scholarly journals Medications for Anxiety: A Drug utilization study in Psychiatry Inpatients from a Tertiary Care Centre of Western Nepal

1970 ◽  
Vol 1 (4) ◽  
pp. 119-125 ◽  
Author(s):  
Indrajit Banerjee ◽  
Bedanta Roy ◽  
Brijesh Sathian ◽  
Indraneel Banerjee ◽  
Sai Sailesh Kumar ◽  
...  

Background   Anxiety is the most widespread psychiatric disorder and generalized anxiety disorder is the most common disease seen in the primary care setting. Currently there are a number of anxiolytic drugs commercially available in the market for treatment of these disorders such as Benzodiazepines like Diazepam, Chlordiazepoxide, Alprazolam, Betablockers like Propranolol and H1 Antihistaminics like Hydroxyzine. Some of the newer anxiolytics like Buspirone in Azapirone group is marketed as better anxiolytic drug than the traditional drugs.  Buspirone is promoted as a better drug for anxiety, as it does not cause any sedation, tolerance or physical dependence. A need for study further increases as there is no sufficient data on utilization pattern of anxiolytics on Nepalese population. This is the first study done in the utilization pattern of anxiolytic drugs in inpatient in Nepal.  Methods This is an observational study undertaken between 1st October 2009 and 31st March 2010 at the Psychiatric inpatient Department of Manipal Teaching Hospital. The prescribing pattern of Anxiolytic drugs was measured. Out of a total of 240 cases who were admitted to psychiatry inpatient ward, 38 cases have received Anxiolytic drugs. Those who were critically ill with anxiety were included in the study.  Results Out of 240 cases who were admitted to psychiatry inpatient, 130 were male patients (54.2%), 95% CI [47.9,60.5] and the rest were female patients (45.8%), CI [39.5,52.1] . In 38 cases of anxiety, the age of the patient <40 years 89.5% and >40 years 10.5%. Anxiety was more common in females 71.1% than in males 28.9%. 68.4% of the patients were unemployed whereas only 31.6% of the patients were employed. 78.9% of the drugs were prescribed by trade name. Among the anxiolytics, the commonest drug prescribed was Alprazolam (50%), followed by Clonazepam (31.6%), Chlordiazepoxide (15.8%) and Lorazepam (2.6%). Conclusion Utilization patterns of drugs for anxiolytics were according to treatment guidelines and suggested a trend towards the use of shorter acting Benzodiazepines such as Alprazolam. Continuous and prolonged use of longer acting Benzodiazepines has resulted in dependence and may have withdrawal symptoms when the dosage of these drugs is reduced or treatment is stopped.http://dx.doi.org/10.3126/nje.v1i4.5753 Nepal Journal of Epidemiology 2011;1(4):119-125

Author(s):  
Kishore Kumar Y. ◽  
Chakrapani Cheekavolu ◽  
G. Obulesu

<p class="abstract"><strong>Background:</strong> The prospective, observational study was designed to assess the prescribing pattern of drug usage in ENT outpatient department in various diseases conditions.</p><p class="abstract"><strong>Methods:</strong> Medication utilization Form has been designed based on a WHO format. The patient’s details including patient particulars, diagnosis, investigations, drug details and information regarding the indication for prescribing agents.  </p><p class="abstract"><strong>Results:</strong> Total 200 prescriptions were analysed, 70% were males and 30 % were females, respectively. The most common disease reported was CSOM in 31 (15.5 %) patients followed by otitis externa 25 (12.5%), pharyngitis 21 (10.5%), URTI patients 20 (10.0%). Antibiotics used were: amoxicillin-clavulanate 200 (57.3%), cefixime 37 (10.6%), levofloxacin 34 (9.74%), cefixime clavulanate 30 (8.59%), cefuroxime 13 (3.72%). The most commonly used NSAID are diclofenac and paracetamol.</p><p><strong>Conclusions:</strong> Prescribing pattern of usage of antibiotics are more compared to other drugs, amoxicillin with clavulanic acid are most commonly prescribed antibiotics in various ENT diseases, usage of brand name are higher than the generic name. </p>


2015 ◽  
Vol 18 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Farzana Sultana ◽  
Ajijur Rahman ◽  
Tripti Rani Paul ◽  
Md Shahid Sarwar ◽  
Md Anwar Ul Islam ◽  
...  

