A passive, objective and implicit measure of recognition memory in Alzheimer’s Disease using Fastball memory assessment.

Earlier diagnosis of Alzheimer’s disease (AD) requires biomarkers sensitive to the structural and functional changes associated with the disease. While considerable progress has been made in the development of structural biomarkers, functional biomarkers of early cognitive change are still needed. We present Fastball, a new EEG method for the passive, objective and implicit measurement of recognition memory, that requires no behavioural response or comprehension of the task. Younger adults (aged M=24 SD=6), older adults (aged M=74 SD=4) and AD patients aged M=79 SD=10), (n=20 per group) completed the Fastball task, lasting just under three minutes. The task required the passive viewing of rapidly presented images and assessed their spontaneous ability to differentiate between images on the basis of previous exposure, i.e. old/new. Participants were not instructed to attend to previously seen images and provided no behavioural response. Following the Fastball task, they completed a cued recall task to measure their explicit recognition of previously seen stimuli. AD patients showed significantly impaired recognition memory compared to healthy older adult controls in the Fastball task (p<0.001, Cohen’s D = 1.52). AD patients’ behavioural recognition memory performance, however, was not significantly different from healthy older adult controls. AD patients could be discriminated with high accuracy from healthy older adult controls using the Fastball measure of recognition memory (AUC=0.86, p<0.001), whereas discrimination performance was poor using behavioural cued-recall accuracy, (AUC=0.63, p=0.148). There were no significant effects of healthy ageing, with older and younger adult controls performing equivalently in both the Fastball task and behavioural cued-recall task. Fastball is sensitive to changes in recognition memory processes in AD that would be missed by behavioural testing alone. It is passive, non-invasive, quick to administer and uses cheap, scalable EEG technology. Fastball provides a new powerful method for the assessment of cognition in dementia and opens a new door in the development of early diagnosis tools.

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Recognition Memory for the Infrequent in Young, Old, and Early Stage Alzheimer's Disease: Evidence for Two Types of Familiarity

PsycEXTRA Dataset ◽

10.1037/e501882009-591 ◽

2000 ◽

Author(s):

David A. Balota ◽

Gregory C. Burgess ◽

Michael J. Cortese ◽

David R. Adams

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Recognition Memory ◽

Early Stage ◽

Young Old

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Detection of Alzheimer’s Disease-Related Cognitive Change With the Mobile Cognitive App Performance Platform

Innovation in Aging ◽

10.1093/geroni/igaa057.2907 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 801-801

Author(s):

Dawn Mechanic-Hamilton ◽

Sean Lydon ◽

Alexander Miller ◽

Kimberly Halberstadter ◽

Jacqueline Lane ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Memory Load ◽

Memory Task ◽

Structural Mri ◽

Cognitive Change ◽

Difficulty Level ◽

Trial Duration ◽

Parahippocampal Cortex ◽

Relationship Of

Abstract This study investigates the psychometric properties of the mobile cognitive app performance platform (mCAPP), designed to detect memory changes associated with preclinical Alzheimer’s Disease (AD). The mCAPP memory task includes learning and matching hidden card pairs and incorporates increasing memory load, pattern separation features, and spatial memory. Participants included 30 older adults with normal cognition. They completed the mCAPP, paper and pencil neuropsychological tests and a subset completed a high-resolution structural MRI. The majority of participants found the difficulty level of the mCAPP game to be “just right”. Accuracy on the mCAPP correlated with performance on memory and executive measures, while speed of performance on the mCAPP correlated with performance on attention and executive function measures. Longer trial duration correlated with measures of the parahippocampal cortex. The relationship of mCAPP variables with molecular biomarkers, at-home and burst testing, and development of additional cognitive measures will also be discussed.

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Functional Neural Correlates of the WAIS-IV Block Design Test in Older Adult with Mild Cognitive Impairment and Alzheimer’s Disease

Neuroscience ◽

10.1016/j.neuroscience.2021.04.001 ◽

2021 ◽

Vol 463 ◽

pp. 197-203

Author(s):

Haejung Joung ◽

Dahyun Yi ◽

Min Soo Byun ◽

Jun Ho Lee ◽

Younghwa Lee ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Older Adult ◽

Block Design ◽

Neural Correlates

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The Category Cued Recall test in very mild Alzheimer's disease: discriminative validity and correlation with semantic memory functions

European Journal of Neurology ◽

10.1111/j.1468-1331.2006.01568.x ◽

2007 ◽

Vol 14 (1) ◽

pp. 102-108 ◽

Cited By ~ 22

Author(s):

A. Vogel ◽

E. L. Mortensen ◽

A. Gade ◽

G. Waldemar

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Semantic Memory ◽

Recall Test ◽

Cued Recall ◽

Discriminative Validity ◽

Memory Functions

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Enhanced cued recall has a high utility as a screening test in the diagnosis of Alzheimer's disease and mild cognitive impairment in Turkish people

