Associative learning-related activity within and between the hippocampus, basal ganglia, and prefrontal cortex: Effects of age and learning stage

2020 ◽  
Author(s):  
Jenna Merenstein ◽  
Jessica R. Petok ◽  
Ilana J. Bennett
Keyword(s):  
Older Adults ◽  
Prefrontal Cortex ◽  
Basal Ganglia ◽  
Associative Learning ◽  
Early Learning ◽  
Brain Regions ◽  
Group Differences ◽  
Age Group ◽  
Related Activity ◽  
Younger Adults

Healthy aging is accompanied by declines in our ability to learn associations between events without awareness, termed implicit associative learning (IAL). Previous functional magnetic resonance imaging (fMRI) studies have attributed these learning deficits in older adults to differential engagement of the hippocampus, basal ganglia, and prefrontal cortex relative to younger adults. But it remains unclear whether there are also age group differences in how these brain regions coordinate learning of associations over time. Here, we acquired fMRI data while 28 younger (20.8 ± 2.3 years) and 22 older (73.6 ± 6.8 years) healthy adults completed the Triplets Learning Task, in which the location of two cues predicted the location of a target with high (HF) or low (LF) frequency. Results revealed significant age group differences in learning as smaller difference in reaction time to HF versus LF triplets in older relative to younger adults, and in the recruitment of hippocampal and prefrontal regions during early learning. Moreover, learning-related activity was significantly related among hippocampal, basal ganglia, and prefrontal regions for both age groups, although younger adults exhibited stronger hippocampal-basal ganglia interactions during early learning whereas older adults showed stronger prefrontal-hippocampal interactions during late learning. Thus, age-related declines in the ability to learn implicit associations may result from both differential engagement of and coordination between these brain regions, which are traditionally thought to comprise separate learning systems.

scholarly journals Age Group Differences in Response to Repeated Exposure to Laboratory Stress Tasks

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 772-772
Author(s):  
James Miller ◽  
Gloria Luong
Keyword(s):  
Older Adults ◽  
Negative Affect ◽  
Task Difficulty ◽  
Repeated Exposure ◽  
Group Differences ◽  
Age Group ◽  
Younger Adults ◽  
Affective Experiences ◽  
Affect Reactivity ◽  
And Task

Abstract Research examining age differences in affect reactivity (i.e. how much affective experiences change in response to stressors) has produced mixed results, suggesting that there are areas of relative strength and weakness in regulatory processes across age-groups. The present study’s goals were to examine potential age-group differences in affect reactivity and subjective task-appraisals across repeated exposures to a psychosocial laboratory stressor. In the Health and Daily Experiences (HEADE) study, younger (18-35 years old; n=107) and older adults (60-90 years old; n=90) were exposed to the Trier Social Stress Test on three occasions in a laboratory setting over a five-day period. Current affective experiences and task-appraisals were assessed at each session using validated self-report scales, with current affective experiences measured at baseline and task periods to determine affect reactivity. Repeated measures ANOVA analyses were conducted to examine age-group differences in affect reactivity and task-appraisals across sessions. In support of our hypotheses, younger adults showed greater reductions in their negative affect reactivity over time compared to older adults [F(2, 390)= 8.18, p<.001]. Additionally, younger adults’ appraisals of task-difficulty decreased [F(2, 384)= 14.79, p<.001] and appraisals of task-performance increased [F(2,384)= 13.39, p<.001] across sessions, while older adults’ task-appraisals remained stable. Age-group differences in negative affect reactivity and task-difficulty appraisals were not evident for the first session and only emerged after repeated exposure to the stressors. These results highlight the importance of identifying age-related vulnerabilities in adapting to repeated stressors, with implications for designing effective interventions aimed at improving health and well-being for older adults.

scholarly journals Age Group Differences in Household Accident Risk Perceptions and Intentions to Reduce Hazards

2019 ◽  
Vol 16 (12) ◽  
pp. 2237 ◽  
Author(s):  
James Morgan ◽  
John Reidy ◽  
Tahira Probst
Keyword(s):  
Older Adults ◽  
Risk Perceptions ◽  
Safety Information ◽  
Personal Control ◽  
Group Differences ◽  
Risk Attitudes ◽  
Accident Risk ◽  
Age Group ◽  
Younger Adults ◽  
Response Efficacy

