scholarly journals Histopathological Study of Endometrial Changes in Hysterectomy Specimens with Cystic Lesion of Ovary

2022 ◽  
Vol 4 (2) ◽  
pp. 495-498
Author(s):  
Parvathi Pillai
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Clinical History ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Histopathological Study ◽  
Cystic Lesions ◽  
Bilateral Oophorectomy ◽  
Follicular Cyst ◽  
Neoplastic Lesions

Introduction: Some of the ovarian lesions become functional and secrete hormones that bring endometrial changes like hyperplasias and polyps. This study aimed to find endometrial changes associated with different types of cystic lesions of the ovary. Materials and Methods: A histopathological study done from 2010 -2013 on all the total abdominal hysterectomy specimens with bilateral oophorectomy having cyst size more than 3cms, with a detailed clinical history received in the Department of Pathology, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry. A total of 112 cases were collected analyzed and statistically correlated. Results: Out of the 112 cases of cystic lesions of the ovary 67% showed endometrium within normal limits, 33% of cystic lesions of ovary showed polyps, simple hyperplasia without atypia, complex hyperplasia without atypia. Among non-neoplastic lesions, follicular cyst produced the most endometrial changes, followed by benign surface epithelial lesions. Granulosa cell tumor was found to induce polyp as well as simple hyperplasia without atypia. Two out of three malignant lesions showed endometrial changes followed by benign lesions. The majority of the cystic lesions of the ovary encountered are non-neoplastic lesions (59%) and follicular cysts were more common (97%). Endometrial hyperplasia of both simple and complex types without atypia was found with serous cystadenoma. Conclusions:  From the current study it implicates the necessity of assessing cystic lesions of the ovary like a follicular cyst, luteal cyst, granulosa cell tumors as they can become functional leading to endometrial changes that can form a fertile ground for carcinomas.

scholarly journals Granulosa cell tumor complicated by torsion, rupture and hemoperitoneum

2021 ◽  
Vol 10 (6) ◽  
pp. 2489
Author(s):  
Kripa Sherchan
Keyword(s):  
Postmenopausal Woman ◽  
Granulosa Cell ◽  
Ovarian Tumor ◽  
Vaginal Bleeding ◽  
Granulosa Cell Tumor ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Cell Tumor ◽  
Primary Therapy ◽  
Malignant Ovarian Tumor

Granulosa cell tumor, a sex cord stromal estrogen secreting tumor presents with vaginal bleeding and is seen in all ages. It accounts for <5% of all ovarian neoplasm. We reported a rare case of granulosa cell tumor in a postmenopausal woman undergoing staging laparotomy with total abdominal hysterectomy and bilateral salpingo-oopherectomy for malignant ovarian tumor, which was complicated by torsion, rupture and hemorrhagic ascitis. Any ovarian tumor with vaginal bleeding should arouse suspicion of granulosa cell tumor in the background of postmenopausal woman. For most patients, surgery alone is sufficient primary therapy, Radiation and chemotherapy are reserved for the treatment of recurrent or metastatic disease.

scholarly journals Ovarian Adult Granulosa Cell Tumor – a rare case report

2018 ◽  
Vol 13 (1) ◽  
pp. 57-60
Author(s):  
Rijuta Joshi ◽  
Gehanath Baral ◽  
Karishma Malla
Keyword(s):  
Granulosa Cell ◽  
Abdominal Mass ◽  
Granulosa Cell Tumor ◽  
Total Abdominal Hysterectomy ◽  
Late Recurrence ◽  
Abdominal Hysterectomy ◽  
Cell Tumor ◽  
Rare Case Report ◽  
Stage Ia ◽  
Post Menopausal

Introduction: Adult granulosa cell tumor is a rare tumor which accounts for 1% of all ovarian tumors.  They usually present with postmenopausal bleeding and abdominal mass. Inhibin is used as the tumor marker.Case: A 76 years multiparous post-menopausal women presented with vaginal bleeding for past three years and  painless  huge mass in lower abdomen.  She underwent total abdominal hysterectomy with bilateral salphingo-oophorectomy with bilateral pelvic lymphnode dissection with appendectomy. Histopathology showed the adult granulosa cell tumor with few mitosis, Stage IA. Her postoperative period was uneventful.Conclusion: Surgery is the mainstay of treatment of granulosa cell tumor and chemotherapy is indicated in advanced cases. Although they have better prognosis, life-long follow up is advised to detect late recurrence.

