scholarly journals Bacteriological profile of blood stream infections among febrile patients attending a tertiary care centre of Western Nepal

2013 ◽  
Vol 4 (3) ◽  
pp. 92-98 ◽  
Author(s):  
Dharm Raj Bhatta ◽  
Abhishek Gaur ◽  
HS Supram
Keyword(s):  
Tertiary Care ◽  
Blood Stream ◽  
Care Centre ◽  
Salmonella Spp ◽  
Tertiary Care Centre ◽  
Coagulase Negative Staphylococci ◽  
Cross Sectional ◽  
Blood Stream Infections ◽  
Acinetobacter Species ◽  
Study Results

Background Blood stream infections (BSI) are significant cause of morbidity and mortality in the world. This study was conducted to determine the common bacterial agents associated with BSI with their antimicrobial susceptibility patterns in a tertiary care centre in the Western region of Nepal. Method This cross-sectional study was conducted for a period of two years from May 2010 to May 2012. All patients with fever (temperature ≥ 38°C) were included in the study. Results A total of 4,145 patients with febrile illness were included in this study, bacterial agents were isolated in 251 (6%) cases. Common bacterial isolates were Salmonella spp., Klebsiella pneumoniae, Escherichia coli, Pseudomonas species, Acinetobacter species, Staphylococcus aureus and Coagulase negative Staphylococci. Paratyphoid fever (Caused by S. Paratyphi A) is more common than typhoid fever. The members of Enterobacteriaceae were found to be resistant to ampicillin and cefazolin. Majority of the nonfermenters were found to be sensitive to most antibiotics. Gentamicin and Ciprofloxacin were sensitive to majority of gram positive bacteria. Conclusion Gram-negative bacteria were the predominant causes of BSIs. The occurrence of drug resistance among the isolated bacteria is of great concern. Imipenem showed 100% sensitivity against Pseudomonas aeruginosa indicating lack or low level of MBL activity. DOI: http://dx.doi.org/10.3126/ajms.v4i3.8165 Asian Journal of Medical Sciences 4(2013) 92-98

Prevalence and antibiogram of non-fermenting Gram-negative bacilli in blood stream infections: Study in a tertiary care centre, Western Uttar Pradesh, India

2021 ◽  
pp. 004947552097929
Author(s):  
Tarana Sarwat ◽  
Mariyah Yousuf ◽  
Ambreen S Khan ◽  
Dalip K Kakru ◽  
Renu Dutta
Keyword(s):  
Burkholderia Cepacia ◽  
Tertiary Care ◽  
Uttar Pradesh ◽  
Blood Stream ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Acinetobacter Baumanii ◽  
Blood Stream Infections ◽  
Antibiotic Susceptibility Pattern ◽  
Gram Negative

Non-fermenting Gram-negative bacilli (NFGNB) are emerging as important cause of blood stream infections. We aimed to determine the prevalence and antibiotic susceptibility pattern of NFGNB isolated from blood of patients with sepsis. We found, in 176 patients, the most common to be Pseudomonas aeruginosa (74) and Acinetobacter baumanii complex (39) followed by Stenotrophomonas maltophilia (16), Sphingomonas paucimobilis (6), Burkholderia cepacia (5) and Ochrobactrum anthropic (1). Generally, organisms showed a good sensitivity towards colistin, carbapenems and fluoroquinolones, whereas cephalosporins were ineffective.

scholarly journals Meropenem Resistance among Acinetobacter Positive Clinical Samples in a Tertiary Care Centre in Nepal: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (241) ◽  
pp. 853-857
Author(s):  
Nisha Sharma ◽  
Bibechan Thapa ◽  
Ashirbad Acharya ◽  
Bijendra Raj Raghubanshi
Keyword(s):  
Confidence Interval ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Clinical Samples ◽  
Care Centre ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Acinetobacter Species ◽  
Tract Infections

Introduction: Antimicrobial-resistant Acinetobacter species are implicated in a variety of infections including nosocomial bacteraemia, secondary meningitis, and urinary tract infections. Carbapenem including meropenem-resistant Acinetobacter is recognized as one of the most difficult antimicrobial resistant gram-negative bacilli to control and treat. It was classified as an urgent threat by Centers for Disease Control and Prevention in 2019 Antibiotic Resistance Threats Report. This study was carriedout to determine the prevalence of meropenem resistance among acinetobacter positive clinical samples in a tertiary care centre. Methods: A descriptive cross-sectional study was carried out in microbiology department of Clinical Laboratory Services among Acinetobacter positive clinical samples of a tertiary care center in Nepal. The culture and sensitivity reports of various clinical samples from April 2018 to April 2020 which were positive for Acinetobacter species were taken from hospital records section. Convenience sampling was done. Meropenem-resistant Acinetobacter samples were studied. Ethical approval was received from Institutional Review Committee (Ref No. 076/77/40). Analysis of data was done using Statistical Package for the Social Sciences version 26. Point estimate at 95% Confidence Interval calculated with ferquency. Results: Out of 121 Acinetobacter isolates, prevalence of meropenem-resistant Acinetobacter was reported in 93 (76.9%) at 95% Confidence Interval (69.39-84.40). Among the meropenem-resistant Acinetobacter samples, most of the samples were collected from the sputum 70 (75.2%) followed by blood 8 (8.6%). Conclusions: High prevalence of meropenem-resistant Acinetobacter species in our hospital setting is alarming. In addition, there is emergence of resistance against even the last resort drugs which is creating a treatment crisis.

