scholarly journals Nano-emulsions. Comprehensive Report

2021 ◽  
Author(s):  
Steven P Allen ◽  
Austin Fergusson ◽  
Connor Edsall ◽  
Richey M Davis ◽  
Eli Vlaisavljevich ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Virginia Tech ◽  
Electromagnetic Properties ◽  
Particle Sizes ◽  
Acoustic Coupling ◽  
Mr Guidance ◽  
Mri Scans ◽  
Cavitation Nuclei ◽  
Nano Emulsion

This report gives comprehensive review of the nano-emulsion project between UVA and Virginia Tech which has been generously supported by the Focused Ultrasound Foundation. The purpose of this project is to develop an acoustic coupling bath that is effectively invisible to MRI scans and also remains acoustically compatible with clinical transcranial FUS procedures. This remains important to the clinical translation of FUS because the commonly used acoustic coupling bath of degassed water persistently degrades the quality of MR guidance imaging. Our project proposes an acoustic coupling bath doped with specially designed iron oxide nanoparticles that 1) have a high ability to decay MRI signals, (as quantified by the r2 relaxivity), 2) have diameters less than 100 nm, and 3) are coated with a hydrophilic coating. We hypothesize that these three innovations will produce a lightly doped water bath with identical mechanical, acoustic, thermal, biocompatibility, and electromagnetic properties as water, but with virtually no observable appearance or effect on guidance MR imaging. Finally, the low particle concentrations, small particle sizes, and specific coating will prevent the particles from stabilizing gas bubbles and seeding cavitation nuclei in the transducer’s pre-focal field.We are pleased to report nearly total success on this project, with an affirmation of all hypotheses stated above.

Interrater reliability of a method to assess hypothalamic involvement in pediatric adamantinomatous craniopharyngioma

2020 ◽  
Vol 25 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Ros Whelan ◽  
Eric Prince ◽  
David M. Mirsky ◽  
Robert Naftel ◽  
Aashim Bhatia ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Interrater Reliability ◽  
Statistical Evaluation ◽  
Grading System ◽  
Reliability Study ◽  
Postoperative Mri ◽  
Mri Scans ◽  
Adamantinomatous Craniopharyngioma

OBJECTIVEPediatric adamantinomatous craniopharyngiomas (ACPs) are histologically benign brain tumors that confer significant neuroendocrine morbidity. Previous studies have demonstrated that injury to the hypothalamus is associated with worsened quality of life and a shorter lifespan. This insight helps many surgeons define the goals of surgery for patients with ACP. Puget and colleagues proposed a 3-tiered preoperative and postoperative grading system based on the degree of hypothalamic involvement identified on MRI. In a prospective cohort from their institution, the authors found that use of the system to guide operative goals was associated with decreased morbidity. To date, however, the Puget system has not been externally validated. Here, the authors present an interrater reliability study that assesses the generalizability of this system for surgeons planning initial operative intervention for children with craniopharyngiomas.METHODSA panel of 6 experts, consisting of pediatric neurosurgeons and pediatric neuroradiologists, graded 30 preoperative and postoperative MRI scans according to the Puget system. Interrater reliability was calculated using Fleiss’ κ and Krippendorff’s α statistics.RESULTSInterrater reliability in the preoperative context demonstrated moderate agreement (κ = 0.50, α = 0.51). Interrater reliability in the postoperative context was 0.27 for both methods of statistical evaluation.CONCLUSIONSInterrater reliability for the system as defined is moderate. Slight refinements of the Puget MRI grading system, such as collapsing the 3 grades into 2, may improve its reliability, making the system more generalizable.

scholarly journals The effects of locations on the build tray on the quality of specimens in powder bed additive manufacturing

2021 ◽  
Author(s):  
Snehashis Pal ◽  
Nenad Gubeljak ◽  
Tonica Bončina ◽  
Radovan Hudák ◽  
Teodor Toth ◽  
...  
Keyword(s):  
Main Role ◽  
Particle Sizes ◽  
Additional Experiment ◽  
Powder Bed ◽  
Melt Pool ◽  
Start Line ◽  
Sample Density ◽  
Powder Layering ◽  
Pool Formation

AbstractIn this study, the effect of powder spreading direction was investigated on selectively laser-melted specimens. The results showed that the metallurgical properties of the specimens varied during fabrication with respect to their position on the build tray. The density, porosity, and tensile properties of the Co–Cr–W–Mo alloy were investigated on cuboid and tensile specimens fabricated at different locations. Two different significant positions on the tray were selected along the powder spreading direction. One set of specimens was located near the start line of powder spreading, and the other set was located near the end of the building tray. The main role in the consequences of powder layering was played by the distribution of powder particle sizes and the packing density of the layers. As a result, laser penetration, melt pool formation, and fusion characteristics varied. To confirm the occurrence of variations in sample density, an additional experiment was performed with a Ti–6Al–4V alloy. Furthermore, the powders were collected at two different fabricating locations and their size distribution for both materials was investigated.

