scholarly journals Frequency and Time Domain Analysis of sRNA-based Treatment for Inflammatory Bowel Disease

2018 ◽  
Author(s):  
Arman Karshenas ◽  
Joseph Windo ◽  
Bhuvana Sudarshan ◽  
Adrian Kozhevnikov ◽  
Jhanna Kryukova ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Frequency Domain ◽  
Bowel Disease ◽  
Feedback Loop ◽  
Reaction Pathway ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Frequency Domain Analysis ◽  
Inflammatory Bowel ◽  
Near Future

The validity of a complex reaction pathway pro- posed to treat Inflammatory Bowel Disease (IBD) was verified by a comprehensive time and frequency domain analysis. The model was taken to the frequency domain to study the effect and the significance of the negative feedback loop introduced by the reaction pathways. It could be shown that such proposed probiotics have very interesting potentials that could be used extensively in near future.

scholarly journals Analysis of Three-Phase Wye-Delta Connected LLC

Energies ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3606
Author(s):  
Jing-Yuan Lin ◽  
Chuan-Ting Chen ◽  
Kuan-Hung Chen ◽  
Yi-Feng Lin
Keyword(s):  
Frequency Domain ◽  
Time Domain ◽  
Operation Time ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Frequency Domain Analysis ◽  
Complete Analysis ◽  
Plane Analysis ◽  
Analysis Methods ◽  
Three Phase

Three-phase wye–delta LLC topology is suitable for voltage step down and high output current, and has been used in the industry for some time, e.g., for server power and EV charger. However, no comprehensive circuit analysis has been performed for three-phase wye–delta LLC. This paper provides complete analysis methods for three-phase wye–delta LLC. The analysis methods include circuit operation, time domain analysis, frequency domain analysis, and state–plane analysis. Circuit operation helps determine the circuit composition and operation sequence. Time domain analysis helps understand the detail operation, equivalent circuit model, and circuit equation. Frequency domain analysis helps obtain the curve of the transfer function and assists in circuit design. State–plane analysis is used for optimal trajectory control (OTC). These analyses not only can calculate the voltage/current stress, but can also help design three-phase wye-delta connected LLC and provide the OTC control reference. In addition, this paper uses PSIM simulation to verify the correctness of analysis. At the end, a 5-kW three-phase wye–delta LLC prototype is realized. The specification of the prototype is a DC input voltage of 380 V and output voltage/current of 48 V/105 A. The peak efficiency is 96.57%.

A Frequency Domain Analysis of Learning Control

1994 ◽  
Vol 116 (4) ◽  
pp. 781-786 ◽  
Author(s):  
C. J. Goh
Keyword(s):  
Frequency Domain ◽  
Time Domain ◽  
Linear Time ◽  
Planning Horizon ◽  
Time Domain Analysis ◽  
Learning Control ◽  
Domain Analysis ◽  
Frequency Domain Analysis ◽  
Convergence Criterion ◽  
The Time Domain

The convergence of learning control is traditionally analyzed in the time domain. This is because a finite planning horizon is often assumed and the analysis in time domain can be extended to time-varying and nonlinear systems. For linear time-invariant (LTI) systems with infinite planning horizon, however, we show that simple frequency domain techniques can be used to quickly derive several interesting results not amenable to time-domain analysis, such as predicting the rate of convergence or the design of optimum learning control law. We explain a paradox arising from applying the finite time convergence criterion to the infinite time learning control problem, and propose the use of current error feedback for controlling possibly unstable systems.

A Portable Detecting and Analytic Instrument of Vibration Signal

2012 ◽  
Vol 442 ◽  
pp. 305-308
Author(s):  
Jian Wei Li ◽  
Ling Wang ◽  
Hong Mei Zhang
Keyword(s):  
Frequency Domain ◽  
Virtual Instrument ◽  
Vibration Signal ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Frequency Domain Analysis ◽  
Time Frequency ◽  
Notebook Computer ◽  
Usb Bus ◽  
Data Acquisition Card

It is often needed in engineering that detecting and analyzing vibration signal of some equipment. To meet the requirement, a portable detecting and analytic instrument was designed using virtual instrument concept. In the instrument, notebook computer was used as the platform of hardware. Vibration signal was obtained by integrated piezoelectric acceleration sensor (DTS0104T), and was transferred to a notebook computer through data acquisition card (NI USB-6210) based on USB bus. The software, running on the notebook computer, was developed under LabVIEW. Vibration signal could be displayed on screen, recorded in disk or printed by printer, retrieved, and analyzed. The analysis functions of the instrument include: time-domain analysis, frequency-domain analysis, time-frequency domain analysis, and correlation analysis. The instrument is compact, portable, powerful, and with friendly interfaces, has broad application prospects.

Behaviour of a Suspended Wellbay Module and Flare Tower in Waves During Transit to Shore

2019 ◽  
Author(s):  
Hoi-Sang Chan ◽  
Evren Armaoğlu ◽  
Matthew Thomson ◽  
Alistair Garner
Keyword(s):  
Frequency Domain ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Frequency Domain Analysis ◽  
Irregular Waves ◽  
Scale Model ◽  
Response Analysis ◽  
Regular Waves ◽  
The North ◽  
Response Amplitude Operators

