scholarly journals A Retrospective Case-Control Study of Lipid Profiles in Carcinoma Breast in Comparison with Normal Controls

2021 ◽  
Vol 20 (2) ◽  
pp. 97-103
Author(s):  
Gurushantappa Yalagachin ◽  
Praveena S
Keyword(s):  
Breast Cancer ◽  
Lipid Metabolism ◽  
Normal Control ◽  
Case Control Study ◽  
Case Control ◽  
Lifestyle Changes ◽  
Retrospective Case ◽  
Carcinoma Breast ◽  
Normal Controls ◽  
Control Study

Introduction: Breast cancer is the second most common cancer in the world. One of the reasons for its increasing prevalence, especially in younger women has been attributed to lifestyle changes. All these factors also have a strong association with lipid metabolism. More evidence is coming forward to emphasise the protective effect of lifestyle modification to lower lipid levels and thus decreasing the risk of breast cancer. Methods: It is a retrospective, case control study. The patients with carcinoma breast and normal controls were taken as subjects. The data for this study includes clinical profile and lipid profile measured in early morning fasting sample of the subjects. The patients of carcinoma breast, normal control aged > 18 years were included, while patients with diabetes, thyroid disorders, on treatment for hyper-lipidaemia, dieting or anorexic, pregnant patients were excluded. Results: There was no statistically significant differences in age (p = 0.920) and BMI (p = 0.137) between study and normal control group. Total Cholesterol (TC) and Triglycerides (TG) levels were significantly elevated (p = 0.009 and 0.000 respectively) in carcinoma breast group compared to normal controls, however no significant differences (p > 0.05) observed in the levels of HDL-C, LDL-C. Conclusions: There is a significant alteration in lipid metabolism in carcinoma breast patients in comparison to normal controls.   

Low-dose metronomic chemotherapy (LDMC) as an efficient treatment option in metastatic breast cancer: Results of an exploratory case-control study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e12578-e12578
Author(s):  
Marco Johannes Battista ◽  
Carola Schnatz ◽  
Katrin Almstedt ◽  
Walburgis Brenner ◽  
Anne-Sophie Heimes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Low Dose ◽  
Case Control Study ◽  
Metastatic Breast ◽  
Metronomic Chemotherapy ◽  
Case Control ◽  
Conventional Chemotherapy ◽  
Retrospective Case ◽  
Metastatic Lesions ◽  
Control Study

e12578 Background: There is a growing importance of low-dose metronomic chemotherapy (LDMC) in metastatic breast cancer (MBC). In this retrospective case-control-analysis we compared the efficacy of LDMC and conventional chemotherapy in MBC. Methods: Each LDMC patient receiving oral cyclophosphamide (CTX) (50 mg daily) and methotrexate (MTX) (2.5 mg every other day) was matched with two patients who received conventional chemotherapy. Age, number of chemotherapy lines and metastatic lesions as well as hormone receptor (HR) status were considered as matching criteria. Primary endpoint was disease control rate greater than 24 weeks (DCR). Secondary endpoints were DCR in subgroups (number of chemotherapy lines, number of different metastatic lesions and HR status), progression-free survival (PFS) and duration of response (DoR). Results: A total of 35 cases and 70 controls entered the study. 31% patients with LDMC and 26% patients with conventional chemotherapy showed DCR (p = 0.644). Among younger patients DCR was 41% in LDMC vs. 30% in the control group (p = 0.534). In addition, DCR was achieved in 35% vs. 27% patients with ≤ 2 chemotherapy lines (p = 0.560) and in 36% vs. 20% patients with ≤ 2 different metastatic lesions (p = 0.168), respectively. In the triple negative group 30% LDMC vs. 5% control patients showed DCR (p = 0.095). PFS was 12.0 vs. 13.5 weeks (p = 0.415), DoR was 26.5 vs. 20.5 weeks (p = 0.628), respectively. Conclusions: In this retrospective case-control study we demonstrated a similar efficacy of LDMC compared to conventional chemotherapy in the treatment of MBC. Moreover, no significant differences were found in the subgroups studied. Therefore, the concept of LDMC may also be a treatment option in both younger and non-heavily pre-treated MBC patients who do not need rapid remission.

scholarly journals Treatment outcomes for male breast cancer: a single-centre retrospective case–control study

2014 ◽  
Vol 21 (3) ◽  
pp. 400 ◽  
Author(s):  
M. Rushton ◽  
A. Kwong ◽  
H. Visram ◽  
N. Graham ◽  
W. Petrcich ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Outcomes ◽  
Male Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Male Breast ◽  
Single Centre ◽  
Retrospective Case ◽  
Control Study

scholarly journals Behavioral risk factors of breast cancer in Bangui of Central African Republic: A retrospective case-control study

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0171154 ◽  
Author(s):  
Augustin Balekouzou ◽  
Ping Yin ◽  
Henok Kessete Afewerky ◽  
Cavin Bekolo ◽  
Christian Maucler Pamatika ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Central African Republic ◽  
Case Control Study ◽  
Case Control ◽  
Behavioral Risk Factors ◽  
Behavioral Risk ◽  
Retrospective Case ◽  
Control Study

Postoperative Radiotherapy in N– Breast Cancer. A Retrospective Case-Control Study

1981 ◽  
Vol 67 (5) ◽  
pp. 443-445 ◽  
Author(s):  
Mario Cappellini ◽  
Stefano Ciatto ◽  
Raffaello Mungai
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Postoperative Radiotherapy ◽  
Survival Rates ◽  
Radical Mastectomy ◽  
Case Control ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Retrospective Case ◽  
Control Study

The role of postoperative radiotherapy in N- breast cancer with centrally or medially located tumors is still controversial. The authors report the results of a retrospective non-randomized case-control study of T1–2 N- breast cancer patients with centrally or medially located tumors, treated or not with postoperative radiotherapy after radical mastectomy. Sixty-four patients were treated with postoperative radiotherapy (Co-60) to the internal mammary chain and supraclavicular nodes. Sixty-four control cases, matched by T size and site, N status, age and menstrual status and simply followed-up after radical mastectomy were selected. No significant differences in actuarial recurrence and NED survival rates were observed at 5 years in the 2 compared groups, thus indicating that postoperative radiotherapy for patients with N- centrally or medially located breast cancers is not worthwhile treatment policy.

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