Photothermal and photodynamic photoactivation of nanomaterials-based prodrugs are two key methods for NIR light-mediated photoactivation

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Cancer Treatment ◽  
Therapeutic Effect ◽  
Therapeutic Efficacy ◽  
Large Scale ◽  
Clinical Translation ◽  
Future Research ◽  
High Quality ◽  
Prodrug Activation ◽  
Nir Light ◽  
New Research

New research focuses on nanomaterials-based prodrugs (NLNPs) activation techniques, mechanisms, and bioapplications. Photothermal and photodynamic photoactivation of nanomaterials-based prodrugs are being explored as two key methods for NIR light-mediated photoactivation. Four common applications of NLNPs in cancer treatment have been completed, but the clinical translation is more complicated. Large-scale manufacturing of high-quality NLNps is critical for valid prodrug activation and delivering the intended therapeutic effect. NILNPs with higher therapeutic efficacy, superior biosafety, and stability are predicted to be developed as a result of future research.

scholarly journals DOCUMENTS ON THE HOLODOMOR OF 1932–1933 IN THE KHERSON REGION

2021 ◽  
pp. 27-33
Author(s):  
Kuzovova N.
Keyword(s):  
Trade Unions ◽  
Large Scale ◽  
Local History ◽  
High Quality ◽  
Soviet Government ◽  
Internet Resources ◽  
Archival Documents ◽  
History Of ◽  
New Research ◽  
Former Ussr

Purpose and methodology of the study. The article is devoted to the analysis of sources on the history of the Holodomor of 1932–1933 in the Kherson region. The results of the study will help to expand knowledge about the famine of 1932–1933 and to conduct an effective search for new archival information about this event. The study is based on source methods of identifying, analyzing and evaluating sources. Methods of archival heuristics are used, with the help of which a circle of archives is established, where the necessary information could potentially be stored, based on information about fundraisers.Results and scientific novelty of the study. A significant array of official records was analyzed: orders, reports, information, correspondence, certifying the crime of the Soviet government against the Ukrainian people - the Holodomor genocide of 1932–1933 in the Kherson region.It was found that the collections of archival documents of Russian archivists, despite the purpose of preparing a source complex, the composition and content of which would deny the Holodomor as genocide of the Ukrainian people, nevertheless contain valuable information from the central archives of the former USSR, including materials about southern Ukraine. One of the significant shortcomings is the lack of documents that would reflect the reaction of the "fraternal" republics to the famine in Ukraine, as Kherson trade unions, in particular, sought food aid from the relevant authorities in Belarus and Russia.In Ukraine, in parallel with the processes of declassification of archives, collections of documents with high-quality archeographic design were also published. In fact, Ukrainian scholars have urged their Russian counterparts to address the issue of famine, as they have previously produced high-quality informational content for the study of the Holodomor in Ukraine, which cannot be ignored.Regional archives play an equally important role in forming the source base of the problem. Their materials have been repeatedly published, including in the large-scale project "National Book of Remembrance of the Holodomor Victims of 1932–1933 pp. in Ukraine” (2008). It seemed that such a number of identified, published, including in the form of Internet resources of documentary monuments, cartographic materials, sources on demographic statistics has already exhausted the subject, but declassification and transfer of documents from the SBU continues, and archives are replenished with new documents. In particular, those that raise the issue of Soviet repression for spreading information about the famine of 1932–1933 in later years. That is, the discovery of new documents and the setting of new research tasks to study the history of the Holodomor is a real prospect for the future.Key words: Holodomor, Kherson region, local history, archive, source, document. Мета та методологія дослідження. Стаття присвячена аналізу джерел з історії Голодомору 1932–1933 років на терито-рії Херсонщини. Результати дослідження допоможуть розширити знання про голод 1932–1933 років та проводити ефективний пошук нової архівної інформації про цю подію. В основі дослідження лежать джерелознавчі методи виявлення, аналізу та оцінки джерел. Застосовуються методи архівної евристики, за допомогою якої встановлено коло архівів, де потенційно могла зберігатись необхідна інформація, виходячи з інформації про фондоутворювачів. Результати та наукова новизна дослідження. Проаналізовано значний масив документів офіційного діловодства: накази, доповідні записки, інформації, листування, що засвідчують злочин радянської влади проти українського народу – Голодомор-геноцид 1932–1933 років на території Херсонщини.З’ясовано, що збірники архівних документів російських архівістів, не зважаючи на мету підготувати джерельний комплекс, склад і зміст якого заперечуватиме Голодомор як геноцид українського народу, тим не менш містять цінну інформацію з центральних архівів колишнього СРСР, в тому числі матеріали про Південь України. Одним з суттєвих недоліків – відсутність документів, що б відображали реакцію «братніх» республік на голод в Україні, оскілки зокрема херсонські профспілки звертались за продовольчою допомогою до відповідних органів в Білорусії та Росії. В Україні, паралельно з процесами розсекречення архівів, також видано збірки документів з якісним археографічним оформленням. Власне українські вчені спонукали російських колег звернутись до теми голоду, оскільки раніше за них сформували якісний інформаційний контент для вивчення Голодомору в Україні, котрий не можливо ігнорувати.Не менш важливу роль у формуванні джерельної бази проблеми відграють регіональні архіви. Їхні матеріали неодноразово публікувались, в тому числі в масштабному проєкті «Національна Книга пам’яті жертв Голодомору 1932–1933 pp. в Україні» (2008). Здавалось, така кількість виявлених, опублікованих, в тому числі – у вигляді Інтернет-ресурсів документаль-них пам’яток, картографічних матеріалів, джерел з демографічної статистики вже вичерпала тематику, проте розсекречення та передача документів з СБУ триває, й архіви поповнюються новими документами. Зокрема, такими, що піднімають питання репресій радянської за поширення інформації про голод 1932–1933 років у пізніші роки. Тобто виявлення нових документів, і постановка нових дослідницьких завдань з вивчення історії Голодомору – реальна перспектива на майбутнє.Ключові слова: Голодомор, Херсонщина, локальна історія, архів, джерело, документ