Abstract The extended lift operation to deliver the Wellbay module (M5) combined with the Flare Tower (M8) from the Miller Platform in the North Sea to the shore using the Semi-Submersible Crane Vessel S7000 was restricted by the clearances between M5/M8 and the vessel crane booms. A method to calculate the clearances of the M5/M8 normal to the vessel crane booms has been developed and used in a frequency-domain response analysis to define operability limits. Investigations based on a series of scale model tests in regular waves and irregular short-crested waves including motion decay tests in calm water, conducted by the Maritime Research Institute (MARIN) in the Netherlands, were also made to further evaluate the behaviour of the suspended M5/M8 on S7000’s main hooks during transit. The time series of decay motions of the suspended M5/M8 obtained from the decay motion tests and a time domain analysis are compared and used to derive rigging damping. The numerical results of the frequency-domain analysis are validated with the experimental data for response amplitude operators (RAOs) found in regular waves and pink noise waves, significant and 3 hour most probable maximum/minimum (MPM) responses of interest in irregular waves.

scholarly journals Endoscopy in inflammatory bowel disease: from guidelines to real life

2019 ◽  
Vol 12 ◽  
pp. 175628481986515 ◽  
Author(s):  
Lucian Negreanu ◽  
Theodor Voiosu ◽  
Monica State ◽  
Andrei Voiosu ◽  
Andreea Bengus ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Real Life ◽  
Mucosal Healing ◽  
Irreversible Damage ◽  
Therapeutic Modalities ◽  
Therapeutic Decisions ◽  
Open Debate ◽  
Inflammatory Bowel ◽  
Near Future

Endoscopy has a central role in the management of inflammatory bowel disease (IBD), providing crucial data for diagnostic and therapeutic decisions, treating disease-related complications, and assisting in the early detection of dysplasia and prevention of colorectal cancer in the setting of IBD. Treatment targets have significantly shifted in IBD, focusing on achieving mucosal healing, a more meaningful endpoint than clinical remission. With the emergence of novel therapies, we aim to alter the course of the disease and prevent irreversible damage to the bowel. To that end, obtaining reliable and reproducible assessments of endoscopic disease activity has become an issue of great importance. Although several guidelines include recommendations regarding endoscopic surveillance in patients with long-standing IBD, there is an open debate regarding the best examination method and the appropriate follow-up intervals. Another important issue is whether surveillance guidelines are actually implemented in real-life practice and what is the preferred surveillance method among endoscopists. Significant changes have occurred in the endoscopic world with the development of new diagnostic and therapeutic modalities and their incorporation in everyday practice. We aimed to assess the real-life application of guideline recommendations regarding endoscopy in IBD patients and to review newly emerged data which might impact these recommendations in the near future.

Analysis of Electrocardio Signal Based on Approximate Entropy

2012 ◽  
Vol 429 ◽  
pp. 195-199
Author(s):  
Xiao Lei Zhao ◽  
Ming Rong Ren ◽  
Ya Ting Zhang ◽  
Pu Wang
Keyword(s):  
Frequency Domain ◽  
Time Domain ◽  
Approximate Entropy ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Frequency Domain Analysis ◽  
Spectrum Estimation ◽  
Transform Method ◽  
Time Frequency ◽  
Relationship Of

The research and detection of heart disease depends on the analysis of the characteristic of electrocardio signal. Current analysis methods mainly include: (1) time domain analysis is a common used approach. With experience learned by observation and calculation, researchers examine errors and interferences to calculate means and variances directly within time domain. Analysis quality of this method demands higher request for researchers’ experience and skill although it’s a direct and significant result. (2) Frequency domain analysis, such as spectrum estimation, is largely applied to electrocardio signal researches and clinical applications. The analysis reflects abundant electrocardio activities, but failed to show details of the characteristics due to lack of time information. (3) time-frequency domain analysis describes energy density under different time and frequency of electrocardio signal at one time. It clarifies the relationship of signal frequency’s changing along with time such as wavelet transform method. (4) Nonlinear analysis is generally applied to biomedicine signal research in recent years. Correlation dimension, kolmogorov entropy, lyapunov component are major research methods to estimate some nonlinear dynamic parameters to represent the characteristic of electrocardio signal.

scholarly journals PLACEBO USE IN THE CONTEXT OF INFLAMMATORY BOWEL DISEASE CLINICAL TRIALS

2020 ◽  
Vol 57 (1) ◽  
pp. 87-90
Author(s):  
Juan Sebastian LASA ◽  
Ignacio ZUBIAURRE ◽  
Astrid RAUSCH ◽  
Pablo OLIVERA
Keyword(s):  
Inflammatory Bowel Disease ◽  
Clinical Trials ◽  
Bowel Disease ◽  
Biologic Therapy ◽  
Biologic Treatment ◽  
Secondary Failure ◽  
Inflammatory Bowel ◽  
Therapeutic Alternatives ◽  
Near Future ◽  
Intense Debate

ABSTRACT Inflammatory bowel disease comprises two distinct conditions - Crohn’s disease and ulcerative colitis - which can be treated with immunomodulators. A non-neglectable proportion of these patients will need biologic therapy, and many patients under biologic treatment will experience either primary or secondary failure. As a consequence, clinical trials evaluating new therapeutic alternatives are being developed. These trials share common features, such as being controlled with placebo. Placebo use in clinical trials is a matter of intense debate. Those who support placebo use highlight the methodologic advantages placebo-controlled trials have. Those against placebo use argue that it would be against ethical principles in clinical research to expose a patient to placebo when a valid therapeutic alternative exists. In this review, we summarize the existing arguments for and against the use of placebo in the context of inflammatory bowel disease research. We finally suggest that it is very likely that in the near future inflammatory bowel disease trials will no longer be controlled with a placebo arm, but instead they will be non-inferiority trials with an active comparator.

Sign in / Sign up

Export Citation Format

Share Document