Mean platelet volume: An economical diagnostic marker of cardiovascular risk assessment in altered fasting blood glucose levels

Background: Platelets with altered morphology or large size are more thrombogenic and are likely to be associated with increased risk of vascular disease. Platelet parameters especially high mean platelet volume (MPV) has been reported in diabetic patients as major contributing factor. The aim of the present study was to find correlation between fasting blood glucose value and hematological variables (PC and MPV), not only in diabetics, but also in the normoglycemic subjects and patients with impaired fasting blood glucose levels.Materials and Methods: In the present study 3471 subjects were analyzed retrospectively and categorized into three groups based on the fasting blood glucose levels as Group I - normoglycemics (FBG ? 109 mg/dl, n = 1158), Group II- impaired fasting blood glucose (FBG ? 126 mg/dl, n = 1158) and Group III – Diabetics (FBG ? 127 mg/dl, n = 1155).Results: We found progressive increase in value of MPV with the increasing FBG levels, in the following order: G1 (8.44 ± 0.842 fl), G2 (8.98 ± 0.898 fl), G3 (9.31 ± 0.967 fl). The platelet count however, did not show much statistical significance with rising glucose levels.Conclusions: MPV increased proportionally with increasing plasma glucose levels. Although the variation between the normoglycemics and impaired fasting group was not very significant, the parameters still showed progressive increase with rising sugar levels significant in diabetic group.Asian Journal of Medical Sciences Vol.7(1) 2015 30-33

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POLYCYSTIC OVARIAN SYNDROME;

The Professional Medical Journal ◽

10.29309/tpmj/2012.19.06.2483 ◽

2012 ◽

Vol 19 (06) ◽

pp. 786-788

Author(s):

KIRAN BUTT ◽

FARAH DEEBA ◽

HAVAIDA ATTIQUE

Keyword(s):

Blood Glucose ◽

Lipid Profile ◽

Glucose Level ◽

Fasting Blood Glucose ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Increased Risk ◽

Commercial Kits ◽

The University ◽

Ovarian Syndrome

Objective: The objective of the present study was to determine the changes in the glucose level and lipid profile in patients withpolycystic ovarian syndrome (PCOS). Study Design: Descriptive study. Place and Duration of the study: This study was conducted atInstitute of Molecular Biology and Biotechnology, The University of Lahore from June 2009 to June 2010. Patients and Methods: Total 50patients with PCOS were included and 50 age-matched control subjects were also selected for comparison. Their glucose levels and lipidprofile were assessed using commercial kits. The data thus obtained was subjected to statistical analysis. Results: Significant differences(P<0.05) in fasting blood glucose level and individual parameters of lipid profile were observed in women with PCOS. A higher prevalence ofhypertriglyceridemia, hypercholesterolemia, higher LDL, lower HDL and higher fasting blood glucose levels was explored in PCOS womenthan controls. Conclusions: Abnormal glucose level and lipid profile in PCOS women showed that these women are at an increased risk ofdeveloping diabetes and subsequently cardiovascular diseases.

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Gastric Myoelectrical Activity, Gastric Emptying, and Correlations with Symptoms and Fasting Blood Glucose Levels in Diabetic Patients

The American Journal of the Medical Sciences ◽

10.1016/s0002-9629(15)40511-7 ◽

1999 ◽

Vol 317 (4) ◽

pp. 226-231 ◽

Cited By ~ 13

Author(s):

Irfan Soykan ◽

Irene Sarosiek ◽

Zhiuye Lin ◽

Richard W. Mccallum

Keyword(s):

Blood Glucose ◽

Gastric Emptying ◽

Fasting Blood Glucose ◽

Diabetic Patients ◽

Gastric Myoelectrical Activity ◽

Myoelectrical Activity ◽

Glucose Levels ◽

Blood Glucose Levels

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Gastric Myoelectrical Activity, Gastric Emptying, and Correlations with Symptoms and Fasting Blood Glucose Levels in Diabetic Patients

