Association of arsenic with recurrence of urinary bladder cancer

2020 ◽  
Vol 50 (4) ◽  
pp. 325-330
Author(s):  
Dilip K Pal ◽  
Akash Agrawal ◽  
Sabnam Ghosh ◽  
Amlan Ghosh
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Urinary Bladder ◽  
West Bengal ◽  
Urinary Bladder Cancer ◽  
Tumour Tissue ◽  
Aetiological Factor ◽  
Arsenic Content ◽  
Urinary Bladder Carcinoma ◽  
Recurrent Bladder Cancer

Arsenic is known to be an important aetiological factor for the development of urinary bladder cancer. It is known to be found excessively in ground water in certain geographical areas, including West Bengal. We have studied patients with recurrent bladder cancer from different areas of this Indian state and correlated arsenic as a causative aetiological factor for development and aggressiveness of the biological behaviour of urinary cancer. We included 31 patients from various parts of West Bengal state with recurrent bladder cancer who were operated in our institute. Their clinical and residential data and their arsenic content of tumour tissue were measured. Statistical analysis was performed to test the association of tissue arsenic with clinicopathological features of recurrent disease. We found very high levels of arsenic in tumour tissue in all residents of the districts with high prevalence of arsenic in the drinking water. We also observed more aggressive clinicopathological progression and early recurrence in patients with high arsenic content. We conclude that arsenic is a causal factor in the clinicopathological progression of recurrent urinary bladder cancer. Measures to decrease the level of arsenic in drinking water should be taken as this may both improve clinicopathological outcomes in the recurrence of urinary bladder carcinoma, as well as reducing its overall incidence.

scholarly journals Urinary Bladder Carcinoma: Impact of Smoking, Age and its Clinico-Pathological Spectrum

2015 ◽  
Vol 11 (4) ◽  
pp. 292-295 ◽  
Author(s):  
HN Joshi ◽  
R Makaju ◽  
A Karmacharya ◽  
RM Kamracharya ◽  
B Shrestha ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Occupational Exposure ◽  
Urinary Bladder ◽  
Bladder Carcinoma ◽  
Urinary Bladder Cancer ◽  
Aetiological Factor ◽  
Urinary Bladder Carcinoma ◽  
Chemical Carcinogen ◽  
History Of ◽  
The Impact

Background Urinary bladder carcinoma is common urological malignancy. Although epidemiological evidence favors role of occupational exposure to chemical carcinogen as the aetiological factor of bladder carcinoma, many cases arise with no obvious occupational exposure to chemical carcinogen. Tobacco and cigarette smoking is common in both rural and urban areas of Nepal.Objective The objective of this study was to determine the impact of smoking and age in urinary bladder carcinoma with related clinicopathological correlations.Method A total of 56 (44 males and 12 females) cases of urinary bladder cancer treated at Dhulikhel Hospital, Kathmandu University Teaching Hospital during time period of January 2004 to December 2013 were included in the study. Data of patients with Urinary bladder cancer were obtained from hospital records and evaluated for age, sex, history of smoking, clinical presentations, cystoscopic findings and histopathological characteristics.Results Out of 56 cases, 51 (91.1%) of the patients had hematuria. History of smoking was found in 44 patients. Smoking was found much higher in males (88%) than females (41.66%). Transitional cell carcinoma (TCC) was the most common histological variety, which was seen in 51 (91.07%) patients. The significant impact of smoking was found in terms of grade of TCC.Conclusion The incidence of bladder carcinoma is higher in male and TCC is the most common variety of Urinary bladder malignancy. History of smoking correlated with grade.Kathmandu Univ Med J 2013; 11(4): 292-295

scholarly journals Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma

2021 ◽  
Vol 10 (16) ◽  
pp. 3683
Author(s):  
Jacek Kudelski ◽  
Grzegorz Młynarczyk ◽  
Monika Gudowska-Sawczuk ◽  
Barbara Mroczko ◽  
Barbara Darewicz ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Matrix Metalloproteinases ◽  
Urinary Bladder ◽  
Matrix Metalloproteinase ◽  
Bladder Carcinoma ◽  
Urinary Bladder Cancer ◽  
Urinary Bladder Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Human Urinary Bladder

