scholarly journals Review article - Impact of Vitamin K on Human Health

Author(s):  
Najwan K. Fakhree ◽  
Sarah H. Mhaibes ◽  
Heba H. Khalil

Vitamins k is an important fat-soluble vitamin that can be obtained from plants, bacteria and animals and is necessary for the blood clotting. It plays a key function as a cofactor in the synthesizing of blood clotting proteins in the liver; recently, the interest for its functions in extra-hepatic tissue has increased. Vitamin k deficiency is usually caused by abnormal absorption rather than in the lack of vitamin in food. Apart from its impact on clotting, chronic subclinical deficiency of vitamin K maybe a risk factor for many diseases such as osteoporosis, atherosclerosis, cancer, insulin resistance, neurodegenerative diseases and others, while current food intake guidelines be focused on the daily dose necessary to avoid blood loss. Several researchers found out that vitamin K needs may be substantially higher for certain health functions.

1968 ◽  
Vol 20 (01/02) ◽  
pp. 078-087 ◽  
Author(s):  
H. C Hemker ◽  
A. D Muller

SummaryPIVKA, the circulating anticoagulant protein found in vitamin K deficiency can, on kinetical grounds, be recognized as an analogue of factor X. The existence of analogues of other vitamin K-dependent clotting factors cannot be ruled out, but need not be assumed to explain the experimental results.


The Lancet ◽  
2001 ◽  
Vol 357 (9273) ◽  
pp. 1995-1996 ◽  
Author(s):  
Pawel Szulc ◽  
Pierre Jean Meunier

Author(s):  
Sir Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley

Vitamin K is involved in blood clotting, and lack of this nutrient results in a hypocoagulable state, associated with a high risk of bleeding events. Deficiency is rare among adults, because vitamin K is widely available in foods. However, the placenta transmits vitamin K relatively poorly, leading to a general deficiency in full-term neonates, who are also particularly vulnerable to the effects of low vitamin K levels because of their immature clotting systems. Deficiency can lead to intracranial haemorrhage following birth trauma, or classic vitamin K deficiency bleeding. It is important to maintain adequate vitamin K status throughout pregnancy in order to avoid added risk to the neonate at birth and in the first few weeks of life. Supplementation of newborns by intramuscular injection should be universal.


1993 ◽  
Vol 16 (3) ◽  
pp. 301-305 ◽  
Author(s):  
E. A. M. Cornelissen ◽  
L. A. A. Kollée ◽  
T. G. P. J. van Lith ◽  
K. Motohara ◽  
L. A. H. Monnens

Author(s):  
Jennifer T. Truong ◽  
Sarah L. Booth

Vitamin K is traditionally recognized for its role in blood clotting. More recently, new roles for vitamin K have emerged. The current evidence for the role of vitamin K in bone, cardiovascular, and reproductive health will be discussed. There will be a particular focus on populations who could be at risk for vitamin K deficiency.


2009 ◽  
Vol 76 (1) ◽  
pp. 18-22 ◽  
Author(s):  
Thilo Krueger ◽  
Ralf Westenfeld ◽  
Markus Ketteler ◽  
Leon J. Schurgers ◽  
Jürgen Floege

1968 ◽  
Vol 19 (03/04) ◽  
pp. 346-363 ◽  
Author(s):  
H. C Hemker ◽  
J. J Veltkamp ◽  
E. A Loeliger

SummaryApplication of enzyme kinetics to the results of thrombotest estimations in correlation with specific clotting factor estimations has led to the recognition of a protein moiety that occurs in plasma in vitamin K deficiency and acts as a competitive inhibitor of thrombin formation. A hypothesis is given by which the occurrence of this inhibitor is explained in terms of a biphasic synthesis of the vitamin K-dependent clotting factors.


2018 ◽  
Vol 9 (1) ◽  
pp. 44
Author(s):  
Mutia Felina ◽  
Marlina Marlina

Vitamin K is a fat-soluble vitamin that has an important role in activating substances that play a role in blood clotting, including substances known as prothrombin and clotting factors. The purpose of this research is to know the knowledge factor of midwife toward vitamin K in the newborn with midwifery in the prevention of vitamin K deficiency in the newborn in Bukitinggi city. This type of research is cross-sectional, and this research is done in Bukittinggi City Year 2017. Sampling technique with Random Sampling or randomly. The research will be carried out in the Working Area of Bukittinggi City in 2017. The population and sample in this study are all midwives who have BPM in Bukittinggi City with a sample size of 21 midwives. Data analysis with chi-square showed that there was no correlation between midwife knowledge on vitamin K administration in BBL with the working period and availability of midwife in preventing vitamin K deficiency on BBL with p = 0,0001 (p> 0,05). It is recommended for health workers in Kota Bukittinggi to improve the standard services of Midwifery, especially to newborns.


2010 ◽  
Vol 51 (6) ◽  
pp. 773-776 ◽  
Author(s):  
PM van Hasselt ◽  
W de Vries ◽  
E de Vries ◽  
K Kok ◽  
ECM Cranenburg ◽  
...  

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