The American Journal of the Medical Sciences ◽

10.1097/00000441-199904000-00003 ◽

1999 ◽

Vol 317 (4) ◽

pp. 226-231 ◽

Cited By ~ 8

Author(s):

IRFAN SOYKAN ◽

ZHIUYE LIN ◽

IRENE SAROSIEK ◽

RICHARD W. McCALLUM

Keyword(s):

Blood Glucose ◽

Gastric Emptying ◽

Fasting Blood Glucose ◽

Diabetic Patients ◽

Gastric Myoelectrical Activity ◽

Myoelectrical Activity ◽

Glucose Levels ◽

Blood Glucose Levels

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Clinical and genetic risk factors for new-onset diabetes mellitus after transplantation (NODAT) in major transplant centres in Malaysia

BMC Nephrology ◽

10.1186/s12882-020-02052-9 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Rhanye Mac Guad ◽

Andrew W. Taylor-Robinson ◽

Yuan Seng Wu ◽

Siew Hua Gan ◽

Nur Lisa Zaharan ◽

...

Keyword(s):

Renal Transplantation ◽

Blood Glucose ◽

Renal Transplant ◽

Fasting Blood Glucose ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Increased Risk ◽

Daily Dose ◽

One Year ◽

New Onset

Abstract Background New-onset diabetes after transplantation (NODAT) is associated with reduced patient and graft survival. This study examined the clinical and selected genetic factors associated with NODAT among renal-transplanted Malaysian patients. Methods This study included 168 non-diabetic patients (58% males, 69% of Chinese ethnicity) who received renal transplantation between 1st January 1994 to 31st December 2014, and were followed up in two major renal transplant centres in Malaysia. Fasting blood glucose levels were used to diagnose NODAT in patients who received renal transplantation within 1 year. Two single nucleotide polymorphisms (SNPs), namely; rs1494558 (interleukin-7 receptor, IL-7R) and rs2232365 (mannose-binding leptin-2, MBL2) were selected and genotyped using Sequenom MassArray platform. Cox proportional hazard regression analyses were used to examine the risk of developing NODAT according to the different demographics and clinical covariates, utilizing four time-points (one-month, three-months, six-months, one-year) post-transplant. Results Seventeen per cent of patients (n = 29, 55% males, 69% Chinese) were found to have developed NODAT within one-year of renal transplantation based on their fasting blood glucose levels. NODAT patients had renal transplantation at an older age compared to non-NODAT (39.3 ± 13.4 vs 33.9 ± 11.8 years, p = 0.03). In multivariate analysis, renal-transplanted patients who received a higher daily dose of cyclosporine (mg) were associated with increased risk of NODAT (Hazard ratio (HR) =1.01 per mg increase in dose, 95% confidence interval (CI) 1.00–1.01, p = 0.002). Other demographic (gender, ethnicities, age at transplant) and clinical factors (primary kidney disease, type of donor, place of transplant, type of calcineurin inhibitors, duration of dialysis pre-transplant, BMI, creatinine levels, and daily doses of tacrolimus and prednisolone) were not found to be significantly associated with risk of NODAT. GA genotype of rs1494558 (HR = 3.15 95% CI 1.26, 7.86) and AG genotype of rs2232365 (HR = 2.57 95% CI 1.07, 6.18) were associated with increased risk of NODAT as compared to AA genotypes. Conclusion The daily dose of cyclosporine and SNPs of IL-7R (rs1494558) and MBL2 (rs2232365) genes are significantly associated with the development of NODAT in the Malaysian renal transplant population.