scholarly journals Two interesting cases of granulosa cell tumor: A case report

2016 ◽  
Author(s):  
Pannu Savita ◽  
Khullar Harsha
Keyword(s):  
Granulosa Cell ◽  
Ovarian Tissue ◽  
Clinical Manifestations ◽  
Granulosa Cell Tumor ◽  
Good Prognosis ◽  
Cell Tumor ◽  
Ovarian Malignancy ◽  
Age Group ◽  
Granulosa Cell Tumors ◽  
Follicular Cyst

Introduction: Granulosa cell tumor (GCT) is an ovarian malignancy that arise from granulosa cells of the ovary. This tumour is a type of the sex cord-gonadal stromal tumour. GCT have good prognosis in comparison with other epithelial tumors. Methodology: Two cases of granulosa cell tumors were diagnosed in sir Ganga ram hospital, Rajender Nagar, New Delhi in December 2015 and January 2016. The patient’s age, clinical manifestations, radiological and histopathological findings were evaluated. One was in perimenopausal age group and other case was in postmenopausal age group. The clinical manifestations were menorrhagia and abdominal pain. Ultrasonographically, in one case focal hypoechoic zone showing peripheral hypervascularity with possibility of old hemorrhage follicular cyst was seen and in other case of granulosa cell tumors was both solid and cystic areas were seen. Histologically, variety of patterns like diffuse, trabecular, nodular, sheets, nests and fascicular patterns with nuclear grooving in ovarian tissue. In addition endometrial findings were suggestive of simple hyperplasia without atypia. Treatment modalility used was surgery i.e. Total hysterectomy and bilateral salpingo-oophorectomy in both cases. Conclusion: Granulosa cell tumor of the ovary is a rare ovarian malignancy. Endometrial pathology to rule out endometrial carcinoma specially when postmenopausal bleeding is concomitant finding is advised. Radical surgery is usually not required.

scholarly journals A Case Report of Ovarian Fibrothecoma in a Premenopausal Women with Recurrent Menorrhagia

2020 ◽  
Vol 8 (C) ◽  
pp. 101-105
Author(s):  
Meral Rexhepi ◽  
Elizabeta Trajkovska ◽  
Hysni Ismaili ◽  
Majlinda Azemi
Keyword(s):  
Uterine Fibroids ◽  
Premenopausal Women ◽  
Granulosa Cell Tumor ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Case Presentation ◽  
Mixed Features ◽  
Ovarian Tumours ◽  
Adnexal Tumor ◽  
Proliferative Endometrium

BACKGROUND: Ovarian fibrothecoma is a rare, benign, sex cord-stromal neoplasm, with a typically unilateral location in the ovary, characterized by mixed features of both fibroma and thecoma. Ovarian fibrothecoma is uncommon tumor of gonadal stromal cell origin accounting for 3-4% of all ovarian tumours. CASE PRESENTATION: We presented a rare case of a 46-year-old patient with recurrent menorrhagia in the past two years with no previous medical, surgical or gynecological history. She underwent two times curettage procedures. At the admission to hospital ultrasonography showed a homogenous solid right ovarian mass of size 2.5 cm x 3.5 cm. Endometrial curettage revealed simple hyperplasia of the endometrium. Diagnostic evaluation and surgical management are discussed along with a brief review of the literature. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was carried out. Histopathology confirmed fibrothecoma of the ovary, proliferative endometrium with hyperplasia without atypia and multiple uterine fibroids. CONCLUSION: In all patients presenting with recurrent menorrhagia and adnexal tumor the possibility of a granulosa cell tumor must be kept in mind during evaluation.

scholarly journals Colouterine and Jejunouterine Fistula Secondary to Chronic Diverticulitis

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Ilias Galanis ◽  
Georgios Floros ◽  
Christophoros Theodoropoulos ◽  
Myriam Metaxa ◽  
Panagiotis Theodoropoulos ◽  
...  
Keyword(s):  
Medical Condition ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Bilateral Oophorectomy ◽  
En Bloc ◽  
Surgical Department ◽  
Unusual Type ◽  
Chronic Diverticulitis

Fistulae between the colon or the small intestine and the uterus are extremely rare as the uterus is a thick, muscular organ. Here, we present the case of a 74-year-old female presenting to our surgical department because of fecal vaginal discharge for the past few months, which proved to be caused by a combined colouterine and jejunouterine fistula due to chronic diverticulitis. Total abdominal hysterectomy with bilateral oophorectomy with en bloc resection of part of the jejunum and the sigmoid colon and primary anastomoses were performed. This case represents an unusual type of diverticulitis complication and aims to point out the diagnostic and therapeutic issues of such a rare medical condition.

