scholarly journals Rebutting Pedro J. Silva’s article in Biophysical Chemistry supporting Mitchell-Boyer’s ideas on bioenergetics and advocating murburn concept as a viable explanation for aerobic respiration and oxygenic photosynthesis

2020 ◽  
Author(s):  
Kelath Murali Manoj
Keyword(s):  
Oxidative Phosphorylation ◽  
Large Volume ◽  
Crucial Role ◽  
Atp Synthesis ◽  
Scientific Discourse ◽  
Oxygenic Photosynthesis ◽  
Aerobic Respiration ◽  
Bioenergetics Model ◽  
Critical Attention ◽  
Biophysical Chemistry

Over the last three years, I had pointed out the untenable nature of the proton-centric ‘chemiosmosis driven rotary ATP-synthesis (CRAS)’ explanation for Oxidative Phosphorylation (OxPhos). Recently, Pedro J. Silva (PJS) [Chemiosmotic misunderstandings (2020). Biophys. Chem. 264, 106424] afforded a part of our work his critical attention, but overlooked the large volume of evidence against CRAS and supporting the oxygen-centric murburn mechanism of OxPhos. In his article, PJS also posed some queries on our bioenergetics model. When I offered my rebuttal, the Editor of Biophysical Chemistry refused to publish it. Therefore, I have no other option than to publish the rebuttal as a preprint. Herein, I demonstrate the flaws and lacunae in PJS’s defense of CRAS hypothesis and answer his specific queries and defend the murburn explanation of mOxPhos. The current scientific discourse is crucial for correcting major historical errors in mitochondrial physiology and understanding oxygen’s crucial role in the powering chemistry of life.

scholarly journals Murburn model of mitochondrial aerobic respiration is robust in comparison to the ‘chemiosmotic rotary or two-ion torsional’ ATP-synthesis proposals

2020 ◽  
Author(s):  
Daniel Andrew Gideon
Keyword(s):  
Oxidative Phosphorylation ◽  
Experimental Research ◽  
Atp Synthesis ◽  
Reaction Scheme ◽  
Aerobic Respiration ◽  
Evidence Based ◽  
Mitochondrial Oxidative Phosphorylation ◽  
Paul Boyer ◽  
Intense Debate ◽  
Biophysical Chemistry

One of the most fundamental questions in biology pertains to how mechano-chemical energy is derived from metabolic fuels. In particular, how oxidation of NADH is linked to ATP synthesis in mitochondrial oxidative phosphorylation (mOxPhos) has been a topic of intense debate. Together, the Peter Mitchell-Paul Boyer proposals for mOxPhos are termed herein as “chemiosmotic rotary ATP synthesis” (or CRAS) model, which was recently defended/advocated by Pedro Silva in Biophysical Chemistry . Over the last two decades, Sunil Nath had questioned some aspects of the CRAS proposal, and made subtle alterations on the roles of Complex V and ions within the reaction scheme, and continues to advocate his framework as “two-ion torsional ATP synthesis” (abbreviated herein as TITAS) model in Biophysical Chemistry . Kelath Murali Manoj had revisited the data on the respiratory machinery’s structures/distributions and based on two-decades of evidence-based experimental research in redox enzymology of heme/flavin proteins, had formulated the murburn model for mOxPhos. In this work, the ETC-CRAS hypothesis and its off-shoot, the TITAS proposal, are questioned in the light of the convincing chemicophysical logic provided by the murburn hypothesis.

The Meaning of Children's Poetry: A Cognitive Approach

2013 ◽  
Vol 6 (2) ◽  
pp. 127-142 ◽  
Author(s):  
Karen Coats
Keyword(s):  
Crucial Role ◽  
The Body ◽  
Critical Discourse ◽  
Holding Environment ◽  
Cognitive Poetics ◽  
Cognitive Approach ◽  
Communal Life ◽  
Clear Sense ◽  
Critical Attention ◽  
Children's Poetry

Critical attention to children's poetry has been hampered by the lack of a clear sense of what a children's poem is and how children's poetry should be valued. Often, it is seen as a lesser genre in comparison to poetry written for adults. This essay explores the premises and contradictions that inform existing critical discourse on children's poetry and asserts that a more effective way of viewing children's poetry can be achieved through cognitive poetics rather than through comparisons with adult poetry. Arguing that children's poetry preserves the rhythms and pleasures of the body in language and facilitates emotional and physical attunement with others, the essay examines the crucial role children's poetry plays in creating a holding environment in language to help children manage their sensory environments, map and regulate their neurological functions, contain their existential anxieties, and participate in communal life.

