Modulation of Trust in Borderline Personality Disorder by Script-Based Imaginal Exposure to Betrayal

2021 ◽  
Author(s):  
Rosa Shapiro-Thompson ◽  
Tanya Shah ◽  
Caroline Yi ◽  
Nasir Jackson ◽  
Daniel Trujillo Diaz ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Learning Task ◽  
Borderline Personality ◽  
Group Differences ◽  
Imaginal Exposure ◽  
Task Behavior ◽  
Healthy Control ◽  
Social Difficulty ◽  
Task Stimulus

Interpersonal and trust-related difficulties are central features of Borderline Personality Disorder (BPD). In this study, we applied script-driven betrayal imagery to evoke mistrustful behavior in a social reinforcement learning task. We compared this approach to the standard confederate paradigm in twenty-one BPD and twenty healthy control (HC) participants. The script-driven imagery evoked transient negative affect and decreased trusting behavior in both groups. Across conditions, we also replicated previously reported between-group differences in affect and task behavior, results that support the validity of script-driven imagery as an alternative social task stimulus. This approach is appealing for eliminating deception, scaling easily, and evoking disorder-specific states of social difficulty.

scholarly journals Psychosocial stress increases testosterone in patients with borderline personality disorder, post-traumatic stress disorder and healthy participants

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Christian E. Deuter ◽  
Moritz Duesenberg ◽  
Julian Hellmann-Regen ◽  
Sophie Metz ◽  
Stefan Roepke ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Mental Disorders ◽  
Stress Disorder ◽  
Gonadal Hormones ◽  
Borderline Personality ◽  
Adult Women ◽  
Testosterone Metabolism ◽  
Testosterone Secretion ◽  
Healthy Control

Abstract Background The gonadal hormone testosterone not only regulates sexual behavior but is also involved in social behavior and cognition in both sexes. Changes in testosterone secretion in response to stress have been reported. In addition, stress associated mental disorders such as borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) are characterized by alterations in basal testosterone metabolism. However, testosterone changes to stress have not been investigated in mental disorders such as BPD and PTSD so far. Methods In the study described, we investigated testosterone reactivity to an acute psychosocial stressor, the Trier Social Stress Test (TSST). Our sample consisted of young adult women with BPD (n = 28), PTSD (n = 22) or both disorders (n = 22), and healthy control (n = 51). Based on previous studies on basal testosterone secretion in these disorders, we expected the stress-associated testosterone reactivity to be higher in the BPD group and lower in the PTSD group, when compared to the healthy control group. Results The study could demonstrate an increase in testosterone after acute stress exposure across all groups and independent of BPD or PTSD status. Different possible explanations for the absence of a group effect are discussed. Conclusions From the results of this study, we conclude that stress-related changes in testosterone release are not affected by BPD or PTSD status in a female patient population. This study expands the knowledge about changes in gonadal hormones and stress reactivity in these disorders.

Is borderline personality disorder really an emotion dysregulation disorder and, if so, how? A comprehensive experimental paradigm

2020 ◽  
pp. 1-13
Author(s):  
Skye Fitzpatrick ◽  
Sonya Varma ◽  
Janice R. Kuo
Keyword(s):  
Emotion Regulation ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Emotion Dysregulation ◽  
Emotional Reactivity ◽  
Vagal Tone ◽  
Borderline Personality ◽  
Self Report ◽  
Healthy Control ◽  
Emotional Recovery

