Nano-functionalized Paper-based IoT enabled Devices for Point-of-Care Testing: A Review
Over the last few years, the microfluidics phenomenon coupled with the Internet of Things (IoT) using innovative nano-functional materials have been recognized as one of the sustainable and economical tools for point of care testing (POCT) of various pathogens influencing the human health. The sensors based on these phenomena are aimed to be designed for their cost-effectiveness, to make it handy, environment-friendly and to get an accurate, easy, and rapid response. Considering the burgeoning importance of analytical devices in the healthcare domain, this review paper is based on the gist of sensing aspects of the micro fabricated paper-based analytical devices (μPADs). The article discusses not only the various used design methodologies and fabrication approaches, but also elucidates the recently reported surface modification strategies, detection mechanisms viz., colorimetric, electrochemical, fluorescence, electrochemiluminescence etc., and sensing characteristics of μPADs along with reported works equipped with the IoT platform for digital readout. In a nutshell, this article summarizes the state-of-the-art research work carried out over the nano functionalized paper-based analytical devices and associated challenges/solutions in the point of care testing domain.