On the mechanism of ATP synthesis in oxidative phosphorylation: A review

1974 ◽  
Vol 3 (1) ◽  
pp. 1-15 ◽  
Author(s):  
John H. Young ◽  
Ephraim F. Korman ◽  
Jerome McLick
Keyword(s):  
Oxidative Phosphorylation ◽  
Atp Synthesis

Derrida and the Legacy of Psychoanalysis

2021 ◽  
Author(s):  
Paul Earlie
Keyword(s):  
Digital Technology ◽  
Crucial Role ◽  
Scientific Discourse ◽  
Detailed Account ◽  
The Political ◽  
Critical Thought ◽  
The Status ◽  
The Relationship ◽  
Key Questions

This book offers a detailed account of the importance of psychoanalysis in Derrida’s thought. Based on close readings of texts from the whole of his career, including less well-known and previously unpublished material, it sheds new light on the crucial role of psychoanalysis in shaping Derrida’s response to a number of key questions. These questions range from the psyche’s relationship to technology to the role of fiction and metaphor in scientific discourse, from the relationship between memory and the archive to the status of the political in deconstruction. Focusing on Freud but proposing new readings of texts by Lacan, Torok, and Abraham, Laplanche and Pontalis, amongst other seminal figures in contemporary French thought, the book argues that Derrida’s writings on psychoanalysis can also provide an important bridge between deconstruction and the recent materialist turn in the humanities. Challenging a still prevalent ‘textualist’ reading of Derrida’s work, it explores the ongoing contribution of deconstruction and psychoanalysis to pressing issues in critical thought today, from the localizing models of the neurosciences and the omnipresence of digital technology to the politics of affect in an age of terror.

Introduction

Ramus ◽  
1979 ◽  
Vol 8 (1) ◽  
pp. 1-5 ◽  
Author(s):  
A. J. Boyle
Keyword(s):  
Complex System ◽  
Twentieth Century ◽  
Eighteenth Century ◽  
Crucial Role ◽  
Central Position ◽  
Critical Gap ◽  
Critical Attention ◽  
Critical Activity ◽  
Stephen Spender ◽  
Positive Force

But chiefly dear for his gift to understand Earth's intricate, ordered heart, and for a vision That saw beyond an imperial day the hand Of man no longer armed against his fellow But all for vine and cattle, fruit and fallow, Subduing with love's positive force the land.C. Day Lewis, The Georgics, ‘Dedicatory Stanzas to Stephen Spender’ (1940)A collection of critical essays on Virgil's Georgics needs no defence. A great, a magnificent poem, widely read, if not universally applauded, the Georgics has received far less critical attention than either the Eclogues or the Aeneid. Index in part of the apparently uncongenial nature of ‘didactic’ verse, the relative dearth of critical activity on the poem is particularly to be regretted in view of the Georgics' chronologically central position in Virgil's poetic career, its crucial role in the development of his style and thought. Indeed, given the peculiar and self-conscious unity of Virgil's poetic oeuvre, its complex system of evolving themes, images, structures, its bonding, meditated network of inter-poem reference, the critical neglect which the Georgics has received — there are brilliant, recent exceptions — seems less omission, more outrage. Even the Georgics' influence on later European poetry — one thinks, for example, of the Italian humanists, Politian and Alamanni, the eighteenth century English poets, especially Thomson and Cowper, and that remarkable twentieth century English georgic, The Land, by Virginia Sackville-West — while not of the magnitude of that of either the Eclogues or the Aeneid, ought to have elicited a more substantial investigation of the poem than has transpired. No boast, Wilkinson's claim that his 1969 book on the Georgics was the first to appear in English was sad affirmation of this major critical gap.

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