scholarly journals How the Future of Sonography May Change the Outlook for Patients With Osteosarcoma

2018 ◽  
Vol 34 (5) ◽  
pp. 368-373
Author(s):  
Stacey Hoya ◽  
Linda Wogeman ◽  
Sara Allstadt ◽  
Glen King
Keyword(s):  
Quality Of Life ◽  
Focused Ultrasound ◽  
Treatment Plan ◽  
Treatment Options ◽  
Therapeutic Ultrasound ◽  
Bone Lesions ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Ultrasound Applications

Sonography currently provides a variety of tools to support the diagnosis and treatment of osteosarcoma and, with the development of therapeutic ultrasound practices, could play an increasingly important role in the treatment of future patients with osteosarcoma. Currently, computed tomography, magnetic resonance imaging, and radiography are the preferred imaging modalities for bone lesions; treatment options for osteosarcoma primarily include highly toxic chemotherapies and surgeries that often result in limb loss. Unfortunately, osteosarcoma is rarely eliminated, and despite this, patients lose their lives after having a significant reduction in quality of life. Evolving therapies such as high-frequency focused ultrasound, ultrasound-enhanced delivery of photodynamic therapy, and low-intensity pulsed ultrasound may offer these patients an improved quality of life while also increasing efficacy of treatment. This canine case study illustrates the various ways in which sonography might contribute to the treatment plan for patients with osteosarcoma. It may provide a comparable model for the reimagining of treatment for future patients with osteosarcoma using a suite of therapeutic ultrasound applications.

scholarly journals Curcumin-removed turmeric oleoresin nano-emulsion as a novel botanical fungicide to control anthracnose (Colletotrichum gloeosporioides) in litchi

2021 ◽  
Vol 10 (1) ◽  
pp. 729-741
Author(s):  
Van Cuong Bui ◽  
The Tam Le ◽  
Tuyen Hong Nguyen ◽  
Nam Thi Pham ◽  
Hoang Dinh Vu ◽  
...  
Keyword(s):  
Field Trial ◽  
Colletotrichum Gloeosporioides ◽  
Inhibitory Concentration ◽  
Particle Sizes ◽  
Control Efficacy ◽  
Potent Inhibition ◽  
Nano Emulsion ◽  
Nano Formulation

Abstract During curcumin production in Vietnam, curcumin-removed turmeric oleoresin (CRTO) has been considered as a by-product. It costs to treat the by-product to prevent environmental pollution. In this study, the by-product was utilized as an active ingredient for preparing a botanical fungicide-based nano-emulsion and evaluated for its in vitro and in vivo control efficacy against Colletotrichum gloeosporioides, a causal agent of anthracnose of litchi, in the laboratory as well as a field trial. The nano-emulsion is colloidally stable and uniform with particle sizes of 95–250 nm. CRTO nano-emulsion significantly affected various Colletotrichum species. Notably, this nano-emulsion showed potent inhibition for the mycelial growth of C. gloeosporioides and solidly suppressed the development of anthracnose on litchi fruits. In the in vitro inhibition test, the equivalent half-maximal inhibitory concentration of CRTO in nano-formulation was 0.11 mg·mL−1, which was 3.0× and 6.1× lower than IC50 values of CRTO alone (0.33 mg·mL−1) and a mixture of curcuminoids (0.48 mg·mL−1), respectively. In the field trial, the litchi anthracnose infection was effectively controlled by nano-formulation. These results suggest that CRTO nano-emulsion could be used as an alternative to harmful synthetic fungicides to control anthracnose on litchi fruits.

scholarly journals STROBE-MR: Guidelines for strengthening the reporting of Mendelian randomization studies

2019 ◽  
Author(s):  
George Davey Smith ◽  
Neil M Davies ◽  
Niki Dimou ◽  
Matthias Egger ◽  
Valentina Gallo ◽  
...  
Keyword(s):  
Observational Studies ◽  
Mendelian Randomization ◽  
Data Sources ◽  
Mr Studies ◽  
Randomised Trials ◽  
Quality Of Reporting ◽  
Journal Editors ◽  
Mr Guidance ◽  
Quality And Reliability

