Septic arthritis due to Mycoplasma orale in a young patient with hypogammaglobulinemia

2021 ◽  
Author(s):  
Aaron C Liu ◽  
Melissa Harvey ◽  
Alison Lee ◽  
Kyla Hildebrand ◽  
Linda Hoang ◽  
...  
Keyword(s):  
Septic Arthritis ◽  
Ribosomal Rna ◽  
Severe Disease ◽  
Left Knee ◽  
Joint Fluid ◽  
Mycoplasma Species ◽  
Obligate Intracellular Bacterium ◽  
Obligate Intracellular ◽  
Humoral Immunodeficiency ◽  
16S Ribosomal Rna Gene

Mycoplasma orale is an obligate intracellular bacterium usually found as a commensal in the human oral cavity. Symptomatic infections with this organism are rare, but severe disease has been described in the setting of impaired humoral immunity. Here, we describe a case in which M. orale was identified from the joint fluid of a patient with septic arthritis, splenic lesions, and agammaglobulinemia. A 15-year-old boy was admitted to the hospital with fever, progressive left knee swelling, and pain. His past medical history was significant for Burkitt’s lymphoma, the treatment of which had included rituximab 6 years earlier. M. orale was identified in the synovial fluid using 16S ribosomal RNA gene sequencing. He was also found to be hypogammaglobulinemic, and imaging revealed multiple splenic lesions. He was treated with doxycycline and intravenous immunoglobulin, which resulted in complete resolution of his arthritis and other symptoms. Mycoplasma species should be suspected in patients with humoral immunodeficiency and compatible findings.

scholarly journals Actinomyces meyeriPopliteal Cyst Infection and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Bharath Raj Palraj ◽  
Ala S. Dababneh
Keyword(s):  
Fluid Collection ◽  
Left Knee ◽  
Joint Fluid ◽  
Popliteal Cyst ◽  
Degenerative Arthritis ◽  
Posterior Aspect ◽  
Medial Meniscectomy ◽  
Complex Fluid ◽  
Magnetic Resonance Imaging Mri ◽  
Mri Study

A 66-year-old, Caucasian male presented with pain and swelling involving the left knee of one-week duration. Arthrocentesis was negative for evidence of septic arthritis. Magnetic resonance imaging (MRI) study of the left knee showed degenerative arthritis, partial tear of medial meniscus, and a complex fluid collection along the posteromedial aspect of the left knee suggestive of popliteal cyst. He underwent arthroscopy with partial medial meniscectomy. Intraoperative joint fluid was noted to be cloudy but cultures were negative. Arthroscopic procedure provided him with temporary relief but the pain and swelling in the posterior aspect of the left knee recurred in 6 weeks. Repeat MRI showed complex fluid collection in the posterolateral aspect of left knee. Ultrasound guided aspiration of the fluid collection revealed purulent material and cultures grewActinomyces meyeri. He was treated with 6 weeks of intravenous penicillin regimen followed by 18 months of oral penicillin.

scholarly journals Mycoplasmas in Australian fur seals (Arctocephalus pusillus doriferus): identification and association with abortion

2011 ◽  
Vol 23 (6) ◽  
pp. 1123-1130 ◽  
Author(s):  
Michael Lynch ◽  
Trevor K. Taylor ◽  
Pádraig J. Duignan ◽  
Jane Swingler ◽  
Marc Marenda ◽  
...  
Keyword(s):  
Ribosomal Rna ◽  
Mycoplasma Species ◽  
Lung Pathology ◽  
Healthy Individuals ◽  
Normal Flora ◽  
Age Classes ◽  
Culture Techniques ◽  
Fur Seals ◽  
Specific Culture ◽  
Apparently Healthy