scholarly journals Emergency Logistics in a Large-Scale Disaster Context: Achievements and Challenges

2019 ◽  
Vol 16 (5) ◽  
pp. 779 ◽  
Author(s):  
Yiping Jiang ◽  
Yufei Yuan
Keyword(s):  
Emergency Response ◽  
Operations Research ◽  
Large Scale ◽  
Future Research ◽  
Research Directions ◽  
Business Operations ◽  
Emergency Logistics ◽  
Key Characteristics ◽  
Future Research Directions ◽  
New Research

There is growing research interest in emergency logistics within the operations research (OR) community. Different from normal business operations, emergency response for large scale disasters is very complex and there are many challenges to deal with. Research on emergency logistics is still in its infancy stage. Understanding the challenges and new research directions is very important. In this paper, we present a literature review of emergency logistics in the context of large-scale disasters. The main contributions of our study include three aspects: First, we identify key characteristics of large-scale disasters and assess their challenges to emergency logistics. Second, we analyze and summarize the current literature on how to deal with these challenges. Finally, we discuss existing gaps in the relevant research and suggest future research directions.

scholarly journals Grafting of Araucaria angustifolia (BERTOL.) kuntze through the four seasons of the year

2011 ◽  
Vol 33 (4) ◽  
pp. 1364-1370 ◽  
Author(s):  
Flávio Zanette ◽  
Liege da Silva Oliveira ◽  
Luiz Antonio Biasi
Keyword(s):  
South America ◽  
Large Scale ◽  
Future Research ◽  
Araucaria Angustifolia ◽  
Conifer Species ◽  
High Quality ◽  
Four Seasons ◽  
Grafting Through ◽  
In The Beginning ◽  
Selection Of