Irrational prescribing of drugs is a major health concern in developing countries like Bangladesh. A study was therefore undertaken in a hospital, situated in Rajshahi region of Bangladesh, to find the prescribing pattern and to detect the prescription errors to the admitted patients. Prescriptions of 200 patients were collected from various departments of the hospital over a period of three months. Prescription pattern was analyzed using general indicators suggested by WHO and prescribing errors were determined by comparing the prescribed drugs with national standard treatment guidelines, textbooks and authentic online resources. The average number of drugs per prescription was found to be 4.89 and 76.5% prescriptions contained complex regimen. In this study, we found no prescription with generic name. The percentage of prescription with antibiotics was 78% that was 15.95% of total drugs. The injectable preparations used were 17.18% of total 978 drugs. About 769 (3.85 per prescription) prescription errors were identified from 978 prescribed drugs. The name of 35 prescribed drugs was not clear due to illegible hand writing. The dose strength was missing for 279 drugs and 31 drugs had improper abbreviation. The study also identified 409 drug interactions. About 6.5% prescription orders were identified for the patients with kidney and urinary problems and there was no dose adjustment. Frequency of occurrence of prescription errors found during the study can be rated high. The prescription pattern and the prescription errors have indicated the need to establish proper system of recording and analyzing therapy before writing a prescription in order to promote rational drug therapy.Bangladesh Pharmaceutical Journal 18(1): 20-24, 2015


2013 ◽  
Vol 4 (3) ◽  
pp. 92-98 ◽  
Author(s):  
Dharm Raj Bhatta ◽  
Abhishek Gaur ◽  
HS Supram

Background Blood stream infections (BSI) are significant cause of morbidity and mortality in the world. This study was conducted to determine the common bacterial agents associated with BSI with their antimicrobial susceptibility patterns in a tertiary care centre in the Western region of Nepal. Method This cross-sectional study was conducted for a period of two years from May 2010 to May 2012. All patients with fever (temperature ≥ 38°C) were included in the study. Results A total of 4,145 patients with febrile illness were included in this study, bacterial agents were isolated in 251 (6%) cases. Common bacterial isolates were Salmonella spp., Klebsiella pneumoniae, Escherichia coli, Pseudomonas species, Acinetobacter species, Staphylococcus aureus and Coagulase negative Staphylococci. Paratyphoid fever (Caused by S. Paratyphi A) is more common than typhoid fever. The members of Enterobacteriaceae were found to be resistant to ampicillin and cefazolin. Majority of the nonfermenters were found to be sensitive to most antibiotics. Gentamicin and Ciprofloxacin were sensitive to majority of gram positive bacteria. Conclusion Gram-negative bacteria were the predominant causes of BSIs. The occurrence of drug resistance among the isolated bacteria is of great concern. Imipenem showed 100% sensitivity against Pseudomonas aeruginosa indicating lack or low level of MBL activity. DOI: http://dx.doi.org/10.3126/ajms.v4i3.8165 Asian Journal of Medical Sciences 4(2013) 92-98


Author(s):  
DASARAJU RAJESH ◽  
M. V. ADVAITHA ◽  
RAJENDRA HOLLA

Objective: Due to the uncertainty about optimal antibiotic treatment, and probably substantial variation in practice, the present study was carried out to determine the bacterial profiles of infected diabetic foot ulcers (DFUs) and also to analyze the prescribing pattern of antibiotics used. Methods: A prospective observational study was carried out in the department of General surgery at a tertiary care teaching hospital, Mangalore. Demographic details and treatment data of 78 patients were collected in a specially designed Proforma, and the data were analyzed using Microsoft Excel. Results: According to Meggit-Wagner's classification, patients admitted with DFUs predominantly belonged to WAGNER 1 category (36%), followed by WAGNER 4 (26%) and WAGNER 2 (22%) categories. Out of 66 culture-positive specimens, 21 (31.8%) had monomicrobial flora, and 45 (68.2%) had polymicrobial flora. A total of 148 organisms were obtained from the specimens. The most common isolates were Staphylococcus aureus (22.3%) and Pseudomonas aeruginosa (17.5%). Ceftriaxone was the most commonly prescribed empirical antibiotic (29%), followed by linezolid (20%), piperacillin-tazobactam (20%), amoxicillin-clavulanic acid (13%), cefoperazone-sulbactam (11%). After the culture and sensitivity (C/S) results, antimicrobials were changed in 74.61% of patients in the preference of Linezolid (51%), Amikacin (27%), Levofloxacin (19%), Ciprofloxacin (17%), Piperacillin-tazobactam (13%), Cefixime (15%), Ceftriaxone (11%) among others. Clindamycin and metronidazole were used to cover anaerobic microorganisms. Conclusion: Most of the microorganisms isolated from DFUs were resistant to many types of antibiotics. Gram-positive organisms were largely sensitive to linezolid and vancomycin, while Gram-negative organisms to amikacin and imipenem. Local treatment of wounds is essential.