Abstract Background Leading theories suggest that borderline personality disorder (BPD) is an emotion dysregulation disorder involving lower basal vagal tone, higher baseline emotion, heightened emotional reactivity, delayed emotional recovery, and emotion regulation deficits. However, the literature to date lacks a unifying paradigm that tests all of the main emotion dysregulation components and comprehensively examines whether BPD is an emotion dysregulation disorder and, if so, in what ways. This study addresses the empirical gaps with a unified paradigm that assessed whether BPD is characterized by five leading emotion dysregulation components compared to generalized anxiety disorder (GAD) and healthy control (HC) groups. Methods Emotion was assessed across self-report, sympathetic, and parasympathetic indices. Participants with BPD, GAD, and HCs (N = 120) first underwent baseline periods assessing basal vagal tone and baseline emotional intensity, followed by rejection-themed stressors assessing emotional reactivity. Participants then either reacted normally to assess emotional recovery or attempted to decrease emotion using mindfulness or distraction to assess emotion regulation implementation deficits. Results Individuals with BPD and GAD exhibited higher self-reported and sympathetic baseline emotion compared to HCs. The BPD group also exhibited self-reported emotion regulation deficits using distraction only compared to the GAD group. Conclusions There is minimal support for several emotion dysregulation components in BPD, and some components that are present appear to be pervasive across high emotion dysregulation groups rather than specific to BPD. However, BPD may be characterized by problems disengaging from emotion using distraction.

[123I] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
N Schaaff ◽  
W Koch ◽  
G Pöpperl ◽  
K Tatsch ◽  
M Reicherzer ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Borderline Personality ◽  
Control Subjects ◽  
Healthy Control

scholarly journals Implicit and Explicit Mentalizing Deficits in Adolescent Inpatients: Specificity and Incremental Value of Borderline Pathology

2020 ◽  
Vol 34 (Supplement B) ◽  
pp. 64-83
Author(s):  
Francesca Penner ◽  
Veronica McLaren ◽  
Jacob Leavitt ◽  
Omer Faruk Akca ◽  
Carla Sharp
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Borderline Personality ◽  
Healthy Controls ◽  
Control Groups ◽  
Incremental Value ◽  
Healthy Control ◽  
Implicit And Explicit ◽  
Adolescent Inpatients ◽  
Internalizing And Externalizing

Research has demonstrated mentalizing impairment associated with borderline personality disorder (BPD) in adolescents. However, mentalizing performance in adolescents with BPD has never been compared to that of psychiatric control and healthy control adolescents simultaneously. The present study aimed to (a) compare implicit and explicit mentalizing, and hypermentalizing errors in implicit mentalizing, across youth with BPD and psychiatric and healthy controls, and (b) evaluate the association of borderline features with mentalizing deficits over and above internalizing and externalizing. Psychiatric inpatients with BPD (n = 139), inpatient psychiatric controls (n = 310), and healthy adolescents (n = 134) completed two mentalizing tasks, an interview assessing BPD, and measures of psychopathology. Results showed that BPD specificity could be demonstrated only for implicit mentalizing and hypermentalizing. Explicit mentalizing deficits did not differ between BPD and psychiatric control groups. Borderline features had unique associations to implicit mentalizing and hypermentalizing, over and above internalizing and externalizing.

Impulsivity in borderline personality disorder

2015 ◽  
Vol 45 (9) ◽  
pp. 1955-1964 ◽  
Author(s):  
V. Barker ◽  
L. Romaniuk ◽  
R. N. Cardinal ◽  
M. Pope ◽  
K. Nicol ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Rating Scales ◽  
Borderline Personality ◽  
Stop Signal Task ◽  
Self Rating ◽  
Significant Difference ◽  
Core Feature ◽  
Healthy Control ◽  
Motor Impulsivity

BackgroundImpulsivity is a core feature of borderline personality disorder (BPD) and is most frequently measured using self-rating scales. There is a need to find objective, valid and reliable measures of impulsivity. This study aimed to examine performance of participants with BPD compared with healthy controls on delay and probabilistic discounting tasks and the stop-signal task (SST), which are objective measures of choice and motor impulsivity, respectively.MethodA total of 20 participants with BPD and 21 healthy control participants completed delay and probabilistic discounting tasks and the SST. They also completed the Barratt Impulsiveness Scale (BIS), a self-rating measure of impulsivity.ResultsParticipants with BPD showed significantly greater delay discounting than controls, manifest as a greater tendency to accept the immediately available lesser reward rather than waiting longer for a greater reward. Similarly they showed significantly greater discounting of rewards by the probability of payout, which correlated with past childhood trauma. Participants with BPD were found to choose the more certain and/or immediate rewards, irrespective of the value. On the SST the BPD and control groups did not differ significantly, demonstrating no difference in motor impulsivity. There was no significant difference between groups on self-reported impulsivity as measured by the BIS.ConclusionsMeasures of impulsivity show that while motor impulsivity was not significantly different in participants with BPD compared with controls, choice or reward-related impulsivity was significantly affected in those with BPD. This suggests that choice impulsivity but not motor impulsivity is a core feature of BPD.

