scholarly journals Type of course of schizophrenia and polymorphisms of neuronal protein kinase genes on the model of PIP5K2A, GSK3B and AKT1

2019 ◽  
pp. 98-100
Author(s):  
E. G. Poltavskaya ◽  
O. Y. Fedorenko
Keyword(s):  
Protein Kinase ◽  
Clinical Manifestations ◽  
Kinase Gene ◽  
Continuous Type ◽  
Neuronal Protein ◽  
Icd 10 ◽  
Episodic Course ◽  
Protein Kinase Gene ◽  
Pcr Method

The role of protein kinases in schizophrenia is being actively studied. However, the effect of protein kinase gene polymorphisms on the clinical manifestations of the disease has been little studied. We examined 384 patients diagnosed with schizophrenia in accordance with ICD-10 (F20) (269 patients with a continuous course of schizophrenia; 115 patients with an episodic course of the disease). Genotyping of polymorphisms PIP5K2A (rs10828317, rs8341, rs746203), GSK3B (rs334558), AKT1 (rs3730358, rs1130214) was carried out by real-time PCR method. An association of rs8341 PIP5K2A with the type of course of schizophrenia was revealed. The CT genotype was associated with a continuous type of schizophrenia, the TT genotype with an episodic one. Disorders of the phosphoinositide pathway may be a possible cause of the transition to a more severe continuous course of schizophrenia.

scholarly journals The role of p38α mitogen-activated protein kinase gene in the HELLP syndrome

2009 ◽  
Vol 15 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Alessandra Corradetti ◽  
Franca Saccucci ◽  
Monica Emanuelli ◽  
Giorgia Vagnoni ◽  
Monia Cecati ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Hellp Syndrome ◽  
Mitogen Activated Protein Kinase ◽  
Kinase Gene ◽  
Mitogen Activated Protein ◽  
Protein Kinase Gene

Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene

1999 ◽  
Vol 1 (8) ◽  
pp. 601-607 ◽  
Author(s):  
So Hata ◽  
A.Hajime Koyama ◽  
Hiroshi Shiota ◽  
Akio Adachi ◽  
Fumi Goshima ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Protein Kinase ◽  
Herpes Simplex Virus Type ◽  
Kinase Gene ◽  
Protein Kinase Gene ◽  
Antiapoptotic Activity ◽  
Simplex Virus

Characterization of a protein kinase gene from two Chlorella viruses

1995 ◽  
Vol 35 (3) ◽  
pp. 291-305 ◽  
Author(s):  
Quideng Que ◽  
James L. Van Etten
Keyword(s):  
Protein Kinase ◽  
Kinase Gene ◽  
Protein Kinase Gene

scholarly journals The Evolutionary History and Diverse Physiological Roles of the Grapevine Calcium-Dependent Protein Kinase Gene Family

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e80818 ◽  
Author(s):  
Fei Chen ◽  
Marianna Fasoli ◽  
Giovanni Battista Tornielli ◽  
Silvia Dal Santo ◽  
Mario Pezzotti ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Gene Family ◽  
Evolutionary History ◽  
Dependent Protein Kinase ◽  
Kinase Gene ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Protein Kinase Gene ◽  
Calcium Dependent Protein Kinase

scholarly journals Distribution and evolution of CTG repeats at the myotonin protein kinase gene in human populations.

1996 ◽  
Vol 6 (2) ◽  
pp. 142-154 ◽  
Author(s):  
R Deka ◽  
P P Majumder ◽  
M D Shriver ◽  
D N Stivers ◽  
Y Zhong ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Human Populations ◽  
Kinase Gene ◽  
Ctg Repeats ◽  
Protein Kinase Gene

Cloning and Expression Analysis of a Mitogen-Activated Protein Kinase Gene OsMPK14 in Rice

Rice Science ◽  
2010 ◽  
Vol 17 (4) ◽  
pp. 269-275 ◽  
Author(s):  
Wei-hong LIANG ◽  
Jia-jia BI ◽  
Wei-feng PENG ◽  
Fan ZHANG ◽  
Hong-hao SHI ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Expression Analysis ◽  
Mitogen Activated Protein Kinase ◽  
Cloning And Expression ◽  
Kinase Gene ◽  
Mitogen Activated Protein ◽  
Protein Kinase Gene

tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene

1992 ◽  
Vol 12 (3) ◽  
pp. 1226-1233
Author(s):  
L M Chow ◽  
M J Ratcliffe ◽  
A Veillette
Keyword(s):  
Protein Kinase ◽  
T Lymphocytes ◽  
Gene Product ◽  
Lymphoid Tissues ◽  
Protein Kinase Activity ◽  
Kinase Gene ◽  
Rnase Protection ◽  
Tyrosine Protein Kinase ◽  
Protein Kinase Gene ◽  
Unique Domain

We have tested the possibility that tkl, a partially characterized avian tyrosine protein kinase gene, is the chicken homolog of lck, a lymphocyte-specific mammalian gene. Using polymerase chain reactions, we have cloned sequences encoding the previously unidentified amino terminus of the tkl gene product. The newly defined unique domain of Tkl displayed significant identity (68%) to the equivalent region of the mammalian lck gene product, p56lck. This identity included a glycine residue at position 2 (present in all Scr-related tyrosine protein kinases) and a cysteine motif at positions 20 and 23, which allows binding of p56lck to CD4 and CD8 in mammalian T lymphocytes. A specific RNase protection assay revealed that, in contrast to a previous report (K. Strebhardt, J. I. Mullins, C. Bruck, and H. Rübsamen-Waigmann, Proc. Natl. Acad. Sci. USA 84:8778-8782, 1987), tkl expression is restricted to the lymphoid tissues thymus and spleen. Moreover, the absence of tkl transcripts in the bursa of Fabricius suggested that this gene is expressed in avian T lymphocytes but not in B lymphocytes. A polyclonal rabbit antiserum raised against the unique domain of Tkl recognized a 56-kDa polypeptide with associated protein kinase activity from avian thymus-derived cells. Additional studies showed that p56tkl is structurally similar to mammalian p56lck and that it is physically associated with the avian CD4 and CD8 T-cell surface antigens. It was also determined that tkl transcripts have one major type of 5' untranslated region (UTR), which differs greatly from the two known 5' UTRs of mammalian lck mRNAs.(ABSTRACT TRUNCATED AT 250 WORDS)

The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability

1995 ◽  
Vol 4 (5) ◽  
pp. 869-878 ◽  
Author(s):  
A. Klink ◽  
K. Schiebel ◽  
M. Winkelmann ◽  
E. Rao ◽  
B. Horsthemke ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Chromosomal Instability ◽  
Human Protein ◽  
Kinase Gene ◽  
Human Protein Kinase ◽  
Protein Kinase Gene ◽  
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