scholarly journals Can Aaripiprazole Normalize Yatrogenic Hyperprolactinemia?

2020 ◽  
Author(s):  
Roberto Lozano ◽  
Reyes Marin ◽  
Asuncion Pascual ◽  
María-Jesús Santacruz
Keyword(s):  
Adverse Effect ◽  
Metabolic Syndrome ◽  
Combined Treatment ◽  
The Other ◽  
Gonadal Function ◽  
Short Term ◽  
Thromboembolic Risk ◽  
Partial Dopamine Agonist ◽  
The Ideal

Aripiprazole is a second generation atypical antipsychotic (AAP), with properties of partial dopamine agonist, used in schizophrenia, bipolar disorder and depression, among others. On the other hand, the side effects associated with AAP treatment are drug-specific, with hyperprolactinemia and metabolic syndrome being some of the most important. Hyperprolactinemia is an adverse effect with consequences both in the short term, alterations in gonadal function and parkinsonism, and in the long term, osteopenia-osteoporosis, metabolic syndrome and / or increased thromboembolic risk. Therefore, normalization or reduction of prolactinemia is sufficient to avoid them. According to our results, aripiprazole would be the ideal component for the combined treatment with those other antipsychotics that cause hyperprolactinemia, such as risperidone, reducing it and alleviating or eliminating the adverse effects derived from chronic hyperprolactinemia.

Hidden “holes” in the capital of banks and the supply of credit to the real sector of economy

2018 ◽  
pp. 49-68 ◽  
Author(s):  
M. E. Mamonov
Keyword(s):  
Credit Risk ◽  
The Other ◽  
Real Sector ◽  
Capital Management ◽  
Loan Loss ◽  
Short Term ◽  
The Real ◽  
Ex Post ◽  
The One

Our analysis documents that the existence of hidden “holes” in the capital of not yet failed banks - while creating intertemporal pressure on the actual level of capital - leads to changing of maturity of loans supplied rather than to contracting of their volume. Long-term loans decrease, whereas short-term loans rise - and, what is most remarkably, by approximately the same amounts. Standardly, the higher the maturity of loans the higher the credit risk and, thus, the more loan loss reserves (LLP) banks are forced to create, increasing the pressure on capital. Banks that already hide “holes” in the capital, but have not yet faced with license withdrawal, must possess strong incentives to shorten the maturity of supplied loans. On the one hand, it raises the turnovers of LLP and facilitates the flexibility of capital management; on the other hand, it allows increasing the speed of shifting of attracted deposits to loans to related parties in domestic or foreign jurisdictions. This enlarges the potential size of ex post revealed “hole” in the capital and, therefore, allows us to assume that not every loan might be viewed as a good for the economy: excessive short-term and insufficient long-term loans can produce the source for future losses.

scholarly journals Short-term and long-term cardiovascular risk, metabolic syndrome and HIV in Tanzania

Heart ◽  
2016 ◽  
Vol 102 (15) ◽  
pp. 1200-1205 ◽  
Author(s):  
Justin R Kingery ◽  
Yona Alfred ◽  
Luke R Smart ◽  
Emily Nash ◽  
Jim Todd ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Short Term

scholarly journals INVEST ASI, EKSPOR DAN MASALAH DE-INDUSTRIALISASI DI INDONESIA

2017 ◽  
Vol 5 (2) ◽  
pp. 179
Author(s):  
Anton Agus Setyawan ◽  
Fatchurrohman Fatchurrohman
Keyword(s):  
Direct Investment ◽  
Econometric Model ◽  
Slow Growth ◽  
Policy Implications ◽  
Economic Recovery ◽  
Investment Climate ◽  
Short Term ◽  
Investment Rate ◽  
The Ideal

There are two constraints in the process of economic recovery in Indonesia. First, investment rate is decreasing in the last five years. This matter happens due to the bad investment climate in Indonesia. Second, slow growth of export rate in Indonesia. At the present, investment rate in Indonesia is only 22 percent of GDP, while the ideal rate is 30 percent of GDP. Another problem, which may be interrupting the economic recovery, is de-industrialization. The sign of de-industrialization occur by relocation phenomena of FDIfrom Indonesia. This research analyze the effects of direct investment and export to GDP. The tool of analyses of this research is econometric model known as Error Correc­tion Models. The results shows that in a long term and short term, export and direct investment do not have a significant effect to GDP. It shows that Indonesia do not have a clear policy about export and investment. The policy implications of this research are government should have a deregulation policy in the industry and recover investment climate.