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HYPOGLYCEMIC EFFECT OF FLAXSEED LIGNAN AND β GLUCAN IN POSTMENOPAUSAL DIABETIC PATIENTS

Agrobiological Records ◽

10.47278/journal.abr/2020.031 ◽

2021 ◽

Vol 5 ◽

pp. 32-40

Author(s):

Faiqa Javed

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Diabetic Patients ◽

Beta Glucan ◽

Weekly Basis ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Liver And Kidney ◽

The Subject ◽

Significant Health

Diabetes mellitus is an important metabolic disorder and owing to its significant health impacts is a leading cause of death around the globe. According to WHO estimates, Pakistan is the 7th highest diabetes affected population of the world where almost 7 million peoples are suffering from the disease. Flaxseed lignan and beta glucan have constructive role in controlling diabetes. In connection to their enhanced insulin sensitivity, dietary supplementation of flaxseed fiber has shown potential results in postmenopausal diabetic women. The subject population was feed with lignan and beta glucan capsules and hypoglycemic activity was monitored both on daily and weekly basis. Blood samples was taken to observe the blood glucose by use of flaxseed lignan and β glucan in postmenopausal women. Fasting and random glucose levels of postmenopausal diabetic women in 4 weeks fed on flaxseed lignan and β glucan (P<0.01). Liver and kidney functioning tests are found to be non-significant. This research indicates that flaxseed lignan and β glucan reduces the random and fasting blood glucose levels in postmenopausal patients.

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Conventional approach to glucose management for diabetic patients undergoing coronary artery bypass surgery

Perfusion ◽

10.1191/0267659102pf539oa ◽

2002 ◽

Vol 17 (2) ◽

pp. 141-144 ◽

Cited By ~ 5

Author(s):

Patricia A Gustafson ◽

Debra L Zarro ◽

David A Palanzo ◽

Norman J Manley ◽

Ralph M Montesano ◽

...

Keyword(s):

Blood Glucose ◽

Insulin Infusion ◽

Diabetic Patients ◽

Type I ◽

Cardioplegic Solution ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Group I ◽

Significant Difference ◽

Group Ii

Continuous insulin infusion was not an effective mode of treatment in maintaining safe blood glucose levels (<200 mg/dl) during the intraoperative period of diabetic patients requiring open-heart surgery. The two modifications investigated to gain better control of the blood glucose were a change in the base solution of the cardioplegia and the use of a sliding insulin scale. Fifty patients including Type I and Type II diabetics were selected for the purpose of this study. The patients were then randomly divided into two groups categorized by the type of cardioplegic solution administered and the mode of insulin treatment. Group I patients received a dextrose 5%-based cardioplegic solution and blood glucose was treated via continuous intravenous insulin infusion. Group II patients received normal saline 0.9%-based cardioplegic solution and blood glucose was treated via sliding scale. Blood glucose levels were monitored pre- and postcardio- pulmonary bypass (CPB) and every 30 min while on CPB. Glucose values were analyzed by group t test. A p value of < 0.05 was considered statistically significant. When comparing Group I (mean=258 mg/dl) with Group II (mean= 158 mg/dl), there was a statistically significant difference between the glucose values at each of the time intervals when the glucose values were recorded. In conclusion, Group II maintained an acceptable blood glucose level (<200 mg/dl) throughout the entire intra- operative period, which suggests that the combination of the sliding insulin scale and modification of the base cardioplegic solution was an effective mode of treatment.

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Assessment of the salivary glucose as a non-invasive test for diabetic patients

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20192286 ◽

2019 ◽

Vol 6 (6) ◽

pp. 2289

Author(s):

Kajol Thapa ◽

Saroj Kunwar ◽

Sonu Thapa ◽

Asmita Phuyal ◽

Sahil Rupakheti

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Glucose Level ◽

Fasting Blood Glucose ◽

Diabetic Patients ◽

Glucose Levels ◽

Non Invasive ◽

Invasive Test ◽

Blood Glucose Levels ◽

Institutional Review

Background: Over the recent year there has been a startling rise in the number of people suffering from diabetes mellitus. Estimation of blood glucose levels has been an essential laboratory investigation for screening and monitoring of diabetes. Saliva is one of the secretions in human body whose collection is easy and non-invasive. Salivary glucose hence could serve as an easy and non-invasive tool.Methods: Institutional review committee of NHRC gave us permission to carry out this study. 105 subjects with Type 2 diabetes mellitus who attended the OPD at Star hospital, Sanepa, Lalitpur, Nepal and 106 healthy individuals were consented to participate in this study. Glucose was measured by the GOD-POD (Glucose oxidase peroxidase) methods using the semi-autoanalyser and salivary glucose was compared with corresponding blood glucose levels.Results: A significant positive correlation of fasting salivary glucose level and fasting blood glucose level was observed in healthy (r=0.241, p=0.001) and in diabetic patients (r=0.202, p=0.001).Conclusions: The study implies a potential for saliva in monitoring and screening of diabetes mellitus.

