scholarly journals Fresh Autologous Blood Transfusion and Platelet Counts after Cardiopulmonary Bypass Surgery

1982 ◽  
Vol 10 (4) ◽  
pp. 348-352 ◽  
Author(s):  
V. S. Iyer ◽  
W. J. Russell
Keyword(s):  
Platelet Count ◽  
Blood Transfusion ◽  
Blood Loss ◽  
Autologous Blood ◽  
Early Postoperative Period ◽  
Postoperative Blood Loss ◽  
Control Group ◽  
Substantial Part ◽  
Autologous Blood Transfusion ◽  
Platelet Counts

The effect of fresh autologous blood transfusion on platelet count and blood requirement in the early postoperative period is examined in a control group and in patients receiving early and late autologous replacement. Withdrawal of blood in the autologous groups appeared to enhance platelet numbers as the autologous groups had higher mean platelet counts than the control group immediately after bypass, in spite of having lower mean haematocrit. After bypass all groups showed a progressive rise in platelet count with time. A substantial part of the rise was explained by haemoconcentration resulting from fluid shifts but there was also an increase in the total circulating platelet numbers. There was no difference in postoperative blood loss between the three groups. Autologous blood replacement hastens the postoperative rise in platelet count but does not alter the postoperative blood loss.

Acute Isovolaemic Haemodilution: The Best Option for Autologous Blood Transfusion in Africa?

1995 ◽  
Vol 25 (4) ◽  
pp. 152-155 ◽  
Author(s):  
Zacharia A Berege ◽  
Bart Jacobs ◽  
Michael R Matasha ◽  
Frank Mpelumbe ◽  
Ernestini Kimaro
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Autologous Blood ◽  
Autologous Blood Transfusion ◽  
Total Blood Volume ◽  
East African ◽  
Homologous Blood ◽  
Total Blood ◽  
Induction Of Anaesthesia ◽  
Donated Blood

The purpose of this study was to identify the best method of autologous blood transfusion to be applied in an East African hospital. One hundred and nine consecutive patients for whom major blood loss was anticipated were enrolled. Seventeen patients donated 1 unit of blood 3 days preoperatively and 92 underwent acute isovolaemic haemodilution prior to induction of anaesthesia. For the haemodiluted patients a 2:1 ratio of sterile pryogen-free saline to collected blood was used. One of the 16 patients from whom 2 units were withdrawn by haemodilution experienced hypovolaemia which was rapidly restored by additional transfusion of colloid. Of the patients who donated blood preoperatively only 23.5% were autotransfused compared to 98.9% of the haemodiluted patients. Of the latter 23.9% (22) had an intraoperative blood loss exceeding 15% of their total blood volume and 7.6% (7) lost more than 25%. Only one received homologous blood in addition. For hospitals with limited blood bank facilities and regular cancellation of surgery, the use of acute isovolaemic haemodilution is recommended. A 3:1 ratio of saline to blood is now advised when 1 unit is withdrawn and a part replacement with crystalloid when 2 units are collected.

Be your own donor: An insight into the technique of Autologous blood transfusion

2011 ◽  
Vol 3 (2) ◽  
pp. 28-30
Author(s):  
Rajendra Desai ◽  
Johnathan Theodore ◽  
Shubhalakshmi LNU ◽  
Kiran V. Nesvi
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Autologous Blood ◽  
Maxillofacial Surgery ◽  
Major Influence ◽  
Oral And Maxillofacial Surgery ◽  
Autologous Blood Transfusion ◽  
Mortality And Morbidity ◽  
Insight Into

Abstract Blood loss has a major influence on mortality and morbidity after surgery. Homologous transfusion has long been in use. With the awareness of associated complications such as risk of transmission of hepatitis and HIV associated with use of homologous transfusion, autologous blood transfusion has gained importance. This paper is an attempt to review the method of autologous blood transfusion, as well as its application in oral and maxillofacial surgery.

scholarly journals Management of intraperitoneal hemorrhage bleeding as a complication of a gynecologic disease

2014 ◽  
Vol 95 (2) ◽  
pp. 211-216
Author(s):  
O Ya Nazarenko ◽  
S V Timofeyeva
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Blood Transfusion ◽  
Blood Loss ◽  
Autologous Blood ◽  
Blood Substitutes ◽  
Autologous Blood Transfusion ◽  
Blood Products ◽  
Female Patients ◽  
Intraperitoneal Hemorrhage

Aim. To evaluate the effectiveness of intra- and post-surgical resuscitation targeted at blood loss replacement in patients with moderate, severe and profuse intraperitoneal hemorrhage caused by ectopic pregnancy and ovarian apoplexy. Methods. Heart rate variability and cardiac intervals assessment were used as additional criteria for patient monitoring. 97 female patients with intraperitoneal hemorrhage of 500-1500 ml underwent endoscopic surgery. Autologous blood transfusion, as well as packed blood products and blood substitutes were used for blood loss replacement. Heart rate variability assessment and analysis of cardiac intervals indicate that pathogenesis of adaptation and blood loss compensation in female patients with intraperitoneal hemorrhage exceeding 500 ml depends on blood loss volume and methods of blood loss replacement. Results. Parameters of adaptation and blood loss compensatory mechanisms in patients with moderate and severe blood loss, who underwent intrasurgical autologous blood transfusion, were close to normal values at days 7 and 14 after treatment. Patients with severe and profuse intraperitoneal hemorrhage treated with packed blood products had the longest red blood count and heart rate variability recovery period. Conclusion. Heart rate variability assessment allowed effectively estimating the treatment effect in female patients with intraperitoneal hemorrhage as a complication of a gynecologic disease exceeding 500 ml.