Very little is known about the extent to which seemingly vulnerable younger and older adults appraise household risks and relatedly whether safety information focused on raising risk awareness influences intentions to reduce hazards in the home. The present study assessed age differences in accident experience, risk attitudes, household accident risk perceptions, comparative optimism, personal control, efficacy judgements, and intentions to remove household hazards. It also examined the predictors of these intentions. Thirty-eight younger adults (aged 18 to 25) and forty older adults (aged 65 to 87) completed study booklets containing all measures. There were significant age group differences for all accident experience and risk-related variables. Younger adults experienced more accidents, had riskier attitudes, and had significantly lower cognitive risk perceptions (i.e., they were less likely to be injured due to a household accident). They also had lower affective risk perceptions (i.e., they were less worried) about their accident risk and perceived more personal control over the risk compared with older adults. Young adults were comparatively optimistic about their risk while older adults were pessimistic. Older adults had higher response efficacy and intentions to reduce hazards in the home. Only worry, response efficacy, and risk attitudes predicted intention, however, these relationships were not moderated by age or efficacy appraisal. Although tentative theoretical and practical implications are presented, further research is required in order to better understand the objective and subjective risk associated with household accidents, and to determine the factors that may improve safety, particularly for those most vulnerable.

scholarly journals The Effects of Aging on the Neural Basis of Implicit Associative Learning in a Probabilistic Triplets Learning Task

2012 ◽  
Vol 24 (2) ◽  
pp. 451-463 ◽  
Author(s):  
Jessica R. Simon ◽  
Chandan J. Vaidya ◽  
James H. Howard ◽  
Darlene V. Howard
Keyword(s):  
Older Adults ◽  
Associative Learning ◽  
Target Location ◽  
Age Groups ◽  
Learning Task ◽  
Brain Regions ◽  
Behavioral Pattern ◽  
Neural Basis ◽  
Younger Adults ◽  
Age Related

Few studies have investigated how aging influences the neural basis of implicit associative learning, and available evidence is inconclusive. One emerging behavioral pattern is that age differences increase with practice, perhaps reflecting the involvement of different brain regions with training. Many studies report hippocampal involvement early on with learning becoming increasingly dependent on the caudate with practice. We tested the hypothesis that the contribution of these regions to learning changes with age because of differential age-related declines in the striatum and hippocampi. We assessed age-related differences in brain activation during implicit associative learning using the Triplets Learning Task. Over three event-related fMRI runs, 11 younger and 12 healthy older adults responded to only the third (target) stimulus in sequences of three stimuli (“triplets”) by corresponding key press. Unbeknown to participants, the first stimulus' location predicted one target location for 80% of trials and another target location for 20% of trials. Both age groups learned associative regularities but differences in favor of the younger adults emerged with practice. The neural basis of learning (response to predictability) was examined by identifying regions that showed a greater response to triplets that occurred more frequently. Both age groups recruited the hippocampus early, but with training, the younger adults recruited their caudate whereas the older adults continued to rely on their hippocampus. This pattern enables older adults to maintain near-young levels of performance early in training, but not later, and adds to evidence that implicit associative learning is supported by different brain networks in younger and older adults.

scholarly journals Age-Related Differences in Resting-State EEG and Allocentric Spatial Working Memory Performance

2021 ◽  
Vol 13 ◽  
Author(s):  
Adeline Jabès ◽  
Giuliana Klencklen ◽  
Paolo Ruggeri ◽  
Jean-Philippe Antonietti ◽  
Pamela Banta Lavenex ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Resting State ◽  
Spatial Working Memory ◽  
Brain Activity ◽  
Memory Performance ◽  
Group Differences ◽  
Age Group ◽  
Eeg Activity ◽  
Recording Conditions

During normal aging resting-state brain activity changes and working memory performance declines as compared to young adulthood. Interestingly, previous studies reported that different electroencephalographic (EEG) measures of resting-state brain activity may correlate with working memory performance at different ages. Here, we recorded resting-state EEG activity and tested allocentric spatial working memory in healthy young (20–30 years) and older (65–75 years) adults. We adapted standard EEG methods to record brain activity in mobile participants in a non-shielded environment, in both eyes closed and eyes open conditions. Our study revealed some age-group differences in resting-state brain activity that were consistent with previous results obtained in different recording conditions. We confirmed that age-group differences in resting-state EEG activity depend on the recording conditions and the specific parameters considered. Nevertheless, lower theta-band and alpha-band frequencies and absolute powers, and higher beta-band and gamma-band relative powers were overall observed in healthy older adults, as compared to healthy young adults. In addition, using principal component and regression analyses, we found that the first extracted EEG component, which represented mainly theta, alpha and beta powers, correlated with spatial working memory performance in older adults, but not in young adults. These findings are consistent with the theory that the neurobiological bases of working memory performance may differ between young and older adults. However, individual measures of resting-state EEG activity could not be used as reliable biomarkers to predict individual allocentric spatial working memory performance in young or older adults.

scholarly journals KNOWLEDGE OF AGING, NEGATIVE AGE BIAS, AND POSITIVE AGE BIAS: AGE GROUP DIFFERENCES

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S80-S81
Author(s):  
Grace Caskie ◽  
Anastasia E Canell ◽  
Hannah M Bashian
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Well Being ◽  
Total Sample ◽  
Group Differences ◽  
Age Group ◽  
Middle Aged ◽  
Age Bias ◽  
Negative Beliefs ◽  
Middle Aged Adults