Archives of Clinical Neuropsychology ◽

10.1016/j.acn.2006.08.007 ◽

2006 ◽

Vol 21 (7) ◽

pp. 745-751 ◽

Cited By ~ 39

Author(s):

E SAKA ◽

E MIHCI ◽

M TOPCUOGLU ◽

S BALKAN

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Screening Test ◽

Cued Recall ◽

Turkish People ◽

High Utility

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Working Memory and the Enactment Effect in Early Alzheimer’s Disease

ISRN Neurology ◽

10.1155/2014/694761 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 9

Author(s):

Lara A. Charlesworth ◽

Richard J. Allen ◽

Suzannah Morson ◽

Wendy K. Burn ◽

Celine Souchay

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Working Memory ◽

Free Recall ◽

Older Adult ◽

Memory Task ◽

Enactment Effect ◽

The Subject ◽

Instruction Sequences ◽

Early Alzheimer’S Disease

This study examines the enactment effect in early Alzheimer’s disease using a novel working memory task. Free recall of action-object instruction sequences was measured in individuals with Alzheimer’s disease (n=14) and older adult controls (n=15). Instruction sequences were read out loud by the experimenter (verbal-only task) or read by the experimenter and performed by the participants (subject-performed task). In both groups and for all sequence lengths, recall was superior in the subject-performed condition than the verbal-only condition. Individuals with Alzheimer’s disease showed a deficit in free recall of recently learned instruction sequences relative to older adult controls, yet both groups show a significant benefit from performing actions themselves at encoding. The subject-performed task shows promise as a tool to improve working memory in early Alzheimer’s disease.

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IC-P-048: Using high density event-related potentials to study recognition memory in presymptomatic individuals with familial Alzheimer's disease due to E280A presenilin-1 mutation

Alzheimer s & Dementia ◽

10.1016/j.jalz.2009.05.068 ◽

2009 ◽

Vol 5 (4S_Part_1) ◽

pp. P23-P24

Author(s):

Yakeel T. Quiroz ◽

Chantal E. Stern ◽

Francisco Lopera ◽

Joshua D. McKeever ◽

Brandon A. Ally ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Recognition Memory ◽

Event Related Potentials ◽

High Density ◽

Presenilin 1 ◽

Familial Alzheimer’S Disease ◽

Related Potentials ◽

Presenilin 1 Mutation ◽

Familial Alzheimer's Disease

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The Impact of Amyloid-β or Tau on Cognitive Change in the Presence of Severe Cerebrovascular Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-200680 ◽

2020 ◽

Vol 78 (2) ◽

pp. 573-585

Author(s):

Hyemin Jang ◽

Hee Jin Kim ◽

Yeong Sim Choe ◽

Soo-Jong Kim ◽

Seongbeom Park ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Cognitive Decline ◽

Interaction Effect ◽

Significant Interaction ◽

Amyloid Β ◽

Cognitive Change ◽

Significant Interaction Effect ◽

The Impact

Background: As Alzheimer’s disease (AD) and cerebral small vessel disease (CSVD) commonly coexist, the interaction between two has been of the considerable interest. Objective: We determined whether the association of Aβ and tau with cognitive decline differs by the presence of significant CSVD. Methods: We included 60 subcortical vascular cognitive impairment (SVCI) from Samsung Medical Center and 82 Alzheimer’s disease-related cognitive impairment (ADCI) from ADNI, who underwent Aβ (florbetaben or florbetapir) and tau (flortaucipir, FTP) PET imaging. They were retrospectively assessed for 5.0±3.9 and 5.6±1.9 years with Clinical Dementia Rating-sum of boxes (CDR-SB)/Mini-Mental State Examination (MMSE). Mixed effects models were used to investigate the interaction between Aβ/tau and group on CDR-SB/MMSE changes. Results: The frequency of Aβ positivity (45% versus 54.9%, p = 0.556) and mean global FTP SUVR (1.17±0.21 versus 1.16±0.17, p = 0.702) were not different between the two groups. We found a significant interaction effect of Aβ positivity and SVCI group on CDR-SB increase/MMSE decrease (p = 0.013/p < 0.001), and a significant interaction effect of global FTP uptake and SVCI group on CDR-SB increase/MMSE decrease (p < 0.001 and p = 0.030). Finally, the interaction effects of regional tau and group were prominent in the Braak III/IV (p = 0.001) and V/VI (p = 0.003) not in Braak I/II region (p = 0.398). Conclusion: The association between Aβ/tau and cognitive decline is stronger in SVCI than in ADCI. Therefore, our findings suggested that Aβ positivity or tau burden (particularly in the Braak III/IV or V/VI regions) and CSVD might synergistically affect cognitive decline.

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