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Effect of ranolazine on HbA1c and blood glucose levels in diabetic patients with chronic angina

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20190647 ◽

2019 ◽

Vol 8 (3) ◽

pp. 377

Author(s):

Shilpa B. N. ◽

Shashikala G. H. ◽

Siddesh . ◽

Mallesh P.

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Preventive Therapy ◽

Antidiabetic Drugs ◽

Diabetic Patients ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Patients With Diabetes ◽

Chronic Angina ◽

Group 2

Background: Diabetes mellitus is the fifth leading cause of death worldwide and is one of the common co-morbid conditions associated with coronary artery disease (CAD). The overall prevalence of CAD is 7.4% but the prevalence of CAD in diabetics is 9%. Hence treatment of hyperglycemia is a key goal of secondary preventive therapy with a target of reducing HbA1c to <7%. The risk of CAD has been reported to occur 2 to3 decades prior in diabetics compared to non-diabetics. Hence discovery of drugs with potential role in both diabetes and CAD seems to be necessary. Ranolazine is a novel oral anti anginal drug known to reduce HbA1c and fasting blood glucose levels in angina patients with diabetes. The objective of this study is to show the effect of ranolazine (antianginal drug) on HbA1c and fasting blood glucose levels in diabetic patients with chronic angina.Methods: Patients were divided into: Group 1 continued with previous antidiabetic drugs and antianginal drugs. Group 2 were prescribed Tab ranolazine 1000mg b.d (orally) as add on therapy along with previous antidiabetic drugs and antianginal drugs.Results: There was a significant reduction in HbA1c and FBS levels in Group 2 patients who were on ranolazine. Reduction of HbA1c in group1 and Group 2 was 0.21±0.65% and 1.30±1.16% respectively. Reduction of FBS in group1 and group2 was 10.66±27.80mg/dl and 29.97±31.49mg/dl respectively.Conclusions: From the present study we can conclude that ranolazine, an antianginal drug when given at a dose of 1000mg bd in diabetic patients with chronic angina reduces HbA1c and FBS levels.

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ALTERATIONS IN FASTING BLOOD GLUCOSE LEVELS IN INDIVIDUALS EXPOSED TO HIGH PROFESSIONAL STRESS

10.36106/gjra/3104125 ◽

2020 ◽

pp. 44-47

Author(s):

Farheen Fatima ◽

D. Joya Rani ◽

B. Chandini Rani

Keyword(s):

Blood Glucose ◽

Mental Stress ◽

Acute Stress ◽

Stress Hormones ◽

Fasting Blood Glucose ◽

Adaptive Responses ◽

Lifestyle Modifications ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Increased Risk

Stress refers to processes involving perception, appraisal and response to noxious events or stimuli. While acute stress can activate adaptive responses, chronic stresses are detrimental to health by altering various physiological parameters1. One such change involves blood glucose levels. This study was done to detect any alterations in blood glucose levels on exposure to chronic mental stress. Mental stress was assessed using the Stress scale of the DASS – 42 questionnaire. Correlation between stress perception and altered blood glucose levels was seen. Reasons for this change range from effects of stress hormones on carbohydrate & lipid metabolism to changes in brain which promote stress eating. There is increased risk for obesity, Diabetes Mellitus and Metabolic syndrome in future. Interventions to reduce this risk include lifestyle modifications which include caloric restriction, increasing physical activity and getting involved in customised activities which reduce stress.

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