scholarly journals Assessment of knowledge, attitudes and practice among the post graduate students of dentistry and physiotherapy towards adverse drug reactions reporting and pharmacovigilance at a tertiary care centre at Indore, India

2018 ◽  
Vol 7 (4) ◽  
pp. 626
Author(s):  
Gopal Gudsurkar ◽  
Vikalp Tiwari ◽  
Pooja Solanki Mishra
Keyword(s):  
Graduate Students ◽  
Graduate Student ◽  
Single Point ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Post Graduate ◽  
Adr Reporting ◽  
Post Graduate Student

Background: Pharmacovigilance knowledge and training in post graduate student doctors is key factor for proper implementation of PvPI. Often the dentists and physiotherapists who are also one of the main stakeholders for ADR reporting are neglected for training and knowledge regarding pharmacovigilance. This study was planned to evaluate the knowledge and awareness of pharmacovigilance in post graduate students in tertiary care centre in Indore.Methods: It was a single point cross sectional questionnaire-based study conducted in a tertiary care Institute MGM Medical College and M.Y. Hospital in the state of Madhya Pradesh at Indore. It was conducted among post graduate student doctors from dentistry and physiotherapy. Total of 55 questionnaires were distributed, 50 of them were returned back and were analysed.Results: Overall knowledge level was average. 90% knew about ADR while 80% were aware about PVPI. 10% knew about local AMC at Indore while only 04% knew global centre for Pharmacovigilance is at Sweden Uppsala. 88% thought Med watch as global database for ADR against only 12% knew its Vigibase. 90% thought ADR reporting is necessary. 96% thought it should be included in UG curriculum. 98% had not reported any ADR till date while 84% had not seen an ADR form.Conclusions: Post graduate doctors are the prime candidates to impart the importance of pharmacovigilance. The study strongly suggested that there was a great need to create awareness and impart training among the post graduate doctors to improve the reporting of ADRs.

scholarly journals Case reports on erosive pustular dermatosis of scalp: a cross sectional study at a tertiary care centre

2020 ◽  
Vol 6 (2) ◽  
pp. 260
Author(s):  
Avanitaben D. Solanki ◽  
Neha S. Nagrani ◽  
Dhara V. Patel ◽  
Neela M. Patel ◽  
Jigna P. Barot ◽  
...  
Keyword(s):  
Case Reports ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Neutrophilic Dermatosis ◽  
Repeated Treatment ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Proper Diagnosis ◽  
Folliculitis Decalvans

<p class="abstract">Erosive pustular dermatosis of the scalp (EPDS) has been reported as a rare chronic and progressive non-infectious inflammatory condition of the actinically damaged scalp characterized by crusts, erosions and pustules. It tends to occur on the scalp of older people who have usually been treated for diffuse actinic damage and actinic keratoses. The list of possible differential diagnosis is long and includes tinea capitis, folliculitis decalvans, neutrophilic dermatosis, autoimmune vesiculobullous disorders, malignancy etc. Notoriously difficult to treat, these cases tend to be chronic and progressive. These patients often present after repeated treatment to various scalp dermatosis that doesn’t result in clearing instead persistence and perpetuation of the process. A cross sectional prospective study was conducted in department of dermatology in a tertiary care centre in which six cases of EPDS attending outpatient department from 2017 to 2019 were included. EPDS is more common but under recognized condition, hence less cases are reported till date. Increased awareness of and proper diagnosis of this condition changes the approach towards these patients, protects the scalp from involuntary insults and other precipitating factors that hinders with a better outcome.</p>

CLINICOEPIDEMIOLOGICAL STUDY OF CHILDHOOD PSORIASIS PATIENTS AND ITS ASSOCIATION WITH HLA-CW6 IN A TERTIARY CARE CENTRE OF EASTERN INDIA

2021 ◽  
pp. 10-11
Author(s):  
Akhilesh Behra
Keyword(s):  
Tertiary Care ◽  
Epidemiological Data ◽  
Clinical History ◽  
Cross Sectional Study ◽  
Care Centre ◽  
Eastern India ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Plaque Type ◽  
Worldwide Population

BACKGROUND- Psoriasis is chronic common papulosquamous disorder. Its aetiology included various environmental and genetic factors. In genetics, HLA-Cw6 is most commonly associated with psoriasis. Childhood psoriasis is also common in worldwide population. However, very few studies done on epidemiological data and HLA-Cw6 analysis in childhood psoriasis patients. AIMS AND OBJECTIVE- Clinicoepidemiological study of childhood psoriasis patients and its association with HLA-Cw6 in a tertiary care centre of Eastern India MATERIALAND METHOD- We conducted a cross-sectional study in a tertiary care centre and recruited 20 patients of psoriasis with age group below 18 years after taking proper consent. Clinical history and blood was taken from them and HLA-Cw6 analysis was done by PCR method. Data compilation was done by Microsoft excel using SPSS software. RESULTS- A total of the 20 childhood psoriasis patients, 9 were males and 11 were females. Generalized plaque type psoriasis (N=19) is commonest followed by guttate psoriasis (N=1). None of the patients had arthalgia. Family history was present in only 3 patients. Higher numbers of childhood psoriasis patients (N=14) were positive for HLA-Cw6. Also Higher numbers of females (N=10) were positive for HLA-Cw6. ve patients had nail changes. CONCLUSION- We found HLA-Cw6 is strongly associated with childhood psoriasis and also HLA-Cw6 frequency is higher in female than male childhood psoriasis patients.

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