Araucaria angustifolia is an endangered conifer species of South America that has been over exploited for timber. To incentivize Araucaria angustifolia planting is essential and may play a key role on the conservation of this species and the ecosystems that depend on it. Hence, techniques that allow the production of seedlings with attributes that may entice farmers to plant A. angustifolia trees are very important. Grafting may permit the selection of female trees and the production of precocious plants that will produce high quality seeds. The aim of this study was to determine the best season of the year to graft. Three-year-old seedlings were used as rootstock and orthotropic branches of young plants were used for scion collection. The technique used for the grafting was the bark patch. This procedure was carried out in the beginning of each season in 2007 and 2008, with a total of 160 grafted plants. Grafting carried out in the beginning of autumn had a 50 % success rate. Grafting success was negligible for all remaining seasons. In conclusion, grafting through bark patching is a viable technique for the production of A. angustifolia seedlings. Future research should be carried out to produce grafted seedlings in large-scale.

scholarly journals WARA-PS: a research arena for public safety demonstrations and autonomous collaborative rescue robotics experimentation

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Olov Andersson ◽  
Patrick Doherty ◽  
Mårten Lager ◽  
Jens-Olof Lindh ◽  
Linnea Persson ◽  
...  
Keyword(s):  
Autonomous Vehicles ◽  
Public Safety ◽  
Large Scale ◽  
Autonomous Systems ◽  
User Interaction ◽  
Test Facility ◽  
Future Research ◽  
Core System ◽  
Research Dissemination ◽  
New Research

AbstractA research arena (WARA-PS) for sensing, data fusion, user interaction, planning and control of collaborative autonomous aerial and surface vehicles in public safety applications is presented. The objective is to demonstrate scientific discoveries and to generate new directions for future research on autonomous systems for societal challenges. The enabler is a computational infrastructure with a core system architecture for industrial and academic collaboration. This includes a control and command system together with a framework for planning and executing tasks for unmanned surface vehicles and aerial vehicles. The motivating application for the demonstration is marine search and rescue operations. A state-of-art delegation framework for the mission planning together with three specific applications is also presented. The first one concerns model predictive control for cooperative rendezvous of autonomous unmanned aerial and surface vehicles. The second project is about learning to make safe real-time decisions under uncertainty for autonomous vehicles, and the third one is on robust terrain-aided navigation through sensor fusion and virtual reality tele-operation to support a GPS-free positioning system in marine environments. The research results have been experimentally evaluated and demonstrated to industry and public sector audiences at a marine test facility. It would be most difficult to do experiments on this large scale without the WARA-PS research arena. Furthermore, these demonstrator activities have resulted in effective research dissemination with high public visibility, business impact and new research collaborations between academia and industry.

Change of Attitude, Technology and Practice: Identifying the Change for Increased Value Creation with Customer Co-creation

2017 ◽  
Vol 5 (1) ◽  
pp. 70-82
Author(s):  
Soumi Paul ◽  
Paola Peretti ◽  
Saroj Kumar Datta
Keyword(s):  
Social Media ◽  
New Product Development ◽  
Value Creation ◽  
Large Scale ◽  
Customer Orientation ◽  
Customer Relationships ◽  
Future Research ◽  
Management Competencies ◽  
Business Decisions ◽  
Prime Concern

Building customer relationships and customer equity is the prime concern in today’s business decisions. The emergence of internet, especially social media like Facebook and Twitter, changed traditional marketing thought to a great extent. The importance of customer orientation is reflected in the axiom, “The customer is the king”. A good number of organizations are engaging customers in their new product development activities via social media platforms. Co-creation, a new perspective in which customers are active co-creators of the products they buy and use, is currently challenging the traditional paradigm. The concept of co-creation involving the customer’s knowledge, creativity and judgment to generate value is considered not only an upcoming trend that introduces new products or services but also fitting their need and increasing value for money. Knowledge and innovation are inseparable. Knowledge management competencies and capacities are essential to any organization that aspires to be distinguished and innovative. The present work is an attempt to identify the change in value creation procedure along with one area of business, where co-creation can return significant dividends. It is on extending the brand or brand category through brand extension or line extension. This article, through an in depth literature review analysis, identifies the changes in every perspective of this paradigm shift and it presents a conceptual model of company-customer-brand-based co-creation activity via social media. The main objective is offering an agenda for future research of this emerging trend and ensuring the way to move from theory to practice. The paper acts as a proposal; it allows the organization to go for this change in a large scale and obtain early feedback on the idea presented. 