Bacteria from the genus Mycoplasma are common inhabitants of the respiratory, gastrointestinal, and genital tracts of mammals. The understanding of the pathological significance of mycoplasmas in seals is poor, as few studies have utilized the specific culture techniques required to isolate these bacteria. The current study surveyed for the Mycoplasma species present in Australian fur seals ( Arctocephalus pusillus doriferus) and investigated the association between infection and pathology. Mycoplasmas were found in the nasal cavities of 55/80 (69%) of apparently healthy individuals. Isolates from 18 individuals were investigated through 16S ribosomal RNA sequencing, and 3 species were identified: M. zalophi, M. phocae, and Mycoplasma sp. (GenBank no. EU714238.1), all of which had previously been isolated from Northern Hemisphere pinnipeds. In addition, mycoplasmas were isolated from the lungs of 4 out of 16 juveniles and 1 out of 5 adults sampled at necropsy. Isolates obtained were M. zalophi, Mycoplasma sp. EU714238.1, and M. phocicerebrale, but infection was not associated with lung pathology in these age classes. Inflammatory disease processes of the heart and/or lungs were present in 12 out of 32 (38%) aborted fetuses on microscopic examination. Predominant findings were interstitial pneumonia, pericarditis, and myocarditis. Mycoplasma phocicerebrale was isolated from the thymus of an aborted fetus, and 3 out of 11 (27%) fetuses with inflammatory heart or lung lesions were PCR-positive for Mycoplasma. In conclusion, several species of Mycoplasma are part of the normal flora of the nasal cavity of Australian fur seals, and some mycoplasmas may be associated with abortion in this species of seal.

scholarly journals CXCR2 Blockade Influences Anaplasma phagocytophilum Propagation but Not Histopathology in the Mouse Model of Human Granulocytic Anaplasmosis

2004 ◽  
Vol 11 (5) ◽  
pp. 963-968 ◽  
Author(s):  
Diana G. Scorpio ◽  
Mustafa Akkoyunlu ◽  
Erol Fikrig ◽  
J. Stephen Dumler
Keyword(s):  
Anaplasma Phagocytophilum ◽  
Tissue Injury ◽  
Treated Group ◽  
Obligate Intracellular Bacterium ◽  
Human Granulocytic Anaplasmosis ◽  
Obligate Intracellular ◽  
Liver Histopathology ◽  
Granulocytic Anaplasmosis ◽  
Infected Cells ◽  
And Control

ABSTRACT Anaplasma phagocytophilum is an obligate intracellular bacterium that infects neutrophils and causes human granulocytic anaplasmosis. Infection induces neutrophil secretion of interleukin-8 or murine homologs and perpetuates infection by recruiting susceptible neutrophils. We hypothesized that antibody blockade of CXCR2 would decrease A. phagocytophilum tissue load by interrupting neutrophil recruitment but would not influence murine hepatic pathology. C3H-scid mice were treated with CXCR2 antiserum or control prior to or on day 14 after infection. Quantitative PCR and immunohistochemistry for A. phagocytophilum were performed and severity of liver histopathology was ranked. Control mice had more infected cells in tissues than the anti-CXCR2-treated group. The histopathological rank was not different between treated and control animals. Infected cells of control mice clustered in tissue more than in treated mice. The results support the hypothesis of bacterial propagation through chemokine induction and confirm that tissue injury is unrelated to A. phagocytophilum tissue load.

scholarly journals Molecular Approaches to Studying Microbial Communities: Targeting the 16S Ribosomal RNA Gene

2016 ◽  
Vol 38 (3) ◽  
pp. 223-232 ◽  
Author(s):  
Kazumasa FUKUDA ◽  
Midori OGAWA ◽  
Hatsumi TANIGUCHI ◽  
Mitsumasa SAITO
Keyword(s):  
Microbial Communities ◽  
Ribosomal Rna ◽  
16S Ribosomal Rna ◽  
Approaches To Studying ◽  
Ribosomal Rna Gene ◽  
Molecular Approaches ◽  
16S Ribosomal Rna Gene

SEPTIC ARTHRITIS IN INFANTS AND CHILDREN: A REVIEW OF 117 CASES

PEDIATRICS ◽  
1966 ◽  
Vol 38 (6) ◽  
pp. 966-971 ◽  
Author(s):  
John D. Nelson ◽  
Wayne C. Koontz
Keyword(s):  
Antibiotic Therapy ◽  
Septic Arthritis ◽  
Age Groups ◽  
Infants And Children ◽  
Joint Fluid ◽  
Hemophilus Influenzae ◽  
In Infants And Children

A review of 117 cases of septic arthritis in infants and children revealed that the concept of staphylococci and streptococci as the major etiologic organisms should be modified to stress the frequency of Hemophilus influenzae in the 6-month to 2-year age bracket and to emphasize the variety of bacteria that must be anticipated in individual cases. Suggestions are made for increasing the frequency of bacteriologic diagnoses and for initiating the antibiotic therapy of patients with septic arthritis based upon age groups and observations of bacterial stains of joint fluid.