Author(s):  
Manju Gari ◽  
Megha Bansal

ABSTRACTBackground: The objective of the present study was to evaluate the prescribing pattern of hypolipidaemic drugs in the outpatient department of cardiology in a tertiary care hospital.Methods: A cross-sectional study was conducted in the department of cardiology for the period of 3 months. A total of 526 prescriptions were analyzed for variants such as the disease patterns, the type of hypolipidaemic drugs which are prescribed for those diseases, the prescribing daily dose of the hypolipidaemic drugs and the prescribing daily dose/daily defined dose ratio of the drugs.Results: On evaluation of the prescriptions, it was conferred that both the patients of normal lipid profile (34.77%) and abnormal lipid profile (65.18%) were prescribed hypolipidaemic drug. Diabetes with hypertension (35.74%) was the most common disease for which hypolipidaemic drugs were prescribed. Atorvastatin (30.98%) was the most common drug which was prescribed as monotherapy, whereas atorvastatin with aspirin and clopidogrel (17.49%) was the most common drug prescribed in combination.Conclusions: Use of statin has become very prevalent with increasing trends of use in both normal and abnormal lipid profile patients, suggesting consideration of rational use of statins to follow good prescribing pattern so that morbidity and mortality can be prevented.


2020 ◽  
Vol 5 (1) ◽  
pp. 897-901
Author(s):  
Sumit Agrawal ◽  
Krishna Hari Subedi ◽  
Rajesh Kumar Shah ◽  
Santoshanand Jha ◽  
Sher Bahadur Pun

Introduction Scrub typhus is the most common ricketisial infection from the Indian subcontinent. It is caused by the organism Orienta tsutsugamushi inhabiting in trombiculid mites and transmitied to humans by the bite of these mites. The disease has a variety of clinical manifestations in children. As this is a common disease in our country so a retrospective study was conducted to study the clinical and laboratory profile and therapeutic outcomes of scrub typhus in children. Methodology A retrospective study was conducted at Sukraraj Tropical and Infectious disease Hospital, Teku, Kathmandu, Nepal after obtaining ethical clearance from Institutional Review Committee, and reviewing the medical records of serologically confirmed scrub typhus in children aged less than 14 years admitted to the hospital between March 2017 and February 2018. Relevant data were entered in excel spreadsheet and analyzed using SPSS 20. Result A total of 20 children were enrolled in the study. Of them 70% were female, with the mean age being 11.45 ± 3.1 years (range 3-14 years) and majority were from Dhading district (40%). All the children had fever; while there was cough, loss of appetite, rashes, headache, myalgia, arthralgia and hepatosplenomegaly in 45%, 90%, 20%, 55%, 35%, 35% and 30% of children respectively. There was thrombocytopenia in 50% of children; while hyponatremia, elevation of SGOT and SGPT was present in 30%, 70% and 55% of patients respectively. Azithromycin was used for treatment in 95% of children and all had defervescence of fever. Conclusion Scrub typhus should be suspected in children having prolonged fever with organomegaly, thrombocytopenia and elevated transaminases. Azithromycin can be used effectively in children diagnosed as scrub typhus.


