Histopathological Analysis of Neoplastic and Non-Neoplastic Lesions of Ovary : A 4 Year Study in Eastern Nepal

IntroductionOvarian neoplastic and nontineoplastic lesions form a pelvic mass and cause gynaecological problems. Therefore, proper recognization and classification is important for appropriate therapy.ObjectiveTo study the morphological patiern and classify the neoplastic and nontineoplastic ovarian lesions in terms of age and size.MethodologyA retrospective study conducted at Sriram Diagnostic Clinic, Biratnagar, Nepal and Birat Medical College, Tankisinwari, Morang, Nepal during a period of March 2012 to February 2016. All abdominal hysterectomy specimens with bilateral or unilateral salpingo-oophorectomy and all ovarian surgeries presenting with either solid or cystic ovarian lesions were included in the study for histopathological analysis. Normal appearing ovaries on gross and microscopic examination were excluded from the study.ResultsA total of 522 cases were studied. Out of which 329 (63%) were non-neoplastic and 193 (37%) were neoplastic. Follicular cysts comprised of 112 (34%) cases, and it was the most common non neoplastic lesion. The age of patients with non-neoplastic lesions and neoplastic lesions varied from 16-54 years and 13-72 years respectively. Size of nonneoplastic and neoplastic lesions varied from 2-12 cm and 2- 19 cm respectively. Among the 193 neoplastic ovarian lesions, 181 (94 %) were benign, as well as 4 (2%) were borderline and 8 (4 %) were malignant. Mature cystic teratoma was the commonest benign tumor followed by Serous cystadenoma. Serous cystadenocarcinoma was the commonest occurring malignant tumor followed by Mucinouscystadenocarcinoma.ConclusionVarying types of both non neoplastic and neoplastic ovarian lesion were seen. Among the non-neoplastic and neoplastic lesion, the most commonly encountered lesion was follicular cyst and mature cystic teratoma respectively.Birat Journal of Health SciencesVol.2/No.1/Issue 2/ Jan - April 2017, Page: 168-174

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Histopathologic spectrum of cystic ovarian masses

Journal of Chitwan Medical College ◽

10.3126/jcmc.v6i1.16574 ◽

2017 ◽

Vol 6 (1) ◽

pp. 16-20

Author(s):

S Ranabhat ◽

M Tiwari ◽

S Maharjan ◽

A Bhandari ◽

M Subedi ◽

...

Keyword(s):

Cystic Lesion ◽

Cystic Teratoma ◽

College Teaching ◽

Serous Cystadenoma ◽

Mature Cystic Teratoma ◽

Ovarian Cysts ◽

Histopathological Study ◽

Cross Sectional ◽

Follicular Cyst ◽

Ovarian Masses

This research was a cross sectional analytic observational histopathological study of cystic ovarian lesions carried out over three years from March, 2012 to February, 2015 at Chitwan Medical College Teaching Hospital in Nepal. The objective of this study was to study cystic ovarian masses histopathologically. A total of one hundred and fourteen patients with cystic ovarian masses were included into the study. 46.5% lesions were non-neoplastic (83% physiologic and 17% pathologic) and 53.5% lesions were neoplastic (91.8% benign and 8.2% malignant). Follicular cyst was the most common ovarian cystic lesion overall, followed by mature cystic teratoma and serous cystadenoma. 14.9% of all the ovarian cysts had undergone torsion; among them mature cystic teratoma was the most common lesion to have undergone the complication. Neoplastic ovarian cysts were more common than non-neoplastic. Follicular cyst was the most common ovarian cyst overall. Mature cystic teratoma was the ovarian cystic lesion to be affected by torsion most commonly.

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Histopathologic spectrum of cystic ovarian masses

Journal of Chitwan Medical College ◽

10.3126/jcmc.v1i1.16574 ◽

2017 ◽

Vol 6 (1) ◽

pp. 16

Author(s):

S Ranabhat ◽

M Tiwari ◽

S Maharjan ◽

A Bhandari ◽

M Subedi ◽

...

