Nano-functionalized Paper-based IoT enabled Devices for Point-of-Care Testing: A Review

2021 ◽  
Author(s):  
Vinay Kishnani ◽  
Ankur Gupta

Over the last few years, the microfluidics phenomenon coupled with the Internet of Things (IoT) using innovative nano-functional materials have been recognized as one of the sustainable and economical tools for point of care testing (POCT) of various pathogens influencing the human health. The sensors based on these phenomena are aimed to be designed for their cost-effectiveness, to make it handy, environment-friendly and to get an accurate, easy, and rapid response. Considering the burgeoning importance of analytical devices in the healthcare domain, this review paper is based on the gist of sensing aspects of the micro fabricated paper-based analytical devices (μPADs). The article discusses not only the various used design methodologies and fabrication approaches, but also elucidates the recently reported surface modification strategies, detection mechanisms viz., colorimetric, electrochemical, fluorescence, electrochemiluminescence etc., and sensing characteristics of μPADs along with reported works equipped with the IoT platform for digital readout. In a nutshell, this article summarizes the state-of-the-art research work carried out over the nano functionalized paper-based analytical devices and associated challenges/solutions in the point of care testing domain.

2019 ◽  
Vol 57 (3) ◽  
pp. 308-311 ◽  
Author(s):  
Larry J. Kricka

Abstract Predictions about the future of laboratory medicine have had a mixed success, and in some instances they have been overambitious and incorrectly assessed the future impact of emerging technologies. Current predictions suggest a more highly automated and connected future for diagnostic testing. The central laboratory of the future may be dominated by more robotics and more connectivity in order to take advantage of the benefits of the Internet of Things and artificial intelligence (AI)-based systems (e.g. decision support software and imaging analytics). For point-of-care testing, mobile health (mHealth) may be in the ascendancy driven by healthcare initiatives from technology companies such as Amazon, Apple, Facebook, Google, IBM, Microsoft and Uber.


2020 ◽  
Vol 27 ◽  
Author(s):  
Yi Zhang

: Point-of-care (POC) testing decentralizes the diagnostic tests to the sites near the patient. Many POC tests rely microfluidic platforms for sample-to-answer analysis. Compared to other microfluidic systems, magnetic digital microfluidics demonstrate compelling advantages for POC diagnostics. In this review, we have examined the capability of magnetic digital microfluidics-based POC diagnostic platforms. More importantly, we have categorized POC settings into three classes based on “where is the point”, “who to care” and “how to test”, and evaluated the suitability of magnetic digital microfluidics in various POC settings. Furthermore, we have addressed other technical issues associated with POC testing such as controlled environment, sample-system interface, system integration and information connectivity. We hope this review would provide a guideline for the future development of magnetic digital microfluidics-based platforms for POC testing.


The Analyst ◽  
2021 ◽  
Author(s):  
Tianshu Chu ◽  
Huili Wang ◽  
Yumeng Qiu ◽  
Haoxi Luo ◽  
Bingfang He ◽  
...  

Wearable sensors play a key role in point-of-care testing (POCT) for its flexible and integration capability on sensitive physiological and biochemical sensing. Here, we present a multifunction wearable silk patch...


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