scholarly journals Ultrasound feature discordance in a bilateral juvenile ovarian granulosa cell tumor: A case report

2021 ◽  
Author(s):  
Li Zhang ◽  
Sheng Cai ◽  
Yahong Wang ◽  
Ying Wang ◽  
Zhitong Ge ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Exploratory Laparotomy ◽  
Cell Tumor ◽  
Cystic Lesions ◽  
Ovarian Granulosa Cell ◽  
Ovarian Granulosa Cell Tumor ◽  
The Right ◽  
Cystic Masses

Abstract BackgroundAs a rare ovarian stromal tumor, the juvenile ovarian granulosa cell tumor (JGCT) is mainly seen in premenstrual and young women. It associates with high malignancy and recurrence rate, and early diagnosis and treatment could improve prognosis. Most cases are unilateral solid-cystic or solid masses, while unilocular cystic masses are rarely seen. As cystic ovarian tumors are often misdiagnosed as benign cystic lesions or functional cysts, cystic JGCT should not be overlooked.Case presentationWe report this special case of a 10-year-old female patient. It’s the first reported JGCT with completely inconsistent bilateral imaging manifestations, including an extremely rare unilocular cystic JGCT. A large solid-cystic JGCT appeared in her left ovary, and left adnexal resection was performed. A unilocular cyst occurred in the right ovary two years later. It was with a regular shape and smooth inner wall, mimicking a benign cyst. Since the patient was young and had the desire to preserve the right ovary, follow-up was initially recommended. However, the cyst size increased rapidly and exploratory laparotomy was finally performed. Pathology showed a unilocular cystic JGCT.ConclusionsAs cystic masses in young patients are easily misdiagnosed as benign or physiologic lesions, this case emphasizes the importance of postoperative follow-up for JGCTs. Exploratory laparotomy of persistent cystic lesions should be considered when necessary.

scholarly journals Clinical profile of 550 cases of surgical and natural menopause

2020 ◽  
Vol 10 (3) ◽  
pp. 168-171
Author(s):  
Nusrat Mahjabeen ◽  
Shaikh Zinnat Ara Nasreen
Keyword(s):  
Ovarian Function ◽  
Natural Aging ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Bilateral Oophorectomy ◽  
Natural Menopause ◽  
Medical College ◽  
Estrogen Production ◽  
Hot Flush ◽  
Surgical Menopause

Background: Menopause represents the permanent cessation of menstrual periods and the loss of fertility due to the loss of ovarian function. It can occur spontaneously (natural menopause) or it can be surgically induced. They are different entirely. One is a natural stage of life that all women experience, the other is the result of surgery, that is, bilateral oophorectomy. Surgical menopause is when surgery, rather than the natural aging process, causes a woman to go through menopause. The ovaries are the main source of estrogen production in the female body. Their removal triggers immediate menopause, despite the age of the person having surgery. While surgery to remove the ovaries can operate as a stand-alone procedure, it is sometimes performed in addition to hysterectomy to reduce the risk of developing chronic diseases. This study was designed to compare the effects of the natural and the surgical menopause. Methods: This prospective observational study was conducted in the Department of Obstetrics and Gynaecology of Z. H. Sikder Women’s Medical College & Hospital, Dhaka from January 2016 to December 2018. During the study period a total of 275 patients with surgical menopause (total abdominal hysterectomy with bilateral salpingo-oophorectomy was done in all cases) and 275 patients with natural menopause were enrolled. After taking written consent detailed information about the patients was collected in a predesigned data collection sheet for each patient. Results: Age of most of the patients in surgical menopause group was within 41 to 50 years and most patients were >50 years old in natural menopause group. Most of the patients were illiterate in both groups and maximum patients were in poor socio-economic condition in both groups. Hot flush (48.0% vs 28.0%), palpitation (28.0% vs 4.0%) and dryness of vagina (12.0% vs 0.0%) were higher and body ache (32.0% vs 48.0%), tiredness (8.0% vs 36.0%), insomnia (8.0% vs 28.0%), depression (4.0% vs 16.0%), lack of concentration (0.0% vs 4.0%), loss of memory (0.0% vs 16.0%) and irritability (4.0% vs 8.0%) were found significantly lower in surgical menopause than natural menopause group. Dyspareunia (72.0% vs 28.0%), dysuria (92.0% vs 40.0%) and increased frequency of urination (68.0% vs 36.0%) were significantly higher in surgical menopause than natural menopause group. Urgency, hesitancy and incontinence of urination were significantly lower in surgical menopause than natural menopause group. Conclusion: Ovaries were removed in all of the surgical menopause cases, which may be the reason of more deleterious effects in surgical menopause than natural menopause. So, it is highly recommended to preserve ovaries in hysterectomies due to benign indications. Birdem Med J 2020; 10(3): 168-171

scholarly journals HISTOPATHOLOGICAL STUDY OF UTERINE LESIONS IN HYSTERECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL.

