scholarly journals Hypercalcemia as a marker of decreased bone mineral density in patients with peptic ulcer disease

Author(s):  
L. A. Fomina ◽  
M. P. Fomina ◽  
V. V. Chernin

Purpose of the study. To study calcium-phosphorus metabolism in patients with peptic ulcer (PU) in comparison with bone mineral density (BMD), its age and gender aspects. Materials and methods. 216 people with ulcer were in remission and 154 people without ulcer history and erosive-ulcerative changes during fibrogastroduodenoscopy (FGDS) were examined. All patients underwent clinical and endoscopic studies, dichromatic X-ray densitometry with the calculation of the T-test of the femoral neck (FN) and the lumbar spine (LS). Calcium and blood phosphorus have been studied. Results. In patients with PU compared with patients without this pathology there was a significant decrease of BMD. In 32% of patients with PU osteoporosis (OP) was diagnosed and in 34% of patients - osteopenia. In the group of persons who had no PU osteoporosis was found in 18%, osteopenia in 26% of cases. In both groups women prevailed. Blood calcium was significantly higher in patients with PU as compared to those examined without an ulcer history. A significant increase of calcium was observed in individuals with a comorbid course of PU and OP. Conclusion. The data obtained show that the study of blood calcium can serve as a simple criterion for diagnosing disorders of BMD and, if its values are high, conduct a more detailed examination of patients with PU for early detection of OP and the possibility of its treatment.

Author(s):  
Narayan Yoganandan ◽  
Frank A. Pintar ◽  
Recai Aktay ◽  
Glenn Paskoff ◽  
Barry S. Shender

While numerous studies exist quantifying the bone mineral content of the human lumber vertebrae, such information is not available for the cervical spine. This study determined the bone mineral densities of cervical vertebrae. Adult healthy human volunteers, ages ranging from 18 to 40 years, underwent quantitative computed tomography scanning of the neck. BMD data were divided according to subject weight (above and below 50th percentile, termed low and heavy mass) and gender. Low-mass subjects did not consistently have higher bone mineral density at all levels of the cervical column. Bone mineral were higher (259 ± 6 mg/cc) for females than males (247 ± 8 mg/cc); for the entire ensemble the mean density was 253 ± 9 mg/cc. Altered strength of cervical vertebrae coupled with the increased mobility of the disc at the inferior levels of the neck may explain regional biomechanical differences and subsequent physiologic effects secondary to aging. This study quantifies BMD of the human neck vertebrae and offers explanations to the biomechanical behaviors of the human cervical spine.


2019 ◽  
Vol 19 (2) ◽  
pp. 238-245 ◽  
Author(s):  
Stephan N. Salzmann ◽  
Courtney Ortiz Miller ◽  
John A. Carrino ◽  
Jingyan Yang ◽  
Jennifer Shue ◽  
...  

2005 ◽  
Vol 0 (0) ◽  
pp. 060721082338049
Author(s):  
M. Y. M. Ng ◽  
P. C. Sham ◽  
A. D. Paterson ◽  
V. Chan ◽  
A. W. C. Kung

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1702
Author(s):  
Alicja Ewa Ratajczak ◽  
Anna Maria Rychter ◽  
Agnieszka Zawada ◽  
Agnieszka Dobrowolska ◽  
Iwona Krela-Kaźmierczak

The chronic character of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, results in various complications. One of them is osteoporosis, manifested by low bone mineral density, which leads to an increased risk of fractures. The aetiology of low bone mineral density is multifactorial and includes both diet and nutritional status. Calcium and vitamin D are the most often discussed nutrients with regard to bone mineral density. Moreover, vitamins A, K, C, B12; folic acid; calcium; phosphorus; magnesium; sodium; zinc; copper; and selenium are also involved in the formation of bone mass. Patients suffering from inflammatory bowel diseases frequently consume inadequate amounts of the aforementioned minerals and vitamins or their absorption is disturbed, resulting innutritional deficiency and an increased risk of osteoporosis. Thus, nutritional guidelines for inflammatory bowel disease patients should comprise information concerning the prevention of osteoporosis.


2017 ◽  
Vol 98 (3) ◽  
pp. 343-348 ◽  
Author(s):  
L A Fomina ◽  
I A Zyabreva

Aim. To evaluate the state of bone tissue in comparison with calcium balance, to clarify the risk for fracture development in women of different age groups. METHODS. 92 females aged 19 to 89 years were examined clinically with densitometry of lumbar spine and femoral neck and measuring the concentration of total calcium in the blood. RESULTS. In females younger than 50 years decreased bone density according to Z-score was revealed in 30% of cases, among patients with its normal values significant trend to bone rarefaction (-2.0 SD <Z-score ≤-1.5 SD) was registered with the same rate. In the group of females older than 50 years osteopenia was revealed in 46.3% of cases and osteoporosis - in 42.7%, while more significant decrease in bone mineral density was found in the lumbar spine. Past medical history of fractures increased the rate of osteoporosis by 18%. In females older than 50 years compared to younger patients a significant increase of blood calcium concentration was revealed. Besides, statistically significant increase of its level was noted in cases of fractures in the past and osteoporosis. The revealed changes of bone tissue in females below 50 years of age are indicative of increased risk of osteoporosis development in the future. CONCLUSION. High prevalence of osteoporosis and osteopenia is revealed in the examined patients older than 50 years, and bone mineral density parameters were significantly inversely correlated with calcemia; hence, blood calcium level can be one of the criteria of bone tissue state and in combination with other risk factors for osteoporosis should be taken into account during periodic health examination of females older than 50 years.


2006 ◽  
Vol 70 (4) ◽  
pp. 428-438 ◽  
Author(s):  
M. Y. M. Ng ◽  
P. C. Sham ◽  
A. D. Paterson ◽  
V. Chan ◽  
A. W. C. Kung

2004 ◽  
Vol 19 (4) ◽  
pp. 370-376 ◽  
Author(s):  
Cyrus Khodadadyan-Klostermann ◽  
Max von Seebach ◽  
William R. Taylor ◽  
Georg N. Duda ◽  
Norbert P. Haas

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Þröstur Pétursson ◽  
Kyle Joseph Edmunds ◽  
Magnús Kjartan Gíslason ◽  
Benedikt Magnússon ◽  
Gígja Magnúsdóttir ◽  
...  

The variability in patient outcome and propensity for surgical complications in total hip replacement (THR) necessitates the development of a comprehensive, quantitative methodology for prescribing the optimal type of prosthetic stem: cemented or cementless. The objective of the research presented herein was to describe a novel approach to this problem as a first step towards creating a patient-specific, presurgical application for determining the optimal prosthesis procedure. Finite element analysis (FEA) and bone mineral density (BMD) calculations were performed with ten voluntary primary THR patients to estimate the status of their operative femurs before surgery. A compilation model of the press-fitting procedure was generated to define a fracture risk index (FRI) from incurred forces on the periprosthetic femoral head. Comparing these values to patient age, sex, and gender elicited a high degree of variability between patients grouped by implant procedure, reinforcing the notion that age and gender alone are poor indicators for prescribing prosthesis type. Additionally, correlating FRI and BMD measurements indicated that at least two of the ten patients may have received nonideal implants. This investigation highlights the utility of our model as a foundation for presurgical software applications to assist orthopedic surgeons with selecting THR prostheses.


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