Keyword(s):

Cystic Lesion ◽

Cystic Teratoma ◽

College Teaching ◽

Serous Cystadenoma ◽

Mature Cystic Teratoma ◽

Ovarian Cysts ◽

Histopathological Study ◽

Cross Sectional ◽

Follicular Cyst ◽

Ovarian Masses

<p><span>This research was a cross sectional analytic observational histopathological study of cystic ovarian lesions carried out over three years from March, 2012 to February, 2015 at Chitwan Medical College Teaching Hospital in Nepal. The objective of this study was to study cystic ovarian masses histopathologically. A total of one hundred and fourteen patients with cystic ovarian masses were included into the study. 46.5% lesions were non-neoplastic (83% physiologic and 17% pathologic) and 53.5% lesions were neoplastic (91.8% benign and 8.2% malignant). Follicular cyst was the most common ovarian cystic lesion overall, followed by mature cystic teratoma and serous cystadenoma. 14.9% of all the ovarian cysts had undergone torsion; among them mature cystic teratoma was the most common lesion to have undergone the complication. Neoplastic ovarian cysts were more common than non-neoplastic. Follicular cyst was the most common ovarian cyst overall. Mature cystic teratoma was the ovarian cystic lesion to be affected by torsion most commonly.</span></p>

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Clinico-pathological profile of ovarian cysts in a tertiary care hospital

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20174456 ◽

2017 ◽

Vol 6 (10) ◽

pp. 4642 ◽

Cited By ~ 1

Author(s):

Sairem Mangolnganbi Chanu ◽

Biswajit Dey ◽

Vandana Raphael ◽

Subrat Panda ◽

Yookarin Khonglah

Keyword(s):

Tertiary Care Hospital ◽

Tertiary Care ◽

Lower Abdominal Pain ◽

Cystic Teratoma ◽

Serous Cystadenoma ◽

Mature Cystic Teratoma ◽

Ovarian Cysts ◽

Histopathological Diagnosis ◽

Care Hospital ◽

North East

Background: Ovarian cystic neoplasms are common in gynaecological practice. These may pose diagnostic difficulty to the pathologists. This study was conducted to analyse the clinical and histological profile of ovarian cystic neoplasms.Methods: This is a retrospective study done from January 2016 to April 2017 in a tertiary care hospital in North East India. All the patients, who were clinically and radiologically diagnosed as ovarian cysts, which had histopathological confirmation were included in the study. Data including the age, parity, clinical symptoms, laterality and histopathological findings were analysed.Results: A total of 101 patients operated for ovarian cysts in the study period were analysed. The most common clinical presentation was lower abdominal pain. There were 11 (10.9%) malignant cases, 4 (4%) were intermediate grade and borderline in nature, and 85 (84.1%) cases were benign in nature. There was 1 (1%) case of metastasis to ovary. Mature cystic teratoma was most common (20.8%) histopathological diagnosis. The second most common cyst was serous cystadenoma (19.8%).Conclusion: Ovarian cysts are commonly encountered in gynaecological practice and equally encountered by the pathologists. Most commonly found ovarian cysts were mature cystic teratoma followed by serous cystadenoma.

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Ovarian Lymphangioma with Mature Cystic Teratoma

Journal of Nepal Health Research Council ◽

10.33314/jnhrc.v17i01.1458 ◽

2019 ◽

Vol 17 (01) ◽

pp. 128-130

Author(s):

Karishma Malla Vaidya ◽

Bigya Shrestha

Keyword(s):

Benign Tumor ◽

Histological Analysis ◽

Adnexal Mass ◽

Histopathological Examination ◽

Cystic Teratoma ◽

Total Abdominal Hysterectomy ◽

Abdominal Hysterectomy ◽

Mature Cystic Teratoma ◽

Long Time ◽

Slow Growing

Lymphangiomas are slow-growing tumors that remain asymptomatic for a long time, with the tumor being identified incidentally during histopathological examination after excision. Mature cystic teratoma is benign tumor consisting of mature tissue derived from two or three germ layers. We have 47-year-old woman who underwent total abdominal hysterectomy for right adnexal mass. As her ultrasound report revealed a right adnexal mass with solid and cystic components. The histological analysis along with immunohistochemistry (D2-40) maker confirmed the diagnosis of lymphangioma of the ovary coexisting with mature cystic teratoma. There is paucity of reported case of co-existing these two tumors in same tissue.Keywords: D2-40; lymphangioma; mature cystic teratoma; ovary.

