleeding induced by r-tPA (10 μg kg-1 min-1) to a similar extent. In the hemorrhagic studies, rPAI-1 effectively antagonized the r-tPA-induced hemorrhage with an ED50 of 3 mg/kg i. v., while the ED50 obtained for EACA was 230 mg/kg i. v. rPAI-1 may be of value in reversing r-tPA-induced blood loss during thrombolytic therapy or in clinical situations where excessive fibrinolysis contributes to bleeding.

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