The psychology of offering an apology: Understanding the barriers to apologizing and how to overcome them

2017 ◽  
Author(s):  
Karina Schumann
Keyword(s):  
Future Research ◽  
Perceived Threat ◽  
High Quality ◽  
Important Decision ◽  
Self Image

After committing an offense, a transgressor faces an important decision regarding whether and how to apologize to the person who was harmed. The actions he or she chooses to take after committing an offense can have dramatic implications for the victim, the transgressor, and their relationship. Although high quality apologies are extremely effective at promoting reconciliation, transgressors often choose to offer a perfunctory apology, withhold an apology, or respond defensively to the victim. Why might this be? In this article, I propose three major barriers to offering high quality apologies: (1) low concern for the victim or relationship, (2) perceived threat to self-image, and (3) perceived apology ineffectiveness. I review recent research examining how these barriers affect transgressors’ apology behavior, and describe insights this emerging work provides for developing methods to move transgressors towards more reparative behavior. Finally, I discuss important directions for future research.

Overview of Subsynchronous Oscillation in Grid-connected Wind Farm

2020 ◽  
Vol 13 (7) ◽  
pp. 969-979
Author(s):  
Xu Pei-Zhen ◽  
Lu Yong-Geng ◽  
Cao Xi-Min
Keyword(s):  
Power Systems ◽  
Wind Turbine ◽  
Large Scale ◽  
Wind Farm ◽  
Wind Farms ◽  
Induction Generator ◽  
Future Research ◽  
Stable Operation ◽  
Subsynchronous Oscillation ◽  
Different Types

Background: Over the past few years, the subsynchronous oscillation (SSO) caused by the grid-connected wind farm had a bad influence on the stable operation of the system and has now become a bottleneck factor restricting the efficient utilization of wind power. How to mitigate and suppress the phenomenon of SSO of wind farms has become the focus of power system research. Methods: This paper first analyzes the SSO of different types of wind turbines, including squirrelcage induction generator based wind turbine (SCIG-WT), permanent magnet synchronous generator- based wind turbine (PMSG-WT), and doubly-fed induction generator based wind turbine (DFIG-WT). Then, the mechanisms of different types of SSO are proposed with the aim to better understand SSO in large-scale wind integrated power systems, and the main analytical methods suitable for studying the SSO of wind farms are summarized. Results: On the basis of results, using additional damping control suppression methods to solve SSO caused by the flexible power transmission devices and the wind turbine converter is recommended. Conclusion: The current development direction of the SSO of large-scale wind farm grid-connected systems is summarized and the current challenges and recommendations for future research and development are discussed.

Bullying, School Violence, and Climate in Evolving Contexts

2018 ◽  
Author(s):  
Ron Avi Astor ◽  
Rami Benbenisthty
Keyword(s):  
School Violence ◽  
School Safety ◽  
Media Coverage ◽  
Large Scale ◽  
Ecological Model ◽  
Empirical Studies ◽  
Practical Applications ◽  
Teacher Student ◽  
Area Of Interest ◽  
New Research

