ReSync: Correcting the trial-to-trial asynchrony of event-related brain potentials to improve neural response representation
For various reasons, the brain response activities in EEG signals are not perfectly synchronized from trial to trial with respect to event markers – a problem commonly referred to as ERP latency jitter. EEG experimental technologies have been greatly advanced to reduce technical timing errors so as to reduce the jitter. However, there are intrinsic sources of jitter that are difficult, if not impossible, to remove. The problem becomes more complicated when facing multiple sub-components with different jitter. The jitter issue renders trial-averaged ERP inaccurate at best and misleading at worst. Effectively correcting the jitter has profound significance in brain research. I present a simple method and easy-to-use toolbox ReSync for correcting ERP jitters based on signal processing theories and techniques. ReSync can be used to correct multiple overlapping ERP sub-components with different degrees of jitter without affecting each other (including the static one). The theories, principles, technical details, and limitations of ReSync were presented in this paper, along with a series of simulation and real data examples for evaluating and validating the method.