Long-Term Growth and Short-Term Policy

1964 ◽  
Vol 29 ◽  
pp. 26-38 ◽  
Author(s):  
W. A. H. Godley ◽  
J. R. Shepherd
Keyword(s):  
Economic Policy ◽  
Balance Of Payments ◽  
The Other ◽  
High Wage ◽  
Short Term ◽  
High Unemployment ◽  
The Government ◽  
Wage Increases

One of the main aims of short-term economic policy in Britain has been to regulate the pressure of demand for labour, and to keep the fluctuations of the unemployment percentage within fairly narrow limits. High unemployment is obviously undesirable; at the other end of the scale, if the pressure of demand for labour is too strong, this tends to lead to excessively high wage increases and to balance of payments difficulties. It is for the Government to decide at what pressure it wishes to run the economy, and to try to keep it there.

Terrorism and Violence

2019 ◽  
pp. 138-180
Author(s):  
Douglas Allen
Keyword(s):  
Complex Analysis ◽  
General Analysis ◽  
The Other ◽  
Short Term ◽  
Absolute Truth ◽  
Relative Truth ◽  
Central Concern ◽  
The Us ◽  
The Status

Ever since 9/11 in the US and 26/11 in India, terrorism has been a central concern. Gandhi is generally assumed to be of little value when confronting terrorism today. At best, he is irrelevant; at worst, he is complicit and contributes to the crisis since he opposes necessary violent responses. This essay argues that while Gandhi does not have all of the answers for dealing with terrorism today, he provides us with a complex analysis essential for understanding and responding to the multidimensional structural crisis. After analyzing the nature and meaning of terrorism, we focus on the following topics: Gandhi’s interactions with terrorists; his means-ends analysis and his short-term and long-term preventative approaches to terrorism; his analysis of absolute truth and relative truth in approaching terrorism; and his general analysis of the status of “the other” in transforming our relations with violent, terrorizing, and terrorized others.

Antimicrobial Applications of Nanoparticles

2022 ◽  
pp. 269-288
Author(s):  
Ayesha Kanwal ◽  
Zeeshan Ahmad Bhutta ◽  
Ambreen Ashar ◽  
Ashar Mahfooz ◽  
Rizwan Ahmed ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Side Effects ◽  
Antibacterial Agent ◽  
Antibacterial Agents ◽  
The Other ◽  
Drug Resistant ◽  
Short Term ◽  
Human Mortality ◽  
Recent Developments

Human mortality due to drug-resistant infections is becoming more prevalent in our society. Antibiotics are impotent due to abuse and/or misuse, leading to new, more expensive, and more effective medicines and treatments. Therefore, it causes many short-term and long-term side effects in the patient. On the other hand, nanoparticles have exhibited antibacterial activity against various pathogens due to their small size and ability to destroy cells by various mechanisms. Unlike antibiotics for the treatment of patients' diseases and infections, nanomaterials provide an exciting way to limit the growth of microorganisms due to infections in humans. This has led to the development of a number of nanoparticles as active antibacterial agents. Therefore, the authors have carefully reviewed the recent developments in the use of nanomaterials for antibacterial applications and the mechanisms that make them an effective alternate antibacterial agent.

Lurasidone and risk for metabolic syndrome: results from short- and long-term clinical studies in patients with schizophrenia

CNS Spectrums ◽  
2020 ◽  
pp. 1-11
Author(s):  
Michael Tocco ◽  
John W. Newcomer ◽  
Yongcai Mao ◽  
Andrei Pikalov ◽  
Antony Loebel
Keyword(s):  
Metabolic Syndrome ◽  
Dose Range ◽  
Dose Effect ◽  
Short Term ◽  
Open Label ◽  
Quetiapine Xr ◽  
Long Term Treatment ◽  
Short And Long Term ◽  
Term Data

Abstract Objective To assess the effects of treatment with lurasidone on risk for metabolic syndrome (MetS) in patients with schizophrenia. Methods Rates of metabolic syndrome during treatment with lurasidone (40-160 mg/d) were analyzed using pooled, short-term data from three randomized, double-blind, placebo-controlled studies (vs olanzapine and quetiapine XR); long-term data from two active-comparator-controlled studies (vs risperidone and quetiapine XR); and data from two open-label studies in which patients were switched from olanzapine or risperidone to lurasidone. Results MetS was defined based on the National Cholesterol Education Program criteria. In short-term studies, the odds of meeting criteria for MetS at week 6 LOCF (adjusted for baseline metabolic syndrome status) was similar for the lurasidone and placebo groups (OR = 1.18; [95% CI, 0.81-1.71]; P = .39), but the odds (vs placebo) were significantly greater for olanzapine (OR = 2.81; [95% CI, 1.53-5.15]; P < .001) and quetiapine (OR = 3.49; [95% CI, 1.93-6.29]; P < .0001). No dose effect was observed for lurasidone across the dose range of 40-160 mg/d. In long-term studies, the odds of MetS after 12 months of treatment was significantly higher for risperidone compared with lurasidone (OR = 2.12; 95% CI, 1.15-3.90; P = .016) and for quetiapine XR compared with lurasidone (OR = 3.92; 95% CI, 1.15-13.40; P = .029). In open-label extension studies, the rate of MetS decreased in patients switched to lurasidone after 6 weeks of treatment with olanzapine or 12 months of treatment with risperidone. Conclusion In this analysis of lurasidone clinical trials, the odds of developing metabolic syndrome were minimal during short- and long-term treatment with lurasidone (40-160 mg/d).