2020 ◽  
pp. 1-2
Author(s):  
Reddythota Sujeeva Swapna ◽  
V Siva Sankar Naik ◽  
C Bhavani ◽  
M Neeraja
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Female Genital Tract ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
The Body ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Wide Range

Background: The Female Genital Tract is a hormone-responsive system to a degree unmatched by any other system in the body. The gross configuration of the uterus changes dramatically throughout life. It is a kind of 'Puppet on a string", thus manipulated throughout life by altering levels of ovarian hormones. Objective of the study: The present study is aimed at detailed histopathological evaluation of uterine lesions of hysterectomy specimens. Methodology: A total of 448 cases of hysterectomy specimens were received in the department of pathology GGH Ananthapur, for two years, were reviewed. The specimens were processed, and the histopathological diagnosis was studied. Result: Peak age group of hysterectomy was 40-49 years with 186 (41.51%) cases. The youngest patient was 21 years old, and the oldest was 75 years old. The most frequent type of hysterectomy done was total abdominal hysterectomy in 293 (65.4%) cases. Conclusion: Hysterectomy is the most common surgery performed in gynecological practice. A wide range of lesions were noted when hysterectomy specimens are subjected to histopathological examination.

scholarly journals The Epidemiology Profile of Hysterectomy in Northern Zimbabwean Women

2021 ◽  
Author(s):  
ANDILE SICOLIWE THAKA
Keyword(s):  
Developing Countries ◽  
Post Partum ◽  
Age Groups ◽  
Clinical History ◽  
Total Abdominal Hysterectomy ◽  
Developed Countries ◽  
Abdominal Hysterectomy ◽  
Awareness Campaign ◽  
Common Procedure ◽  
Histology Report

Abstract Hysterectomy is a procedure commonly performed to treat uterine and cervical disorders. It is a common procedure in developing countries, others listing it as the most common gynecological procedure in developed countries. The aim of the study is to determine the epidemiology profile of hysterectomy in Northern Zimbabwean women. It can either be classified according to the procedure used to perform the hysterectomy; which could be a total abdominal hysterectomy, uterus only, subtotal hysterectomy, total abdominal hysterectomy plus salphingo-oophorectomy, total abdominal hysterectomy plus bisalphingo-oophorectomy and radical hysterectomy. It can be vaginally, abdominally or laparoscopy assisted. Laparoscopy assisted vaginal hysterectomy is less common as the procedure is semi-automated. The aim of the study was to determine the prevalence of hysterectomy among the women in northern Zimbabwe, identifying patterns of occurrences and distribution of hysterectomy and determining possible indicators of hysterectomy. Parirenyatwa Group of Hospitals undertakes Histology laboratory testing of samples from hospitals in Northern Zimbabwe as the referral laboratory. A retrospective study was conducted using the census sampling method to determine the epidemiology profile of hysterectomy. The study collected 350 reports from 2019 that indicated to have been from hysterectomy and therefore the estimated prevalence rate of hysterectomy was 9.81%. The study looked at the reports of specimens brought in due to the performance of hysterectomy. The inclusion criteria of a report was a complete histology report from the Pathologist from specimens processed and microscopy slides prepared by the Scientist. Exclusion criteria was an incomplete report. Leiomyomata, post-partum hemorrhaging and chronic pelvic pain were the leading possible indicators of hysterectomy. The procedure was most commonly performed on women between the ages of 41-50 years. The total abdominal hysterectomy was 59.81% performed most of the time with most reports from Parirenyatwa Group of Hospitals and then Mutare Provincial Hospital. Delimitations was the low resource costing of the study and the automated collection of the data. The limitations were clerical errors, lack of patient data such as clinical history and lack of history or socio-economic demographics collected by the laboratory form. There is need for better data management and increase in the variation of data to collect such as clinical history, parity, marital status, income setting and other factors. Further studies can be done to give a holistic picture of the epidemiology profile of hysterectomy in Zimbabwe. There is need for an awareness campaign on hysterectomy as it is a growing common procedure among women in developing countries. Case studies would give intrinsic details unavailable in reports. Better Sexual and reproductive health information should be availed on indicators of hysterectomy according to their prevalence in different age groups.

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