scholarly journals Paraoxonase in women with hypertension of different reproductive age. Relationship with cardio-metabolic risk factors

2021 ◽  
Vol 25 (2) ◽  
pp. 252-257
Author(s):  
L. O. Pentiuk ◽  
N. O. Pentiuk
Keyword(s):  
Risk Factors ◽  
Blood Vessels ◽  
Left Ventricular ◽  
Metabolic Risk Factors ◽  
Reproductive Age ◽  
Metabolic Risk ◽  
Paraoxonase Activity ◽  
Healthy Women ◽  
The Mean ◽  
Serum Paraoxonase

Annotation. Paraoxonase is a high-density lipoprotein-associated pleiotropic enzyme able to detoxify proatherogenic compounds such as oxi-low-density-lipoproteins and homocysteine-thiolactone. Low paraoxonase activity is likely to be involved in the development of cardiovascular diseases. The aim of the study – to investigate the relationship between paraoxonase activity, structural and functional markers of the heart and blood vessels, cardio-metabolic risk factors in women with hypertension of different reproductive age. The study included 193 women aged 32-70 years (55.4±0.68 years) with essential stage II hypertension. The control group consisted of 46 healthy women. The arylesterase activity of paraoxonase (EC 3.1.1.2) in blood serum was determined by spectrophotometric method. Statistical processing of the obtained results was performed in the application package SPSS22 (© SPSS Inc.). The mean and standard error of the mean (M ± m) were calculated. Student's t-test was used. Pearson correlation analysis was performed at p <0.05. It was found that in women with hypertension there was a significant decrease (16%) in serum paraoxonase activity, compared with healthy women. Low paraoxonase activity was registered in 33.3% of premenopausal patients and 56.7% of postmenopausal patients (p˂0.05) and was associated with serum estradiol levels (r=0.33, 0.41, p<0.05). Low paraoxonase activity was associated with aberrant levels of lipids, homocysteine, obesity, metabolic syndrome, increased left ventricular mass index and carotid intima-media thickness, decreased brachial artery endothelium-dependent vasodilation. Thus, the decrease in serum paraoxonase activity in women with hypertension is related with the reproductive age of patients and the development of unfavorable metabolic, structural and functional changes in the heart and blood vessels.

Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN study

2002 ◽  
Vol 20 (2) ◽  
pp. 323-331 ◽  
Author(s):  
Giovanni de Simone ◽  
Vittorio Palmieri ◽  
Jonathan N. Bella ◽  
Aldo Celentano ◽  
Yuling Hong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Metabolic Risk Factors ◽  
Metabolic Risk

Determinants of left ventricular mass and presence of metabolic risk factors in normotensive individuals

2009 ◽  
Vol 135 (3) ◽  
pp. 323-330 ◽  
Author(s):  
Sérgio Lamêgo Rodrigues ◽  
Lílian C.S. Ângelo ◽  
Alexandre C. Pereira ◽  
José Eduardo Krieger ◽  
José Geraldo Mill
Keyword(s):  
Risk Factors ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Ventricular Mass

scholarly journals Relationships Among HIV Infection, Metabolic Risk Factors, and Left Ventricular Structure and Function

2013 ◽  
Vol 29 (8) ◽  
pp. 1151-1160 ◽  
Author(s):  
William Todd Cade ◽  
Edgar Turner Overton ◽  
Kristin Mondy ◽  
Lisa de las Fuentes ◽  
Victor G. Davila-Roman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Left Ventricular ◽  
Structure And Function ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Left Ventricular Structure ◽  
Ventricular Structure ◽  
And Function

Cluster analysis of cardiovascular and metabolic risk factors in women of reproductive age

2014 ◽  
Vol 101 (5) ◽  
pp. 1404-1410.e1 ◽  
Author(s):  
Chii-Ruey Tzeng ◽  
Yuan-chin Ivan Chang ◽  
Yu-chia Chang ◽  
Chia-Woei Wang ◽  
Chi-Huang Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cluster Analysis ◽  
Metabolic Risk Factors ◽  
Reproductive Age ◽  
Metabolic Risk ◽  
Women Of Reproductive Age