While the number of studies using Mendelian randomization (MR) methods has grown exponentially in the last decade, the quality of reporting of these studies often has been poor. Similar to other reporting guidelines such as CONSORT (Consolidated Standards of Reporting Trials) for randomised trials and STROBE (STrenghtening the Reporting of Observational studies in Epidemiology) for observational studies in epidemiology, the STROBE-MR working group aims to provide guidance to authors on how to improve reporting of MR studies and help readers, reviewers, and journal editors to evaluate the quality of the presented evidence. Empirical evidence indicates that many reports of MR studies do not clearly state or examine the various assumptions of MR methods and report insufficient details on the data sources, which makes it hard to evaluate the quality and reliability of the results. The STROBE-MR guidance covers both one sample and two sample MR studies. At present, the draft checklist consists of 20 items, organized into the title and abstract, introduction, methods, results and discussion sections of articles. As these guidelines aim to reach the entire MR community, we would like to give everyone the opportunity to contribute their comments. The following draft of the STROBE-MR checklist is open for public discussion and all feedback will be taken into account during its next revision. For feedback, please use the comment section below this post on PeerJ Preprints. We hope the final guidelines will serve the entire community and contribute to improving the reporting of MR studies in the future.

scholarly journals THE EFFECT OF CAVITATION TREATMENT ON THE EXTINGUISHING OF PARTICLES OF OILS IN FUEL BOILERS

2019 ◽  
Vol 20 (9-10) ◽  
pp. 52-59
Author(s):  
M. A. Taymarov ◽  
R. V. Akhmetova ◽  
S. M. Margulis ◽  
L. I. Kasimova
Keyword(s):  
Particle Size ◽  
Combustion Zone ◽  
Consumption Rate ◽  
Fuel Oil ◽  
Particle Sizes ◽  
Oil Consumption ◽  
Boiler Efficiency ◽  
Large Particles ◽  
Oil Particles

The difficulties of burning the watered fuel oil used at the TPP as a reserve fuel for boilers are associated with its preparation by heating to reduce viscosity and the choice of a method of spraying with nozzles into the combustion zone. The quality of the preparation of fuel oil for combustion affecting the boiler efficiency is estimated by the length of the flame, the presence of burning large particles of fuel oil, the injection of coke and unburned particles onto screen and other heat-receiving surfaces. One of the ways to prepare fuel oil for combustion is cavitation treatment, which results in an emulsion consisting of fine micronsized particles. Heating of fuel oil particles after the nozzle in contact with the combustion zone is due to the flow of radiation from the burning torch. Therefore, in this article, the values of the flux density from the torch during the combustion of fuel oil are experimentally determined. The influence of particle size on the burning rate of the fuel oil M100 with the different density of the thermal radiation of the flame. It is found that the effect of cavitation treatment of fuel oil on the combustion rate is most significantly manifested in particle sizes less than 10 microns. For this purpose, the use of hydrodynamic cavitators are preferred at high fuel oil consumption rate.

scholarly journals KUALITAS PAPAN KOMPOSIT DARI LIMBAH FINIR KAYU LAPIS BERDASARKAN UKURAN PARTIKEL DAN WAKTU PENGEMPAAN DENGAN MENGGUNAKAN PEREKAT LIMBAH PLASTIK POLIPROPILENA

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Alfonsus Rodriquez ◽  
Ahmad Yani ◽  
Fathul Yusro
Keyword(s):  
Particle Size ◽  
Physical And Mechanical Properties ◽  
Particle Sizes ◽  
Hot Press ◽  
Factor B ◽  
Pressing Time ◽  
Materials Used ◽  
Absorption Thickness ◽  
Water Contents

This study aims to analyze the quality of composite boards from plywood veneers waste and polypropylene plastic waste adhesives base on particle sizes, pressing times, and both of interaction towards physical and mechanical properties also to obtain the particle sizes and pressing time properly with the result that produce the qualified standard boards of JIS A 5908-2003. This research carried out at the wood workshop, laboratory of technology and processing of woods (the faculty of forestry, university of Tanjungpura), and the laboratory of PT. Duta Pertiwi Nusantara. The materials used in this study were plywood veneers waste and polypropylene plastic by 50% : 50% comparison. The research method was utilized the completely randomized factorial design by two treatment factors. Factor A was particle sizes that consisting of 6 mesh, 8 mesh, and 10 mesh. Factor B was pressing time that consisting of 10 minutes, 15 minute, and 20 minutes. Composite boards were created by 30 x 30 x 1 size in centimetres by means the density target was 0,7 gr/cm3. The pressing was done by hot press in 180oC temperature and composite boards conditioning for 14 days. The results of this study showed that the density, water absorption, thickness, Modulus of Repture (MOR), internal bonding, holding strength of screws in the composite boards have been qualified the standard of JIS A 5908-2003. While, the water contents and Modulus of Elasticity (MOE) testing were not qualified the standard of JIS 5908-2003. The treatment that produce the optimum composite boards which quality JIS A 5908-2003 standard was on the 8 mesh particle size treatment by means of 15 minutes pressing time.Keywords: Composite Board, Particle Size, Polypropylene Plastics, Pressing Time, Veneers Waste.

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