scholarly journals A psychophysiological assessment of delayed emotional recovery across discrete emotions in borderline personality disorder and the impact of self-harm and suicidality

2021 ◽  
Author(s):  
Skye Fitzpatrick
Keyword(s):  
Borderline Personality Disorder ◽  
Suicidal Ideation ◽  
Personality Disorder ◽  
Learning Strategies ◽  
Borderline Personality ◽  
Self Report ◽  
Healthy Control ◽  
Self Harm ◽  
Emotional Recovery ◽  
The Impact

This study examined Linehan’s (1993) theory of delayed emotional recovery (i.e., emotions last longer) in borderline personality disorder (i.e., BPD), and whether non-suicidal self-injury and suicidal ideation modulate this process. BPD and healthy control (HC) groups were monitored via parasympathetic, sympathetic, and self-report indices after fear, anger, and sadness inductions. After the fear induction, the BPD group showed increases in emotional arousal as indicated by parasympathetic indices and no changes in sympathetic indices, whereas HCs showed no change in parasympathetic indices and decreases in sympathetic indices. Further, individuals with BPD with higher urges to commit suicide after the fear induction exhibited faster decreases in sympathetic responding than others. These findings suggest that individuals with BPD selectively show delayed emotional recovery and that suicidal ideation may quicken emotional recovery in this group. Those with BPD may benefit from learning strategies to quicken, or tolerate, delayed emotional recovery.

scholarly journals Differential valuation and learning from social and non-social cues in Borderline Personality Disorder

2018 ◽  
Author(s):  
Sarah K Fineberg ◽  
Jacob Leavitt ◽  
Dylan S Stahl ◽  
Sharif Kronemer ◽  
Christopher D. Landry ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Interpersonal Relationships ◽  
Learning Task ◽  
Borderline Personality ◽  
Social Cues ◽  
Quantitative Models ◽  
The Social ◽  
Valuation Task ◽  
Social Valuation

AbstractBackgroundVolatile interpersonal relationships are a core feature of Borderline Personality Disorder (BPD), and lead to devastating disruption of patients’ personal and professional lives. Quantitative models of social decision making and learning hold promise for defining the underlying mechanisms of this problem. In this study, we tested BPD and control subject weighting of social versus non-social information, and their learning about choices under stable and volatile conditions. We compared behavior using quantitative models.MethodsSubjects (n=20 BPD, n=23 control) played an extended reward learning task with a partner (confederate) that requires learning about non-social and social cue reward probability (The Social Valuation Task). Task experience was measured using language metrics: explicit emotions/beliefs, talk about the confederate, and implicit distress (using the previously established marker self-referentiality). Subjects’ weighting of social and non-social cues was tested in mixed-effects regression models. Subjects’ learning rates under stable and volatile conditions were modelled (Rescorla-Wagner approach) and group x condition interactions tested.ResultsCompared to controls, BPD subject debriefings included more mentions of the confederate and less distress language. BPD subjects also weighted social cues more heavily, but had blunted learning responses to (non-social and social) volatility.ConclusionsThis is the first report of patient behavior in the Social Valuation Task. The results suggest that BPD subjects expect higher volatility than do controls. These findings lay the groundwork for a neuro-computational dissection of social and non-social belief updating in BPD, which holds promise for the development of novel clinical interventions that more directly target pathophysiology.