Abstract 16636: Cardiac Microstructural Associations With Metabolic Syndrome Differ by Sex

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Gerran Salto ◽  
Alan C Kwan ◽  
Ewa Osypiuk ◽  
Plamen Stantchev ◽  
Elizabeth H Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiac Disease ◽  
Tissue Level ◽  
Left Ventricular ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Metabolic Syndrome ◽  
Tissue Alteration ◽  
Myocardial Fibers

Background: Alterations in the orientation and integrity of myocardial fibers can be assessed using ultrasonic image analysis. The ability to detect such microstructural abnormalities may shed light on sex differences in the progression from metabolic risk factors to overt cardiac disease. Methods: In a community-based cohort of N=2510 adults (age 66±9 years, 56% women) without overt cardiovascular disease, we evaluated whether a novel echocardiography-based assessment of left ventricular myocardial microstructure, the signal intensity coefficient (SIC), could detect tissue-level alterations that are associated with metabolic risk factors, such as body mass index (BMI) and the metabolic syndrome. Results: In multivariable models adjusting for age and BMI, women had a significantly greater degree of cardiac microstructural alteration (coeff 0.15; s.e. 0.06, P=0.007) in the presence of metabolic syndrome, whereas this association was only borderline significant in men (coeff 0.11; s.e. 0.06, P=0.07) ( Figure ). Notably, there was no sex-specificity in the associations of either age or BMI with cardiac microstructure. Conclusion: A novel index of myocardial tissue alteration is significantly associated with presence of metabolic syndrome, even after adjusting for body size, and more prominently in women than in men. Further research is needed to examine the extent to which cardiac microstructural abnormalities may mediate the metabolic risks for cardiac disease, particularly in women.

scholarly journals Ten-year risk of fatal cardiovascular disease and its association with metabolic risk factors among waste pickers in South Africa

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Felix Made ◽  
Engelbert A. Nonterah ◽  
Nonhlanhla Tlotleng ◽  
Vusi Ntlebi ◽  
Nisha Naicker
Keyword(s):  
Risk Factors ◽  
South Africa ◽  
Cardiovascular Disease ◽  
Regression Model ◽  
Ordinary Least Squares ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Informal Workers ◽  
The Mean ◽  
Waste Pickers

Abstract Background Cardiovascular disease (CVD) is the leading cause of death among non-communicable diseases in South Africa. Several metabolic risk factors contribute to the development of CVD. Informal workers such as waste pickers could be unhealthy lifestyle naive, and most public health research on CVD does not include this understudied population. This study estimated the 10-year risk of fatal CVD and its association with metabolic risk factors in an understudied study population of waste pickers in Johannesburg, South Africa. Methods A cross-sectional survey was conducted among waste pickers in two landfill sites in Johannesburg. We used the Systematic Coronary Risk Evaluation (SCORE) risk charts to estimate the 10-year risk of fatal CVD. We then employed ordinary least squares regression to assess the association between the 10-year risk of fatal CVD with metabolic risk factors. Other variables adjusted in the regression model were HIV status, education, income, injuries from work, clinic visits in the previous 12 months, and alcohol consumption. Results A total of 370 waste pickers were included in this analysis, 265 (73.41%) were males. The mean age of the participants was 34 years. The majority were between the age of 20 and 39 years. More than 55% of the waste pickers did not visit a clinic in the previous 12 months, and 68.57% were smoking. The 10-year survival probability from CVD was more than 99% for both males and females. In the multivariable regression model, elevated blood glucose showed a non-significant increase in the mean percentage of 10-year risk of fatal CVD. Waste pickers who were overweight/obese, and hypertensive had high statistically significant mean percentages of the 10-year risk of fatal CVD compared to those who did not have the metabolic risk factors. Conclusions Prevention of 10-year risk of fatal CVD in this understudied population of waste pickers should target the control of obesity, hypertension, and diabetes. Health awareness and education for waste pickers will be an important step in reducing the burden of these metabolic risk factors. We further recommend that health systems should recognize waste pickers as a high-risk group and consider extensive CVDs surveillance.

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