Since 2005, the bullying, school violence, and school safety literatures have expanded dramatically in content, disciplines, and empirical studies. However, with this massive expansion of research, there is also a surprising lack of theoretical and empirical direction to guide efforts on how to advance our basic science and practical applications of this growing scientific area of interest. Parallel to this surge in interest, cultural norms, media coverage, and policies to address school safety and bullying have evolved at a remarkably quick pace over the past 13 years. For example, behaviors and populations that just a decade ago were not included in the school violence, bullying, and school safety discourse are now accepted areas of inquiry. These include, for instance, cyberbullying, sexting, social media shaming, teacher–student and student–teacher bullying, sexual harassment and assault, homicide, and suicide. Populations in schools not previously explored, such as lesbian, gay, bisexual, transgender, and queer students and educators and military- and veteran-connected students, become the foci of new research, policies, and programs. As a result, all US states and most industrialized countries now have a complex quilt of new school safety and bullying legislation and policies. Large-scale research and intervention funding programs are often linked to these policies. This book suggests an empirically driven unifying model that brings together these previously distinct literatures. This book presents an ecological model of school violence, bullying, and safety in evolving contexts that integrates all we have learned in the 13 years, and suggests ways to move forward.

Cancer and Cancer Treatment-Related Cognitive Impairment

2019 ◽  
pp. 60-83
Author(s):  
James C.  Root ◽  
Elizabeth Ryan ◽  
Tim A. Ahles
Keyword(s):  
Cancer Survivors ◽  
Cancer Treatment ◽  
Clinical Presentation ◽  
Functional Neuroimaging ◽  
Theoretical Models ◽  
Future Research ◽  
Cognitive Changes ◽  
Central Nervous System Cancer ◽  
Pharmacologic Treatments

As the population of cancer survivors has grown into the millions, there is increasing emphasis on understanding how late effects of treatment impact survivors’ ability return to work/school, ability to function and live independently, and overall quality of life. Cognitive changes are one of the most feared problems among cancer survivors. This chapter describes the growing literature examining cognitive changes associated with non-central nervous system cancer and cancer treatment. Typical elements of cancer treatment are discussed, followed by a description of clinical presentation, self-reported and objectively assessed cognitive findings, and results of structural and functional neuroimaging research. Genetic and other risk factors for cognitive decline following treatment are identified and discussed, together with biomarkers and animal models of treatment-related effects. This is followed by a discussion of behavioral and pharmacologic treatments. Finally, challenges and recommendations for future research are provided to help guide subsequent research and theoretical models.

scholarly journals ‘CTRL’: an online, Dynamic Consent and participant engagement platform working towards solving the complexities of consent in genomic research

2021 ◽  
Author(s):  
Matilda A. Haas ◽  
Harriet Teare ◽  
Megan Prictor ◽  
Gabi Ceregra ◽  
Miranda E. Vidgen ◽  
...  
Keyword(s):  
Large Scale ◽  
Genomic Medicine ◽  
International Standards ◽  
Security And Privacy ◽  
Genomic Research ◽  
Return Of Results ◽  
Future Research ◽  
Design And Development ◽  
Participant Engagement ◽  
Dynamic Consent

AbstractThe complexities of the informed consent process for participating in research in genomic medicine are well-documented. Inspired by the potential for Dynamic Consent to increase participant choice and autonomy in decision-making, as well as the opportunities for ongoing participant engagement it affords, we wanted to trial Dynamic Consent and to do so developed our own web-based application (web app) called CTRL (control). This paper documents the design and development of CTRL, for use in the Australian Genomics study: a health services research project building evidence to inform the integration of genomic medicine into mainstream healthcare. Australian Genomics brought together a multi-disciplinary team to develop CTRL. The design and development process considered user experience; security and privacy; the application of international standards in data sharing; IT, operational and ethical issues. The CTRL tool is now being offered to participants in the study, who can use CTRL to keep personal and contact details up to date; make consent choices (including indicate preferences for return of results and future research use of biological samples, genomic and health data); follow their progress through the study; complete surveys, contact the researchers and access study news and information. While there are remaining challenges to implementing Dynamic Consent in genomic research, this study demonstrates the feasibility of building such a tool, and its ongoing use will provide evidence about the value of Dynamic Consent in large-scale genomic research programs.

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