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Two rare cases of ovarian collision tumor

10.21203/rs.3.rs-37752/v1 ◽

2020 ◽

Author(s):

yan tian ◽

xinshan cao ◽

mimi ma ◽

yunfu cui ◽

qingchao mu

Keyword(s):

Lower Abdominal Pain ◽

Cystic Teratoma ◽

Pelvic Mass ◽

Collision Tumor ◽

Serous Cystadenoma ◽

Biological Behavior ◽

Anatomical Site ◽

Normal Range ◽

Primary Tumors ◽

Case Presentation

Abstract Background: Collision tumor is a clinically rare disease, it is defined as two or more primary tumors from different tissues occurring at the same anatomical site. Ovarian collision tumor is more rare. Case presentation: A patient was hospitalized with a pelvic mass. The CA125 level was 53.46U per milli liter (normal range, 0 to 30u/ml). Another patient was hospitalized with lower abdominal pain and no apparent hormonal abnormalities. Ovarian lesions were found in both patients after examination, and postoperative pathology showed that both patients were ovarian collision tumors. Conclusion: Collision tumor composed of mature cystic teratoma, follicular membranous cell tumor and serous cystadenoma was first reported. The biological behavior of collision tumor is different due to its different components. Accurate diagnosis is of great significance to treatment.

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Torsion of dermoid cyst in a perimenopausal woman: a case report

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20184177 ◽

2018 ◽

Vol 7 (10) ◽

pp. 4321

Author(s):

Kondareddy Radhika ◽

Sonam Singh ◽

Munikrishna M.

Keyword(s):

Dermoid Cyst ◽

Histopathological Examination ◽

Lower Abdominal Pain ◽

Cystic Teratoma ◽

Pelvic Mass ◽

Total Abdominal Hysterectomy ◽

Mature Cystic Teratoma ◽

Gravid Uterus ◽

Abdominal Ultrasonography ◽

Perimenopausal Woman

Mature cystic teratoma comprise 20-30% of all ovarian tumours. They are mostly seen in patients between 20 and 40 years of age and are mostly asymptomatic. Incidence of malignancy is high in perimenopausal and postmenopausal group. Here, authors report a case of torsion of dermoid cyst presenting unusually in a 45-year-old perimenopausal woman with acute abdomen. A 45-year-old perimenopausal woman presented with lower abdominal pain of 8 hours duration and 3-4 episodes of vomiting. Abdominal examination revealed a regular, firm to cystic, tender abdomino-pelvic mass corresponding to the size of 28 weeks gravid uterus by palpation. Abdominal ultrasonography revealed the presence of right ovarian cyst measuring 12.9x12.8x10.1 cm. Total abdominal hysterectomy with bilateral salpingo oopherectomy was done. Histopathological examination confirmed mature cystic teratoma. Although mature cystic teratoma is rare after 40 years age, especially in perimenopausal women and are usually malignant in that age group, it can have an unusual age presentation at 45 years with benign nature as in present case.

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Laparoscopic Surgery in Elderly Patients Aged 65 Years and Older with Gynecologic Disease

ISRN Obstetrics and Gynecology ◽

10.5402/2012/678201 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Haruhiko Kanasaki ◽

Aki Oride ◽

Kohji Miyazaki

Keyword(s):

Laparoscopic Surgery ◽

Postoperative Complications ◽

Elderly Patients ◽

Ovarian Tumor ◽

Mucinous Cystadenoma ◽

Cystic Teratoma ◽

Serous Cystadenoma ◽

Histological Diagnosis ◽

Mature Cystic Teratoma ◽

Surgery In Elderly

Objectives. The study was conducted to characterize the use of the laparoscopic surgery in elderly patients. Methods. The medical records of elderly patients aged ≥65 years who underwent laparoscopic surgery were retrospectively reviewed for diseases, surgical procedures, histological diagnosis, intraoperative and postoperative complications, and reasons for presentation. Results. Of the 405 patients who underwent laparoscopic surgery between January 2005 and March 2012, 41 (10.1%) were aged ≥65 years. The most common disease treated by surgery was ovarian tumor, followed by uterine prolapse. Histological diagnosis of ovarian tumor specimens obtained from 23 patients included serous cystadenoma (44.0%), mature cystic teratoma (20.0%), mucinous cystadenoma (20.0%), and endometrioma (4%). In contrast, in the non-elderly group, the most common histological diagnosis was endometrioma (42.9%), followed in order by mature cystic teratoma (28.3%), serous cystadenoma (18.0%), and mucinous cystadenoma (4.7%). While 23.7% of the non-elderly patients required emergency laparoscopic surgery, none of the elderly patients required emergency surgery. Only 1 of 27 patients who underwent surgery for an ovarian or adnexal mass presented with abdominal pain. No one developed serious intraoperative or postoperative complications. Conclusion. Laparoscopic surgery can be safely performed in elderly patients. It should be noted, however, that few elderly patients with benign pelvic mass manifest symptoms before undergoing surgery.