scholarly journals Digital Communication Biomarkers of Mood and Diagnosis in Borderline Personality Disorder, Bipolar Disorder, and Healthy Control Populations

2021 ◽  
Vol 12 ◽  
Author(s):  
George Gillett ◽  
Niall M. McGowan ◽  
Niclas Palmius ◽  
Amy C. Bilderbeck ◽  
Guy M. Goodwin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Digital Communication ◽  
Borderline Personality ◽  
Phone Call ◽  
Call Duration ◽  
Manic Symptoms ◽  
Trait Impulsivity ◽  
Healthy Control

Background: Remote monitoring and digital phenotyping harbor potential to aid clinical diagnosis, predict episode course and recognize early signs of mental health crises. Digital communication metrics, such as phone call and short message service (SMS) use may represent novel biomarkers of mood and diagnosis in Bipolar Disorder (BD) and Borderline Personality Disorder (BPD).Materials and Methods: BD (n = 17), BPD (n = 17) and Healthy Control (HC, n = 21) participants used a smartphone application which monitored phone calls and SMS messaging, alongside self-reported mood. Linear mixed-effects regression models were used to assess the association between digital communications and mood symptoms, mood state, trait-impulsivity, diagnosis and the interaction effect between mood and diagnosis.Results: Transdiagnostically, self-rated manic symptoms and manic state were positively associated with total and outgoing call frequency and cumulative total, incoming and outgoing call duration. Manic symptoms were also associated with total and outgoing SMS frequency. Transdiagnostic depressive symptoms were associated with increased mean incoming call duration. For the different diagnostic groups, BD was associated with increased total call frequency and BPD with increased total and outgoing SMS frequency and length compared to HC. Depression in BD, but not BPD, was associated with decreased total and outgoing call frequency, mean total and outgoing call duration and total and outgoing SMS frequency. Finally, trait-impulsivity was positively associated with total call frequency, total and outgoing SMS frequency and cumulative total and outgoing SMS length.Conclusion: These results identify a general increase in phone call and SMS communications associated with self-reported manic symptoms and a diagnosis-moderated decrease in communications associated with depression in BD, but not BPD, participants. These findings may inform the development of clinical tools to aid diagnosis and remote symptom monitoring, as well as informing understanding of differential psychopathologies in BD and BPD.

Associative learning profiles in Borderline Personality Disorder: Acquisition, Kamin blocking, and metacognitive performance

2019 ◽  
Author(s):  
Sarah Kathryn Fineberg ◽  
Jason C. Hu ◽  
Kaylee Null ◽  
Eli S. Neustadter ◽  
Madison Sakheim ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Reversal Learning ◽  
Learning Task ◽  
Borderline Personality ◽  
The Novel ◽  
Learning Deficits ◽  
Neuropsychological Measures ◽  
Set Up ◽  
Previous Learning

Borderline personality disorder (BPD) is associated with deficits in neuropsychological measures such as memory, cognitive flexibility, and learning. Mixed findings suggest that deficits may be specific to particular aspects of learning. This is the first study to examine Kamin blocking in a BPD sample. A sample of 51 female subjects (N = 24 control, N = 27 BPD) were recruited. Participants completed a learning task in three phases: a first acquisition phase to learn cue-outcome associations, a second pairing phase to set up blocked cues, and a third testing phase to measure the extent of blocking and to test reversal learning. Participants indicated choice and certainty at each trial, and received feedback immediately after each trial. In phase one, mean correctness but not learning rate was less in BPD than control. Participants with BPD were also less certain about their responses, which correlated positively with correctness – this correlation was not found for control subjects. Kamin blocking, maintenance of previous learning, and reversal learning did not differ between groups. These results cohere with the idea that learning deficits in BPD are in specific domains, including the novel finding that Kamin blocking is preserved in BPD. The significant correlation between certainty and correctness in BPD may hint at mechanisms underlying the maintenance of low mood.

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