scholarly journals Is There a Role for Preoperative Local Infiltration of Tranexamic Acid in Elective Spine Surgery? A Prospective Randomized Controlled Trial Analyzing the Efficacy of Intravenous, Local Infiltration, and Topical Administration of Tranexamic Acid

2019 ◽  
Vol 11 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Viswanadha Arun-Kumar ◽  
J. Naresh-Babu
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Spine Surgery ◽  
Postoperative Blood Loss ◽  
Control Group ◽  
Intraoperative Blood Loss ◽  
Local Infiltration ◽  
Safety And Efficacy ◽  
Instrumented Spine Surgery

Study Design: Randomized control trial. Objective: The purpose of the study is to evaluate the safety and efficacy of tranexamic acid in reducing blood loss when administered through various routes in instrumented spine surgeries. Methods: A total of 104 patients undergoing instrumented spine surgery were randomly assigned to 4 groups (n = 26 in each group). Groups included (1) ivTXA—intravenous administration of tranexamic acid (TXA) 1 hour prior to surgery, (2) loTXA—local infiltration of TXA bilaterally into the paraspinal musculature prior to incision, (3) tTXA—topical application of TXA just before wound closure, and (4) control group. Outcome measures included intraoperative blood loss, postoperative blood loss, need for blood transfusion, length of hospital stay, and hematological parameters. Results: All the 3 different modes of TXA administration were found to be effective in reducing blood loss in the treated groups compared with the control group. Intraoperative blood loss was significantly reduced in ivTXA (223.6 ± 40.1 mL, P < .0001) and loTXA (256.07 ± 119 mL, P = .0039) groups when compared with controls (344 ± 88.5 mL).The postoperative blood loss was least in tTXA followed by ivTXA, loTXA, and controls. There was 67% reduction in need for blood transfusion in tTXA group, 55.5% reduction in ivTXA group, and 33% reduction in loTXA group when compared with the control group. Conclusion: In instrumented spine surgery, ivTXA and loTXA were found to be equally effective in reducing the intraoperative blood loss. The tTXA has better postoperative blood conserving effects. This is the first study to detail about safety and efficacy on local infiltration of TXA in spine surgery, which is an effective and safe method for reducing intraoperative blood loss.

scholarly journals Efficacy and safety of pre-operative single dose parenteral tranexamic acid in moderately anaemic parturients undergoing caesarean section

2017 ◽  
Vol 6 (8) ◽  
pp. 3423
Author(s):  
Robin Medhi ◽  
Sonika Bawri ◽  
Chaitra S.K. ◽  
Mansur Ahmed ◽  
Asmita Mishra
Keyword(s):  
Caesarean Section ◽  
Blood Transfusion ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Postoperative Blood Loss ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Total Blood ◽  
Moderate Anaemia

Background: Preoperative administration of Tranexamic acid (TXA) has been found to be effective in reducing the amount of blood loss following Caesarean section in low risk women. However, studies in high risk women such as women with anaemia, where blood loss needs to be minimised are scarce.Methods: An experimental case control study was conducted with a total of 174 patients with moderate anaemia undergoing CS in a teaching hospital. Study group consisting of 87 patients received pre-operative TXA 1g intravenously. Intra operative and up to 6hours postpartum blood loss was calculated in both the groups. Requirement of blood transfusions were noted. Data analysed using Graphpad Instat® 3 statistical software.Results: Present study showed statistically significant reduction in intraoperative and postoperative blood loss among patients who received TXA compared to control group. The blood loss from placental delivery till completion of the procedure was significantly lowered (304.02ml vs 393.36ml; p value <0.0001). Postoperative blood loss (from end of the procedure up to 6hrs postpartum) was 62.57ml in comparison to 85.40ml in control group (p value <0.0001). The total blood loss from the placental delivery up to 6 hours postpartum was significantly reduced in study group (366.59ml vs 478.76ml; p value <0.0001). There was significant reduction of blood transfusion in study group (RR: 0.20, 95% CI, 0.045-0.887), without immediate adverse effect on mothers and new-borns.Conclusions: Administration of TXA preoperatively causes significant decrease in blood loss and the need for blood transfusion in patients with moderate anaemia undergoing CS. 

Autotransfusion in urology: Control study on 59 cases

1992 ◽  
Vol 59 (1_suppl) ◽  
pp. 73-75
Author(s):  
S. Spatafora ◽  
D. Lasagni ◽  
R. Baricchi ◽  
R. Rossi-Cesolari ◽  
C. Lusenti ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Autologous Blood ◽  
Performance Status ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Autologous Blood Transfusion ◽  
Homologous Blood ◽  
Significant Difference ◽  
Discharge From Hospital ◽  
Control Study

We studied the hematologic and clinical patterns of 59 patients undergoing urologic surgery who entered in a predeposit autologous blood transfusion program and of 59 controls to evaluate the feasibility and safety of the autotransfusional procedure in Urology. 174 units of autologous blood were donated (average 2.94 per pt.) with a high frequency of donation (2.6 days). No side effect or alteration of performance status was reported. We had a dramatic reduction of the need for homologous blood (2.21 units per pt.) without a significant difference of the average hemoglobin concentration between the two groups at discharge from hospital. Autotransfusion has significant advantages compared with conventional transfusion, reducing the complications correlated with homologous blood infusion as also our study demonstrated. Infact 1 post-transfusional hepatitis and 3 complications due to an alteration of coagulation were reported in the control group. The procedure resulted safe and feasible in most urologic operations that require almost two units of blood transfusion.

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