2021 ◽  
Vol 11 (2) ◽  
pp. 122-128
Author(s):  
Vandana Kumari ◽  

A liver abscess, also known as a hepatic abscess, is an accumulation of pus within the liver as a result of an infection. Overall liver abscesses are fairly rare and more frequently seen in developing nations. Most liver abscesses are caused by bacteria and amebic parasites (protozoa). However, other protozoa, fungi and helminths (parasitic worms) may also be responsible for hepatic abscesses. Methods: The present study was conducted in the indoor patients of medicine ward as well as on patients attending medicine OPD at M.G.M. Medical College and L.S.K. Hospital Kishanganj, Bihar. This study included 60 patients, out of 75 patients who were reported in Outdoor or admitted in Emergency Department remaining 15 patients were dropped out. The study period was Nov 2017 to September 2018 in M.G.M. Medical College and L.S.K. Hospital. The selection of the patients was based on clinical history, clinical examination and ultrasound findings. Those patients who were serologically positive for viral hepatitis, malaria (optimal test) and kalazar (rK 39) were excluded from this study. Results: There are 85 % male and 15 % female in this study. Age range varied from 12 to 70 years. The highest incidence was found in 31-40-year age group. Maximum number of cases were from rural areas 78.3% and remaining 21.7% from urban. The majority of cases 42/60 had leukocytosis (median -14,100) but 18 cases had white blood cells count within normal limit. Polymorphnuclear cells (median-81%) were predominantely present. Abnormally high alkaline phosphatase were seen in 82% of cases. There were six cases in which E. histolytica was detected in routine examination of stool. No single case was seropositive to HIV I and II serum creatinine level found to be within normal range in all cases. Conclusion: There was no mortality. Prognosis was better. It was due to early diagnosis of the diseases and early intervention.


Author(s):  
Shehla Jamal ◽  
Ruchi Srivastava ◽  
Arpit Jain ◽  
Nimmi Chutani ◽  
Shelly Agarwal ◽  
...  

Background: Reduction in the maternal morbidity has been the key strategy towards achievement of Millennium Development Goal. Despite exhaustive measures at all levels, the decline has been slow. WHO in 2007 established a technical working group to identify cases of severe acute maternal morbidity. It served dual goals to identify the causes and pointing out delays leading to SAMM. SAMM is now an established superior indicator of surviving women’s health and allows uniform comparisons. The present study was conducted with an aim to identify cases of SAMM at our centre. The objective is to determine the frequency of maternal near miss and conduct an epidemiological survey.Methods: This retrospective study was conducted in the department of Obstetrics and Gynecology and ICU of School of Medical Sciences and Research, Greater Noida, from November 2014 to October 2017. All the cases identified as SAMM, as per WHO 2009 criteria (modified according to the local protocol), were included in the study.  Results: During the study period there were a total of 2252 delivery, out of which 2051 were live births. There were 123 SAMM cases and 47 were excluded out of study. So, study was done on 76 cases of SAMM, and on 11 maternal deaths in the study period. Calculated MNM incidence ratio was 37.05 per 1000 live births. A mortality index of 12.64% was calculated. MNM to maternal death ratio was 6.9:1. Major identifiable cause for SAMM was hypertension (35.5%)), followed by haemorrhage (18.4%). Haematologic system was the commonest organ system involved. 67.8% of the admissions were done in critical condition.Conclusions: Maternal mortality and SAMM cases shared characteristics, and study of SAMM cases can provide an insight into the causative etiology and give time for early intervention.


2018 ◽  
Vol 103 (2) ◽  
pp. e1.46-e1
Author(s):  
Aragon Cuevas Octavio ◽  
Roughley Amy ◽  
Morecroft Charles

