Clinical case of non-alcoholic fatty liver disease successful treatment in a young patient

Non-alcoholic fatty liver disease (NAFLD) is a problem that is getting increasingly important and is often considered in the literature as a sign of liver damage in the metabolic syndrome. Currently, there is a tendency to rapid growth and rejuvenation of patients with this pathology. Metabolic syndrome, which is a polyetiological disease and is characterized by metabolic disorders and the launch of various pathological cascade reactions, can cause cardiovascular diseases, diabetes mellitus and their complications. Problem of comorbidity leads to deterioration in the quality of life of the patient and in severe cases can cause death. The article describes a clinical case of newly diagnosed NAFLD in a young patient with obesity in comorbidity with hyperandrogenism, postcholecystectomy syndrome, and reactive pancreatitis. The article presents a system analysis, bibliosemantics and case analysis of a particular patient with NAFLD. The search for sources was carried out using the scientific and statistical database of medical information. The absence of pathognomonic signs and complaints of this disease draws the attention of scientists and clinicians to conduct a comprehensive study of this problem, as well as improving the detection system of NAFLD in the early stages. This will help to avoid the development of the disease and various complications associated with the metabolic syndrome, as well as save and improve the patient’s life. Fighting against the “diseases of the 21st century” should begin long before the manifestation of obvious signs of the disease. This clinical case emphasizes the relevance of this problem in medical practice. Active identification and prevention of the initial manifestations of this disease in young people will help reduce the risk of developing comorbid diseases. Patients with NAFLD and obesity have an increased risk of various complications, therefore, they need more medical attention and frequent monitoring of liver indices and functional status.

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The feasibility of using ursodeoxycholic acid in the treatment of patients with non-alcoholic fatty liver disease: a clinical case

GASTROENTEROLOGY ◽

10.22141/2308-2097.52.3.2018.141848 ◽

2018 ◽

Vol 52 (3) ◽

pp. 179-185

Author(s):

Ye.S. Sirchak

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Ursodeoxycholic Acid ◽

Fatty Liver Disease ◽

Clinical Case ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Metabolic tandem: non-alcoholic fatty liver disease and pancreatic steatosis; therapeutic significance of probiotics (clinical case)

Herald of Pancreatic Club ◽

10.33149/vkp.2020.03.09 ◽

2020 ◽

Vol 48 (3) ◽

pp. 70-75

Author(s):

O. O. Bondarenko ◽

M. I. Sorochka

Keyword(s):

Metabolic Syndrome ◽

Liver Disease ◽

Gut Microbiota ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Clinical Case ◽

Alcoholic Fatty Liver ◽

Pancreatic Steatosis ◽

Alcoholic Fatty Liver Disease

Non-communicable diseases are a serious global problem for humanity. Metabolic syndrome, cardiovascular disease, type 2 diabetes, obesity, and their complications lead to increased mortality and reduce quality of patients’ life. Non-alcoholic fatty liver disease (NAFLD) is currently recognized as one of the most common causes of chronic liver disease worldwide. Current scientific evidence suggests that there is a close relationship between the gut microbiota and chronic pathologies. The results of studies have established the existence of cause and effect relations between impaired microbiocenosis of the intestine, imbalance of the immune system, as well as in one of the key pathogenetic roles in the development and progression of NAFLD, pancreatic steatosis, increasing intestinal permeability, reducing the protective properties of mucosa, enhancing translocation of microorganisms into the systemic circulation. As no conventional approaches to the diagnosis and treatment of patients with NAFLD and metabolic syndrome have been developed at present, the therapy of such patients should be directed, first of all, to factors that contribute to their development and progression. Considering the latest research findings, the role of gut microbiota in the pathogenesis of metabolic syndrome is justified. The use of techniques affecting this correlation is substantiated. A promising method of treating such diseases is the prescription of pre- and probiotics to modify the gut microbiota. This article analyzes the case of a patient with NAFLD, pancreatic steatosis, who used a therapy that had an effect on the patient’s microbiota. The article contains system analysis, bibliosemantics, and case analysis of a specific patient. The sources were obtained from the scientific and statistical database of medical information. This clinical case highlights the relevance of this problem in medical practice and the feasibility of further research in this field. The impact of microbiome on human body is significant, and correcting disorders can reduce the risk of associated diseases. Therefore, preventing and correcting early-stage pathologies will reduce mortality rate and improve patients’ quality of life.

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Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000667 ◽

2020 ◽

pp. 1-8

Author(s):

Jeniffer Danielle M. Dutra ◽

Quelson Coelho Lisboa ◽

Silvia Marinho Ferolla ◽

Carolina Martinelli M. L. Carvalho ◽

Camila Costa M. Mendes ◽

...

Keyword(s):

Vitamin D ◽

Liver Disease ◽

Fatty Liver ◽

Disease Severity ◽

Fatty Liver Disease ◽

Hypovitaminosis D ◽

Alcoholic Fatty Liver ◽

Vitamin D Levels ◽

The Mean ◽

Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

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Non-Alcoholic Fatty Liver Disease in Overweight Children and its Relationship with Retinol Serum Levels

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.78.1.27 ◽

2008 ◽

Vol 78 (1) ◽

pp. 27-32 ◽

Cited By ~ 15

Author(s):

Suano de Souza ◽

Silverio Amancio ◽

Saccardo Sarni ◽

Sacchi Pitta ◽

Fernandes ◽

...

Keyword(s):

Insulin Resistance ◽

Liver Disease ◽

Fatty Liver ◽

Lipid Profile ◽

Fatty Liver Disease ◽

Thiobarbituric Acid ◽

Serum Levels ◽

Control Group ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Objectives: To evaluate the frequency of non-alcoholic fatty liver disease, the retinol serum levels, lipid profile, and insulin resistance in overweight/obese children. To relate these biochemical variables with the risk of this disease in the population studied. Methods: The study was cross-sectional and prospective, with 46 overweight/obese school children (28 female, 18 male; mean age 8.6 years). The control group consisted of 45 children, paired by age and gender. Hepatic steatosis, evaluated by ultrasound, was classified as normal, mild, moderate, or severe. Also evaluated were serum retinol levels; thiobarbituric acid reactive substances; lipid profile; and fasting glucose and serum insulin levels, used for the calculation of the Homeostasis Model Assessment. Results: Hepatic ultrasound alterations were found in 56.5% and 48,9% of the overweight/obese and control group children, respectively. Presence of obesity was associated with high levels of triglycerides (OR = 4.6; P = 0.002). In the studied children, the risk of steatosis was related to a trend to a higher percentage of retinol inadequacy (OR = 2.8; p = 0.051); there was no association with thiobarbituric acid reactive substances, lipid profile, or insulin resistance. Conclusions: The high frequency of non-alcoholic fatty liver disease in both groups, evaluated by hepatic ultrasound, in low-socioeconomic level children, independent of nutritional condition and without significant association with insulin resistance, emphasizes that especially in developing countries, other risk factors such as micronutrient deficiencies (e.g. vitamin A) are involved.

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