Septic Arthritis in an Infant Due to Clostridium ghoni and Hemophilus parainfluenzae

PEDIATRICS ◽  
1976 ◽  
Vol 57 (4) ◽  
pp. 573-574
Author(s):  
James W. Renne ◽  
Herbert B. Tanowitz ◽  
Jeffrey D. Chulay
Keyword(s):  
Case Report ◽  
Septic Arthritis ◽  
Otitis Media ◽  
Human Infection ◽  
Joint Fluid ◽  
Benzathine Penicillin ◽  
White Girl ◽  
History Of

Clostridium ghoni and Hemophilus parainfluenzae are uncommon causes of human infection. Both of these agents were isolated from joint fluid in a child with septic arthritis. CASE REPORT An 8-month-old white girl was admitted with a three-day history of irritability, fever, and inability to lie on her right side. Ten days prior to admission bilateral otitis media was treated with 600,000 units of benzathine penicillin intramuscularly and sulfisoxazole suspension (1 gm daily until admission). Fever and irritability from otitis abated by the fifth day of therapy. On admission the infant appeared acutely ill and had a temperature of 39.7 C.

scholarly journals Evaluation of 16S, map1 and pCS20 probes for detection of Cowdria and Ehrlichia species

1999 ◽  
Vol 122 (2) ◽  
pp. 323-328 ◽  
Author(s):  
M. T. E. P. ALLSOPP ◽  
C. M. HATTINGH ◽  
S. W. VOGEL ◽  
B. A. ALLSOPP
Keyword(s):  
16S Rrna ◽  
Ribosomal Rna ◽  
Pcr Amplification ◽  
16S Ribosomal Rna ◽  
16S Rrna Genes ◽  
Rrna Genes ◽  
Amblyomma Hebraeum ◽  
Ribosomal Rna Gene ◽  
Group Iii ◽  
16S Ribosomal Rna Gene

A panel of 16S ribosomal RNA gene probes has been developed for the study of the epidemiology of heartwater; five of these detect different cowdria genotypes, one detects five distinct genotypes; one detects any Group III Ehrlichia species other than Cowdria and one detects any Group II Ehrlichia species. These probes have been used on PCR-amplified rickettsial 16S rRNA genes from over 200 Amblyomma hebraeum ticks. Control ticks were laboratory-reared and either uninfected or fed on sheep experimentally infected with different cowdria isolates, field ticks were collected from animals in heartwater-endemic areas. All tick-derived DNA samples were also examined by PCR amplification and probing for two other cowdria genes (map1 and pCS20) which have previously been used for heartwater epidemiology. This paper describes the first direct comparison of all currently available DNA probes for heartwater-associated organisms.

scholarly journals A Case of Sepsis in a 92-Year-Old Korean Woman Caused byAerococcus urinaeand Identified by Sequencing the 16S Ribosomal RNA Gene

2016 ◽  
Vol 47 (2) ◽  
pp. e15-e17 ◽  
Author(s):  
Min Young Lee ◽  
Myeong Hee Kim ◽  
Woo In Lee ◽  
So Young Kang ◽  
You La Jeon
Keyword(s):  
Ribosomal Rna ◽  
16S Ribosomal Rna ◽  
Korean Woman ◽  
Ribosomal Rna Gene ◽  
16S Ribosomal Rna Gene

scholarly journals Bacterial diversity in aortic aneurysms determined by 16S ribosomal RNA gene analysis

2006 ◽  
Vol 44 (5) ◽  
pp. 1055-1060 ◽  
Author(s):  
Rafael Marques da Silva ◽  
Dominique A. Caugant ◽  
Emenike R.K. Eribe ◽  
Jørn A. Aas ◽  
Per S. Lingaas ◽  
...  
Keyword(s):  
Bacterial Diversity ◽  
Ribosomal Rna ◽  
Aortic Aneurysms ◽  
16S Ribosomal Rna ◽  
Gene Analysis ◽  
Ribosomal Rna Gene ◽  
16S Ribosomal Rna Gene
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