AimThe primary objective of this study was to audit the centre’s and its satellite clinics’ compliance with the British Society for Paediatric and Adolescent Rheumatology (BSPAR) and the Royal College of Ophthalmology (RCO) uveitis screening guidelines. The secondary objective of the study was to compare the centre’s compliance with the treatment guidelines of JIA and uveitis, as recommended by NHS England and following results from the SYCAMORE trial.MethodThe clinical records of 54 patients recruited from the Childhood Arthritis Prospective Study (CAPS) were analysed over a six-week period. The data collected included patient demographics, JIA sub-type, date of referral and uveitis screening, presence of uveitis and treatment (if applicable), and details of medication prescribed for JIA. Information was gathered from the centre’s EPMA system and paper records, and was requested from the satellite centres if needed. The raw data was inputted into the statistical software SPSS v23 to evaluate the categorical data. Chi-squared tests were performed on the data to detect any potential correlation between various demographic variables and primary and secondary outcomes.Results92.6% (50/54) of patients were referred for uveitis screening after being diagnosed with JIA. For 3 (5.6%) patients there was no evidence of referral and for 1 (1.9%) patient the documentation was not clear. 90% (45/50) of the referred patients were screened for uveitis. For the remaining 5 (10%) patients, there was no documentation of whether screening had taken place. The compliance of ophthalmology departments with the BSPAR/RCO guidelines was poor with only 17.8% (8/45) of patients being screened within six weeks of the ophthalmology referral. 8.9% of patients (4/45) were diagnosed with uveitis and 2 of these patients received adalimumab as part of the treatment regime. The treatment for JIA was documented for 75.9% (41/54) of patients and all treatments (100%) were in line with the current recommendations from NHS England. Statistical correlations could not be identified due to the low numbers of patients.ConclusionThe BSPAR/RCO guidelines suggest that all new patients are to be screened as soon as possible, no longer than 6 weeks after referral.1 As uveitis is commonly an asymptomatic condition2 with severe complications such as blindness,3 routine screening is imperative. Overall, the compliance of the tertiary care centre and satellite clinics with the BSPAR/RCO guidelines was poor. Immediate changes are required to improve patient care, focusing on facilitating sharing of documentation and communication between the primary centre and its satellite clinics. Raising awareness of targets recommended by BSPAR/RCO to emphasise the importance of timely uveitis screening via regional training days should take place. Ensuring all junior staff that might see JIA patients in clinic are aware of the need of uveitis screening via offering structured training during their rotation is recommended.ReferencesBSPAR: Guidelines for Screening for Uveitis in Juvenile Idiopathic Arthritis (JIA) (1st ed.)6 Oct 2016.Engelhard SB, Asima B, Ashvini RK. Causes of uveitis in children without juvenile idiopathic arthritis. Clinical Ophthalmology2015;9:1121–1128.Juvenile Idiopathic Arthritis (JIA). Cincinnatichildrens.org. N.p., 5 Oct 2016.


2011 ◽  
Vol 1 (5) ◽  
pp. 144-152 ◽  
Author(s):  
Indrajit Banerjee ◽  
Bedanta Roy ◽  
Indraneel Banerjee ◽  
Brijesh Sathian ◽  
Monami Mondal ◽  
...  

Background: According to WHO, it is estimated that major depression would be the second most leading cause of disability in the world by 2020. Drug utilization study is defined as study of the marketing, distribution, prescription and use of drugs in a society highlighting on the resulting medical, social and economic consequences. The main objective of this study was to find the utilization pattern of antidepressants prescribed in a tertiary care centre with major depression in hospitalized patients of Western Nepal.Methods: A hospital based observational study was done between 1st October 2009 and 31st March 2010 at Psychiatry Ward of Manipal Teaching Hospital, Nepal. Both qualitative and quantitative data was collected from bed side. The outcome variables were essential drug, generic and trade, treatment, groups of antidepressants and antidepressants used. The explanatory variables were age, gender, monthly income, employment of the patient. Z test and logistic regression was used for the analysis. P-value < 0.05 was considered to be statistically significant. This is the first study done to understand the utilization pattern of antidepressant drugs in hospitalized patients in Nepal.Results: Among the 240 psychiatric patients studied, 38 (15.8%) cases were suffering from major depression. Male and female patients were 44.7% and 55.3% respectively, 95% CI [28.9, 60.5 and 39.5, 71.1]. Depression was more common in housewives (42.1%) followed by teachers 18.4% and students 10.5%. Fluoxetine was the commonest antidepressants to be prescribed 42.1% followed by Amitriptyline 26.3%, Trazodone 21.1% etc. Psychiatrists has a tendency of prescribing essential drugs if monthly income <10000, 1.063 times as compared to monthly income >10000, 2.63 times more in Hindus and 1.197 times more in Brahmins than any other ethnic groups. 9.179 times more tendency of prescribing antidepressants by trade names in case of unemployed patients as compared to employed patients in Nepal.Conclusion: According to the utilization pattern of antidepressants it was found that among the Selective serotonin reuptake inhibitors Fluoxetine was used relatively higher than conventional drugs like Tricyclic antidepressants, recommend that there is a trend of using Typical antidepressants drugs for depression rather than Newer antidepressants.DOI: http://dx.doi.org/10.3126/nje.v1i5.6152 Nepal Journal of Epidemiology 2011;1 (5):144-52 


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