Abstract Attitudes towards aging include both positive and negative beliefs about older adults (Iverson et al., 2017; Palmore, 1999). Palmore’s (1998) Facts on Aging Quiz, a widely used assessment of knowledge about aging, also identifies common societal misconceptions about aging. Findings regarding age group differences in attitudes toward aging are mixed (Bodner et al., 2012; Cherry & Palmore, 2008; Rupp et al., 2005). The current study compared knowledge of aging, negative age bias, and positive age bias between young adults (18-35 years, n=268) and middle-aged adults (40-55 years; n=277). Middle-aged adults reported significantly greater average knowledge of aging than young adults (p=.019), although both groups had relatively low knowledge (MA: M=13.0, YA: M=12.2). Middle-aged adults also showed significantly less negative age bias (p<.001) and significantly more positive age bias than young adults (p=.026). Although the total sample was significantly more likely to be incorrect than correct on 23 of the 25 facts (p<.001), young adults were significantly more likely than middle-aged adults (p<.001) to respond incorrectly for only 2 of 25 facts. Both facts reflected greater negative age bias among young adults than middle-aged adults. These facts concerned older adults’ ability to work as effectively as young adults (fact 9) and frequency of depression in older adults (fact 13). Results demonstrate that age bias is not limited to young adults and may continue through midlife, though negative age bias in particular may be lower for individuals approaching older adulthood, which could have implications for their psychological and physical well-being.

scholarly journals Electrophysiological differences in older and younger adults’ anaphoric but not cataphoric pronoun processing in the absence of age-related behavioural slowdown

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Seçkin Arslan ◽  
Katerina Palasis ◽  
Fanny Meunier
Keyword(s):  
Older Adults ◽  
Short Term Memory ◽  
Memory Span ◽  
Event Related Potentials ◽  
Brain Regions ◽  
Younger Adults ◽  
Behavioural Responses ◽  
Age Related ◽  
Related Potentials ◽  
Anterior Negativity

Abstract This study reports on an event-related potentials experiment to uncover whether per-millisecond electrophysiological brain activity and analogous behavioural responses are age-sensitive when comprehending anaphoric (referent-first) and cataphoric (pronoun-first) pronouns. Two groups of French speakers were recruited (young n = 18; aged 19–35 and older adults n = 15; aged 57–88) to read sentences where the anaphoric/cataphoric pronouns and their potential referents either matched or mismatched in gender. Our findings indicate that (1) the older adults were not less accurate or slower in their behavioural responses to the mismatches than the younger adults, (2) both anaphoric and cataphoric conditions evoked a central/parietally distributed P600 component with similar timing and amplitude in both the groups. Importantly, mean amplitudes of the P600 effect were modulated by verbal short-term memory span in the older adults but not in the younger adults, (3) nevertheless, the older but not the younger adults displayed an additional anterior negativity emerging on the frontal regions in response to the anaphoric mismatches. These results suggest that pronoun processing is resilient in healthy ageing individuals, but that functional recruitment of additional brain regions, evidenced with the anterior negativity, compensates for increased processing demands in the older adults’ anaphora processing.

Age group differences in learning-related activity reflect task stage, not learning stage

2022 ◽  
Vol 416 ◽  
pp. 113570
Author(s):  
Jenna L. Merenstein ◽  
Jessica R. Petok ◽  
Ilana J. Bennett
Keyword(s):  
Group Differences ◽  
Age Group ◽  
Related Activity ◽  
Learning Stage

Contributions of the Prefrontal Cortex and Basal Ganglia to Set Shifting

2002 ◽  
Vol 14 (3) ◽  
pp. 472-483 ◽  
Author(s):  
Susan M. Ravizza ◽  
Michael A. Ciranni
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Basal Ganglia ◽  
Cognitive Deficits ◽  
Memory Load ◽  
Working Memory Capacity ◽  
Response Competition ◽  
Set Shifting ◽  
Working Memory Load ◽  
Younger Adults

Impairments of set shifting have been associated with damage to both the prefrontal cortex (PFC) and to the basal ganglia. The purpose of these experiments was to determine whether damage to the PFC was associated with shifting impairments per se or whether any switching deficits could be attributed to a reduction of working memory capacity. In contrast, shifting impairments were expected for Parkinson patients regardless of memory load, given that these patients seem to have no cognitive deficits other than when having to shift set. To vary working memory demands, a cue to the relevant dimension (letter or shape) in an odd-man-out task was presented or withheld. Pathology to prefrontal areas associated with normal aging was not linked to shifting deficits when working memory load was reduced in a comparison of older and younger adults (Experiment 1). In contrast, set-shifting abilities were still impaired for stroke patients with prefrontal damage regardless of working memory demands (Experiment 2). Parkinson patients were relatively unimpaired on this task (Experiment 2), but began to display shifting deficits when response competition was present in the display (Experiment 3).

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