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A Study of Neoplastic and Non-neoplastic Sinonasal Masses at a Tertiary Center

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1310 ◽

2017 ◽

Vol 10 (2) ◽

pp. 66-69

Author(s):

Kavita Sachdeva ◽

Saurav Naskar

Keyword(s):

X Ray ◽

Medical College ◽

Adenoid Cystic ◽

Neoplastic Lesion ◽

Contrast Enhanced ◽

Tertiary Center ◽

Neoplastic Lesions ◽

Enhanced Computed Tomography ◽

Contrast Enhanced Computed Tomography ◽

Nasal Biopsy

ABSTRACT Aim The aim of this study was to evaluate all the cases of sinonasal masses based on histopathology into neoplastic and non-neoplastic lesions and to study their clinical and radiological presentations. Materials and methods The present study was carried out in 42 patients coming to the outpatient and inpatient Department of ENT of Netaji Subhash Chandra Bose Medical College & Hospital with the complaint of nasal obstruction during the period of March 2015 to August 2016. Patients were subjected to thorough clinical examinations and radiological investigations, which included digital X-ray paranasal sinus (PNS) and contrast-enhanced computed tomography PNS, and diagnosis was confirmed by nasal biopsy for histopathology reports. Results and observations A total of 42 patients were studied, of which 71.43% were non-neoplastic and 28.57% were neoplastic. Nasal polyps were the commonest non-neoplastic lesions (61.91%). Most common benign neoplastic lesion was angiofibroma (11.9%), while the commonest malignant neoplastic mass was found to be squamous cell carcinoma (7.14%). There was one case of adenoid cystic carcinoma. Conclusion Patients with sinonasal masses may present with trivial complaints, but proper evaluation of all the cases will enable us to make specific diagnosis and treat them accordingly. How to cite this article Sachdeva K, Naskar S. A Study of Neoplastic and Non-neoplastic Sinonasal Masses at a Tertiary Center. Clin Rhinol An Int J 2017;10(2):66-69.

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Histopathological Study of Endometrial Changes in Hysterectomy Specimens with Cystic Lesion of Ovary

Nepalese Medical Journal ◽

10.3126/nmj.v4i2.41661 ◽

2022 ◽

Vol 4 (2) ◽

pp. 495-498

Author(s):

Parvathi Pillai

Keyword(s):

Granulosa Cell ◽

Granulosa Cell Tumor ◽

Clinical History ◽

Total Abdominal Hysterectomy ◽

Abdominal Hysterectomy ◽

Histopathological Study ◽

Cystic Lesions ◽

Bilateral Oophorectomy ◽

Follicular Cyst ◽

Neoplastic Lesions

Introduction: Some of the ovarian lesions become functional and secrete hormones that bring endometrial changes like hyperplasias and polyps. This study aimed to find endometrial changes associated with different types of cystic lesions of the ovary. Materials and Methods: A histopathological study done from 2010 -2013 on all the total abdominal hysterectomy specimens with bilateral oophorectomy having cyst size more than 3cms, with a detailed clinical history received in the Department of Pathology, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry. A total of 112 cases were collected analyzed and statistically correlated. Results: Out of the 112 cases of cystic lesions of the ovary 67% showed endometrium within normal limits, 33% of cystic lesions of ovary showed polyps, simple hyperplasia without atypia, complex hyperplasia without atypia. Among non-neoplastic lesions, follicular cyst produced the most endometrial changes, followed by benign surface epithelial lesions. Granulosa cell tumor was found to induce polyp as well as simple hyperplasia without atypia. Two out of three malignant lesions showed endometrial changes followed by benign lesions. The majority of the cystic lesions of the ovary encountered are non-neoplastic lesions (59%) and follicular cysts were more common (97%). Endometrial hyperplasia of both simple and complex types without atypia was found with serous cystadenoma. Conclusions: From the current study it implicates the necessity of assessing cystic lesions of the ovary like a follicular cyst, luteal cyst, granulosa cell tumors as they can become functional leading to endometrial changes that can form a fertile ground for carcinomas.

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