Human urinary bladder cancer is a huge worldwide oncological problem causing many deaths every year. The degradation of extracellular matrix (ECM) induced by molecules such as matrix metalloproteinases (MMPs) is one of the main factors influencing the process of metastasis origination. The MMP expression is tied to tumor aggressiveness, stage, and patient prognosis. The cleavage of constituent proteins is initiated and prolonged by matrix metalloproteinases, such as MMP-3 and MMP-10. The aim of this study was to evaluate the expression and activity of both MMPs in human urinary bladder cancer occurring at various stages of the disease. Tissue samples from patients with urinary bladder cancer were analyzed. Samples were collected from patients with a low- and high-grade cancer. Control tissue was collected from the site opposite to the tumor. DNA content, MMPs content, and activity of MMP-3 and MMP-10 were measured using ELISA and Western blot techniques. MMP-3 and MMP-10 occur in high molecular complexes in human urinary bladder in healthy and cancerous tissues. Particularly, in high-grade tumors, the content of MMP-10 prevails over MMP-3. The actual and specific activities vary in both grades of urinary bladder cancer; however, the highest activity for MMP-3 and MMP-10 was found in low-grade tissues. In conclusion, MMP-10 had a higher content, but a lower activity in all investigated tissues compared to MMP-3. Generally, obtained results demonstrated a contrary participation of MMP-3 and MMP-10 in ECM remodeling what may be crucial in the pathogenesis of human urinary bladder carcinoma.

777: Tissue Microarray Analysis of pAkt, PTEN and L-Plastin in Urinary Bladder Cancer

2005 ◽  
Vol 173 (4S) ◽  
pp. 211-211
Author(s):  
Loleta D. Harris ◽  
Tomasz Tuziak ◽  
Jorge De Lo Cerda ◽  
Anita L. Sabichi ◽  
Ying Yang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Tissue Microarray ◽  
Microarray Analysis ◽  
Urinary Bladder Cancer ◽  
Tissue Microarray Analysis

scholarly journals Knowledge, perception and screening of local dye workers regarding urinary bladder cancer in Ghana

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Babatunde M. Duduyemi ◽  
Divine Lardey Agyemang ◽  
Ernest Adankwah ◽  
Hannah Nyarko ◽  
Derrick Andoh
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Educational Level ◽  
Response Rate ◽  
Urinary Bladder Cancer ◽  
Clinical History ◽  
Level Of Knowledge ◽  
Knowledge Levels ◽  
Cancerous Cells ◽  
Structured Questionnaire

Abstract Background Cancer is the leading cause of death with 7.6 million deaths worldwide annually. About 19% of bladder cancer cases are attributed to environmental and occupational factors. The knowledge of any disease is very vital in the control or prevention of such disease. This study examined the knowledge and perception of urinary bladder cancer among 104 local dye workers in Ghana (Kumasi, Koforidua and Somanya). Methods A well-structured questionnaire was used to measure participants’ knowledge and perception towards bladder cancer. Forty out of the 104 participants were recruited to provide their urine samples for cytomorphological study. Thin smears were prepared and stained with Papanicolaou stain. Respondents were selected based on clinical history and working experience. Result The response rate to the questionnaires was 100% of the 104 respondents interviewed. The respondents had a mean age of 26 years. Overall, about 10% of the respondents in this study had good knowledge levels on bladder cancer and 16% had good perception of the disease. There was a significant correlation between knowledge and educational level of the participants (p < 0.001). Report of the cytomorphological study indicates that none of the samples of the participants screened had cancerous cells. Conclusion The findings suggest that level of knowledge about bladder cancer among local dye workers in this study was low, while their level of perception was just above average.

scholarly journals A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

2010 ◽  
Vol 42 (5) ◽  
pp. 415-419 ◽  
Author(s):  
Lambertus A Kiemeney ◽  
Patrick Sulem ◽  
Soren Besenbacher ◽  
Sita H Vermeulen ◽  
Asgeir Sigurdsson ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Urinary Bladder Cancer ◽  
Sequence Variant
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