scholarly journals Entrepreneurship Education with Companies: Teachers Organizing School-Company Interaction

2020 ◽  
Vol 10 (10) ◽  
pp. 268
Author(s):  
Kaarina Sommarström ◽  
Elena Oikkonen ◽  
Timo Pihkala
Keyword(s):  
Basic Education ◽  
School Principals ◽  
Education Level ◽  
The Other ◽  
School Level ◽  
Structured Interviews ◽  
School Teachers ◽  
Short Term ◽  
Entrepreneurial Learning

Previous research into entrepreneurial learning has focused mainly on defining its aims; however, there seems to be little discussion on understanding the barriers or incentives involved when carrying out the pedagogical solutions that would enable entrepreneurial learning. In this study, we examine basic education level schools’ cooperation with outside partners, especially from the school principals’ and teachers’ viewpoints. The study aims to understand the perspectives of teachers and principals on planning and organizing school-company interaction. To do this, content analysis was used in this qualitative study. The data were collected via semi-structured interviews with school teachers and principals, involving a total of 35 people working in basic education. The findings of the study show that principals and teachers intentionally select long-term cooperation methods to meet the aims of entrepreneurial learning. On the other hand, teachers that have chosen to apply short-term school-company cooperation methods have highlighted the ease of these methods rather than learning. Finally, our findings suggest that planning and organizing entrepreneurial learning would benefit from school-level commitment where collaboration between teachers and between teachers and company representatives is valued. We believe that would lead to more satisfied teachers and longer-term school-company cooperation, and also believe that short-term school-company cooperation methods would better meet the aims of entrepreneurial learning.

Effects of Proactive Interference and Rehearsal on the Primary and Secondary Components of Short-Term Retention

1975 ◽  
Vol 27 (1) ◽  
pp. 47-62 ◽  
Author(s):  
M. T. Turvey ◽  
Robert A. Weeks
Keyword(s):  
Proactive Interference ◽  
Primary Memory ◽  
The Other ◽  
Secondary Memory ◽  
Retention Function ◽  
Short Term ◽  
Retention Period ◽  
Term Retention ◽  
Proactive Effects

Under the conditions of the distractor paradigm, short-term retention declines to a minimum in a very brief period. The rapid forgetting can be said to reflect the declining contribution of the short-term store or primary memory and the asymptote can be taken as a measure of the contribution of the long-term store or secondary memory. It was shown that manipulating proactive effects by varying the recency of prior material affected only the primary memory component of the short-term retention function. On the other hand manipulating the difficulty of the subsidiary task performed during the retention period with proactive effects held constant affected both the primary and the secondary components. The results were discussed with respect to the relation between the two memory components and the idea that proactive effects are limited to long-term store.

scholarly journals Influence of Progesterone-Treatment Length and eCG Administration on Appearance of Estrus Behavior, Ovulatory Success and Fertility in Sheep

Animals ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 9 ◽  
Author(s):  
Paula Martinez-Ros ◽  
Alejandro Rios-Abellan ◽  
Antonio Gonzalez-Bulnes
Keyword(s):  
Drug Release ◽  
Chorionic Gonadotrophin ◽  
Ovulation Rate ◽  
The Other ◽  
Short Term ◽  
Treatment Length ◽  
Progesterone Secretion ◽  
Progesterone Treatment ◽  
Estrus Behavior

The present study characterizes, for sheep, the occurrence and timing of the onset of estrus behavior and ovulation and the yields obtained (ovulation rate, progesterone secretion, and fertility) after Controlled Internal Drug Release (CIDR) insertion for five, six, seven, or fourteen days, with or without equine chorionic gonadotrophin (eCG) in ewes of the Segureña meat breed. All the treatments showed above 80% of females displaying estrus, but the onset of estrus was earlier and more synchronized when using eCG and, among groups with eCG, onset of estrus was earlier in the sheep treated for 14 days than in the short-term treatments (p < 0.05 for all). Administration of eCG after either short- or long-term treatments assured the occurrence of fertile ovulations in all the animals. Conversely, ovulatory success without eCG was found to be dependent on treatment length, with a high percentage of animals ovulating after five days of treatment (83.3%) and very low percentages after treatment for six or seven days (40% and 20%, respectively). Ovulation rate and progesterone secretion were similar among animals ovulating, but ovulation failures predetermined the fertility yields obtained in response to the treatments. Hence, the best results were found after treatment for 14 days plus eCG, and for 5 days without eCG (83.3 for both, p < 0.05 when compared to the other groups with different treatment lengths and with or without eCG).

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